Dr.  Peixin Dong, MD, PhD - Hokkaido University

Dr. Peixin Dong

MD, PhD

Hokkaido University

Japan

ORCID logohttps://orcid.org/0000-0002-2335-1394

Dr.  Peixin Dong, MD, PhD - Hokkaido University

Dr. Peixin Dong

MD, PhD

Introduction

Primary Affiliation: Hokkaido University - Japan

Research Interests:

Education

Apr 2004 - Mar 2008
Hokkaido University
Ph.D.
Department of Gynecology

Experience

Apr 2008 - Mar 2010
Fudan University

Hospital of Obstetrics & Gynecology
Apr 2010
Hokkaido University

Department of Obstetrics & Gynecology

Publications

82Publications

1434Reads

651Profile Views

403PubMed Central Citations

Molecular-targeted therapies and precision medicine for endometrial cancer.

Jpn J Clin Oncol 2019 Feb;49(2):108-120

Department of Obstetrics and Gynecology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, North 15, West 7, Kita-ku, Sapporo, Hokkaido, Japan.

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https://academic.oup.com/jjco/advance-article/doi/10.1093/jj
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http://dx.doi.org/10.1093/jjco/hyy159DOI Listing
February 2019
30 Reads
1.750 Impact Factor

Exploring lncRNA-Mediated Regulatory Networks in Endometrial Cancer Cells and the Tumor Microenvironment: Advances and Challenges.

Cancers (Basel) 2019 Feb 16;11(2). Epub 2019 Feb 16.

Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Hokkaido University, Sapporo 060-8638, Japan.

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http://dx.doi.org/10.3390/cancers11020234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406952PMC
February 2019
2 Reads

Knockout of MTF1 Inhibits the Epithelial to Mesenchymal Transition in Ovarian Cancer Cells.

J Cancer 2018 11;9(24):4578-4585. Epub 2018 Nov 11.

Department of Anatomy, College of Basic Medical Science, Harbin Medical University, Harbin, China.

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http://www.jcancer.org/v09p4578.htm
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http://dx.doi.org/10.7150/jca.28040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299381PMC
November 2018
23 Reads
2.639 Impact Factor

Long Non-coding RNA NEAT1: A Novel Target for Diagnosis and Therapy in Human Tumors.

Front Genet 2018 15;9:471. Epub 2018 Oct 15.

Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Hokkaido University, Sapporo, Japan.

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https://www.frontiersin.org/article/10.3389/fgene.2018.00471
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http://dx.doi.org/10.3389/fgene.2018.00471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196292PMC
October 2018
24 Reads

Tumor-Intrinsic PD-L1 Signaling in Cancer Initiation, Development and Treatment: Beyond Immune Evasion.

Front Oncol 2018 19;8:386. Epub 2018 Sep 19.

Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Hokkaido University, Sapporo, Japan.

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https://www.frontiersin.org/article/10.3389/fonc.2018.00386/
Publisher Site
http://dx.doi.org/10.3389/fonc.2018.00386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156376PMC
September 2018
62 Reads

miR-203 inhibits ovarian tumor metastasis by targeting BIRC5 and attenuating the TGFβ pathway.

J Exp Clin Cancer Res 2018 Sep 21;37(1):235. Epub 2018 Sep 21.

Department of Pathology, the University of Tennessee Health Science Center, 19 S. Manassas St., Rm. 266, Memphis, TN, 38163, USA.

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http://dx.doi.org/10.1186/s13046-018-0906-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150978PMC
September 2018
81 Reads

Control of PD-L1 expression by miR-140/142/340/383 and oncogenic activation of the OCT4-miR-18a pathway in cervical cancer.

Oncogene 2018 09 31;37(39):5257-5268. Epub 2018 May 31.

Department of Women's Health Educational System, Hokkaido University School of Medicine, Hokkaido University, Sapporo, 0608638, Japan.

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http://dx.doi.org/10.1038/s41388-018-0347-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160397PMC
September 2018
106 Reads
1 Citation
8.460 Impact Factor

B7H3 As a Promoter of Metastasis and Promising Therapeutic Target.

Front Oncol 2018 6;8:264. Epub 2018 Jul 6.

Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Hokkaido University, Sapporo, Japan.

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http://dx.doi.org/10.3389/fonc.2018.00264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043641PMC
July 2018
68 Reads
1 Citation

miR-34a, miR-424 and miR-513 inhibit MMSET expression to repress endometrial cancer cell invasion and sphere formation.

Oncotarget 2018 May 1;9(33):23253-23263. Epub 2018 May 1.

Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Hokkaido University, Sapporo, Japan.

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http://dx.doi.org/10.18632/oncotarget.25298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955424PMC
May 2018
99 Reads
6.360 Impact Factor

Lentiviral vector mediated-ASAP1 expression promotes epithelial to mesenchymal transition in ovarian cancer cells.

Oncol Lett 2018 Apr 22;15(4):4432-4438. Epub 2018 Jan 22.

Center for Cancer Research, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.

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http://dx.doi.org/10.3892/ol.2018.7834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835873PMC
April 2018
45 Reads
0.990 Impact Factor

Lentiviral vector mediated-ASAP1 expression promotes epithelial to mesenchymal transition in ovarian cancer cells.

Oncol Lett. 2018 Apr;15(4):4432-443

Oncol Lett

Ovarian cancer is one of the most common malignancies in women and has a high mortality rate due to metastatic progression and tumor recurrence. ASAP1 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 1) is an ADP-ribosylation factor GTPase-activating protein, which is involved in tumor metastasis. However, the role of ASAP1 in ovarian cancer is completely unknown. The present study reported that ASAP1 was highly expressed in ovarian carcinoma, and expression positively-correlated with overall poor survival and prognosis of patients. Lentiviral vector mediated ASAP1 expression promoted cell migration and invasion in ovarian cancer cell lines SKOV3 and OVCAR3. In addition, ASAP1 promoted cell proliferation, survival and inhibited chemotherapy drug paclitaxel-induced cell apoptosis. Furthermore, ASAP1 expression promoted epithelial to mesenchymal transition (EMT) by upregulating the mesenchymal cell markers N-cadherin and vimentin, and downregulating epithelial cell marker E-cadherin in the ovarian cancer cell lines. The data indicate for the first time that ASAP1 exhibits an oncogenic role by promoting EMT in ovarian cancer cells.

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April 2018
51 Reads

Lentiviral CRISPR/Cas9 nickase vector mediated BIRC5 editing inhibits epithelial to mesenchymal transition in ovarian cancer cells.

Oncotarget 2017 Nov 17;8(55):94666-94680. Epub 2017 Oct 17.

Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, USA.

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http://dx.doi.org/10.18632/oncotarget.21863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706903PMC
November 2017
23 Reads
3 Citations
6.360 Impact Factor

Musashi-2, a novel oncoprotein promoting cervical cancer cell growth and invasion, is negatively regulated by p53-induced miR-143 and miR-107 activation.

J Exp Clin Cancer Res 2017 10 26;36(1):150. Epub 2017 Oct 26.

Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Hokkaido University, Sapporo, 0608638, Japan.

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http://dx.doi.org/10.1186/s13046-017-0617-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659032PMC
October 2017
64 Reads
1 Citation

Enhancer of Zeste homolog 2 (EZH2) induces epithelial-mesenchymal transition in endometriosis.

Sci Rep 2017 07 28;7(1):6804. Epub 2017 Jul 28.

Shanghai OB/GYN Hospital, Fudan University, Shanghai, China.

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http://dx.doi.org/10.1038/s41598-017-06920-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533797PMC
July 2017
42 Reads
1 Citation
5.080 Impact Factor

iASPP induces EMT and cisplatin resistance in human cervical cancer through miR-20a-FBXL5/BTG3 signaling.

J Exp Clin Cancer Res 2017 04 11;36(1):48. Epub 2017 Apr 11.

Department of Gynecology, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.

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http://dx.doi.org/10.1186/s13046-017-0520-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387376PMC
April 2017
27 Reads
10 Citations

KLF4 expression enhances the efficacy of chemotherapy drugs in ovarian cancer cells.

Biochem Biophys Res Commun 2017 03 18;484(3):486-492. Epub 2017 Jan 18.

Department of Pathology and Laboratory Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA; Center for Cancer Research, The University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.01.062DOI Listing
March 2017
70 Reads
2 Citations
2.300 Impact Factor

EZH2 inhibition suppresses endometrial cancer progression via miR-361/Twist axis.

Oncotarget 2017 Feb;8(8):13509-13520

Department of Gynecology, Hokkaido University School of Medicine, Hokkaido University, Sapporo 0608638, Japan.

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http://dx.doi.org/10.18632/oncotarget.14586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355116PMC
February 2017
66 Reads
12 Citations
6.360 Impact Factor

Suppression of iASPP-dependent aggressiveness in cervical cancer through reversal of methylation silencing of microRNA-124.

Sci Rep 2016 10 21;6:35480. Epub 2016 Oct 21.

Department of Women's Health Educational System, Hokkaido University School of Medicine, Hokkaido University, N15, W7, Sapporo 0608638, Japan.

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http://dx.doi.org/10.1038/srep35480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073231PMC
October 2016
100 Reads
8 Citations
5.080 Impact Factor

HPV self-sampling in Japanese women: A feasibility study in a population with limited experience of tampon use.

Hanley SJ, Fujita H, Yokoyama S, Kunisawa S, Tamakoshi A, Dong P, Kobayashi N, Watari H, Kudo M, Sakuragi N, Journal of medical screening, 2016, vol. 23, no. 3, pp. 164-170, 2016

http://europepmc.org/abstract/med/26919866

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October 2016
10 Reads

MiR-137 and miR-34a directly target Snail and inhibit EMT, invasion and sphere-forming ability of ovarian cancer cells.

J Exp Clin Cancer Res 2016 09 5;35(1):132. Epub 2016 Sep 5.

Department of Women's Health Educational System, Hokkaido University School of Medicine, Hokkaido University, N15, W7, Sapporo, 0608638, Japan.

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http://dx.doi.org/10.1186/s13046-016-0415-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011787PMC
September 2016
31 Reads
19 Citations

Challenges in breast and cervical cancer control in Japan.

Lancet Oncol 2016 09 30;17(9):e372. Epub 2016 Aug 30.

Department of Women's Health Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan; Department of Reproductive Endocrinology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

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http://dx.doi.org/10.1016/S1470-2045(16)30411-9DOI Listing
September 2016
8 Reads
1 Citation
24.690 Impact Factor

HPV self-sampling in Japanese women: A feasibility study in a population with limited experience of tampon use.

J Med Screen 2016 09 25;23(3):164-70. Epub 2016 Feb 25.

Department of Women's Health Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan Department of Reproductive Endocrinology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

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http://dx.doi.org/10.1177/0969141315625702DOI Listing
September 2016
12 Reads
1 Citation
2.722 Impact Factor

Reactivating p53 functions by suppressing its novel inhibitor iASPP: a potential therapeutic opportunity in p53 wild-type tumors.

Oncotarget 2015 Aug;6(24):19968-75

Department of Women's Health Educational System, Hokkaido University School of Medicine, Hokkaido University, Sapporo, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652980PMC
http://dx.doi.org/10.18632/oncotarget.4847DOI Listing
August 2015
32 Reads
13 Citations
6.360 Impact Factor

MicroRNA-101 targets EZH2, MCL-1 and FOS to suppress proliferation, invasion and stem cell-like phenotype of aggressive endometrial cancer cells.

Oncotarget 2014 Aug;5(15):6049-62

Department of Gynecology, Hokkaido University, Sapporo, Japan; Department of Women's Health Educational System, Hokkaido University, Sapporo, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171612PMC
http://dx.doi.org/10.18632/oncotarget.2157DOI Listing
August 2014
29 Reads
57 Citations
6.360 Impact Factor

The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer.

J Transl Med 2014 Aug 21;12:231. Epub 2014 Aug 21.

Department of Women's Health Educational System, Hokkaido University School of Medicine, Hokkaido University, N15, W7, Sapporo 0608638, Japan.

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http://dx.doi.org/10.1186/s12967-014-0231-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145234PMC
August 2014
25 Reads
14 Citations
3.930 Impact Factor

MicroRNA-106b modulates epithelial-mesenchymal transition by targeting TWIST1 in invasive endometrial cancer cell lines.

Mol Carcinog 2014 May 3;53(5):349-59. Epub 2013 Sep 3.

Department of Women's Health Educational System, Hokkaido University School of Medicine, Hokkaido University, Sapporo, Japan.

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http://dx.doi.org/10.1002/mc.21983DOI Listing
May 2014
35 Reads
31 Citations
4.810 Impact Factor

Identification of KLF17 as a novel epithelial to mesenchymal transition inducer via direct activation of TWIST1 in endometrioid endometrial cancer.

Carcinogenesis 2014 Apr 11;35(4):760-8. Epub 2013 Nov 11.

Department of Women's Health Educational System, Hokkaido University School of Medicine, Hokkaido University, Sapporo 0608638, Japan.

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http://dx.doi.org/10.1093/carcin/bgt369DOI Listing
April 2014
27 Reads
17 Citations
5.334 Impact Factor

Emerging therapeutic biomarkers in endometrial cancer.

Biomed Res Int 2013 11;2013:130362. Epub 2013 Jun 11.

Department of Women's Health Educational System, Hokkaido University School of Medicine, Hokkaido University, N15, W7, Sapporo 060-8638, Japan.

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http://dx.doi.org/10.1155/2013/130362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693108PMC
December 2013
24 Reads
15 Citations

Prognostic significance of miR-194 in endometrial cancer.

Biomark Res 2013 ;1

Translational Research Laboratory Department of Pathology Stony Brook Cancer Center, Stony Brook University School of Medicine, BST-2, L-9, Room 185, Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.1186/2050-7771-1-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772652PMC
November 2013
18 Reads
17 Citations

New revised FIGO 2008 staging system for endometrial cancer produces better discrimination in survival compared with the 1988 staging system.

J Surg Oncol 2012 Dec 27;106(8):938-41. Epub 2012 Jun 27.

Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

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http://dx.doi.org/10.1002/jso.23203DOI Listing
December 2012
15 Reads
3 Citations
3.244 Impact Factor

Allopurinol attenuates oxidative stress and cardiac fibrosis in angiotensin II-induced cardiac diastolic dysfunction.

Cardiovasc Ther 2012 Apr 26;30(2):117-23. Epub 2010 Oct 26.

Ruijin Hospital, Shanghai Institute of Hypertension, Shanghai Jiao Tong University Medical School, Shanghai, PR China.

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http://dx.doi.org/10.1111/j.1755-5922.2010.00243.xDOI Listing
April 2012
24 Reads
9 Citations
2.362 Impact Factor

MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1.

Mol Cancer 2011 Aug 18;10:99. Epub 2011 Aug 18.

Department of Gynecology, Hokkaido University Graduate School of Medicine and School of Medicine, Hokkaido University, Sapporo, Japan.

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http://dx.doi.org/10.1186/1476-4598-10-99DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173388PMC
August 2011
13 Reads
78 Citations
4.260 Impact Factor

Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway.

Mol Cancer 2009 Nov 16;8:103. Epub 2009 Nov 16.

Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, PR China.

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http://dx.doi.org/10.1186/1476-4598-8-103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779797PMC
November 2009
17 Reads
22 Citations
4.260 Impact Factor

Cardioprotective effects of granulocyte colony-stimulating factor in angiotensin II-induced cardiac remodelling.

Clin Exp Pharmacol Physiol 2009 Mar 10;36(3):262-6. Epub 2008 Sep 10.

Department of Cardiology, Shanghai Jiaotong University Affiliated First People's Hospital, China.

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http://dx.doi.org/10.1111/j.1440-1681.2008.05052.xDOI Listing
March 2009
11 Reads

p53 dominant-negative mutant R273H promotes invasion and migration of human endometrial cancer HHUA cells.

Clin Exp Metastasis 2007 18;24(6):471-83. Epub 2007 Jul 18.

Department of Gynecology, Hokkaido University Graduate School of Medicine and School of Medicine, Hokkaido University, Sapporo 060-8638, Japan.

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http://dx.doi.org/10.1007/s10585-007-9084-8DOI Listing
January 2008
13 Reads
19 Citations
3.491 Impact Factor

Overexpression and diffuse expression pattern of IQGAP1 at invasion fronts are independent prognostic parameters in ovarian carcinomas.

Cancer Lett 2006 Nov 4;243(1):120-7. Epub 2006 Jan 4.

Department of Pathology, Fukuoka University Hospital and School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.

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http://dx.doi.org/10.1016/j.canlet.2005.11.024DOI Listing
November 2006
21 Reads
16 Citations
5.621 Impact Factor

Top co-authors

Hidemichi Watari
Hidemichi Watari

Hokkaido University Graduate School of Medicine

30
Noriaki Sakuragi
Noriaki Sakuragi

Hokkaido University Graduate School of Medicine

20
Junming Yue
Junming Yue

University of Tennessee Health Science Center

17
Ying Xiong
Ying Xiong

Zhongshan Hospital

14
Masataka Kudo
Masataka Kudo

Tohoku University Graduate School of Medicine

10
Masayoshi Hosaka
Masayoshi Hosaka

Hokkaido University Graduate School of Medicine

7
Yosuke Konno
Yosuke Konno

Hokkaido University School of Medicine

7
Satoko Sudo
Satoko Sudo

Stanford University School of Medicine

6