Publications by authors named "Peishan Cong"

2 Publications

  • Page 1 of 1

Risk factors for pelvic lymph node metastasis in endometrial cancer.

Arch Gynecol Obstet 2019 10 21;300(4):1007-1013. Epub 2019 Aug 21.

Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.

Purpose: To evaluate the risk factors for pelvic lymph node metastasis (LNM) in endometrial cancer (EC).

Methods: Clinicopathological characteristics and preoperative laboratory results were retrospectively analyzed in 393 surgically staged patients with EC (January 2014-February 2019).

Results: Pelvic LNM was detected in 45 (11.5%) patients. Univariate analysis showed that increased preoperative levels of human epididymis protein 4 (HE4), carbohydrate antigen 125 (CA125), monocyte to lymphocyte ratio (MLR), platelet to lymphocyte ratio (PLR), and decreased absolute lymphocyte count (ALC), as well as non-endometrioid histology, grade 3 tumor, deep myometrial invasion, vaginal or para-uterine involvement, adnexal involvement, positive peritoneal cytology, and lymphovascular space invasion (LVSI) were risk factors for pelvic LNM (All p < 0.05). Multivariate analysis revealed that preoperative serum HE4 ≥ 132 pmol/L (odds ratio (OR) 4.25, 95% confidence interval (CI) 1.65-10.94, p = 0.003), serum CA 125 ≥ 27.6 U/mL (OR 6.10, 95% CI 2.31-16.07, p = 0.000), non-endometrioid histology (OR 16.64, 95% CI 5.96-46.47, p = 0.000), myometrial invasion ≥ 50% (OR 5.30, 95% CI 2.07-13.55, p = 0.001), positive peritoneal cytology (OR 4.70, 95% CI 1.21-18.27, p = 0.025), and LVSI (OR 3.11, 95% CI 1.09-8.92, p = 0.034) remained as independent risk factors for pelvic LNM in EC. With the increase of these independent risk factors, the rate of pelvic LNM was increased significantly.

Conclusions: Higher preoperative levels of serum HE4 and CA125, non-endometrioid histology, deep myometrial invasion, positive peritoneal cytology, and LVSI are independent risk factors for pelvic LNM in EC, which can provide scientific basis for lymphadenectomy.
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http://dx.doi.org/10.1007/s00404-019-05276-9DOI Listing
October 2019

The Combination of the Tumor Markers Suggests the Histological Diagnosis of Lung Cancer.

Biomed Res Int 2017 18;2017:2013989. Epub 2017 May 18.

Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao 266003, China.

Tumor markers are beneficial for the diagnosis and therapy monitoring of lung cancer. However, the value of tumor markers in lung cancer histological diagnosis is unknown. In this study, we analyzed the serum levels of six tumor markers (CEA, CYFRA21-1, SCC, NSE, ProGRP, and CA125) in 2097 suspected patients with lung cancer and determined whether the combination of the tumor markers was useful for histological diagnosis of lung cancer. We found that CYFRA21-1 was the most sensitive marker in NSCLC. ProGRP showed a better clinical performance than that of NSE in discriminating between SCLC and NSCLC. The serum level of CYFRA21-1 or SCC was significantly higher in squamous carcinoma ( < 0.05), and the levels of ProGRP and NSE were significantly higher in SCLC ( < 0.05). According to the criteria established, SCLC and NSCLC were discriminated with sensitivity of 87.12 and 62.63% and specificity of 64.61 and 99.5%, respectively. The sensitivity and specificity in the differentiation of adenocarcinoma and squamous carcinoma were 68.1 and 81.63% and 70.73 and 65.93%, with NPV of 46.03 and 68.97% and PPV of 85.82 and 79.47%, respectively. Our results suggested the combination of six tumor markers could discriminate the histological types of lung cancer.
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http://dx.doi.org/10.1155/2017/2013989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451759PMC
March 2018
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