Publications by authors named "Peng Lin"

891 Publications

Various Nodal Lines in P6/mmc-type TiTe Topological Metal and its (001) Surface State.

Front Chem 2021 28;9:755350. Epub 2021 Sep 28.

Engineering and Technology Center, The Fourth Medical College of Harbin Medical University, Harbin, China.

Searching for existing topological materials is a hot topic in quantum and computational chemistry. This study uncovers P6/mmc type TiTe compound-an existing material-is a newly discovered topological metal that hosts the various type of nodal line states. Different nodal line states normally exhibit different properties; they may have their individual applications. We report that TiTe hosts I, II, and hybrid type nodal line (NL) states at its ground state without chemical doping and strain engineering effects. Specifically, two type I NLs, two hybrid-type NLs, and one Γ-centered type II NL can be found in the k = 0 plane. Moreover, the spin-orbit coupling induced gaps for these NLs are very small and within acceptable limits. The surface states of the TiTe (001) plane were determined to provide strong evidence for the appearance of the three types of NLs in TiTe. We also provide a reference for the data of the dynamic and mechanical properties of TiTe. We expect that the proposed NL states in TiTe can be obtained in future experiments.
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http://dx.doi.org/10.3389/fchem.2021.755350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510513PMC
September 2021

Conditional dependence of enzyme cascade reaction efficiency on the inter-enzyme distance.

Chem Commun (Camb) 2021 Oct 8. Epub 2021 Oct 8.

Institute of Advanced Energy, Kyoto University, Uji, Kyoto 611-0011, Japan.

A dual-enzyme cascade, xylitol dehydrogenase and xylulose kinase, derived from the xylose metabolic pathway, was constructed on a three-dimensional DNA scaffold which exhibited a dynamic shape transition from an open state to a closed hexagonal prism. Evaluation of the cascade reaction efficiencies in the open and closed states revealed little to no inter-enzyme distance dependence, presumably due to the far larger catalytic constant of the downstream enzyme. The inter-enzyme distance was not the dominant factor for cascade efficiency when the kinetic parameters of the cascade enzymes were imbalanced with the highly efficient downstream enzyme.
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http://dx.doi.org/10.1039/d1cc04162bDOI Listing
October 2021

Clinical Features and Serological Markers Risk Model Predicts Overall Survival in Patients Undergoing Breast Cancer and Bone Metastasis Surgeries.

Front Oncol 2021 17;11:693689. Epub 2021 Sep 17.

Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: Surgical therapy of breast cancer and bone metastasis can effectively improve the prognosis of breast cancer. However, after the first operation, the relationship between preoperative indicators and outcomes in patients who underwent metastatic bone surgery remained to be studied. Purpose 1. Recognize clinical and laboratory prognosis factors available to clinical doctors before the operation for bone metastatic breast cancer patients. 2. Develop a risk prediction model for 3-year postoperative survival in patients with breast cancer bone metastasis.

Methods: From 2014 to 2020, patients who suffered from breast cancer bone metastasis and received therapeutic procedures in our institution were included for analyses (n=145). For patients who underwent both breast cancer radical surgery and bone metastasis surgery, comprehensive datasets of the parameters of interest (clinical features, laboratory factors, and patient prognoses) were collected (n=69). We performed Multivariate Cox regression to identify factors that were associated with postoperative outcome. 3-year survival prediction model and nomograms were established by 100 bootstrapping. Its benefit was evaluated by calibration plot, C-index, and decision curve analysis. The Surveillance, Epidemiology, and End Results database was also used for external validation.

Results: Radiotherapy for primary cancer, pathological type of metastatic breast cancer, lymph node metastasis, elevated serum alkaline phosphatase, lactate dehydrogenase were associated with postoperative prognosis. Pathological types of metastatic breast cancer, multiple bone metastasis, organ metastases, and elevated serum lactate dehydrogenase were associated with 3-year survival. Then those significant variables and serum alkaline phosphatase counts were integrated to construct nomograms for 3-year survival. The C-statistic of the established predictive model was 0.83. The calibration plot presents a graphical representation of calibration. In the decision curve analysis, the benefits are higher than those of the extreme curve. The receiver operating characteristic of the external validation of the model was 0.82, indicating a favored fitting degree of the two models.

Conclusion: Our study suggests that several clinical features and serological markers can predict the overall survival among the patients who are about to receive bone metastasis surgery after breast cancer surgery. The model can guide the preoperative evaluation and clinical decision-making for patients. Level of evidence Level III, prognostic study.
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http://dx.doi.org/10.3389/fonc.2021.693689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484887PMC
September 2021

A novel battery separator coated by a europium oxide/carbon nanocomposite enhances the performance of lithium sulfur batteries.

Nanoscale 2021 Oct 14;13(39):16696-16704. Epub 2021 Oct 14.

School of Chemistry, South China Normal University, Guangzhou, 510006, China.

Lithium sulfur (Li-S) batteries represent one of the most promising future power batteries due to their remarkable advantages of low cost and ultrahigh theoretical energy density. However, the commercial applications of Li-S batteries have long been plagued by the shuttling effect of polysulfides and sluggish redox kinetics of these species. Herein, we designed a novel battery separator coated by a europium oxide-doped porous Ketjen Black (EuO/KB) and tested its performance for the Li-S batteries for the first time. Experimental results and theoretical calculations reveal that the improved electrochemical performance can be attributed to the presence of EuO. The strong binding effect between EuO and polysulfides is demonstrated in two aspects: (1) there exist strong interactions between EuO as a Lewis acid and polysulfides of strong Lewis basicity; (2) EuO with oxygen-vacancy defects provides active sites for catalyzing polysulfide conversion and polysulfide trapping. Thus, a Li-S battery with the EuO/KB modified separator delivers highly stable cycling performance and excellent rate capability, with the capacity decay ratio of merely 0.05% per cycle under 1 C rate during 500 cycles, and high specific capacity of 563 mAh g at 3 C rate. This work offers a meaningful exploration of the application of rare earth oxides for the modification of the separator towards high performance Li-S batteries.
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http://dx.doi.org/10.1039/d1nr04855dDOI Listing
October 2021

Trimethylamine N-oxide-a marker for atherosclerotic vascular disease.

Rev Cardiovasc Med 2021 Sep;22(3):787-797

Department of Cardiology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, 300120 Tianjin, China.

As a potential causative factor in various cardiovascular diseases, the gut microbe-generated metabolite trimethylamine N-oxide (TMAO) has courted considerable research interest as a potential biomarker. TMAO is a small molecule considered to be beneficial for the health of deep-water animals due to its ability to protect proteins against hydrostatic pressure stress. However, it may cause deleterious effects in humans as mounting evidence suggests that TMAO may enhance atherosclerosis, independent of traditional risk factors. This may be mediated by its capacity to enhance inflammation, platelet activation and thrombosis, and inhibit reverse cholesterol transport. In humans, circulating levels of TMAO have been found to be associated with increased risk of developing atherosclerotic diseases such as carotid atherosclerosis, coronary atherosclerotic heart disease, stroke, and peripheral arteriosclerosis. This review aims to discuss the current role of TMAO in the atherosclerosis process, using animal models and clinical studies, with special attention to determining whether TMAO could be used as a marker for monitoring severity and prognosis in atherosclerosis and to evaluate evidence for its role as a mediator in the pathogenesis of atherosclerotic vascular disease.
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http://dx.doi.org/10.31083/j.rcm2203085DOI Listing
September 2021

CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma.

Signal Transduct Target Ther 2021 09 25;6(1):347. Epub 2021 Sep 25.

National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.

SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape, compromising the effectiveness of existing vaccines and neutralizing antibodies. An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants. Here, we identified CD147 as a universal receptor for SARS-CoV-2 and its variants. Meanwhile, Meplazeumab, a humanized anti-CD147 antibody, could block cellular entry of SARS-CoV-2 and its variants-alpha, beta, gamma, and delta, with inhibition rates of 68.7, 75.7, 52.1, 52.1, and 62.3% at 60 μg/ml, respectively. Furthermore, humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants, alpha and beta. When infected, these mice developed exudative alveolar pneumonia, featured by immune responses involving alveoli-infiltrated macrophages, neutrophils, and lymphocytes and activation of IL-17 signaling pathway. Mechanistically, we proposed that severe COVID-19-related cytokine storm is induced by a "spike protein-CD147-CyPA signaling axis": Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway, which further induced expression of cyclophilin A (CyPA); CyPA reciprocally bound to CD147 and triggered MAPK pathway. Consequently, the MAPK pathway regulated the expression of cytokines and chemokines, which promoted the development of cytokine storm. Importantly, Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants. Therefore, our findings provided a new perspective for severe COVID-19-related pathogenesis. Furthermore, the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment.
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http://dx.doi.org/10.1038/s41392-021-00760-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464593PMC
September 2021

Coherent Raman scattering imaging with a near-infrared achromatic metalens.

APL Photonics 2021 Sep 14;6(9):096107. Epub 2021 Sep 14.

John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.

Miniature handheld imaging devices and endoscopes based on coherent Raman scattering are promising for label-free optical diagnosis. Toward the development of these small-scale systems, a challenge arises from the design and fabrication of achromatic and high-end miniature optical components for both pump and Stokes laser wavelengths. Here, we report a metasurface converting a low-cost plano-convex lens into a water-immersion, nearly diffraction-limited and achromatic lens. The metasurface comprising amorphous silicon nanopillars is designed in a way that all incident rays arrive at the focus with the same phase and group delay, leading to corrections of monochromatic and chromatic aberrations of the refractive lens, respectively. Compared to the case without the metasurface, the hybrid metasurface-refractive lens has higher Strehl ratios than the plano-convex lens and a tighter depth of focus. The hybrid metasurface-refractive lens is utilized in spectroscopic stimulated Raman scattering and coherent anti-Stokes Raman scattering imaging for the differentiation of two different polymer microbeads. Subsequently, the hybrid metalens is harnessed for volumetric coherent Raman scattering imaging of bead and tissue samples. Finally, we discuss possible approaches to integrate such hybrid metalens in a miniature scanning system for label-free coherent Raman scattering endoscopes.
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http://dx.doi.org/10.1063/5.0059874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442248PMC
September 2021

Computational discovery of PtS/GaSe van der Waals heterostructure for solar energy applications.

Phys Chem Chem Phys 2021 Sep 22;23(36):20163-20173. Epub 2021 Sep 22.

School of Materials Science and Engineering, and Center for Integrated Computational Materials Science, International Research Institute for Multidisciplinary Science, Beihang University, Beijing 100191, P. R. China.

2D van der Waals (vdW) heterostructures as potential materials for solar energy-related applications have been brought to the forefront for researchers. Here, by employing first-principles calculations, we proposed that the PtS/GaSe vdW heterostructure is a distinguished candidate for photocatalytic water splitting and solar cells. It is shown that the PtS/GaSe heterostructure exhibits high thermal stability with an indirect band gap of 1.81 eV. We further highlighted the strain induced type-V to type-II band alignment transitions and band gap variations in PtS/GaSe heterostructures. More importantly, the outstanding absorption coefficients in the visible light region and high carrier mobility further guarantee the photo energy conversion efficiency of PtS/GaSe heterostructures. Interestingly, the natural type-V band alignments of PtS/GaSe heterostructures are appropriate for the redox potential of water. On the other hand, the power conversion efficiency of ZnO/(PtS/GaSe heterostructure)/CIGS (copper indium gallium diselenide) solar cells can achieve ∼17.4%, which can be further optimized up to ∼18.5% by increasing the CIGS thickness. Our present study paves the way for facilitating the potential application of vdW heterostructures as a promising photocatalyst for water splitting as well as the buffer layer for solar cells.
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http://dx.doi.org/10.1039/d1cp02436aDOI Listing
September 2021

Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer.

Nat Commun 2021 09 14;12(1):5431. Epub 2021 Sep 14.

Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

Small cell lung cancer (SCLC) is a highly malignant tumor which is eventually refractory to any treatment. Intratumoral heterogeneity (ITH) may contribute to treatment failure. However, the extent of ITH in SCLC is still largely unknown. Here, we subject 120 tumor samples from 40 stage I-III SCLC patients to multi-regional whole-exome sequencing. The most common mutant genes are TP53 (88%) and RB1 (72%). We observe a medium level of mutational heterogeneity (0.30, range 0.0~0.98) and tumor mutational burden (TMB, 10.2 mutations/Mb, range 1.1~51.7). Our SCLC samples also exhibit somatic copy number variation (CNV) across all patients, with an average CNV ITH of 0.49 (range 0.02~0.99). In terms of mutation distribution, ITH, TMB, mutation clusters, and gene signatures, patients with combined SCLC behave roughly the same way as patients with pure SCLC. This condition also exists in smoking patients and patients with EGFR mutations. A higher TMB per cluster is associated with better disease-free survival while single-nucleotide variant ITH is linked to worse overall survival, and therefore these features may be used as prognostic biomarkers for SCLC. Together, these findings demonstrate the intratumoral genetic heterogeneity of surgically resected SCLC and provide insights into resistance to treatment.
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http://dx.doi.org/10.1038/s41467-021-25787-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440529PMC
September 2021

Role of ammonia in secondary inorganic aerosols formation at an ammonia-rich city in winter in north China: A comparative study among industry, urban, and rural sites.

Environ Pollut 2021 Sep 9;291:118151. Epub 2021 Sep 9.

Key Laboratory of Resources and Environmental Systems Optimization, Ministry of Education, College of Environmental Science and Engineering, North China Electric Power University, Beijing, 102206, China.

Ammonia is essential for the generation of secondary inorganic aerosols (SIA) in particulate matter, which affects severely the air quality in north China. In this study, PM sampling was conducted as well as gaseous pollutant concentration and meteorological parameters were measured from November 2017 to January 2018. PM concentration was highest in the industrial site (94.8 ± 41.7 μg m), followed by urban (40.9 ± 24.1 μg m) and rural (35.6 ± 20.3 μg m) sites. The mass ratio of NO/SO exhibited clear site variations, with the highest average value of 1.2 was found at the urban site, likely due to the dense traffic volume resulting in higher emissions of NO, and the lowest value of 0.9 at the industry site. The presence of Excess-NHx (E-NHx), raising the pH 24 by 1.4, 1.3, and 1.4 units in industry, urban, and rural sites, respectively, might be vital for raising the aerosol pH. Correlation coefficients of Nitrogen oxidation rate (NOR, NOR = [NO]/[NO] + [NO]) vs. Photochemical oxidants (O, NO +O in our study) and NOR vs. aerosol water content (AWC) at three sites were implied that both homogeneous and heterogeneous reactions occurred for nitrate formation in industry site, while heterogeneous reactions were dominant in urban and rural sites. Oxidation rates were most sensitive to the variation of E-NHx concentration at rural site, followed by the urban and industry sites, which was shown by the fact that the increase in E-NHx concentration by 1.0 μg m increased the SIA concentration by 1.21, 1.02, and 0.37 μg m at rural, urban, and industry sites, respectively. With the increase in NH emissions at present, the role of NH in SIA formation at ammonia-rich atmosphere requires more attention, especially in the less-noticed rural areas.
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http://dx.doi.org/10.1016/j.envpol.2021.118151DOI Listing
September 2021

Prostaglandin E2 Receptor 4 (EP4) Affects Trophoblast Functions via Activating the cAMP-PKA-pCREB Signaling Pathway at the Maternal-Fetal Interface in Unexplained Recurrent Miscarriage.

Int J Mol Sci 2021 Aug 24;22(17). Epub 2021 Aug 24.

Center of Gynecological Endocrinology and Reproductive Medicine, Department of Gynecology and Obstetrics, Ludwig-Maximilians University of Munich, Marchioninistr. 15, 81377 Munich, Germany.

Implantation consists of a complex process based on coordinated crosstalk between the endometrium and trophoblast. Furthermore, it is known that the microenvironment of this fetal-maternal interface plays an important role in the development of extravillous trophoblast cells. This is mainly due to the fact that tissues mediate embryonic signaling biologicals, among other molecules, prostaglandins. Prostaglandins influence tissue through several cell processes including differentiation, proliferation, and promotion of maternal immune tolerance. The aim of this study is to investigate the potential pathological mechanism of the prostaglandin E2 receptor 4 (EP4) in modulating extravillous trophoblast cells (EVTs) in unexplained recurrent marriage (uRM). Our results indicated that the expression of EP4 in EVTs was decreased in women experiencing uRM. Furthermore, silencing of EP4 showed an inhibition of the proliferation and induced apoptosis in vitro. In addition, our results demonstrated reductions in β- human chorionic gonadotropin (hCG), progesterone, and interleukin (IL)-6, which is likely a result from the activation of the cyclic adenosine monophosphate (cAMP)- cAMP-dependent protein kinase A (PKA)-phosphorylating CREB (pCREB) pathway. Our data might provide insight into the mechanisms of EP4 linked to trophoblast function. These findings help build a more comprehensive understanding of the effects of EP4 on the trophoblast at the fetal-maternal interface in the first trimester of pregnancy.
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http://dx.doi.org/10.3390/ijms22179134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430623PMC
August 2021

A Review of Parallel Implementations for the Smith-Waterman Algorithm.

Interdiscip Sci 2021 Sep 6. Epub 2021 Sep 6.

School of Computer, National University of Defense Technology, Changsha, 410073, China.

The rapid advances in sequencing technology have led to an explosion of sequence data. Sequence alignment is the central and fundamental problem in many sequence analysis procedure, while local alignment is often the kernel of these algorithms. Usually, Smith-Waterman algorithm is used to find the best subsequence match between given sequences. However, the high time complexity makes the algorithm time-consuming. A lot of approaches have been developed to accelerate and parallelize it, such as vector-level parallelization, thread-level parallelization, process-level parallelization, and heterogeneous acceleration, but the current researches seem unsystematic, which hinders the further research of parallelizing the algorithm. In this paper, we summarize the current research status of parallel local alignments and describe the data layout in these work. Based on the research status, we emphasize large-scale genomic comparisons. By surveying some typical alignment tools' performance, we discuss some possible directions in the future. We hope our work will provide the developers of the alignment tool with technical principle support, and help researchers choose proper alignment tools.
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http://dx.doi.org/10.1007/s12539-021-00473-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419822PMC
September 2021

The use of a novel deer antler decellularized cartilage-derived matrix scaffold for repair of osteochondral defects.

J Biol Eng 2021 Sep 3;15(1):23. Epub 2021 Sep 3.

School of Life Science, Taizhou University, 1139 Shifu Avenue, Jiaojiang District, Zhejiang, 318000, Taizhou, China.

Background: The physiologic regenerative capacity of cartilage is severely limited. Current studies on the repair of osteochondral defects (OCDs) have mainly focused on the regeneration of cartilage tissues. The antler cartilage is a unique regenerative cartilage that has the potential for cartilage repair.

Methods: Antler decellularized cartilage-derived matrix scaffolds (adCDMs) were prepared by combining freezing-thawing and enzymatic degradation. Their DNA, glycosaminoglycans (GAGs), and collagen content were then detected. Biosafety and biocompatibility were evaluated by pyrogen detection, hemolysis analysis, cytotoxicity evaluation, and subcutaneous implantation experiments. adCDMs were implanted into rabbit articular cartilage defects for 2 months to evaluate their therapeutic effects.

Results: AdCDMs were observed to be rich in collagen and GAGs and devoid of cells. AdCDMs were also determined to have good biosafety and biocompatibility. Both four- and eight-week treatments of OCDs showed a flat and smooth surface of the healing cartilage at the adCDMs filled site. The international cartilage repair society scores (ICRS) of adCDMs were significantly higher than those of controls (porcine dCDMs and normal saline) (p < 0.05). The repaired tissue in the adCDM group was fibrotic with high collagen, specifically, type II collagen.

Conclusions: We concluded that adCDMs could achieve excellent cartilage regeneration repair in a rabbit knee OCDs model. Our study stresses the importance and benefits of adCDMs in bone formation and overall anatomical reconstitution, and it provides a novel source for developing cartilage-regenerating repair materials.
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http://dx.doi.org/10.1186/s13036-021-00274-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414868PMC
September 2021

Prediction of Genetic Alterations in Oncogenic Signaling Pathways in Squamous Cell Carcinoma of the Head and Neck: Radiogenomic Analysis Based on Computed Tomography Images.

J Comput Assist Tomogr 2021 Aug 31. Epub 2021 Aug 31.

From the Department of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning GE Healthcare, Shanghai, China.

Objective: This study investigated the role of radiomics in evaluating the alterations of oncogenic signaling pathways in head and neck cancer.

Methods: Radiomics features were extracted from 106 enhanced computed tomography images with head and neck squamous cell carcinoma. Support vector machine-recursive feature elimination was used for feature selection. Support vector machine algorithm was used to develop radiomics scores to predict genetic alterations in oncogenic signaling pathways. The performance was evaluated by the area under the curve (AUC) of the receiver operating characteristic curve.

Results: The alterations of the Cell Cycle, HIPPO, NOTCH, PI3K, RTK RAS, and TP53 signaling pathways were predicted by radiomics scores. The AUC values of the training cohort were 0.94, 0.91, 0.94, 0.93, 0.87, and 0.93, respectively. The AUC values of the validation cohort were all greater than 0.7.

Conclusions: Radiogenomics is a new method for noninvasive acquisition of tumor molecular information at the genetic level.
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http://dx.doi.org/10.1097/RCT.0000000000001213DOI Listing
August 2021

DNA Damage Repair Profiles Alteration Characterize a Hepatocellular Carcinoma Subtype With Unique Molecular and Clinicopathologic Features.

Front Immunol 2021 12;12:715460. Epub 2021 Aug 12.

Department of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Hepatocellular carcinoma (HCC) is one of the most common malignancies and displays high heterogeneity of molecular phenotypes. We investigated DNA damage repair (DDR) alterations in HCC by integrating multi-omics data. HCC patients were classified into two heterogeneous subtypes with distinct clinical and molecular features: the DDR-activated subtype and the DDR-suppressed subtype. The DDR-activated subgroup is characterized by inferior prognosis and clinicopathological features that result in aggressive clinical behavior. Tumors of the DDR-suppressed class, which have distinct clinical and molecular characteristics, tend to have superior survival. A DDR subtype signature was ultimately generated to enable HCC DDR classification, and the results were confirmed by using multi-layer date cohorts. Furthermore, immune profiles and immunotherapy responses are also different between the two DDR subtypes. Altogether, this study illustrates the DDR heterogeneity of HCCs and is helpful to the understanding of personalized clinicopathological and molecular mechanisms responsible for unique tumor DDR profiles.
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http://dx.doi.org/10.3389/fimmu.2021.715460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387599PMC
August 2021

Comparison of Histone H3K4me3 between IVF and ICSI Technologies and between Boy and Girl Offspring.

Int J Mol Sci 2021 Aug 9;22(16). Epub 2021 Aug 9.

Department of Obstetrics and Gynecology, University Hospital, LMU Munich, 80337 Munich, Germany.

Epigenetics play a vital role in early embryo development. Offspring conceived via assisted reproductive technologies (ARTs) have a three times higher risk of epigenetic diseases than naturally conceived children. However, investigations into ART-associated placental histone modifications or sex-stratified analyses of ART-associated histone modifications remain limited. In the current study, we carried out immunohistochemistry, chip-sequence analysis, and a series of in vitro experiments. Our results demonstrated that placentas from intra-cytoplasmic sperm injection (ICSI), but not in vitro fertilization (IVF), showed global tri-methylated-histone-H3-lysine-4 (H3K4me3) alteration compared to those from natural conception. However, for acetylated-histone-H3-lysine-9 (H3K9ac) and acetylated-histone-H3-lysine-27 (H3K27ac), no significant differences between groups could be found. Further, sex -stratified analysis found that, compared with the same-gender newborn cord blood mononuclear cell (CBMC) from natural conceptions, CBMC from ICSI-boys presented more genes with differentially enriched H3K4me3 ( = 198) than those from ICSI-girls ( = 79), IVF-girls ( = 5), and IVF-boys ( = 2). We also found that varying oxygen conditions, RNA polymerase II subunit A (Polr2A), and lysine demethylase 5A (KDM5A) regulated H3K4me3. These findings revealed a difference between IVF and ICSI and a difference between boys and girls in H3K4me3 modification, providing greater insight into ART-associated epigenetic alteration.
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http://dx.doi.org/10.3390/ijms22168574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395251PMC
August 2021

Fresh Tissue Multi-omics Profiling Reveals Immune Classification and Suggests Immunotherapy Candidates for Conventional Chondrosarcoma.

Clin Cancer Res 2021 Aug 23. Epub 2021 Aug 23.

Department of Orthopedics, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Purpose: There is still no standard nonsurgical regimen for conventional chondrosarcoma (CHS). We aimed to identify whether any CHSs have a favored microenvironment for immunotherapy via multidimensional evaluation of the immunologic characteristics of this tumor.

Experimental Design: We obtained 98 newly-diagnosed CHS fresh tumors from several institutions and performed comprehensive analysis of data from CyTOF, whole-exome sequencing, and flow cytometry in 22 cases. Clinical data from immunotherapy responders and nonresponders were compared to explore possible biomarkers of immunotherapy response. Mechanism studies were conducted to interpret the biomarker phenotype.

Results: Based on the integrated data of single-cell CyTOF and flow cytometry, the CHS immune-microenvironment phenotypes were classified into three groups: subtype I, the "granulocytic-myeloid-derived suppressor cell (G-MDSC) dominant" cluster, with high number of HLA-DR CD14 myeloid cells; subtype II, the "immune exhausted" cluster, with high exhausted T-cell and dendritic-cell infiltration; and subtype III, the "immune desert" cluster, with few immune cells. Immune cell-rich subtypes (subtype I and II) were characterized by mutation, pathologic high grade, and peritumoral edema, while subtype I cases were exclusively featured by myxoid transformation. In clinical practice involving 12 individuals who received PD-1 antibody immunotherapy, all of the 3 cases with controlled diseases were retrospectively classified as subtype II. In mechanism, mutation significantly elevated chemokine levels and immune-cell infiltration in immune-inactivated tumors.

Conclusions: This study is the first to provide immune characterization of CHS, representing a major step to precise immunotherapy against this malignancy. Immunotherapy is promising for the "immune exhausted" subtype of patients with CHS.
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http://dx.doi.org/10.1158/1078-0432.CCR-21-1893DOI Listing
August 2021

Chitosan modified squalene nanostructured lipid carriers as a promising adjuvant for freeze-dried ovalbumin vaccine.

Int J Biol Macromol 2021 Oct 16;188:855-862. Epub 2021 Aug 16.

Engineering Center of Innovative Veterinary Drugs, Center for Veterinary Drug Research and Evaluation, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, China; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, China. Electronic address:

As immune adjuvants assisting vaccines, nanoparticle delivery systems have been widely exploited. Squalene, the major ingredient of approved adjuvant MF59, has great potential in activating immune responses. In the current study, model antigen ovalbumin (OVA) was encapsulated into squalene-based nanostructured lipid carriers (NLCs), and the chitosan, a cationic polysaccharide, was used for modifying nanoparticles to develop a functionalized and cationic nanoparticle delivery system (OVA-csNLCs). Firstly, the optimal formulation of csNLCs was successfully screened out, and had hydrodynamic diameter of 235.80 ± 5.99 nm and zeta potential of 34.90 ± 6.95 mV. Then, the generated OVA-csNLCs had no significant difference in hydrodynamic diameter and exhibited lower zeta potential of 19.03 ± 0.31 mV and high encapsulation efficiency of 83.4%. Sucrose (10%, w/w) was selected as optimal lyoprotectant, exhibiting good stability of OVA-csNLCs in the form of freeze-dried powder. More importantly, the OVA-csNLCs effectively promoted OVA antigen uptake by macrophage, significantly enhanced the level of OVA-specific IgG, and induced a Th2-based immune response in vivo. Furthermore, mice immunization experiment demonstrated that OVA-csNLCs had well biocompatibility and facilitated spleen lymphocytes proliferation. Above findings indicate that chitosan modified squalene nanostructured lipid carriers show promise as antigen delivery system and an open adjuvant platform.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.08.074DOI Listing
October 2021

Blue-Violet Emission with Near-Unity Photoluminescence Quantum Yield from Cu(I)-Doped RbInCl Single Crystals.

J Phys Chem Lett 2021 Aug 13;12(33):7928-7934. Epub 2021 Aug 13.

State Key Laboratory of Advanced Optical Communication Systems and Networks, School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.

Low-dimensional metal halides have attracted considerable attention due to their unique optoelectronic properties. In this study, we report a solid-state synthesis of air-stable all-inorganic Pb-free zero-dimensional (0D) RbInCl single crystals (SCs). By a heterovalent doping of Cu ions, the RbInCl:Cu SCs featured an efficient blue-violet emission with a greatly enhanced photoluminescence (PL) quantum yield (95%) and an ultralong PL lifetime (13.95 μs). Combined with temperature-dependent PL and density functional theory calculations, we conclude that the efficient electronic isolation, enhanced exciton-phonon coupling, and electronic structure modulation after doping lead to bright blue-violet emission. Furthermore, the SCs exhibited excellent stability, maintaining 90% of the initial PL intensity after being stored in ambient conditions for more than two months. The results provide a new strategy for improving the optoelectronic properties of 0D all-inorganic metal halides, which is promising for potential light-emitting applications.
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http://dx.doi.org/10.1021/acs.jpclett.1c01751DOI Listing
August 2021

The effect of health literacy on health status among residents in Qingdao, China: a path analysis.

Environ Health Prev Med 2021 Aug 12;26(1):78. Epub 2021 Aug 12.

Qingdao Municipal Center for Disease Control and Prevention, Qingdao, Shandong, China.

Background: Health literacy is a public health goal which can be used as an independent factor of health outcomes. This study aimed to assess the association between health literacy and health status, as well as the two mediating factors of behavior and self-efficacy among residents aged 15-69 years in Qingdao.

Methods: A cross-sectional survey was implemented among residents aged 15-69 years (N = 3793) in Qingdao, China. A combination of stratified cluster random and proportional probability sampling methods was used to select subjects for this study. Data were collected using "The Chinese Citizen Health Literacy Questionnaire (2019)". We proposed a hypothetical model for the relationship between sociodemographic characteristics, health literacy, self-efficacy, health behavior, and health status, and used path analysis to validate the hypothesis.

Results: The path analysis showed that higher education (β = 0.293) and income (β = 0.135) are positively and directly associated with greater health literacy, which was positively associated with health status (β = 0.057). Health literacy is a direct influencing factor of health behavior (β = 0.070) and self-efficacy (β = 0.099). Health behavior (β = 0.041) and self-efficacy (β = 0.173) exerted a positive direct effect on health status. The model explained 14.1% of variance for health literacy, 3.8% for self-efficacy, 5.7% for health behavior, and 15.0% for health status.

Conclusions: Health literacy was identified to be a critical factor in health status. The results emphasized that the dissemination of health knowledge, development of healthy behavior, and cultivation of self-efficacy should be jointly promoted to reinforce the level of health status among residents in future work.
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http://dx.doi.org/10.1186/s12199-021-01001-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361851PMC
August 2021

Numerical study on the influence of wall temperature gradient on aerodynamic characteristics of low aspect ratio flying wing configuration.

Sci Rep 2021 Aug 11;11(1):16295. Epub 2021 Aug 11.

China Aerodynamics Research and Development Center, High Speed Aerodynamic Institute, Mianyang, 621000, China.

With the aim for a low-aspect-ratio flying wing configuration, this study explores the influence of wall temperature gradient on the laminar and turbulent boundary layers of aircraft surface and determines the effect on the transition Reynolds number and wall friction drag. A four-equation turbulence model with transition mode is used to numerically simulate the flow around the model. The variation of wall friction coefficient, transition Reynolds number, and turbulent boundary layer flow with wall temperature are emphatically investigated. Results show that when the wall temperature increases from 288 to 500 K, the boundary layer transition Reynolds number for the wing section increased by approximately 28% and the surface friction drags decreases by approximately 10.7%. The hot wall enhances the viscous effects of the laminar temperature boundary layer, reduces the Reynolds shear stress and turbulent kinetic energy, and increases the flow stability. However, the velocity gradient and shear stress in the bottom of the turbulent boundary layer decreases, which leads to reduced friction shear stress on the wall surface. Therefore, for the low-aspect-ratio flying wing model, the hot wall can delay the boundary layer transition and reduce the friction drag coefficient in the turbulent region.
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http://dx.doi.org/10.1038/s41598-021-94261-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357923PMC
August 2021

JunD Regulates Pancreatic β-Cells Function by Altering Lipid Accumulation.

Front Endocrinol (Lausanne) 2021 16;12:689845. Epub 2021 Jul 16.

Department of Endocrinology, Qilu Hospital of Shandong University, Shandong University, Jinan, China.

The impairment of pancreatic β-cells function is partly caused by lipotoxicity, which aggravates the development of type 2 diabetes mellitus. Activator Protein 1 member JunD modulates apoptosis and oxidative stress. Recently, it has been found that JunD regulates lipid metabolism in hepatocytes and cardiomyocytes. Here, we studied the role of JunD in pancreatic β-cells. The lipotoxic effects of palmitic acid on INS-1 cells were measured, and JunD small-interfering RNA was used to assess the effect of JunD in regulating lipid metabolism and insulin secretion. The results showed that palmitic acid stimulation induced the overexpression of JunD, impaired glucose-stimulated insulin secretion, and increased intracellular lipid accumulation of β-cells. Moreover, the gene expression involved in lipid metabolism (Scd1, Fabp4, Fas, Cd36, Lpl, and Plin5) was upregulated, while gene expression involved in the pancreatic β-cells function (such as Pdx1, Nkx6.1, Glut2, and Irs-2) was decreased. Gene silencing of JunD reversed the lipotoxic effects induced by PA on β-cells. These results suggested that JunD regulated the function of pancreatic β-cells by altering lipid accumulation.
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http://dx.doi.org/10.3389/fendo.2021.689845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322846PMC
July 2021

Establishment and verification of anthropogenic volatile organic compound emission inventory in a typical coal resource-based city.

Environ Pollut 2021 Nov 16;288:117794. Epub 2021 Jul 16.

Key Laboratory of Resources and Environmental Systems Optimization, Ministry of Education, College of Environmental Science and Engineering, North China Electric Power University, Beijing, 102206, China. Electronic address:

A few studies on volatile organic compound (VOC) emission inventories in coal resource-based cities have been reported, and previous emission inventories lacked verification. Herein, using Yangquan as a case study, emission factor (EF) method and "(tracer ratio) TR - positive matrix factorization (PMF)" combined method based on atmospheric data were used to establish and verify the VOC emission inventory in coal resource-based cities, respectively. The total VOC emissions in Yangquan were 9283.2 t [-40.0%, 62.1%] in 2018, with industrial processes being the major contributors. Alkanes (35.8%), aromatics (25.0%), and alkenes (19.8%) were the main compounds in the emission inventory. The verification results for both species emission and source structure were in agreement, indicating the accuracy of VOC emission inventory based on EF method to a certain extent. However, for some species (ethane, propane, benzene, and acetylene), the EF method indicated emissions lower than those obtained from the TR results. Furthermore, the summer-time emission contribution from fossil fuel combustion indicated by the EF method (23.4%) was lower than that obtained from the PMF results (38.4%). Overall, these discrepancies could be attributed to the absence of a coal gangue source in the EF method. The verification results determined the accuracy of the VOC emission inventory and identified existing problems in the estimation of the VOC emission inventory in coal resource-based cities. In particular, not accounting for the coal gangue emissions may result in an underestimation of VOC emissions in coal resource-based cities. Thus, coal gangue emissions should be considered in future research.
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http://dx.doi.org/10.1016/j.envpol.2021.117794DOI Listing
November 2021

Temperature-driven phase transition and transition dipole moment of two-dimensional (BA)CsPbBr perovskite.

Phys Chem Chem Phys 2021 Aug;23(30):16341-16348

Department of Physics, Shanghai University of Electric Power, Shanghai 201300, China.

The structures of hybrid two-dimensional (2D) Ruddlesden-Popper (RP) phase-layered halide perovskite (BA)2CsPb2Br7 in the temperature range of 100 to 450 K were constructed and systematically investigated by first-principles calculations. The results showed that the perovskite materials were thermodynamically stable and exhibited the properties of direct band gap semiconductors in the temperature range of 100 to 400 K. However, a first-order phase transition occurred when the temperature was raised to 450 K, causing transformation of the orthorhombic to tetragonal space group. The absorption spectra and transition dipole moments of (BA)2CsPb2Br7 were discussed at the temperature range of 300 to 450 K. A large dipole transition matrix element P2 is observed at 300 K, which implies that the emissive property of the 2D RP phase-layered perovskite (BA)2CsPb2Br7 is less affected by thermal quenching at room temperature. This highlights the potential of 2D layered halide perovskites for large-area and low-cost light-emitting diodes.
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http://dx.doi.org/10.1039/d1cp01941dDOI Listing
August 2021

Iodine Immobilized Metal-Organic Framework for NIR-Triggered Antibacterial Therapy on Orthopedic Implants.

Small 2021 Sep 26;17(35):e2102315. Epub 2021 Jul 26.

Orthopedics Research Institute of Zhejiang University, Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, P. R. China.

Iodine has been known as an effective disinfectant with broad-spectrum antimicrobial potency yet without drug resistance risk when used in clinic. However, the exploration of iodine for antibacterial therapy in orthopedics remains sparse due to its volatile nature and poor solubility. Herein, leveraging the superior absorption capability of metal-organic frameworks (MOFs) and their inherent photocatalytic properties, iodine-loaded MOF surface is presented to realize responsive iodine release along with intracellular reactive oxygen species(ROS) oxidation under near-infrared (NIR) exposure to achieve synergistic antibacterial effect. Iodine is successfully loaded using vapor deposition process onto zeolitic imidazolate framework-8(ZIF-8), which is immobilized onto micro arc oxidized titanium via a hydrothermal approach. The combination of NIR-triggered iodine release and ZIF-8 mediated ROS oxidative stress substantially augments the antibacterial efficacy of this approach both in vitro and in vivo. Furthermore, this composite coating also supported osteogenic differentiation of bone marrow stromal cells, as well as improved osseointegration of coated implants using an intramedullary rat model, suggesting improvement of antibacterial efficacy does not impair osteogenic potential of the implants. Altogether, immobilization of iodine via MOF on orthopedic implants with synergistic antibacterial effect can be a promising strategy to combat bacterial infections.
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http://dx.doi.org/10.1002/smll.202102315DOI Listing
September 2021

Incomplete thermal ablation-induced up-regulation of transcription factor nuclear receptor subfamily 2, group F, member 6 (NR2F6) contributes to the rapid progression of residual liver tumor in hepatoblastoma.

Bioengineered 2021 12;12(1):4289-4303

Department of Medical Ultrasonics, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, P.R. China.

Hepatoblastoma is a kind of extreme malignancy frequently diagnosed in children. Although surgical resection is considered as the first-line treatment for hepatoblastoma, a relatively large population of patients have lost the preferred opportunity for surgery. Administration of locoregional ablation enables local tumor control but with the deficiency of insufficient ablation, residual tumor, and rapid progression. In this study, we integrated 219 hepatoblastoma and 121 non-cancer liver tissues to evaluate the expression of NR2F6, from which a higher NR2F6 level was found in hepatoblastoma compared with non-cancer livers with a standard mean difference (SMD) of 1.04 (95% CI: 0.79, 1.29). The overexpression of NR2F6 also appeared to be an efficient indicator in distinguishing hepatoblastoma tissues from non-cancer liver tissues from the indication of a summarized AUC of 0.90, with a pooled sensitivity of 0.76 and a pooled specificity of 0.89. Interestingly, nude mouse xenografts provided direct evidence that overexpressed NR2F6 was also detected in residual tumor compared to untreated hepatoblastoma. Chromatin immunoprecipitation-binding data in HepG2 cells and transcriptome analysis of HepG2 xenografts were combined to identify target genes regulated by NR2F6. We finally selected 150 novel target genes of NR2F6 in residual tumor of incomplete ablation, and these genes appeared to be associated with the biological regulation of lipid metabolism-related pathway. Accordingly, targeting NR2F6 holds a therapeutic promise in treating residual recurrent hepatoblastoma after incomplete ablation.
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http://dx.doi.org/10.1080/21655979.2021.1945521DOI Listing
December 2021

Pan-cancer analysis of clinical significance and associated molecular features of glycolysis.

Bioengineered 2021 12;12(1):4233-4246

Department of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Tumor glycolysis is a major promoter of carcinogenesis and cancer progression. Given its complex mechanisms and interactions, comprehensive analysis is needed to reveal its clinical significance and molecular features. On the basis of a well-established glycolysis gene expression signature, we quantified 8633 patients with different cancer types from the Cancer Genome Atlas (TCGA) and evaluated their prognostic associations. High tumor glycolytic activity correlated with inferior overall survival in the pan-cancer patients (hazard ratio: 1.70, 95% confidence interval: 1.20-2.40, P = 0.003). The prognostic value of glycolysis correlated with the molecular subtypes and was stable regardless of clinical parameters. The prognostic significance of glycolysis was validated using three independent datasets. In addition, genome, transcriptome, and proteome profiles were utilized to characterize the distinctive molecular features associated with glycolysis. Mechanistically, glycolysis fulfilled the fundamental needs of tumor proliferation in multiple ways. Exploration of the relationships between glycolysis and tumor-infiltrating immune cells showed that glycolysis enabled the immune evasion of tumor cells. Mammalian target of rapamycin (mTOR) inhibitors and dopamine receptor antagonists can effectively reverse the glycolytic status of cancers. Overall, our study provides an in-depth molecular understanding of tumor glycolysis and may have practical implications for clinical cancer therapy.
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http://dx.doi.org/10.1080/21655979.2021.1955510DOI Listing
December 2021

Development and Validation of a Radiomic Nomogram for Predicting the Prognosis of Kidney Renal Clear Cell Carcinoma.

Front Oncol 2021 6;11:613668. Epub 2021 Jul 6.

Department of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Purpose: The present study aims to comprehensively investigate the prognostic value of a radiomic nomogram that integrates contrast-enhanced computed tomography (CECT) radiomic signature and clinicopathological parameters in kidney renal clear cell carcinoma (KIRC).

Methods: A total of 136 and 78 KIRC patients from the training and validation cohorts were included in the retrospective study. The intraclass correlation coefficient (ICC) was used to assess reproducibility of radiomic feature extraction. Univariate Cox analysis and least absolute shrinkage and selection operator (LASSO) as well as multivariate Cox analysis were utilized to construct radiomic signature and clinical signature in the training cohort. A prognostic nomogram was established containing a radiomic signature and clinicopathological parameters by using a multivariate Cox analysis. The predictive ability of the nomogram [relative operating characteristic curve (ROC), concordance index (C-index), Hosmer-Lemeshow test, and calibration curve] was evaluated in the training cohort and validated in the validation cohort. Patients were split into high- and low-risk groups, and the Kaplan-Meier (KM) method was conducted to identify the forecasting ability of the established models. In addition, genes related with the radiomic risk score were determined by weighted correlation network analysis (WGCNA) and were used to conduct functional analysis.

Results: A total of 2,944 radiomic features were acquired from the tumor volumes of interest (VOIs) of CECT images. The radiomic signature, including ten selected features, and the clinical signature, including three selected clinical variables, showed good performance in the training and validation cohorts [area under the curve (AUC), 0.897 and 0.712 for the radiomic signature; 0.827 and 0.822 for the clinical signature, respectively]. The radiomic prognostic nomogram showed favorable performance and calibration in the training cohort (AUC, 0.896, C-index, 0.846), which was verified in the validation cohort (AUC, 0.768). KM curves indicated that the progression-free interval (PFI) time was dramatically shorter in the high-risk group than in the low-risk group. The functional analysis indicated that radiomic signature was significantly associated with T cell activation.

Conclusions: The nomogram combined with CECT radiomic and clinicopathological signatures exhibits excellent power in predicting the PFI of KIRC patients, which may aid in clinical management and prognostic evaluation of cancer patients.
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http://dx.doi.org/10.3389/fonc.2021.613668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290524PMC
July 2021

Marine Gel Interactions with Hydrophilic and Hydrophobic Pollutants.

Gels 2021 Jul 6;7(3). Epub 2021 Jul 6.

Institute of Marine Environment and Ecology, National Taiwan Ocean University, Keelung 20224, Taiwan.

Microgels play critical roles in a variety of processes in the ocean, including element cycling, particle interactions, microbial ecology, food web dynamics, air-sea exchange, and pollutant distribution and transport. Exopolymeric substances (EPS) from various marine microbes are one of the major sources for marine microgels. Due to their amphiphilic nature, many types of pollutants, especially hydrophobic ones, have been found to preferentially associate with marine microgels. The interactions between pollutants and microgels can significantly impact the transport, sedimentation, distribution, and the ultimate fate of these pollutants in the ocean. This review on marine gels focuses on the discussion of the interactions between gel-forming EPS and pollutants, such as oil and other hydrophobic pollutants, nanoparticles, and metal ions.
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http://dx.doi.org/10.3390/gels7030083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293255PMC
July 2021
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