Publications by authors named "Peng Hu"

866 Publications

Visible-Light-Induced Decarboxylative Fluorination of Aliphatic Carboxylic Acids Catalyzed by Iron.

Org Lett 2022 Aug 11. Epub 2022 Aug 11.

Lehn Institute of Functional Materials, School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China.

An efficient and inexpensive protocol for the direct decarboxylative fluorination of aliphatic carboxylic acids catalyzed with iron salts under visible light is presented. This new method allows the facile fluorination of a diverse array of carboxylic acids even on gram scale using a Schlenk flask without loss of efficiency. Mechanistic studies suggest that the photoinduced ligand-to-metal charge transfer process enables the generation of the key step to generate the carboxyl radical intermediates.
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http://dx.doi.org/10.1021/acs.orglett.2c02242DOI Listing
August 2022

Comparative Study of the Efficacy and Safety of Radical Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy in Locally Advanced Gastric Cancer: A Propensity Score-Matching Analysis.

Ann Surg Oncol 2022 Aug 8. Epub 2022 Aug 8.

Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, Hubei Province, China.

Background: The effectiveness and safety of preventive hyperthermic intraperitoneal chemotherapy (HIPEC) for gastric cancer (GC) remain controversial. This study aimed to describe the safety and efficacy of radical surgery (RS) with or without HIPEC for patients with locally advanced GC (LAGC).

Methods: The study identified 394 patients with LAGC who underwent RS with or without HIPEC in China.

Results: Of the 394 patients, 146 received RS+HIPEC, and 248 received RS alone. The RS-HIPEC procedure improved the relapse-free survival (RFS) of the GC patients (2-year RFS, 62.9 % vs 37.8 %; χ = 4.468; P = 0.035) compared with those who received RS alone. The incidence of postoperative myelosuppression (Z = 4.077; P = 0.043) was higher in the RS+HIPEC group, whereas the incidence of wound complications was lower (Z = 4.077; P = 0.043). In the subgroup analysis, HIPEC improved the OS (2-year OS, 69.9 % vs 40.8 %; χ = 5.537; P =0.019) and RFS (2-year RFS, 65.6 % vs 33.3 %; χ = 7.380, P = 0.007) of the patients with nerve invasion and the RFS of the patients with vascular invasion (2-year RFS, 60.7 % vs 31.6 %; χ = 3.891; P = 0.049). In addition, the prognosis of the patients who underwent HIPEC was better when the tumor diameter was smaller than 5 cm (2-year RFS, 68.6 % vs 37.9 %; χ = 3.957; P = 0.047).

Conclusions: The RS + HIPEC procedure improved the RFS of the patients with LAGC compared with RS alone, especially the patients with nerve or vascular invasion and the patients with tumor smaller than 5 cm. Moreover, it reduced the incidence of wound complications and did not induce more perioperative complications in addition to myelosuppression.
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http://dx.doi.org/10.1245/s10434-022-12348-9DOI Listing
August 2022

IL-33/ST2 axis contributes to the dermal fibrosis of systemic sclerosis via promoting fibroblasts activation.

J Dermatol Sci 2022 Aug 2. Epub 2022 Aug 2.

Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address:

Background: Systemic sclerosis (SSc) is a chronic immune-mediated rheumatic disease that is characterized by fibrosis of the skin and internal organs. Interleukin-33 (IL-33) has been recently implicated in several autoimmune diseases through its receptor ST2.

Objective: The aim of this study was to investigate the role and underlying mechanism of IL-33/ST2 axis in the fibrotic disorder of SSc.

Methods: The bleomycin (BLM)-induced fibrotic skin and skin biopsies of SSc patients were used to detect the expression of IL-33 and ST2. Human dermal fibroblasts were stimulated with recombinant IL-33(rIL-33) protein and their activation, proliferation and migration were assessed. The role of IL-33/ST2 axis was investigated in mouse fibrosis model via histologically assessing skin fibrosis after IL-33 gene knockout. ST2 neutralizing antibody treatment was also obtained to estimate the possible effect.

Results: The number IL-33 cells and ST2 cells were increased in the lesion skin of SSc patients and BLM-induced mouse. Human skin fibroblasts highly expressed ST2 protein, and the proliferation, migration, and collagen expression were significantly elevated after rIL-33 stimulation, accompanied by the activation of MAPKs and NF-kB pathways. The severity of skin fibrosis was significantly reduced in il33-/- mice compared with WT mice. Blockade of IL-33 receptor using an anti-ST2 neutralizing antibody effectively ameliorated the skin fibrosis.

Conclusion: These data indicate that IL-33/ST2 axis contributes to the fibrotic skin injury of SSc via promoting fibroblasts activation, and IL-33/ST2 blockade might serve as a novel strategy to inhibit the fibrosis progression in patients of SSc.
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http://dx.doi.org/10.1016/j.jdermsci.2022.07.009DOI Listing
August 2022

Visible light-induced unactivated δ-C(sp3)-H amination of alcohols catalyzed by iron.

ChemSusChem 2022 Aug 2. Epub 2022 Aug 2.

Sun Yat-Sen University, School of Chemistry, Waihuan Dong Road 132#, Panyu, 510006, Guangzhou, CHINA.

An iron-catalyzed remote C(sp 3 )-H amination of aliphatic alcohols through 1,5-hydrogen atom transfer is developed. This protocol provides a method to generate δ-C(sp 3 )-N bonds from primary, secondary, and tertiary alcohols under mild conditions. A wide substrate scope and a good functional group tolerance are presented. Mechanistic studies show that a LMCT course of an Fe-OR species and a chlorine radical-induced hydrogen abstraction of an alcohol are both possible to generate an alkoxy radical.
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http://dx.doi.org/10.1002/cssc.202201241DOI Listing
August 2022

Urethral Interfractional Geometric and Dosimetric Variations of Prostate Cancer Patients: A Study Using an Onboard MRI.

Front Oncol 2022 15;12:916254. Epub 2022 Jul 15.

Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United States.

Purpose: For a cohort of prostate cancer patients treated on an MR-guided radiotherapy (MRgRT) system, we retrospectively analyzed urethral interfractional geometric and dosimetric variations based on onboard MRIs acquired at different timepoints and evaluated onboard prostatic urethra visualization for urethra-focused online adaptive RT.

Methods: Twenty-six prostate cancer patients were prospectively scanned on a 0.35-T MRgRT system using an optimized T2-weighted HASTE sequence at simulation and final fraction. Two radiation oncologists (RO1 and RO2) contoured the urethras on all HASTE images. The simulation and final fraction HASTE images were rigidly registered, and urethral interobserver and interfractional geometric variation was evaluated using the 95th percentile Hausdorff distance (HD95), mean distance to agreement (MDA), center-of-mass shift (COMS), and DICE coefficient. For dosimetric analysis, simulation and final fraction HASTE images were registered to the 3D bSSFP planning MRI and 3D bSSFP final setup MRI, respectively. Both ROs' urethra contours were transferred from HASTE images for initial treatment plan optimization and final fraction dose estimation separately. Stereotactic body radiotherapy (SBRT) plans, 40 Gy in 5 fractions, were optimized to meet clinical constraints, including urethral V42Gy ≤0.03 cc, on the planning MRI. The initial plan was then forward calculated on the final setup MRI to estimate urethral dose on the final fraction and evaluate urethral dosimetric impact due to anatomy change.

Results: The average interobserver HD95, MDA, COMS, and DICE were 2.85 ± 1.34 mm, 1.02 ± 0.36 mm, 3.16 ± 1.61 mm, and 0.58 ± 0.15, respectively. The average interfractional HD95, MDA, COMS, and DICE were 3.26 ± 1.54 mm, 1.29 ± 0.54 mm, 3.34 ± 2.01 mm, and 0.49 ± 0.18, respectively. All patient simulation MRgRT plans met all clinical constraints. For RO1 and RO2, 23/26 (88%) and 21/26 (81%) patients' final fraction estimated urethral dose did not meet the planned constraint. The average urethral V42Gy change was 0.48 ± 0.58 cc.

Conclusion: Urethral interfractional motion and anatomic change can result in daily treatment violating urethral constraints. Onboard MRI with good visualization of the prostatic urethra can be a valuable tool to help better protect the urethra through patient setup or online adaptive RT.
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http://dx.doi.org/10.3389/fonc.2022.916254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334678PMC
July 2022

Novel Method for Fetal and Maternal Heart Rate Measurements Using 2-D Ultrasound Color Doppler Flow Images.

Ultrasound Med Biol 2022 Jul 22. Epub 2022 Jul 22.

Department of Ultrasound, First Affiliated Hospital of Anhui Medical University, Hefei, China. Electronic address:

Fetal heart rate (FHR) and maternal heart rate (MHR) are important indicators of fetal well-being during pregnancy. A common method in clinical examination is to estimate the FHR using the Doppler shift of echoes from umbilical artery blood flow based on an ultrasound pulsed-wave (PW) Doppler technique. Similarly, a sampling gate can be located at the maternal blood flow to measure MHR using PW Doppler. Ultrasound color Doppler flow imaging (CDFI) is one of the most commonly used imaging modes for clinical fetal examinations. Color coding is employed to display the blood flow velocity and direction in color grades according to the Doppler shift. Continuous CDF images contain dynamic changes characteristics of the blood flow. The periodic characteristics can be used to obtain heart rate information. Therefore, here we propose a novel method to measure FHR and MHR simultaneously using CDF images. The proposed method calculates the histogram of color similarity of CDF images to initially extract the periodic characteristics of the CDF image sequence. The histogram of color similarity function is then processed by a bandpass filter and autocorrelation operation to reduce noise and enhance periodicity. Finally, peak detection is performed on the processed signal to obtain the period and estimate the heart rate. The proposed method can measure the FHR and MHR in parallel after selecting two regions containing the umbilical artery and maternal blood flow, respectively. Thus, the method has high computational efficiency. The proposed method was evaluated on a Doppler flow phantom and clinical CDF images and then compared with the PW Doppler method. The correlation analysis and Bland-Altman plots reveal that the proposed method agrees well with the PW Doppler. It is a sanity check method for real-time clinical FHR and MHR measurements.
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http://dx.doi.org/10.1016/j.ultrasmedbio.2022.05.027DOI Listing
July 2022

Two-stage fermentation enhanced single-cell protein production by Yarrowia lipolytica from food waste.

Bioresour Technol 2022 Jul 22;361:127677. Epub 2022 Jul 22.

Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Department of Environmental Science and Engineering, Fudan University, Shanghai 200433, China; Shanghai Technical Service Platform for Pollution Control and Resource Utilization of Organic Wastes, Shanghai 200438, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China. Electronic address:

The resource utilization of food waste is crucial, and single-cell protein (SCP) is attracting much attention due to its high value. This study aimed to convert food waste to SCP by Yarrowia lipolytica. It was found the chemical oxygen demand (COD) removal rate 77 ± 1.70% was achieved at 30 g COD/L with the protein content of biomass only 24.1 ± 0.4% w/w biomass dry weight (BDW) in one-stage fermentation system. However, the protein content was significantly increased to 38.8 ± 0.2% w/w BDW with the COD removal rate 85.5 ± 0.7% by a two-stage fermentation process, where the food waste was firstly anaerobically fermented to volatile fatty acids and then converted to SCP with Yarrowia lipolytica. Transcriptomic analysis showed that the expression of SCP-producing genes including ATP citrate (pro-S)-lyase and fumarate hydratase class II were up-regulated in the two-stage transformation, resulting in more organic degradation for SCP synthesis.
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http://dx.doi.org/10.1016/j.biortech.2022.127677DOI Listing
July 2022

The efficacy of pegylated interferon alpha-2a and entecavir in HBeAg-positive children and adolescents with chronic hepatitis B.

BMC Pediatr 2022 07 20;22(1):426. Epub 2022 Jul 20.

Department of Infection, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders. Chongqing Key Laboratory of Child Infection and Immunity, Chongqing Medical University, 136, Zhongshan Road, Yuzhong District, Chongqing, 400014, People's Republic of China.

Background And Objectives: Pegylated interferon alpha-2a (peg-IFN α-2a) and entecavir (ETV) are both recommended as the first-line antiviral drugs for chronic hepatitis B (CHB) at present. We aimed to compare the efficacy and safety between peg-IFN α-2a and ETV initial therapy in children and adolescents with CHB and investigate the potential factors affecting the treatment response during the first 48 weeks.

Methods: We retrospectively selected 70 treatment-naïve children and adolescents with CHB who received peg-IFN α-2a(n = 26) or ETV(n = 44) as initial therapy and completed 48-week follow-up for data analysis. Blood samples before treatment were collected from 26 patients of the cohort to assess the cytokine profiles.

Results: We found that initial peg-IFN therapy results in higher rates of hepatitis B surface antigen (HBsAg) serological response (SR) but lower rates of virological and biochemical response rates compared to ETV at week 48. As for achieving hepatitis B e antigen (HBeAg) SR, peg-IFN was comparable to ETV in the univariate analysis and turned out to be better than ETV after adjustment for important baseline factors. We also found that elevated pre-treatment IL-18 level was significantly associated with HBeAg SR, and remained as the only independent factor of predicting HBeAg SR after adjustment for other important factors. No serious adverse effects of the 2 drugs were reported during the 48-week follow-up.

Conclusions: comparing to ETV, peg-IFN was superior in achieving HBsAg and HBeAg SR; higher baseline IL-18 levels were independently associated with HBeAg SR in this study of children and adolescents with CHB.
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http://dx.doi.org/10.1186/s12887-022-03482-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297582PMC
July 2022

Incremental Value of Radiomics in 5-Year Overall Survival Prediction for Stage II-III Rectal Cancer.

Front Oncol 2022 30;12:779030. Epub 2022 Jun 30.

Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Although rectal cancer comprises up to one-third of colorectal cancer cases and several prognosis nomograms have been established for colon cancer, statistical tools for predicting long-term survival in rectal cancer are lacking. In addition, previous prognostic studies did not include much imaging findings, qualitatively or quantitatively. Therefore, we include multiparametric MRI information from both radiologists' readings and quantitative radiomics signatures to construct a prognostic model that allows 5-year overall survival (OS) prediction for advance-staged rectal cancer patients. The result suggested that the model combined with quantitative imaging findings might outperform that of conventional TNM staging or other clinical prognostic factors. It was noteworthy that the identified radiomics signature consisted of three from dynamic contrast-enhanced (DCE)-MRI, four from anatomical MRI, and one from functional diffusion-weighted imaging (DWI). This highlighted the importance of multiparametric MRI to address the issue of long-term survival estimation in rectal cancer. Additionally, the constructed radiomics signature demonstrated value to the conventional prognostic factors in predicting 5-year OS for stage II-III rectal cancer. The presented nomogram also provides a practical example of individualized prognosis estimation and may potentially impact treatment strategies.
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http://dx.doi.org/10.3389/fonc.2022.779030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279662PMC
June 2022

Association of Serum Pepsinogens With Esophageal Squamous Cell Carcinoma Risk: A Systematic Review and Meta-Analysis.

Front Oncol 2022 30;12:928672. Epub 2022 Jun 30.

School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.

Background: Serum pepsinogens are serological biomarkers of gastric atrophy, and the latter is a risk factor for esophageal squamous cell carcinoma (ESCC). However, the association of serum pepsinogens with ESCC risk remains unclear. This systematic review and meta-analysis aimed to assess the relationship between serum pepsinogen I (PGI) and pepsinogen I: pepsinogen II ratio (PGR) and ESCC risk.

Methods: PubMed, Embase, and Web of Science were searched for articles on the effect of serum PGI and PGR on ESCC risk, published up to the end of February 2022. Meta-analysis with a random-effect model was used to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs).

Results: Five case-control studies and three prospective studies were included. In comparison with the high categories, the low categories of serum PGI (OR: 1.92, 95% CI: 1.45-2.56) and PGR (OR: 1.70, 95% CI: 1.01-2.85) were associated with an increased risk of ESCC, although a substantial heterogeneity was observed in serum PGR ( = 60.2%, = 0.028) rather than in serum PGI ( = 46.4%, = 0.070). In stratified analysis by study quality, the significant risk effect on ESCC was remained for PGI (OR: 2.05, 95% CI: 1.48-2.84) and PGR (OR: 2.07, 95% CI: 1.17-3.75) when only the studies with high quality were pooled.

Conclusions: Based on the available studies, although limited in number, this systematic review along with meta-analysis suggests that low serum PGI and low PGR may be related to an increased risk of ESCC. This present study provides evidence for using serum pepsinogen biomarkers in predicting ESCC. More delicate well-designed cohort studies with high study quality are needed, and dose-response analysis should be performed.
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http://dx.doi.org/10.3389/fonc.2022.928672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280489PMC
June 2022

Systemic glucocorticoids confound SARS-CoV-2 acquisition or even clinical outcomes in autoimmune disease patients treated with biologics.

Arthritis Rheumatol 2022 Jul 12. Epub 2022 Jul 12.

Department of Pediatrics, the First Affiliated Hospital of Anhui Medical University, No. 218 Ji-Xi Road, Hefei, 230022, PR China.

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http://dx.doi.org/10.1002/art.42303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349498PMC
July 2022

Association of Habitual Physical Activity With the Risk of All-Cause Mortality Among Chinese Adults: A Prospective Cohort Study.

Front Public Health 2022 24;10:919306. Epub 2022 Jun 24.

Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.

Objective: This study was conducted to evaluate the association of the risk of all-cause mortality with habitual physical activity (HPA) and its different domains among Chinese adults.

Methods: A total of 11,994 participants from the Guangzhou Heart Study were followed up until 1 January 2020. Information on HPA, including leisure-time physical activity (LTPA) and commute activity, was collected using a modified Global Physical Activity Questionnaire. Individual cause of death was obtained from the National Death Registry of China. Cox proportional hazards regression model was used to estimate hazard ratio () and 95% confidence interval () after adjustment for covariates.

Results: During 37,715 person-years of follow-up, 208 deaths (1.73%) were observed. When compared with the highest with the lowest exposure tertiles, HPA and LTPA were associated with 34% (: 0.66, 95% : 0.46-0.95) and 30% (: 0.70, 95% : 0.49-0.99) reduced risk of all-cause mortality after adjustment for covariates. Commute activity was not associated with mortality risk. For the specific component of LTPA, we found that every 1 MET-h/week increment of the housework was associated with a 1% (: 0.99, 95% : 0.98-0.99) decreased mortality risk, and performing brisk walking/health exercises/Yangko was associated with a 46% reduced mortality risk (: 0.54, 95% : 0.29-0.99).

Conclusion: This study suggests that a higher level of HPA and LTPA was associated with a lower risk of all-cause mortality. Our findings suggest people to perform HPA, especially LTPA, as a strategy for mortality reduction and health promotion.
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http://dx.doi.org/10.3389/fpubh.2022.919306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263353PMC
July 2022

Cu-TCPP Nanosheets-Sensitized Electrode for Simultaneous Determination of Hydroquinone and Catechol.

Materials (Basel) 2022 Jun 30;15(13). Epub 2022 Jun 30.

Hubei Key Laboratory of Radiation Chemistry and Functional Materials, School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning 437100, China.

It is quite important to develop sensitive, simple, and convenient methods for the simultaneous determination of Hydroquinone (HQ) and Catechol (CC) due to their wide existence, the difficulty of degradation, and the high toxicity. Herein, Cu-TCPP nanosheets were prepared in ,-dimethylformamide (DMF) through the solvent exfoliation method. The morphology and electrochemical performance of Cu-TCPP were characterized, revealing its stacked sheet structure with abundant pores, a fast electron transfer ability, and a large electrode active area. Using Cu-TCPP nanosheets as the sensitive material to modify the glassy carbon electrodes (Cu-TCPP/GCEs), it was found that they had an obvious enhancement effect on the electrochemical oxidation currents of HQ and CC. The signal enhancement mechanism was explored. The Cu-TCPP nanosheets not only enhanced the accumulation abilities of HQ and CC, but also improved their apparent catalytic rate, displaying high sensitivity for HQ and CC. The values of the detection limit were calculated to be 3.4 and 2.3 nM for HQ and CC. A satisfactory recovery was obtained when this method was used in measuring HQ and CC in the water samples.
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http://dx.doi.org/10.3390/ma15134625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267553PMC
June 2022

The role of toll-like receptors (TLRs) in pan-cancer.

Ann Med 2022 12;54(1):1918-1937

Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: Toll-like receptors (TLRs) are important components of the innate and adaptive immune systems, and abnormal TLR expression has been linked to a variety of cancers. However, there was a lack of clarity on the association of TLR stimulation with the carcinogenesis of cancer. The study's goal was to analyse the clinical importance of TLRs expression at the mRNA level in pan-cancer datasets, as well as the link between TLR expression and carcinogenesis, progression, and clinical prognosis.

Methods: The expression profile of TLRs derived from UCSC pan-cancer data was analysed in multiple dimensions, including clinical analysis, immunological subtype analysis, tumour microenvironment (TME) analysis, tumour stem cell correlation analysis, and drug sensitivity analysis. Additionally, we analyse protein-protein interactions, functional enrichment, and chromatin accessibility, as well as TLR expression in single-cell sequencing data.

Results: Our multi-omics analysis results imply that TLRs may operate as a biological marker for carcinogenesis and progression, a potential target for anti-tumour therapy, and a prognostic biomarker, laying the theoretical groundwork for future translational medicine research.

Conclusion: TLRs are involved in the formation of malignancies and can be explored in further detail as potential prognostic indicators. Key MessagesToll-like receptors (TLRs) are key factors in the process of the innate and adaptive immune response, and their aberrant expression of TLRs have been widely reported in various cancer. However, the association between TLRs stimulation and tumorigenesis of cancer has not been well clarified.In this study, in the pan-cancer data, integrated TLR family gene expression analysis, clinical correlation analysis, immune subtype correlation analysis, tumour microenvironment correlation analysis, tumour stem cell correlation analysis, and drug sensitivity correlation analysis were performed.TLRs play an important role in the development of tumours and can be studied in depth as potential prognostic markers.
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http://dx.doi.org/10.1080/07853890.2022.2095664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272932PMC
December 2022

Titanium Clip-dental Floss Traction-assisting Endoscopy in Patients With Difficulty in Cannulation Into the Duodenal Peridiverticular Papilla.

Surg Laparosc Endosc Percutan Tech 2022 08 1;32(4):462-465. Epub 2022 Aug 1.

Department of Hepatobiliary Surgery, Taizhou Hospital, Linhai City, Taizhou, China.

Objective: To assess titanium clip-dental floss traction-assisting endoscopy in patients with difficulty in cannulation into the papilla located at the lower, left or right side of the periampullary diverticulum.

Materials And Methods: Sixty-eight patients who had difficulty in cannulation into the papilla located at the lower, left, or right side of the periampullary diverticulum upon endoscopic retrograde cholangiopancreatography (ERCP) were recruited at Taizhou Hospital from July 2016 to June 2020. A random number table was used to divide the patients into an intervention (with titanium clip-dental floss traction) group and a control group (n=34 in each group). Patients in both groups underwent ERCP. The cannulation time, cannulation success rate, incidence of postprocedural complications after ERCP, hospitalization time, and hospitalization expenses in the 2 groups were compared.

Result: The cannulation time was 15.3±4.1 minutes in the intervention group, which was less than that in the control group (25.7±6.5 min). The cannulation success rate was 77±12.1% in the intervention group, which was higher than that in the control group (43±16.7%). Postprocedural complications occurred in 2 patients in the intervention group and 6 patients in the control group, with no significant differences. The hospitalization time and expenses were 3.8±2.6 days and 11.1±6 thousand yuan in the intervention group, respectively, and 6.1±3.7 days and 18.2±8 thousand yuan in the control group, respectively. The differences were statistically significant ( P <0.05).

Conclusion: Titanium clip-dental floss traction-assisting endoscopy achieved excellent efficacy in patients with difficulty in cannulation into the papilla located at the lower, left or right side of the periampullary diverticulum. The cannulation success rate was improved after treatment, with good safety and prognosis.
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http://dx.doi.org/10.1097/SLE.0000000000001068DOI Listing
August 2022

Molecular landscapes of human hippocampal immature neurons across lifespan.

Nature 2022 07 6;607(7919):527-533. Epub 2022 Jul 6.

Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity and unique brain functions in rodents and are dysregulated in multiple human neurological disorders. Little is known about the molecular characteristics of adult human hippocampal imGCs, and even their existence is under debate. Here we performed single-nucleus RNA sequencing aided by a validated machine learning-based analytic approach to identify imGCs and quantify their abundance in the human hippocampus at different stages across the lifespan. We identified common molecular hallmarks of human imGCs across the lifespan and observed age-dependent transcriptional dynamics in human imGCs that suggest changes in cellular functionality, niche interactions and disease relevance, that differ from those in mice. We also found a decreased number of imGCs with altered gene expression in Alzheimer's disease. Finally, we demonstrated the capacity for neurogenesis in the adult human hippocampus with the presence of rare dentate granule cell fate-specific proliferating neural progenitors and with cultured surgical specimens. Together, our findings suggest the presence of a substantial number of imGCs in the adult human hippocampus via low-frequency de novo generation and protracted maturation, and our study reveals their molecular properties across the lifespan and in Alzheimer's disease.
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http://dx.doi.org/10.1038/s41586-022-04912-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316413PMC
July 2022

Nitro-Decorated Microporous Covalent Organic Framework (TpPa-NO) for Selective Separation of CH from a CH/CH/CO Mixture and CO Capture.

ACS Appl Mater Interfaces 2022 Jul 6;14(28):32105-32111. Epub 2022 Jul 6.

MOE Laboratory of Bioinorganic and Synthetic Chemistry, Lehn Institute of Functional Materials, School of Chemistry, Sun Yat-Sen University, Guangzhou 510006, China.

A nitro-decorated microporous covalent organic framework, TpPa-NO, has been synthesized in a gram scale with a one-pot reaction. It can effectively selectively separate CH from a CH/CH/CO mixture and capture CO from CO/N based on ideal adsorption solution theory calculations and transient breakthrough experiments. Theoretical calculations illustrated that the hydrogen atoms of imine bonds, carbonyl oxygen, and nitro group show high affinity toward CH and CO, playing vital roles in efficient separation.
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http://dx.doi.org/10.1021/acsami.2c08338DOI Listing
July 2022

Chinese Cancer Patients' Attitudes Toward Psychotherapy and Their Willingness to Participate in Clinical Trials of Psychotherapy.

Cancer Control 2022 Jan-Dec;29:10732748221112664

Department of Medical Oncology, Cancer Center, West China Hospital, 34753Sichuan University, Chengdu, People's Republic of China.

Introduction: Psychotherapy is considered part of the standard treatment of cancer in Western countries. However, there is no literature on the attitudes of Chinese cancer patients toward psychotherapy.

Methods: In a multicenter, cross-sectional study in China, a homemade questionnaire was delivered to cancer patients. The targeted population was Chinese hospitalized cancer patients who were informed of their state of illness.

Results: Five hundred and fifty cancer patients received our questionnaire, and 83.3% completed the questionnaire. Among the 458 patients, 43.2% indicated that they had never heard of psychotherapy before the survey. However, after a brief introduction of psychotherapy, most (92.1%) cancer patients indicated that psychotherapy is essential for cancer patients, and over half of patients (57.4%) were willing to take psychotherapy on the advice of the oncologist in charge. Participants aged 45 years or younger, had a family income > 10000 yuan per month, and had an ECOG PS (Eastern Cooperative Oncology Group Performance Status) of 2-4 were more willing to receive psychotherapy. Of all patients, 59.2% and 57.6% were willing to participate in individual and group psychotherapy clinical trials, respectively. Participants who had a bachelor's degree or higher (odds ratio, OR = 2.09) and were aged 45 years or younger (OR = 1.67) were more willing to participate in individual and group psychotherapy clinical trials, respectively.

Conclusion: The unmet psychological needs of cancer patients in China remain high, and doctors' advice is likely to positively impact the patients' acceptance of psychotherapy. Psychological education for Chinese cancer patients should be strengthened. More high-quality clinical trials of psychotherapy should be conducted in China to achieve greater benefits for cancer patients and their families.
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http://dx.doi.org/10.1177/10732748221112664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260575PMC
July 2022

Phylogenetic signature and prevalence of natural resistance-associated substitutions for hepatitis C virus genotypes 3a and 3b in southwestern China.

J Virus Erad 2022 Jun 15;8(2):100071. Epub 2022 Jun 15.

Department of Infectious Diseases, Institute for Viral Hepatitis, The Key Laboratory of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Patients infected with hepatitis C (HCV) genotype (GT) 3, especially GT3b, are still difficult to cure. GT3b is more common than GT3a in southwestern China. Here we aimed to investigate the prevalence of naturally occurring RASs in HCV GT3 in southwestern China and performed phylogenetic analysis.

Methods: Serum samples were collected from patients with HCV GT3 infection. Sanger sequencing was used to validate resistance-associated substitutions (RASs). Phylogenetic analysis was performed using MEGA X and the observed-minus-expected-squared algorithm was used to analyze amino acid covariance.

Results: A total of 136 patients were enrolled, including 41 HCV GT3a and 95 GT3b infected patients. In the NS5A region, the proportion of RASs found in GT3b (99%) was notably higher than in GT3a (9%). In the NS3 region, RASs prevalence in GT3b (5%) was lower than in GT3a (24%). NS5B-specific RASs were rare. Both the NS5A30k and L31 M substitutions occurred in 96% of GT3b sequences. The A30K + L31M combination was found in 94% of GT3b isolates, however, there were no A30K or L31M mutations observed in the GT3a sequence.

Conclusions: Significant differences were observed between HCV GT3a and GT3b in terms of RAS prevalence. The origin of GT3a appears to be more diverse compared with GT3b in southern China. Studies specifically aimed at HCV GT3b infection should be initiated to gain more insight into this subtype.
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http://dx.doi.org/10.1016/j.jve.2022.100071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218835PMC
June 2022

Clinical features and outcomes of perimedullary arteriovenous fistulas: comparison between micro- and macro-type lesions.

J Neurointerv Surg 2022 Jun 22. Epub 2022 Jun 22.

Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China

Background: Although the angioarchitecture of perimedullary arteriovenous fistulas (PMAVFs) is straightforward, their size and blood flow are highly heterogeneous. This study aimed to evaluate the differences in clinical features and outcomes of PMAVFs based on lesion size and blood flow.

Methods: 114 consecutive patients with PMAVFs from two institutes were retrospectively reviewed. The lesions were classified as either micro-PMAVFs (shunt point diameter <1 cm) or macro-PMAVFs (shunt point diameter ≥1 cm).

Results: The patients with micro-PMAVFs were older at the first presentation (33.50 vs 13.50 years, p<0.001). Macro-PMAVFs were more commonly associated with spinal metameric arteriovenous shunts (6.9% vs 28.6%, p=0.003). Compared with the macro-PMAVFs, the micro-PMAVFs showed a significantly higher risk of gradual clinical deterioration after initial onset (73.6%/year vs 10.0%/year; HR 3.888, 95% CI 1.802 to 8.390, p=0.001). A total of 58.6% of the micro-PMAVFs were treated surgically, whereas 85.7% of the macro-PMAVFs were treated via endovascular approaches. Complete obliteration was 73.7% for the whole cohort, and was more common for the micro-PMAVFs than for the macro-PMAVFs (87.9% vs 58.9%, p=0.001). At the last follow-up, spinal function was significantly improved compared with the pretreatment status, and the rate of severe disability of patients with macro-PMAVFs was slightly but not significantly higher than that of patients with micro-PMAVFs (16.1% vs 8.6%, p=0.315) CONCLUSIONS: The clinical risks, treatment strategies and obliteration rates of PMAVFs differ based on their size and blood flow.
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http://dx.doi.org/10.1136/neurintsurg-2021-018412DOI Listing
June 2022

A piecewise sine waveguide for terahertz traveling wave tube.

Sci Rep 2022 Jun 21;12(1):10449. Epub 2022 Jun 21.

School of Electronic Science and Engineering, University of Electronic Science and Technology University of China, Chengdu, 610054, China.

In this paper, a piecewise sine waveguide (PWSWG) is proposed as the slow-wave structure (SWS) to develop high-power terahertz (THz) traveling wave tubes (TWTs). The PWSWG is an improvement over the rectangular waveguide wherein its two E-planes simultaneously oscillate up and down along the longitudinal direction. The oscillation curve in the H-plane is a piecewise sine curve formed by inserting line segments into the peaks and troughs of the sine curve. The simulation analysis and experimental verification show that the PWSWG offers the advantages of large interaction impedance and excellent electromagnetic transmission performance. Furthermore, the calculation results of beam-wave interaction show that the TWT based on PWSWG SWS can generate a radiated power of 253.1 W at the typical frequency of 220 GHz, corresponding to a gain of 37.04 dB and an interaction efficiency of 6.92%. Compared with the conventional SWG TWTs, the PWSWG TWT has higher interaction efficiency and shorter saturation tube length. In conclusion, the PWSWG proposed in this paper can be considered a suitable SWS for high-power THz radiation sources.
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http://dx.doi.org/10.1038/s41598-022-14587-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213447PMC
June 2022

Vertebral Artery Transposition and Dural Ring Reconstruction: A New Treatment Modality for Cervical Spinal Cord Compression Resulting From Aberrant Vertebral Arteries.

Oper Neurosurg (Hagerstown) 2022 07 9;23(1):e26-e30. Epub 2022 May 9.

Department of Neurosurgery, China International Neuroscience Institute, Xuanwu Hospital, Capital Medical University, Beijing, China.

Background: Two of three patients who were consecutively treated within the past 7 years using traditional methods in our center presented with recurrence and even aggravation during follow-up. Therefore, a new approach was developed to treat a recent patient to provide for complete decompression of the spinal cord.

Objective: To illustrate a new treatment modality for patients with cervical spinal cord compression resulting from aberrant vertebral arteries.

Methods: The aberrant vertebral arteries were freed after substantial dissection of their dural rings. The compression was released after moving the aberrant vertebral arteries, which were sutured to the lateral mass to the extradural space. New dural rings above the atlas were created to allow the vertebral artery to enter the dura mater into a wider subdural space.

Results: The patient experienced full relief from her initial complaints except for mild numbness of the bilateral lower extremities immediately after surgery. Postoperative imaging studies indicated successful transposition of bilateral aberrant vertebral arteries and significant decompression of the spinal cord. Her symptoms did not recur over a 6-month follow-up period. Imaging studies at the 6-month follow-up showed stable vertebral artery transposition and spinal cord decompression.

Conclusion: A patient with cervical spinal cord compression resulting from aberrant vertebral arteries was successfully treated by our new technique, which includes vertebral artery transposition, fixation, and dural ring reconstruction. Our approach could be an alternative for durable spinal cord decompression in such patients.
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http://dx.doi.org/10.1227/ons.0000000000000233DOI Listing
July 2022

Minimum variance beamforming combined with covariance matrix-based adaptive weighting for medical ultrasound imaging.

Biomed Eng Online 2022 Jun 18;21(1):40. Epub 2022 Jun 18.

Department of Biomedical Engineering, Hefei University of Technology, 230009, Hefei, China.

Background: The minimum variance (MV) beamformer can significantly improve the image resolution in ultrasound imaging, but it has limited performance in noise reduction. We recently proposed the covariance matrix-based statistical beamforming (CMSB) for medical ultrasound imaging to reduce sidelobes and incoherent clutter.

Methods: In this paper, we aim to improve the imaging performance of the MV beamformer by introducing a new pixel-based adaptive weighting approach based on CMSB, which is named as covariance matrix-based adaptive weighting (CMSAW). The proposed CMSAW estimates the mean-to-standard-deviation ratio (MSR) of a modified covariance matrix reconstructed by adaptive spatial smoothing, rotary averaging, and diagonal reducing. Moreover, adaptive diagonal reducing based on the aperture coherence is introduced in CMSAW to enhance the performance in speckle preservation.

Results: The proposed CMSAW-weighted MV (CMSAW-MV) was validated through simulation, phantom experiments, and in vivo studies. The phantom experimental results show that CMSAW-MV obtains resolution improvement of 21.3% and simultaneously achieves average improvements of 96.4% and 71.8% in average contrast and generalized contrast-to-noise ratio (gCNR) for anechoic cyst, respectively, compared with MV. in vivo studies indicate that CMSAW-MV improves the noise reduction performance of MV beamformer.

Conclusion: Simulation, experimental, and in vivo results all show that CMSAW-MV can improve resolution and suppress sidelobes and incoherent clutter and noise. These results demonstrate the effectiveness of CMSAW in improving the imaging performance of MV beamformer. Moreover, the proposed CMSAW with a computational complexity of [Formula: see text] has the potential to be implemented in real time using the graphics processing unit.
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http://dx.doi.org/10.1186/s12938-022-01007-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206759PMC
June 2022

Imaging findings of vertebral osteomyelitis caused by nontuberculous mycobacterial organisms: Three case reports and literature review.

Medicine (Baltimore) 2022 Jun 17;101(24):e29395. Epub 2022 Jun 17.

Department of Radiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Rationale: Prompt diagnosis of nontuberculous Mycobacterial (NTM) vertebral osteomyelitis is challenging, yet necessary to prevent serious morbidity and mortality. Here, we report 3 cases of vertebral osteomyelitis caused by NTM with imaging findings.

Patient Concerns: Case 1, a 58-year-old male patient, was admitted to our hospital because of the presence of a pulmonary mass for 6 months with cough and chest pain.Case 2, a 50-year-old male patient, had fever and cough for 3 years and was diagnosed with tuberculosis. Antituberculosis treatment was ineffective, accompanied by lymph node enlargement and osteosclerotic changes involving vertebral bodies.Case 3, a 66-year-old female patient, was admitted to our hospital with a mass on the top of her head for 1 month, which ruptured in the last 2 weeks.

Diagnoses: Case 1: Sputum culture revealed Mycobacterium (M.) avium.Case 2: The final culture results of the lymph node biopsy samples were M. intracellulare.Case 3: Culture results of the sputum and pus from the abscess were M. gordon.We found sclerosing lesions in the spine in all 3 NTM patients, which were easily misdiagnosed as metastatic tumors. In 2 cases, there was bone destruction in the ilium with limbic sclerosis, and there were abscesses near the ilium and in front of the sacrum in 1 case.

Interventions: Case 1 was transferred to other specialist hospital.Case 3 received surgical treatment for cranial lesions and abscess drainage.Case 2 and case 3 received targeted treatment for nontuberculous mycobacteria in our hospital.

Outcome: The condition of case 1 was unknown.Recovery of case 2 was uneventful because of prolonged illness; however, inflammation gradually improved overall.Case 3 had no recurrence following surgical treatment.

Lessons: In our 3 cases of NTM vertebral osteomyelitis, bone lesions were often misdiagnosed as bony metastases because of the presence of multiple sclerotic lesions. Diagnoses were challenging and delayed. It is important to consider osteomyelitis by NTM when disseminated osteosclerosis with or without osteolytic bone lesions is present in conjunction with continuous inflammatory symptoms and signs. Moreover, an open biopsy of the lesion should be performed for a definitive diagnosis.
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http://dx.doi.org/10.1097/MD.0000000000029395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276087PMC
June 2022

T cell epitopes are largely conserved in the SARS-CoV-2 Omicron subvariant (BA.1, BA.2, BA.3, and GKA).

J Med Virol 2022 Jun 8. Epub 2022 Jun 8.

Department of Infectious Diseases, Institute for Viral Hepatitis, The Key Laboratory of Molecular Biology for Infectious Diseases, Chinese Ministry of Education, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

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http://dx.doi.org/10.1002/jmv.27925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348460PMC
June 2022

Association of Dietary Phytosterols Intake and Survival of Esophageal Squamous Cell Carcinoma: A Prospective Cohort Study.

Nutr Cancer 2022 Jun 7:1-10. Epub 2022 Jun 7.

School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.

Background: The association of dietary phytosterols intake with survival of esophageal squamous cell carcinoma (ESCC) remains unclear. This study was to examine the effect of dietary phytosterols intake on ESCC survival in a Chinese rural population.

Methods: A total of 942 incident ESCC patients diagnosed between 2011 and 2013 in Yanting area were followed up until March 1, 2020. Dietary intake five years before ESCC diagnosis was collected using a food frequency questionnaire. The outcome of interest was all-cause mortality. Cox proportional hazards regression model was used to estimate hazard ratio (HR) and 95% confidence intervals (CI).

Results: When comparing the highest with lowest intake quartiles, intake of five specific and total phytosterols was not significantly associated with risk of death after adjustment for covariates, the adjusted HR (95% CI) for β-sitosterol, campesterol, stigmasterol, β-sitostanol, campestanol and total phytosterols was 0.90 (95% CI: 0.70-1.16), 0.92 (95% CI: 0.71-1.19), 0.86 (95% CI: 0.66-1.12), 0.93 (95% CI: 0.73-1.20), 0.94 (95% CI: 0.72-1.21), 0.89 (95% CI: 0.69-1.15), respectively.

Conclusion: This study does not find any association between pre-diagnostic phytosterols intake and risk of all-cause mortality among ESCC patients. Further research is required to determine the effect of post-diagnostic phytosterols intake on ESCC survival.
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http://dx.doi.org/10.1080/01635581.2022.2085311DOI Listing
June 2022

A review of spatiotemporal patterns of neonicotinoid insecticides in water, sediment, and soil across China.

Environ Sci Pollut Res Int 2022 Jun 4. Epub 2022 Jun 4.

International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), School of Water Conservancy and Civil Engineering, Northeast Agricultural University, Harbin, 150030, Heilongjiang, China.

Neonicotinoid insecticides (NNIs) have been widely used to control insect pests, while their environmental residues and associated hazardous impacts on human and ecosystem health have attracted increasing attention worldwide. In this study, we examined the current levels and associated spatial and temporal patterns of NNIs in multiple environmental media across China. Concentrations of NNIs in surface water, sediment, and soil were in the range of 9.94-755 ng·L, 0.07-8.30 ng·g DW, and 0.009-356 ng·g DW, respectively. The high levels of NNIs in surface water, such as in Yangtze River (755 ng·L), North River (539 ng·L), Nandu River (519 ng·L), and Minjiang River (514 ng·L), were dominated by imidacloprid, thiamethoxam, and acetamiprid due to their extensive use. The levels of NNIs in sediments were relatively low, and the highest concentration (8.30 ng·g DW) was observed in Dongguan ditch. Sediment-water exchange calculated from fugacity fraction indicated that NNIs in sediment can be released back into the water due to their high solubility and low K. Soils from agricultural zones contained the largest residual NNIs, with imidacloprid concentrations in cultivated soil reaching 119 ng·g DW. The calculated leaching potential showed that clothianidin has the highest migration potential to deep soil or groundwater. The monitored data of NNIs presented a decreasing trend from 2016 to 2018, which might be caused by the implementation of relevant control policies for NNI applications. The high levels of NNIs mainly occurred in southern China due to frequent agricultural activities and warm and humid meteorological conditions. The results from this study improve our understanding of the pollution levels and environmental behavior of NNIs in different environmental media across China and provide new knowledge that is needed for making future control policies for NNIs production and application.
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http://dx.doi.org/10.1007/s11356-022-21226-6DOI Listing
June 2022

Unsupervised Neural Rendering for Image Hazing.

IEEE Trans Image Process 2022 9;31:3987-3996. Epub 2022 Jun 9.

Image hazing aims to render a hazy image from a given clean one, which could be applied to a variety of practical applications such as gaming, filming, photographic filtering, and image dehazing. To generate plausible haze, we study two less-touched but challenging problems in hazy image rendering, namely, i) how to estimate the transmission map from a single image without auxiliary information, and ii) how to adaptively learn the airlight from exemplars, i.e., unpaired real hazy images. To this end, we propose a neural rendering method for image hazing, dubbed as HazeGEN. To be specific, HazeGEN is a knowledge-driven neural network which estimates the transmission map by leveraging a new prior, i.e., there exists the structure similarity (e.g., contour and luminance) between the transmission map and the input clean image. To adaptively learn the airlight, we build a neural module based on another new prior, i.e., the rendered hazy image and the exemplar are similar in the airlight distribution. To the best of our knowledge, this could be the first attempt to deeply render hazy images in an unsupervised fashion. Compared with existing haze generation methods, HazeGEN renders the hazy images in an unsupervised, learnable, and controllable manner, thus avoiding the labor-intensive efforts in paired data collection and the domain-shift issue in haze generation. Extensive experiments show the promising performance of our method comparing with some baselines in both qualitative and quantitative comparisons. The code is available at https://github.com/XLearning-SCU.
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http://dx.doi.org/10.1109/TIP.2022.3177321DOI Listing
June 2022

Effect of Integrated Care on Patients With Atrial Fibrillation: A Systematic Review of Randomized Controlled Trials.

Front Cardiovasc Med 2022 17;9:904090. Epub 2022 May 17.

School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.

Aims: The integrated management was evidenced to improve the hospitalization and its associated complications in patients with atrial fibrillation (AF), but the strategies of integrated care varied and results were inconsistent. This systematic review and meta-analysis aimed to evaluate the effect of integrated care on AF-related outcomes with comparison with usual care.

Methods: PubMed, Embase, and Web of Science were searched for articles published until 10th January 2022. Eligible studies were randomized controlled trials to study the effect of integrated care on AF-related outcomes. Meta-analysis with a random-effect model was used to calculate risk ratio (RR) and 95% confidence interval (CI) by comparing the integrated care with usual care.

Results: A total of five studies with 6,486 AF patients were selected. By synthesizing available data, integrated care effectively reduced the risk of all-cause mortality (RR = 0.54, 95% CI = 0.42-0.69), cardiovascular hospitalization (RR = 0.72, 95% CI = 0.55-0.94), and cardiovascular mortality (RR = 0.52, 95% CI = 0.36-0.78) when compared with usual care; however, there was no superior effect on preventing AF-related hospitalization (RR = 0.86, 95% CI = 0.72-1.02), cerebrovascular events (RR = 1.13, 95% CI = 0.75-1.70), and major bleeding (RR = 1.29, 95% CI = 0.86-1.94) when comparing integrated care with usual care.

Conclusion: Integrated care can reduce the risk of all-cause mortality, cardiovascular mortality, and cardiovascular hospitalizations in AF patients compared with usual care, while the benefit was not observed in other outcomes.
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http://dx.doi.org/10.3389/fcvm.2022.904090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152009PMC
May 2022

Changes in glycaemic control of oral anti-diabetic medications assessed by continuous glucose monitors among patients with type 2 diabetes: a protocol of network meta-analysis.

Syst Rev 2022 06 2;11(1):110. Epub 2022 Jun 2.

School of Management, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.

Background: Continuous glucose monitors (CGMs) can measure interstitial fluid glucose levels to provide comprehensive real-time glucose profile among people with type 2 diabetes. These can accurately detect glucose levels, hyperglycaemia and hypoglycaemia events compared with conventional self-monitoring. Increased application of CGMs provides a valuable opportunity to evaluate glucose control on oral anti-diabetic medications. This review will compare the efficacy and safety of oral anti-diabetic medications among patients with type 2 diabetes, evaluated by CGM.

Methods: The following databases will be searched: Cochrane Library, PubMed, EMBASE, CINAHL, PsycINFO, Scopus and grey literature (ClinicalTrials.gov, PsycEXTRA, ProQuest Dissertations, Google Scholar and Theses Global) for the identification of studies. The review will include and summarise evidence from randomised clinical trials that use CGMs for blood glucose management in adults (aged ≥ 18 years), published in English between January 2000 and May 2021 without any restrictions of countries. Reference list of all selected articles will independently be screened to identify additional studies left out in the initial search. Primary outcomes will be HbA1c (≤ 7.0%), time spent with hypoglycaemia (< 70 mg/dl) or hyperglycaemia (≥ 180 mg/dl). Secondary outcomes will be change in weight, blood pressure and related comorbidities (cardiovascular mortality, heart failure events, myocardial infarction and stroke). Study selection, data extraction and quality assessment will be conducted independently by at least two reviewers. A third reviewer will determine and resolve discrepancies. At least two independent reviewers will cross-check data synthesis. The quality of evidence of the review will be assessed according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Tool.

Discussion: The review is anticipated to provide up to date evidence for further studies and clinic practices regarding glycaemic control, hypoglycaemia, and hyperglycaemia issues. The results will be published in a peer-reviewed journal.

Trial Registration: PROSPERO CRD42020188399 .
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http://dx.doi.org/10.1186/s13643-022-01986-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161457PMC
June 2022
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