Publications by authors named "Peng Jia"

395 Publications

SORBS2 as a molecular target for atherosclerosis in patients with familial hypercholesterolemia.

J Transl Med 2022 May 19;20(1):233. Epub 2022 May 19.

Cardiovascular Metabolic Center, State Key Laboratory of Cardiovascular Diseases, Fu Wai Hospital, National Clinical Research Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 BeiLiShi Road, XiCheng District, Beijing, China.

Background: Familial hypercholesterolemia (FH) is a metabolic disease in which patients are prone to develop premature atherosclerosis (AS). Sorbin and SH3 Domain Containing 2 (SORBS2) is known to play a role in coronary heart disease (CHD). However, the mechanism underlying SORBS2 involvement in the development of hypercholesterolemia remains unknown. Here, we investigated the effects of SORBS2 on inflammation and foam cell formation and its underlying mechanisms.

Methods: Using Bioinformatics analysis, we established that SORBS2 is upregulated in patients with FH. Circulating concentrations of SORBS2 were measured using ELISA kit (n = 30). The association between circulating SORBS2 levels and inflammatory factors or lipid indexes were conducted using Spearman correlation analysis. We further conducted in vitro experiments that the expression of SORBS2 were analyzed, and SORBS2 siRNA were transfected into oxidized LDL (OxLDL)-induced macrophages, followed by western blot and immunofluorescence.

Results: Circulating SORBS2 levels were positively associated with inflammatory factors and lipid indexes. We also observed that high in vitro expression of SORBS2 in OxLDL-induced macrophages. After SORBS2 silencing, Nod like receptor family pyrin domain-containing 3 protein(NLRP3)-Caspase1 activation and NF-κB activation were attenuated, and secretion of pro-inflammatory cytokines (IL-1β and IL-18) was decreased. Moreover, SORBS2 silencing blocked reactive oxygen species (ROS) production and lipid accumulation, and promoted cholesterol efflux through ABCG1-PPARγ pathway.

Conclusions: SORBS2 regulates lipid-induced inflammation and foam cell formation, and is a potential therapeutic target for hypercholesterolemia.
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http://dx.doi.org/10.1186/s12967-022-03381-zDOI Listing
May 2022

Ventricular septal defect with recurrent abdominal pain misdiagnosed as mesenteric lymphadenitis: A case report.

Asian J Surg 2022 May 16. Epub 2022 May 16.

Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China; Department of Perinatology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China; Sichuan Clinical Research Center for Birth Defects, Luzhou, Sichuan, 646000, China. Electronic address:

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http://dx.doi.org/10.1016/j.asjsur.2022.04.125DOI Listing
May 2022

Ethnic disparities in the association between ambient air pollution and risk for cardiometabolic abnormalities in China.

Sci Total Environ 2022 May 14:155940. Epub 2022 May 14.

West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address:

Background: Long-term exposure to ambient air pollution has been associated with cardiometabolic abnormalities (CAs), which, however, may be stronger in vulnerable populations, such as minorities. The variation of the association between ambient air pollution and CAs between the majority (Han) and minority populations in China have been poorly studied.

Objectives: We aimed to estimate and compare the Hans' and minorities' risks for CAs associated with long-term exposure to ambient air pollution in Southwest China.

Methods: A cross-sectional study was conducted on the basis of the China Multi-Ethnic Cohort. CAs were defined by the presence of at least three pre-defined metabolic dysfunctions (central obesity, elevated triglycerides, reduced high-density lipoprotein cholesterol, elevated blood pressure, and elevated fasting glucose). The concentrations of ambient air pollutants, including particulate matters (PM, PM, and PM) and nitrogen dioxide (NO), were generated from random forest models on the basis of multi-source data. One- and two-pollutant regression models were fit to assess associations between air pollutant exposure and CA risks. Sensitivity analyses were performed to examine the robustness of the associations.

Results: The final sample included 51,037 Hans and 28,702 minority participants. The prevalence of CAs was 25.0%, slightly higher in the minorities (25.5%) than the Hans (24.4%). The higher risks for CAs in the overall population were associated with each 10 μg/m increase in the exposure to PM (OR = 1.07 [1.05-1.09]), PM (OR = 1.11 [1.06-1.17]), PM (OR = 1.04 [1.03-1.06]), and NO (OR = 1.04 [1.03-1.07]). Compared to the Hans, the higher risks for CAs were observed in the minorities for PM (OR = 1.35 [1.18-1.53]), PM (OR = 1.61 [1.34-1.93]), and PM (OR = 1.15 [1.07-1.23]). The associations of metabolic dysfunctions (CA components) with ambient air pollution also varied between the Han and minority populations.

Conclusions: The associations between exposure to ambient air pollution and CA risks were stronger in the minorities than Hans. Our findings provide a better understanding of ethnic disparities in CA risks when being exposed to ambient air pollution in China, which also have important implications for other low- and middle-income countries where less health resources (e.g., cohort populations) are available to conduct such studies.
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http://dx.doi.org/10.1016/j.scitotenv.2022.155940DOI Listing
May 2022

ATF1/miR-214-5p/ITGA7 axis promotes osteoclastogenesis to alter OVX-induced bone absorption.

Mol Med 2022 May 14;28(1):56. Epub 2022 May 14.

Department of Orthopedics, The First Affiliated Hospital of Gannan Medical University, No.128, Jinling Road, Ganzhou, 341000, Jiangxi, People's Republic of China.

Background: The dynamic balance of osteoblast and osteoclast is critical for bone homeostasis and overactive osteoclastic function may lead to osteoporosis. Activating transcription factor 1 (ATF1) is involved in osteoclastogenesis. However, the detailed mechanisms remain to be explored.

Methods: RAW264.7 cells were used and induced toward osteoclast by RANKL administration. We performed flow cytometry, CCK-8 assay and tartrate-resistant acid phosphatase (TRAP) staining to examine cell apoptosis, proliferation and differentiation of RAW264.7 cells, respectively. Mice were subjected to ovariectomy to induce osteoporosis. Micro CT, HE staining and TRAP staining were performed to evaluate bone loss in the OVX mouse model. Bioinformatics methods, luciferase assays and Chromatin Immunoprecipitation (ChIP) were used to predict and validate the interaction among ATF1, miR-214-5p, and ITGA7.

Results: ATF1 and miR-214-5p were up-regulated while ITGA7 was inhibited in RANKL-induced osteoclasts. MiR-214-5p was transcriptionally activated by ATF1. ATF1 knockdown suppressed osteoclast formation by miR-214-5p inhibition. ITGA7 was the direct target of miR-214-5p. Knockdown of miR-214-5p abolished osteoclastogenesis, which was reversed by ITGA7 knockdown. In OVX model, miR-214-5p knockdown suppressed osteoclast differentiation and prevented bone loss.

Conclusion: ATF1/miR-214-5p/ITGA7 axis regulated osteoclast formation both in vivo and in vitro, thereby affecting OVX-induced bone resorption in mice. Knockdown of ATF1 might be a promising strategy to manage osteoporosis.
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http://dx.doi.org/10.1186/s10020-022-00476-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107670PMC
May 2022

The "Hand as Foot" teaching method in the anatomy of the stomach.

Asian J Surg 2022 Apr 27. Epub 2022 Apr 27.

Inner Mongolia Medical University, Department of Pediatric, Affiliated Hospital of Inner Mongolia Medical University, Hohhot North Street, Inner Mongolia, 010050, China.

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http://dx.doi.org/10.1016/j.asjsur.2022.04.050DOI Listing
April 2022

The "Hand as Foot" teaching method in the branching of the intrahepatic portal vein.

Asian J Surg 2022 Apr 27. Epub 2022 Apr 27.

Inner Mongolia Medical University, Department of Pediatric, Affiliated Hospital of Inner Mongolia Medical University, Hohhot North Street, Inner Mongolia, 010050, China.

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http://dx.doi.org/10.1016/j.asjsur.2022.04.021DOI Listing
April 2022

The "Hand as Foot" teaching method in the branching of the intrahepatic portal vein.

Asian J Surg 2022 Apr 27. Epub 2022 Apr 27.

Inner Mongolia Medical University, Department of Pediatric, Affiliated Hospital of Inner Mongolia Medical University, Hohhot North Street, Inner Mongolia, 010050, China.

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http://dx.doi.org/10.1016/j.asjsur.2022.04.021DOI Listing
April 2022

Eco-Friendly and Complete Recycling of Waste Bamboo-Based Disposable Paper Cups for Value-Added Transparent Cellulose-Based Films and Paper Plastic Composites.

Polymers (Basel) 2022 Apr 13;14(8). Epub 2022 Apr 13.

Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China.

Disposable paper cups are widely used in daily life and most of them are landfilled or incinerated after use, resulting in a serious ecological hazard and significant waste of resources due to the usage of thin polyethylene (PE) as their inner coating. Hence, converting these common solid domestic wastes into high-value added materials is attractive and meaningful. In this study, transparent cellulose-based films were achieved from old bamboo-based disposable paper cups after pretreatment through using the room ionic liquid 1-allyl-3-methylimidazolium chloride (AmimCl) as solvent. The cellulose-based film with a dense texture demonstrated a relatively nice mechanical and UV-shielding performances, and its tensile strength was as high as 48 MPa, much higher than that of commercial polyethylene (PE, 12 MPa) film. Thus, the resultant cellulose-based film showed a great potential in the packaging field. Besides, the flexible paper plastic composites (PPC) were also fabricated from the rest thin PE coating with the stuck fibers, and it was found that PPC showed excellent mechanical property and hydrophobicity. Consequently, a feasible and eco-friendly process of recycling and reusing waste disposable paper cups was developed to achieve a complete utilization and valorization of waste disposable paper cups.
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http://dx.doi.org/10.3390/polym14081589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028521PMC
April 2022

Reversible domain closure modulates GlnBP ligand binding affinity.

PLoS One 2022 21;17(4):e0263102. Epub 2022 Apr 21.

School of Mechanical, Electrical & Information Engineering, Shandong University, Weihai, Shandong Province, China.

Glutamine binding protein (GlnBP) is an Escherichia Coli periplasmic binding protein, which binds and carries glutamine to the inner membrane ATP-binding cassette (ABC) transporter. GlnBP binds the ligand with affinity around 0.1μM measured by isothermal titration calorimetry (ITC) and ligand binding stabilizes protein structure shown by its increase in thermodynamic stability. However, the molecular determinant of GlnBP ligand binding is not known. Electrostatic and hydrophobic interaction between GlnBP and glutamine are critical factors. We propose that the freedome of closure movement is also vital for ligand binding. In order to approve this hypothesis, we generate a series of mutants with different linker length that has different magnitude of domain closure. Mutants show different ligand binding affinity, which indicates that the propensity of domain closure determines the ligand binding affinity. Ligand binding triggers gradual ensemble conformational change. Structural changes upon ligand binding are monitored by combination of small angle x-ray scattering (SAXS) and NMR spectroscopy. Detailed structure characterization of GlnBP contributes to a better understanding of ligand binding and provides the structural basis for biosensor design.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0263102PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022810PMC
April 2022

The "Hand as Foot" teaching method in hepatic portal vein branch.

Asian J Surg 2022 Apr 9. Epub 2022 Apr 9.

Department of Critical Care Medicine, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia, 010017, China.

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http://dx.doi.org/10.1016/j.asjsur.2022.03.109DOI Listing
April 2022

The "Hand as Foot" teaching method in thyroid morphology.

Asian J Surg 2022 Apr 8. Epub 2022 Apr 8.

Department of Critical Care Medicine, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia, 010017, China.

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http://dx.doi.org/10.1016/j.asjsur.2022.03.090DOI Listing
April 2022

Dynamic Observation of Lung Nodules on Chest CT Before Diagnosis of Early Lung Cancer.

Front Oncol 2022 9;12:713881. Epub 2022 Mar 9.

Medical Imaging Center, Zhongshan People's Hospital, Zhongshan, China.

Objective: Early recognition and diagnosis of lung cancer can help improve the prognosis of patients. However, early imaging patterns of malignant lung nodules are not fully clear. To understand the early imaging signs of malignant lung cancer nodules, the changes of the lung nodules before diagnosis were dynamically observed and analyzed.

Materials And Methods: This retrospective study observed dynamic changes of lung nodules before pathological confirmation with consecutive regular chest CT examination from January 2003 to December 2018. At least 3 follow-up CT scans were performed in all cases, and the interval between each follow-up was about 1 year. The size, density, and morphological signs of the nodules were evaluated based on the CT axial image, and a reverse line chart or scatter plot with the diagnosis time as coordinate origin was constructed.

Results: A total of 55 lung nodules in 53 patients (mean age, 58.40 years ±11.43 [standard deviation]; 20 women) were accessed. The follow-up time was 5.96 ± 2.68 years. The average diameters in maximum slice of the lesion at baseline and last scan were 6.83 ± 2.92 mm and 16.65 ± 7.34 mm, respectively. According to the reverse line chart, the nodule growth curve segments within 4 years from the last scan showed an ascending shape, and those beyond 4 years showed a flat shape. There are 90.9% (50/55) GGN and 9.1% (5/55) SN when the lesion first appears, and 21.8% (12/55) GGN, 38.2% (21/55) PSN, and 40% (22/55) SN in the last scan. There are 12.7% (7/55) and 98.2% (54/55) nodules with poor morphological signs at baseline and last scan, respectively.

Conclusion: At the time node close to the diagnosis, the growth curve showed an upward pattern; the proportion of PSN and SN rose as the main density types; and the appearance of poor morphological signs of nodules increased. When a persistent lung nodule starts to show a malignant change, a further diagnostic workup is warranted.
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http://dx.doi.org/10.3389/fonc.2022.713881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959853PMC
March 2022

Comparative virulence of spring viremia of carp virus (SVCV) genotypes in two koi varieties.

Dis Aquat Organ 2022 Mar 17;148:95-112. Epub 2022 Mar 17.

US Geological Survey, Western Fisheries Research Center, Seattle, WA 98115, USA.

Spring viremia of carp virus (SVCV), is a lethal freshwater pathogen of cyprinid fish, and Cyprinus carpio koi is a primary host species. The virus was initially described in the 1960s after outbreaks occurred in Europe, but a global expansion of SVCV has been ongoing since the late 1990s. Genetic typing of SVCV isolates separates them into 4 genotypes that are correlated with geographic origin: Ia (Asia), Ib and Ic (Eastern Europe), and Id (Central Europe). We compared infectivity and virulence of 8 SVCV strains, including 4 uncharacterized Chinese Ia isolates and representatives of genotypes Ia-d in 2 morphologically distinct varieties of koi: long-fin semi-scaled Beni Kikokuryu koi and short-fin fully scaled Sanke koi. Mortality ranged from 4 to 82% in the Beni Kikokuryu koi and 0 to 94% in the Sanke koi following immersion challenge. Genotype Ia isolates of Asian origin had a wide range in virulence (0-94%). Single isolates representing the European genotypes Ib and Ic were moderately virulent (38-56%). Each virus strain produced similar levels of mortality in both koi breeds, with the exception of the SVCV Id strain that appeared to have both moderate and high virulence phenotypes (60% in Beni Kikokuryu koi vs. 87% in Sanke koi). Overall SVCV strain virulence appeared to be a dominant factor in determining disease outcomes, whereas intraspecies variation, based on koi variety, had less of an impact. This study is the first side-by-side comparison of Chinese SVCV isolates and genotype Ia-d strain virulence in a highly susceptible host.
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http://dx.doi.org/10.3354/dao03650DOI Listing
March 2022

Current patterns of plant diversity and phylogenetic structure on the Kunlun Mountains.

Plant Divers 2022 Jan 7;44(1):30-38. Epub 2021 May 7.

State Key Laboratory of Grassland and Agro-Ecosystems, School of Life Sciences, Lanzhou University, Lanzhou, Gansu Province, 730000, P. R. China.

Large-scale patterns of biodiversity and the underlying mechanisms that regulate these patterns are central topics in biogeography and macroecology. The Qinghai-Tibet Plateau serves as a natural laboratory for studying these issues. However, most previous studies have focused on the entire Qinghai-Tibet Plateau, leaving independent physical geographic subunits in the region less well understood. We studied the current plant diversity of the Kunlun Mountains, an independent physical geographic subunit located in northwestern China on the northern edge of the Qinghai-Tibet Plateau. We integrated measures of species distribution, geological history, and phylogeography, and analyzed the taxonomic richness, phylogenetic diversity, and community phylogenetic structure of the current plant diversity in the area. The distribution patterns of 1911 seed plants showed that species were distributed mainly in the eastern regions of the Kunlun Mountains. The taxonomic richness, phylogenetic diversity, and genera richness showed that the eastern regions of the Kunlun Mountains should be the priority area of biodiversity conservation, particularly the southeastern regions. The proportion of Chinese endemic species inhabiting the Kunlun Mountains and their floristic similarity may indicate that the current patterns of species diversity were favored via species colonization. The Hengduan Mountains, a biodiversity hotspot, is likely the largest source of species colonization of the Kunlun Mountains after the Quaternary. The net relatedness index indicated that 20 of the 28 communities examined were phylogenetically dispersed, while the remaining communities were phylogenetically clustered. The nearest taxon index indicated that 27 of the 28 communities were phylogenetically clustered. These results suggest that species colonization and habitat filtering may have contributed to the current plant diversity of the Kunlun Mountains via ecological and evolutionary processes, and habitat filtering may play an important role in this ecological process.
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http://dx.doi.org/10.1016/j.pld.2021.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897310PMC
January 2022

N Protein of Viral Hemorrhagic Septicemia Virus Suppresses STAT1-Mediated MHC Class II Transcription to Impair Antigen Presentation in Sea Perch, .

J Immunol 2022 03 18;208(5):1076-1084. Epub 2022 Feb 18.

School of Marine Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China; Southern Marine Science and Engineering Guangdong Laboratory, Zhuhai, Guangdong, China; and Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering Guangdong, Guangzhou, Guangdong, China

Upon virus invasion of the host, APCs process Ags to short peptides for presentation by MHC class II (MHC-II). The recognition of virus-derived peptides in the context of MHC-II by CD4 T cells initiates the adaptive immune response for virus clearance. As a survival instinct, viruses have evolved mechanisms to evade Ag processing and presentation. In this study, we discovered that IFN-γ induced endogenous MHC-II expression by a sea perch brain cell line through the STAT1/IFN regulatory factor 1 (IRF1)/CIITA signaling pathway. Furthermore, viral hemorrhagic septicemia virus infection significantly inhibited the IFN-γ-induced expression of IRF1, CIITA, MHC-II-α, and MHC-II-β genes. By contrast, although STAT1 transcript was upregulated, paradoxically, the STAT1 protein level was attenuated. Moreover, overexpression analysis revealed that viral hemorrhagic septicemia virus N protein blocked the IFN-γ-induced expression of IRF1, CIITA, MHC-II-α, and MHC-II-β genes, but not the STAT1 gene. We also found out that N protein interacted with STAT1 and enhanced the overall ubiquitination level of proteins, including STAT1 in brain cells. Enhanced ubiquitination of STAT1 through K48-linked ubiquitination led to its degradation through the ubiquitin-proteasome pathway, thereby inhibiting the biological function of STAT1. Our study suggests that aquatic viruses target Ag presentation in lower vertebrates for immune evasion as do mammalian viruses.
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http://dx.doi.org/10.4049/jimmunol.2100939DOI Listing
March 2022

Spatiotemporal epidemiology of COVID-19 from an epidemic course perspective.

Geospat Health 2022 02 10;17(s1). Epub 2022 Feb 10.

International Institute of Spatial Lifecourse Epidemiology (ISLE), Wuhan University, Wuhan, China; School of Resource and Environmental Sciences, Wuhan University, Wuhan.

Although coronavirus disease 2019 (COVID-19) remains rampant in many countries, it has recently waned in Sichuan, China. This study examined spatiotemporal variations of the epidemiological characteristics of COVID-19 across its course. Three approaches, i.e. calendar-based, measure-driven and data-driven ones, were applied to all individual cases reported as of 30th November 2020, dividing the COVID-19 pandemic into five periods. A total of 808 people with confirmed diagnosis and 279 asymptomatic cases were reported, the majority of whom were aged 30-49 and <30 years, respectively. The highest risk was seen in Chengdu (capital city), with 411 confirmed and 195 asymptomatic cases. The main sources of infection changed from importation from Hubei Province to importation from other provinces, then local transmission and ultimately importation from foreign countries. The periods highlighted by the three methods presented different epidemic patterns and trends. The calendar-based periods were even with most cases aggregated in the first period, which did not reflect various transmission patterns of COVID-19 due to various sources of infection; the measure-driven and data-driven periods were not consistent with each other, revealing that the effects of implementing prevention measures were reflected on the epidemic trend with a time lag. For example, the decreasing trends of new cases occurred 7, 3 and 4 days later than the firstlevel emergency response, the district-level prevention measures and the second-level emergency response, respectively. This study has advanced our understanding of epidemic course and foreshown all stages of COVID-19 epidemic. Many countries can learn from our findings about what will occur next in their timelines and how to be better prepared.
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http://dx.doi.org/10.4081/gh.2022.1023DOI Listing
February 2022

Current biogeographical roles of the Kunlun Mountains.

Ecol Evol 2022 Jan 15;12(1):e8493. Epub 2022 Jan 15.

School of Life Sciences State Key Laboratory of Grassland and Agro-Ecosystems Lanzhou University Lanzhou China.

Large-scale patterns of biodiversity and formation have garnered increasing attention in biogeography and macroecology. The Qinghai-Tibet Plateau (QTP) is an ideal area for exploring these issues. However, the QTP consists of multiple geographic subunits, which are understudied. The Kunlun Mountains is a geographical subunit situated in the northern edge of the QTP, in northwest China. The diversity pattern, community phylogenetic structures, and biogeographical roles of the current flora of the Kunlun Mountains were analyzed by collecting and integrating plant distribution, regional geological evolution, and phylogeography. A total of 1911 species, 397 genera, and 75 families present on the Kunlun Mountains, of which 29.8% of the seed plants were endemic to China. The mean divergence time (MDT) of the Kunlun Mountains flora was in the early Miocene (19.40 Ma). Analysis of plant diversity and MDT indicated that the eastern regions of the Kunlun Mountains were the center of species richness, endemic taxa, and ancient taxa. Geographical origins analysis showed that the Kunlun Mountains flora was diverse and that numerous clades were from East Asia and Tethyan. Analysis of geographical origins and geological history together highlighted that the extant biodiversity on the Kunlun Mountains appeared through species recolonization after climatic fluctuations and glaciations during the Quaternary. The nearest taxon index speculated that habitat filtering was the most important driving force for biodiversity patterns. These results suggest that the biogeographical roles of the Kunlun Mountains are corridor and sink, and the corresponding key processes are species extinction and immigration. The Kunlun Mountains also form a barrier, representing a boundary among multiple floras, and convert the Qinghai-Tibet Plateau into a relatively closed geographical unit.
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http://dx.doi.org/10.1002/ece3.8493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809438PMC
January 2022

Osteocytic HIF-1α Pathway Manipulates Bone Micro-structure and Remodeling via Regulating Osteocyte Terminal Differentiation.

Front Cell Dev Biol 2021 18;9:721561. Epub 2022 Jan 18.

Department of Orthopedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Traumatology and Orthopedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

The activation of hypoxia-inducible factor 1α (HIF-1α) signaling has promising implications for the treatment of bone diseases such as osteoporosis and skeletal fractures. However, the effects of manipulating HIF-1α pathway on bone micro-structure and remodeling should be fully studied before the clinical application of therapeutics that interfere with the HIF-1α pathway. In this study, we found that osteocyte-specific HIF-1α pathway had critical role in manipulating bone mass accrual, bone material properties and micro-structures, including bone mineralization, bone collagen fiber formation, osteocyte/canalicular network, and bone remodeling. In addition, our results suggest that osteocyte-specific HIF-1α pathway regulates bone micro-structure and remodeling via impairing osteocyte differentiation and maturation.
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http://dx.doi.org/10.3389/fcell.2021.721561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804240PMC
January 2022

Impacts of COVID-19 Lockdown on Food Ordering Patterns among Youths in China: The COVID-19 Impact on Lifestyle Change Survey.

Obes Facts 2022 26;15(2):135-149. Epub 2022 Jan 26.

School of Resource and Environmental Sciences, Wuhan University, Wuhan, China.

Introduction: Limited studies have focused on how the COVID-19 outbreak and thereby lockdown had affected the youth's food ordering patterns, which was associated with their dietary behaviors and could have longer term impacts on their later-life health status if the trend persists. This study aimed to evaluate changes in food ordering patterns among youths in China after the COVID-19 outbreak.

Methods: The data were obtained from a national retrospective survey (COINLICS) conducted in early May 2020 via social media platforms in China among more than 10,000 youth participants at 3 educational levels. Participants reported their basic sociodemographic characteristics, weight status, and lifestyles including food ordering patterns. We described and compared their weight status and food ordering patterns before COVID-19 (January) and under lockdown (February).

Results: We observed significant changes in youths' weight status and food ordering patterns under lockdown. A significant increase was observed in the prevalence of overweight/obesity (13.5%-17.0%) and obesity (8.7-10.8%), which varied by sex and educational level. Overall, the average weekly frequency of food ordering among the Chinese students had declined, with the largest decrease seen among graduate students, followed by undergraduate and high/vocational school students. Regardless of types of food, the percentage of participating youths who started ordering under lockdown was all lower than that of youths who stopped ordering. Among those who had still ordered foods under lockdown, a larger percentage of female than male high/vocational school students ordered barbecue/grill and cakes/pastries; no significant differences were found across the educational levels.

Conclusion: The participating youths' food ordering patterns had significantly changed during the COVID-19 lockdown, with heterogeneities observed to different extents between sexes and across educational levels. Our findings would inform policy makers and health professionals of these changes in time, for better policy making and public health practice.
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http://dx.doi.org/10.1159/000520160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021656PMC
March 2022

Severe vaginal bleeding due to vaginal metastasis from renal cell carcinoma with inferior vena cava tumor thrombus: A case report.

Medicine (Baltimore) 2022 Jan;101(3):e28586

Department of Urology, Taizhou First People's Hospital, Zhejiang Province, China.

Rationale: Renal cell carcinoma (RCC) is the most common type of kidney cancer and is the second most common urologic neoplasm. Vaginal metastasis from RCC is extremely rare clinically.

Patient Concerns: A 56-year-old woman presented with intermittent vaginal bleeding that had persisted for 1 month. Enhanced computed tomography examination suggested a vaginal mass (3 × 2 × 2 cm), right kidney tumor (15 × 12 × 10 cm), and an inferior vena cava tumor thrombus. During gynecologic examination, the mass was necrotic and caused uncontrollable vaginal bleeding.

Diagnoses: Based on clinical and imaging examinations and the pathology, she was diagnosed as vaginal metastasis from RCC.

Interventions: The patient received percutaneous transcatheter arterial embolization to stop uncontrollable vaginal bleeding, and then treated with targeted therapy.

Outcomes: Vaginal bleeding disappeared after interventional embotherapy. However, disease progressed, and the patient died 9 months later.

Lessons: In cases of vaginal bleeding, the possibility of metastatic renal cell carcinoma should be considered. Percutaneous transcatheter arterial embolization is an effective and novel treatment for uncontrollable vaginal bleeding caused by vaginal metastasis of RCC.
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http://dx.doi.org/10.1097/MD.0000000000028586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772633PMC
January 2022

Risk of Accidents or Chronic Disorders From Improper Use of Mobile Phones: A Systematic Review and Meta-analysis.

J Med Internet Res 2022 01 20;24(1):e21313. Epub 2022 Jan 20.

School of Public Health, Tianjin Medical University, Tianjin, China.

Background: Mobile phone use has brought convenience, but the long or improper use of mobile phones can cause harm to the human body.

Objective: We aimed to assess the impact of improper mobile phone use on the risks of accidents and chronic disorders.

Methods: We systematically searched in PubMed, EMBASE, Cochrane, and Web of Science databases for studies published prior to April 5, 2019; relevant reviews were also searched to identify additional studies. A random-effects model was used to calculate the overall pooled estimates.

Results: Mobile phone users had a higher risk of accidents (relative risk [RR] 1.37, 95% CI 1.22 to 1.55). Long-term use of mobile phones increased accident risk relative to nonuse or short-term use (RR 2.10, 95% CI 1.63 to 2.70). Compared with nonuse, mobile phone use resulted in a higher risk for neoplasms (RR 1.07, 95% CI 1.01 to 1.14), eye diseases (RR 2.03, 95% CI 1.27 to 3.23), mental health disorders (RR 1.16, 95% CI 1.02 to 1.32), and headaches (RR 1.25, 95% CI 1.18 to 1.32); the pooled risk of other chronic disorders was 1.20 (95% CI 0.90 to 1.59). Subgroup analyses also confirmed the increased risk of accidents and chronic disorders.

Conclusions: Improper use of mobile phones can harm the human body. While enjoying the convenience brought by mobile phones, people have to use mobile phones properly and reasonably.
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http://dx.doi.org/10.2196/21313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814932PMC
January 2022

HIV-1 genetic transmission networks among people living with HIV/AIDS in Sichuan, China: a genomic and spatial epidemiological analysis.

Lancet Reg Health West Pac 2022 Jan 23;18:100318. Epub 2021 Nov 23.

West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.

Background: Spatialized HIV genetic transmission networks can help understand dynamic changes of HIV-1 at the regional level. This study aimed to combine genomic, epidemiological, and spatial data to investigate the patterns of the HIV-1 epidemic at both individual and regional levels among people living with HIV (PLWH) with virological failure of antiretroviral therapy (ART).

Methods: We evaluated the transmission patterns of 5,790 PLWH with identified pol sequences of the five main HIV-1 subtypes (B, CRF08_BC, CRF85_BC, CRF07_BC, and CRF01_AE) in Sichuan Province, China. A phylogenetic cluster was defined as a group of sequences with genetically similar HIV strains, with all phylogenetic clusters forming an HIV-1 genetic transmission network for each subtype. Logistic regression was used to identify the potential risk factors for phylogenetic clustering. Spatial analysis was applied to demonstrate the geographic patterns of phylogenetic clustering rates; intensity matrices and flow maps were made to demonstrate the intensity of transmission within and between cities.

Findings: There were 2,159 (37.3%) of 5,790 PLWH, distributed in 452 phylogenetic clusters. Some individual clinical and behavioral factors were associated with phylogenetic clustering, including a viral load of >50,000 copies/ml (OR=1.16, 95%CI=1.02-1.33), infection of other sexually transmitted diseases (OR=1.38, 95%CI=1.12-1.69), and ≥5 non-marital sexual partners (OR=1.25, 95%CI=1.03-1.51), while >3 years of treatment since the initial ART was associated with less likelihood of phylogenetic clustering (OR=0.82, 95%CI=0.70-0.97). The phylogenetic clustering rates varied regionally and were highest in the central region of Sichuan, especially for subtype CRF08_BC. The significant spatial clusters of high and low phylogenetic clustering rates were detected in the east (Dazhou for B; Zigong and Luzhou for CFR08_BC) and west (Yaan and Ganzi for CRF07_BC), respectively. The proportion of intercity transmission varied across cities from 0.14 (Yibin) and 1.00 (Ganzi). Stronger intercity transmission than average existed between some cities, e.g., between Deyang and Neijiang. CRF07_BC was the most widespread subtype between cities, and CRF85_BC (a novel HIV-1 subtype) showed strong intercity transmission (e.g., between Yibin and Guangan).

Interpretation: The phylogenetic clustering rates and intercity connections of HIV-1 have varied geographically, possibly due to varying human mobility, traffic convenience, and economic activities. Our findings enhanced the understanding of the dynamics of HIV-1 transmission from individual to city level, and demonstrated a novel cross-disciplinary (epidemiological, genetic, and spatial) approach by which we identified high-risk populations and areas. Our approach could be adapted to other regions for precision public health interventions.

Funding: The National Natural Science Foundation of China, Sichuan Science and Technology Program, Project of Sichuan Provincial Health Committee, Science and Technology Project of Sichuan Provincial Health Committee, Wuhan University 351 Talent Program, 2020, and the International Institute of Spatial Lifecourse Epidemiology (ISLE).
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http://dx.doi.org/10.1016/j.lanwpc.2021.100318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669382PMC
January 2022

Cohort Profile: Chengdu Positive Child Development (CPCD) survey.

Int J Epidemiol 2021 Nov 19. Epub 2021 Nov 19.

School of Resources and Environmental Science, Wuhan University, Wuhan, China.

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http://dx.doi.org/10.1093/ije/dyab237DOI Listing
November 2021

Hydrogel Complex Electrospun Scaffolds and Their Multiple Functions in In Situ Vascular Tissue Engineering.

ACS Appl Bio Mater 2021 03 9;4(3):2373-2384. Epub 2021 Feb 9.

School of Materials Science & Engineering, Beijing Institution of Technology, Beijing 100081, China.

Hydrogel complex scaffolds (hydrogel scaffolds) are prepared by coating precursor solutions onto heparin-modified poly(ε-caprolactone) (PCLH) scaffolds followed by subsequent in situ gelation. Here, we show that hydrogel complexation can significantly strengthen the scaffold and slow its degradation. The hydrogel scaffold was implanted into the abdominal aorta of a rat model, and the aneurysm incidence rate of the hydrogel scaffolds sharply decreased compared with that of the hydrogel-free scaffolds. Histological and immunohistological analyses showed that the implanted grafts had good vascular regeneration. The absence of calcification and occurrence of contractile smooth muscle cells (SMCs) at the first month was found in the hydrogel-free PCLH scaffold due to the presence of surface-modified heparin, whereas the hydrogel scaffold exhibited mild calcification and later occurrence of contractile SMCs as the complexed hydrogel covered the fibers and blocked the interaction between heparin and cells. Heparin was further physically encapsulated into the hydrogel before gelation, and its sustainable release was demonstrated by an in vitro release test. A pilot implantation in a rabbit carotid model showed that the encapsulated heparin modulated the scaffold characteristics including anticoagulation, anticalcification, and the early occurrence of contractile SMCs in vivo. Consequently, hydrogel complexation can significantly improve the in vivo regeneration property of the scaffold due to its multiple beneficial characteristics.
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http://dx.doi.org/10.1021/acsabm.0c01225DOI Listing
March 2021

NAFLD fibrosis score is correlated with PCSK9 and improves outcome prediction of PCSK9 in patients with chest pain: a cohort study.

Lipids Health Dis 2022 Jan 7;21(1). Epub 2022 Jan 7.

Cardiometabolic medicine center, State Key Laboratory of Cardiovascular Diseases, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No 167 BeiLiShi Road, XiCheng District, Beijing, 100037, China.

Background: The risk of liver fibrosis in non-alcoholic fatty liver disease (NAFLD) can be easily evaluated by noninvasive scoring systems, of which the NAFLD fibrosis score (NFS) is the most commonly used. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a new predictor of cardiovascular events, has been reported to be associated with cardiovascular outcomes and NAFLD. However, the relationship of NFS with PCSK9 and their prognostic abilities in cardiovascular risks are unknown.

Methods: A total of 2008 hospitalized subjects who had chest pain without lipid-lowering therapy were consecutively included. Baseline clinical data were collected, and the NFS was calculated. The circulating PCSK9 concentration was determined by enzyme immunoassay. The major adverse cardiovascular event (MACE) occurrences were recorded in the follow-up period. Associations of PCSK9 concentration with NFS were examined. All of the participants were categorized into three groups according to NFS levels and were further stratified by PCSK9 tertiles to evaluate the MACEs.

Results: 158 (7.87%) MACEs were observed during a mean of 3.2 years of follow-up. NFS levels were independently related to higher PCSK9 levels according to multivariable linear regression analysis. Furthermore, elevated PCSK9 and NFS concentrations were respectively associated with increased MACE incidence in multivariable Cox regression models. When combining NFS status with PCSK9 tertiles as a stratifying factor, patients with intermediate-high NFS and high PCSK9 levels had higher risks of events than those with low NFS and low PCSK9 levels.

Conclusions: This study revealed for the first time that NFS is positively related to PCSK9 and that the combination of NFS and PCSK9 greatly increased the risk of MACEs in patients with chest pain, providing a potential link between NFS and PCSK9 for predicting cardiovascular events.
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http://dx.doi.org/10.1186/s12944-021-01610-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742334PMC
January 2022

Six Air Pollutants Associated With Increased Risk of Thyroid Nodules: A Study of 4.9 Million Chinese Adults.

Front Endocrinol (Lausanne) 2021 13;12:753607. Epub 2021 Dec 13.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center (PKUHSC), Beijing, China.

Background: Thyroid nodules has become a significant public health issue worldwide with a rapidly increasing prevalence. However, its association with outdoor air pollution remains poorly understood. We aim to investigate the relationship between six outdoor air pollutants (PM, PM, NO, SO, CO, and O) and the risk of thyroid nodules.

Methods: We utilized a database including 4,920,536 participants who attended the annual physical examinations in the Meinian HealthCare Screening Center in 157 Chinese cities in 2017. City-specific concentrations of six pollutants (PM, PM, NO, SO, CO, and O) from 2015 to 2017 were estimated based on the China's National Urban Air Quality Real Time Publishing Platform. Thyroid nodule was measured with ultrasound. Multivariable Logistic regression was used to examine the associations between air pollutants and thyroid nodules with adjustment for age, sex, education, smoking, body mass index, fasting blood glucose, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, urine iodine, gross domestic product, and thyroid stimulating hormone. We conducted stratified analyses to investigate potential effect modification by sex, age, and urine iodine groups.

Results: Approximately 38% of the participants (1,869,742) were diagnosed with thyroid nodules. Each of the six air pollutants was significantly and linearly associated with the risk for thyroid nodules. The adjusted odds ratios [95% CI] for every increase of 10 μg/m for PM, PM, NO, SO, and O were 1.062 [1.061, 1.064], 1.04 [1.03, 1.04], 1.10 [1.09, 1.10], 1.11 [1.11, 1.12], and 1.151 [1.149, 1.154], respectively; The odds ratio for each increase of 1 mg/m for CO was 1.50 [1.49 to 1.52]. Furthermore, these associations were significantly higher in the participants who were men, younger, or having lower urine iodine level (0.001).

Conclusion: The six air pollutants may contribute to the high prevalence of thyroid nodules in China.
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http://dx.doi.org/10.3389/fendo.2021.753607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710776PMC
February 2022

Mental Disorders and Emotional Competence Among Chinese Adolescents Before and During COVID-19 Pandemic: A Longitudinal Mediation Model.

Front Public Health 2021 10;9:767004. Epub 2021 Dec 10.

Institute for Disaster Management and Reconstruction (IDMR), Sichuan University, Chengdu, China.

The outbreak of the COVID-19 pandemic has had a profound influence on the mental health and well-being of individuals across the globe. Emotional competence, defined as one's ability to recognize, understand, and manage their emotions, has been found linked with mental health problems (e.g., depression and anxiety) in previous studies. However, there is limited knowledge about the direction of the association between these factors among populations exposed to COVID-19. This study examined the possible mediation relationships between depression, anxiety, emotional competence, and COVID-19 exposure among Chinese adolescents. Responses from 7,958 Chinese adolescents who had previously taken part in a two-wave study before (December 23, 2019-January 13, 2020) and during COVID-19 (June 16, 2020-July 8, 2020) were analyzed (51.67% males, mean age = 11.74, SD = 2.15). Structural equation modeling with three covariates (i.e., age, gender, and ethnicity) was used to test the longitudinal mediation relationships between COVID-19 exposure and depression, anxiety via emotional competence. Results indicated that the prevalence of depression (38.67 to 36.74%) and anxiety (13.02 to 12.77%) decreased from Time 1 to Time 2. The T2 emotional competence significantly mediated the relationship between T2 COVID-19 exposure and T2 anxiety (indirect effect [95% CI] = 0.011 [0.004-0.019], < 0.05). T2 emotional competence also significantly mediated the relationship between T2 COVID-19 exposure and T2 depression (indirect effect [95% CI] = 0.013 [0.005-0.022], < 0.05). The results indicated that T2 emotional competence had a significant and negative influence on T2 anxiety (β = -0.266, SE = 0.005, < 0.001), and T2 depression (β = -0.326, SE = 0.029, < 0.001). This longitudinal research study demonstrated the crucial role of emotional competence in influencing the severity of long-term mental health problems, and suggested that emotional competence interventions can be conducted to improve mental well-being among Chinese adolescents exposed to COVID-19.
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http://dx.doi.org/10.3389/fpubh.2021.767004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702639PMC
January 2022

Lipoprotein (a)-mediated vascular calcification: population-based and in vitro studies.

Metabolism 2022 02 23;127:154960. Epub 2021 Dec 23.

State Key Laboratory of Cardiovascular Diseases, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No 167 BeiLiShi Road, XiCheng District, Beijing 100037, China. Electronic address:

Background: Lipoprotein (a) [Lp(a)] is a causal risk factor for cardiovascular diseases, while its role in vascular calcification has not been well-established. Here, we investigated an association of Lp(a) with vascular calcification using population-based and in vitro study designs.

Methods: A total of 2806 patients who received coronary computed tomography were enrolled to assess the correlation of Lp(a) with the severity of coronary artery calcification (CAC). Human aortic smooth muscle cells (HASMCs) were used to explore mechanisms of Lp(a)-induced vascular calcification.

Results: In the population study, Lp(a) was independently correlated with the presence and severity of CAC (all p < 0.05). In vitro study showed that cell calcific depositions and alkaline phosphatase (ALP) activity were increased and the expression of pro-calcific proteins, including bone morphogenetic protein-2 (BMP2) and osteopontin (OPN), were up-regulated by Lp(a) stimulation. Interestingly, Lp(a) activated Notch1 signaling, resulting in cell calcification, which was inhibited by the Notch1 signaling inhibitor, DAPT. Lp(a)-induced Notch1 activation up-regulated BMP2-Smad1/5/9 pathway. In contrast, Noggin, an inhibitor of BMP2-Smad1/5/9 pathway, significantly blocked Lp(a)-induced HASMC calcification. Notch1 activation also induced translocation of nuclear factor-κB (NF-κB) accompanied by OPN overexpression and elevated inflammatory cytokines production, while NF-κB silencing alleviated Lp(a)-induced vascular calcification.

Conclusions: Elevated Lp(a) concentrations are independently associated with the presence and severity of CAC and the impact of Lp(a) on vascular calcification is involved in the activation of Notch1-NF-κB and Notch1-BMP2-Smad1/5/9 pathways, thus implicating Lp(a) as a potential novel therapeutic target for vascular calcification.
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http://dx.doi.org/10.1016/j.metabol.2021.154960DOI Listing
February 2022

CoO Nanoneedle Array Grown on Carbon Fiber Paper for Air Cathodes towards Flexible and Rechargeable Zn-Air Batteries.

Nanomaterials (Basel) 2021 Dec 7;11(12). Epub 2021 Dec 7.

State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China.

An economical and efficient method is developed for preparing flexible cathodes. In this work, a dense mesoporous CoO layer was first hydrothermally grown in situ on the surface of chopped carbon fibers (CFs), and then carbon fiber paper (CoO/CP) was prepared by a wet papermaking process as a flexible zinc-air battery (ZAB). The high-performance air cathode utilizes the high specific surface area of a single chopped carbon fiber, which is conducive to the deposition and adhesion of the CoO layer. Through the wet papermaking process, CoO/CP has ultra-thin, high mechanical stability and excellent electrical conductivity. In addition, the assembled ZAB exhibits relatively excellent electrochemical performance, with a continuous cycle of more than 180 times at a current density of 2 mA·cm. The zinc-air battery can maintain a close fit and work stably and efficiently even under high bending conditions. This process of combining single carbon fibers to prepare ultra-thin, high-density, high-conductivity carbon fiber paper through a papermaking process has huge application potential in the field of flexible wearables.
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http://dx.doi.org/10.3390/nano11123321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706223PMC
December 2021

Size-Dependent Chemomechanical Failure of Sulfide Solid Electrolyte Particles during Electrochemical Reaction with Lithium.

Nano Lett 2022 Jan 23;22(1):411-418. Epub 2021 Dec 23.

Clean Nano Energy Center, State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, P.R. China.

The very high ionic conductivity of LiGePS (LGPS) solid electrolyte (SE) makes it a promising candidate SE for solid-state batteries in electrical vehicles. However, chemomechanical failure, whose mechanism remains unclear, has plagued its widespread applications. Here, we report imaging lithiation-induced failure of LGPS SE. We revealed a strong size effect in the chemomechanical failure of LGPS particles: namely, when the particle size is greater than 3 μm, fracture/pulverization occurred; when the particle size is between 1 and 3 μm, microcracks emerged; when the particle size is less than 1 μm, no chemomechanical failure was observed. This strong size effect is interpreted by the interplay between elastic energy storage and dissipation. Our finding has important implications for the design of high-performance LGPS SE, for example, by reducing the particle size to less than 1 μm the chemomechanical failure of LGPS SE can be mitigated.
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http://dx.doi.org/10.1021/acs.nanolett.1c04076DOI Listing
January 2022
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