Pei-Jer Chen

Pei-Jer Chen

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Serum Mac-2-Binding Protein Glycosylation Isomer at Virological Remission Predicts Hepatocellular Carcinoma and Death in Chronic Hepatitis B-Related Cirrhosis.

J Infect Dis 2020 Feb;221(4):589-597

Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1093/infdis/jiz496DOI Listing
February 2020

Cost-effectiveness of preventing hepatitis B virus reactivation in patients with lymphoma and resolved HBV infection.

J Formos Med Assoc 2020 Jan 22;119(1 Pt 2):335-344. Epub 2019 Jun 22.

Department of Oncology, National Taiwan University Hospital and National Taiwan University Cancer Center, Taipei, Taiwan; Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2019.05.027DOI Listing
January 2020

Glecaprevir/pibrentasvir for patients with chronic hepatitis C virus infection and severe renal impairment.

J Viral Hepat 2020 Jan 25. Epub 2020 Jan 25.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/jvh.13265DOI Listing
January 2020

HEV superinfection accelerates disease progression in patients with chronic HBV infection and increases mortality in those with cirrhosis.

J Hepatol 2020 Jan 29. Epub 2020 Jan 29.

Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2020.01.012DOI Listing
January 2020

NIACE score refines the overall survival of hepatocellular carcinoma by Barcelona clinic liver cancer staging.

J Gastroenterol Hepatol 2019 Dec 18;34(12):2179-2186. Epub 2019 Jun 18.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/jgh.14705DOI Listing
December 2019

Specific diacylglycerols generated by hepatic lipogenesis stimulate the oncogenic androgen receptor activity in male hepatocytes.

Int J Obes (Lond) 2019 12 27;43(12):2469-2479. Epub 2019 Aug 27.

Department of Microbiology, National Taiwan University College of Medicine, Taipei, 100, Taiwan.

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http://dx.doi.org/10.1038/s41366-019-0431-zDOI Listing
December 2019

High Level of Hepatitis B Core-Related Antigen Associated With Increased Risk of Hepatocellular Carcinoma in Patients With Chronic HBV Infection of Intermediate Viral Load.

Gastroenterology 2019 12 27;157(6):1518-1529.e3. Epub 2019 Aug 27.

Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.08.028DOI Listing
December 2019

Antiviral treatment for hepatitis B in infancy: Still an issue for debate.

J Hepatol 2019 Dec 30;71(6):1264-1265. Epub 2019 Sep 30.

Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2019.07.023DOI Listing
December 2019

Antiviral therapy against chronic hepatitis C is associated with a reduced risk of oral cancer.

Int J Cancer 2019 Dec 19. Epub 2019 Dec 19.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1002/ijc.32840DOI Listing
December 2019

Evolution of eGFR in chronic HCV patients receiving sofosbuvir-based or sofosbuvir-free direct-acting antivirals.

J Hepatol 2019 Nov 29. Epub 2019 Nov 29.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2019.11.014DOI Listing
November 2019

Sofosbuvir-based direct acting antiviral therapies for patients with hepatitis C virus genotype 2 infection.

J Gastroenterol Hepatol 2019 Sep 17;34(9):1620-1625. Epub 2019 Feb 17.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/jgh.14615DOI Listing
September 2019

Expression of Metastatic Tumor Antigen 1 Splice Variant Correlates With Early Recurrence and Aggressive Features of Hepatitis B Virus-Associated Hepatocellular Carcinoma.

Hepatology 2019 Jul 14;70(1):184-197. Epub 2019 Apr 14.

Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1002/hep.30581DOI Listing
July 2019

Association Between High Levels of Hepatitis B Core Antibody and Seroclearance of Hepatitis B e Antigen in Individuals With Chronic Hepatitis B Virus Infection.

Clin Gastroenterol Hepatol 2019 Jun 26;17(7):1413-1415. Epub 2018 Sep 26.

Genomics Research Center, Academia Sinica, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15423565183102
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http://dx.doi.org/10.1016/j.cgh.2018.09.037DOI Listing
June 2019

Smoking and Hepatitis B Virus-Related Hepatocellular Carcinoma Risk: The Mediating Roles of Viral Load and Alanine Aminotransferase.

Hepatology 2019 Apr 19;69(4):1412-1425. Epub 2019 Feb 19.

Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

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http://doi.wiley.com/10.1002/hep.30339
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http://dx.doi.org/10.1002/hep.30339DOI Listing
April 2019

Chronic hepatitis B is associated with an increased risk of B-cell non-Hodgkin's lymphoma and multiple myeloma.

Aliment Pharmacol Ther 2019 03 25;49(5):589-598. Epub 2019 Jan 25.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/apt.15132DOI Listing
March 2019

Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region.

Hepatology 2019 Feb 16;69(2):498-512. Epub 2019 Jan 16.

Department of Microbiology, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1002/hep.30201DOI Listing
February 2019

Profile and value of FIB-4 in patients with dual chronic hepatitis C and B.

J Gastroenterol Hepatol 2019 Feb 20;34(2):410-417. Epub 2018 Sep 20.

Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/jgh.14455DOI Listing
February 2019

Early antiviral therapy reduces the risk of lymphoma in patients with chronic hepatitis C infection.

Aliment Pharmacol Ther 2019 02 27;49(3):331-339. Epub 2018 Dec 27.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/apt.15101DOI Listing
February 2019

Level of Hepatitis B (HB) Core Antibody Associates With Seroclearance of HBV DNA and HB Surface Antigen in HB e Antigen-Seronegative Patients.

Clin Gastroenterol Hepatol 2019 01 9;17(1):172-181.e1. Epub 2018 May 9.

Genomics Research Center, Academia Sinica, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15423565183047
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http://dx.doi.org/10.1016/j.cgh.2018.04.064DOI Listing
January 2019

Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development.

Gastroenterology 2019 01 19;156(2):338-354. Epub 2018 Sep 19.

National Institute of Infectious Diseases, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.06.093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649672PMC
January 2019

Taiwan consensus statement on the management of chronic hepatitis B.

J Formos Med Assoc 2019 Jan 6;118(1 Pt 1):7-38. Epub 2018 Dec 6.

Liver Research Unit, Linkou Chang Gung Memorial Hospital and University College of Medicine, Taoyuan, Taiwan.

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http://dx.doi.org/10.1016/j.jfma.2018.11.008DOI Listing
January 2019

Real-world effectiveness of direct-acting antiviral agents for chronic hepatitis C in Taiwan: Real-world data.

J Microbiol Immunol Infect 2018 Sep 26. Epub 2018 Sep 26.

Department of Internal Medicine and Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S16841182183040
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http://dx.doi.org/10.1016/j.jmii.2018.09.005DOI Listing
September 2018

Quantification of HBV core antibodies may help predict HBV reactivation in patients with lymphoma and resolved HBV infection.

J Hepatol 2018 08 16;69(2):286-292. Epub 2018 Mar 16.

Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan; National Taiwan University Cancer Center, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2018.02.033DOI Listing
August 2018

Vaccine-induced antigen-specific regulatory T cells attenuate the antiviral immunity against acute influenza virus infection.

Mucosal Immunol 2018 07 21;11(4):1239-1253. Epub 2018 Feb 21.

Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1038/s41385-018-0004-9DOI Listing
July 2018

The unique antibody suppresses HBV viremia and reduces hepatocarcinogenesis in HBV-transgenic mice.

Hum Vaccin Immunother 2018 07 12;14(7):1779-1781. Epub 2018 Apr 12.

a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health & School of Life Science, Xiamen University , Xiamen , China.

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http://dx.doi.org/10.1080/21645515.2018.1449553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067855PMC
July 2018

Acoustic Radiation Force Impulse US Imaging: Liver Stiffness in Patients with Chronic Hepatitis B with and without Antiviral Therapy.

Radiology 2018 07 27;288(1):293-299. Epub 2018 Mar 27.

From the Division of Gastroenterology and Hepatology, Department of Internal Medicine (T.H.S., Chen-Hua Liu, T.C.T., H.C.Y., C.J.L., P.J.C., D.S.C., J.H.K.), Hepatitis Research Center (T.H.S., Chen-Hua Liu, K.W.H., T.C.T., C.J.L., P.J.C., D.S.C., J.H.K.), Department of Surgery (K.W.H.), and Department of Medical Research (P.J.C., J.H.K.), National Taiwan University Hospital, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Jin-shan Branch, New Taipei City, Taiwan (T.C.T.); School of Medicine, National Taiwan University, Taipei, Taiwan (Chun-Hsun Liao); and Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, 1 Chang-Te Street, Taipei 10048, Taiwan (C.J.L., P.J.C., D.S.C., J.H.K.).

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http://dx.doi.org/10.1148/radiol.2018171116DOI Listing
July 2018

Boceprevir-based triple therapy to rescue HCV genotype 1/HBV dually infected patients refractory to peginterferon plus ribavirin combination therapy in Taiwan.

J Formos Med Assoc 2018 Jun 8;117(6):497-504. Epub 2017 Jul 8.

School of Medicine, Graduate Institute of Clinical Medicine, College of Medicine, Lipid Science and Aging Research Center, Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan; Hepatitis Center and Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan; Liver Center, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2017.06.007DOI Listing
June 2018

Efficacy of Ledipasvir and Sofosbuvir Treatment of HCV Infection in Patients Coinfected With HBV.

Gastroenterology 2018 03 22;154(4):989-997. Epub 2017 Nov 22.

Graduate Institute of Clinical Medicine, Hepatitis Research Center and Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085173636
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http://dx.doi.org/10.1053/j.gastro.2017.11.011DOI Listing
March 2018

Distinct Relapse Rates and Risk Predictors After Discontinuing Tenofovir and Entecavir Therapy.

J Infect Dis 2018 03;217(8):1193-1201

Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1093/infdis/jix690DOI Listing
March 2018

Targeting histone deacetylase 4/ubiquitin-conjugating enzyme 9 impairs DNA repair for radiosensitization of hepatocellular carcinoma cells in mice.

Hepatology 2018 02 26;67(2):586-599. Epub 2017 Dec 26.

Graduate Institutes of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan.

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http://doi.wiley.com/10.1002/hep.29328
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http://dx.doi.org/10.1002/hep.29328DOI Listing
February 2018

Hydrodynamic HBV Transfection Mouse Model.

Methods Mol Biol 2017 ;1540:227-235

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, 100, Taiwan.

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http://link.springer.com/10.1007/978-1-4939-6700-1_19
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http://dx.doi.org/10.1007/978-1-4939-6700-1_19DOI Listing
January 2018

A noninvasive diagnosis of hepatic fibrosis by BioFibroScore® in chronic hepatitis C patients.

J Gastroenterol Hepatol 2018 Jan;33(1):291-297

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/jgh.13834DOI Listing
January 2018

The potential and challenges of CRISPR-Cas in eradication of hepatitis B virus covalently closed circular DNA.

Virus Res 2018 01 13;244:304-310. Epub 2017 Jun 13.

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan; Department of Medical Research, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.virusres.2017.06.010DOI Listing
January 2018

Corrigendum to "Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activity" [Eur. J. Med. Chem. 55 (2012) 220-227].

Eur J Med Chem 2018 01 4;143:2015. Epub 2017 Nov 4.

Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.10.053DOI Listing
January 2018

Intracellular hepatitis B virus increases hepatic cholesterol deposition in alcoholic fatty liver via hepatitis B core protein.

J Lipid Res 2018 01 13;59(1):58-68. Epub 2017 Nov 13.

Department and Institute of Infectious Disease Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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http://dx.doi.org/10.1194/jlr.M079533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748497PMC
January 2018

Genome-wide association analysis identifies a GLUL haplotype for familial hepatitis B virus-related hepatocellular carcinoma.

Cancer 2017 Oct 29;123(20):3966-3976. Epub 2017 Jun 29.

Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1002/cncr.30851DOI Listing
October 2017

Fibrosis-4 Index Helps Identify HBV Carriers With the Lowest Risk of Hepatocellular Carcinoma.

Am J Gastroenterol 2017 Oct 29;112(10):1564-1574. Epub 2017 Aug 29.

Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1038/ajg.2017.254DOI Listing
October 2017

Impact of occult hepatitis B on the clinical outcomes of patients with chronic hepatitis C virus infection: A 10-year follow-up.

J Formos Med Assoc 2017 Sep 21;116(9):697-704. Epub 2016 Dec 21.

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2016.11.002DOI Listing
September 2017

Erratum to: Corrigendum to "Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma".

J Hepatol 2017 06 13;66(6):1334-1335. Epub 2017 Mar 13.

Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan; National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.02.021DOI Listing
June 2017

Prescription Patterns of Sorafenib and Outcomes of Patients with Advanced Hepatocellular Carcinoma: A National Population Study.

Anticancer Res 2017 05;37(5):2593-2599

Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan, R.O.C.

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http://dx.doi.org/10.21873/anticanres.11604DOI Listing
May 2017

Addition of ribavirin to daclatasvir plus asunaprevir for chronic hepatitis C 1b patients with baseline NS5A resistance-associated variants improved response.

J Formos Med Assoc 2017 Apr 26;116(4):295-299. Epub 2016 Dec 26.

Department of Traumatology, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2016.11.014DOI Listing
April 2017

Corrigendum to "Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma".

J Hepatol 2017 03 6;66(3):666-668. Epub 2017 Jan 6.

Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan; National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.12.007DOI Listing
March 2017

Genome-wide identification of blood DNA methylation patterns associated with early-onset hepatocellular carcinoma development in hepatitis B carriers.

Mol Carcinog 2017 02 10;56(2):425-435. Epub 2016 Jun 10.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1002/mc.22505DOI Listing
February 2017

Hepatitis B Virus Reactivation in Patients Receiving Interferon-Free Direct-Acting Antiviral Agents for Chronic Hepatitis C Virus Infection.

Open Forum Infect Dis 2017 11;4(1):ofx028. Epub 2017 Feb 11.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei.

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http://dx.doi.org/10.1093/ofid/ofx028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414056PMC
February 2017

A novel toolbox for the in vitro assay of hepatitis D virus infection.

Sci Rep 2017 01 12;7:40199. Epub 2017 Jan 12.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Science &School of Public Health, Xiamen University, Xiamen 361102, PR China.

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http://dx.doi.org/10.1038/srep40199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228157PMC
January 2017

Prevalence and clinical implications of IL28B genotypes in Taiwanese patients with chronic hepatitis C.

J Formos Med Assoc 2016 Nov 15;115(11):953-960. Epub 2016 Oct 15.

Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan; Department of Medical Research, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2016.07.013DOI Listing
November 2016

Hypoxia-activated cytotoxic agent tirapazamine enhances hepatic artery ligation-induced killing of liver tumor in HBx transgenic mice.

Proc Natl Acad Sci U S A 2016 10 4;113(42):11937-11942. Epub 2016 Oct 4.

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan; Genomics Research Center, Academia Sinica, Taipei 115, Taiwan

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http://dx.doi.org/10.1073/pnas.1613466113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081602PMC
October 2016

Progressive accumulation of mutations in the hepatitis B virus genome and its impact on time to diagnosis of hepatocellular carcinoma.

Hepatology 2016 09 7;64(3):720-31. Epub 2016 Jul 7.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1002/hep.28654DOI Listing
September 2016

Perspectives on dual hepatitis B and C infection in Taiwan.

J Formos Med Assoc 2016 May 15;115(5):298-305. Epub 2015 Jul 15.

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.jfma.2015.06.005DOI Listing
May 2016

Prolonged suppression of HBV in mice by a novel antibody that targets a unique epitope on hepatitis B surface antigen.

Gut 2016 Apr 30;65(4):658-71. Epub 2015 Sep 30.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Science & School of Public Health, Xiamen University, Xiamen, China National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Science & School of Public Health, Xiamen University, Xiamen, China.

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http://dx.doi.org/10.1136/gutjnl-2014-308964DOI Listing
April 2016

Chronic Hepatitis B Virus Infection: Disease Revisit and Management Recommendations.

J Clin Gastroenterol 2016 Apr;50(4):286-94

*Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong†Department of Internal Medicine, Yonsei University College of Medicine, Brain Korea 21 Project for Medical Science, Seoul, South Korea‡Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan§Royal Free and University College, School of Medicine, London, UK∥Hepatology Unit and Key Laboratory for Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China¶Southwestern Medical Center, University of Texas, Dallas, TX#The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan**INSERM Unité 1052, Cancer Research Center of Lyon, Lyon University, Lyon, France.

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http://dx.doi.org/10.1097/MCG.0000000000000478DOI Listing
April 2016

The Hepatitis Viral Status in Patients With Hepatocellular Carcinoma: a Study of 3843 Patients From Taiwan Liver Cancer Network.

Medicine (Baltimore) 2016 Apr;95(15):e3284

From the Liver Research Unit, Chang Gung Memorial Hospital Linko Branch, Chang-Gung University, Taoyuan, Taiwan (I-CC, C-CH, Y-FL), Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan (I-CC, S-FH, C-CH), Department of Pathology, Chang Gung Memorial Hospital Linko Branch, Taoyuan, Taiwan (S-FH), Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan (P-JC, C-LC), Department of General Surgery, Chang Gung Memorial Hospital Kaohsiung Branch, Chang-Gung University, Kaohsiung, Taiwan (C-LC), Department of General Surgery, Taichung Veteran General Hospital, Taichung, Taiwan (C-CW), Department of General Surgery, Kaohsiung Veteran General Hospital, Kaohsiung, Taiwan (C-CT), Department of General Surgery, National Taiwan University Hospital, Taipei, Taiwan (P-HL), Department of General Surgery, Chang Gung Memorial Hospital Linko Branch, Chang-Gung University, Taoyuan, Taiwan (M-FC), Department of Hepato-gastroenterology, Chang Gung Memorial Hospital Kaohsiung Branch, Chang-Gung University, Kaohsiung, Taiwan (C-ML), Department of Hepato-gastroenterology, Kaohsiung Veteran General Hospital, Kaohsiung, Taiwan (H-CY, G-HL), Department of Hepato-gastroenterology, Chang Gung Memorial Hospital Linko Branch, Chang-Gung University, Taoyuan, Taiwan (C-TY), Department of Pathology, Chang Gung Memorial Hospital Kaohsiung Branch, Chang-Gung University, Kaohsiung, Taiwan (H-LE), Department of Pathology, Taichung Veteran General Hospital, Taichung, Taiwan (JW), Department of Pathology, Kaohsiung Veteran General Hospital, Kaohsiung, Taiwan (H-HT), Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan (C-HH), Department of Applied Mathematics and Institute of Statistics, National Chung-Hsing University, TaiChung, Taiwan (H-DIW, T-CY).

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http://dx.doi.org/10.1097/MD.0000000000003284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839810PMC
April 2016

Hepatitis C viral infection increases the risk of lymphoid-neoplasms: A population-based cohort study.

Hepatology 2016 Mar 14;63(3):721-30. Epub 2016 Jan 14.

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1002/hep.28387DOI Listing
March 2016

Hepatitis B Surface Antigen Loss and Hepatocellular Carcinoma Development in Patients With Dual Hepatitis B and C Infection.

Medicine (Baltimore) 2016 Mar;95(10):e2995

From the Division of Gastroenterology (T-CT, C-CW), Department of Internal Medicine, Taipei Tzuchi Hospital, The Buddhist Tzuchi Medical Foundation; Division of Gastroenterology (H-CY, T-HS, C-HL, P-JC, C-JL, J-HK), Department of Internal Medicine; Graduate Institute of Clinical Medicine (C-LC, T-HS, C-HL, C-JL, J-HK); Hepatitis Research Center (W-TY, C-HL, J-HK); Department of Medical Research (J-HK); Department of Microbiology (H-CY), National Taiwan University College of Medicine and National Taiwan University Hospital; Master of Public Health Degree Program (W-TY), National Taiwan University, Taipei; Division of Gastroenterology (L-WW), Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei; School of Medicine (T-CT, C-CW), Tzu Chi University, Hualien; Genomics Research Center Academia Sinica (D-SC), Taipei, Taiwan; St Vincent's Hospital (SF-TK), Melbourne VIC, Australia; and Taiwan Liver Disease Consortium (TLC) (C-JL), Taipei, Taiwan.

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http://dx.doi.org/10.1097/MD.0000000000002995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998890PMC
March 2016

Rapid fluorescent lateral-flow immunoassay for hepatitis B virus genotyping.

Anal Chem 2015 5;87(10):5173-80. Epub 2015 May 5.

†National Institute of Diagnostics and Vaccine Development in Infectious Diseases, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen 361102, China.

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http://dx.doi.org/10.1021/ac504832cDOI Listing
December 2015

Sorafenib Action in Hepatitis B Virus X-Activated Oncogenic Androgen Pathway in Liver through SHP-1.

J Natl Cancer Inst 2015 Oct 23;107(10). Epub 2015 Jul 23.

Department of Microbiology (SHW, SHY, WHL, PJC), NTU Center for Genomic Medicine (SHY, DSC, PJC), and Graduate Institute of Clinical Medicine (DSC, PJC), National Taiwan University College of Medicine, Taipei, Taiwan; Department of Laboratory Medicine (SHY), Department of Medical Research (KFC), and National Center of Excellence for Clinical Trial and Research (KFC), National Taiwan University Hospital, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (DSC, PJC); Institute of Biopharmaceutical Sciences (CWS) and Department of Life Sciences and Institute of Genome Sciences (TFT, YCT), National Yang-Ming University, Taipei, Taiwan.

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http://jnci.oxfordjournals.org/content/107/10/djv190.full.pd
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http://jnci.oxfordjournals.org/lookup/doi/10.1093/jnci/djv19
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October 2015

Gender disparity in chronic hepatitis B: Mechanisms of sex hormones.

J Gastroenterol Hepatol 2015 Aug;30(8):1237-45

Department of Microbiology, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan.

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http://doi.wiley.com/10.1111/jgh.12934
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August 2015

Slow decline of hepatitis B burden in general population: Results from a population-based survey and longitudinal follow-up study in Taiwan.

J Hepatol 2015 Aug 17;63(2):354-63. Epub 2015 Mar 17.

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Genomics Research Center, Academia Sinica, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.03.013DOI Listing
August 2015

Peginterferon plus weight-based ribavirin for treatment-naïve hepatitis C virus genotype 2 patients not achieving rapid virologic response: a randomized trial.

Sci Rep 2015 Jul 1;5:11710. Epub 2015 Jul 1.

1] Institute of Clinical Medicine and Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan [2] Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan [3] Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486927PMC
July 2015

Treatment of Liver Cancer.

Cold Spring Harb Perspect Med 2015 Jul 17;5(9):a021535. Epub 2015 Jul 17.

Department of Medical Research, National Taiwan University College of Medicine, Taipei 112, Taiwan National Center of Excellence for Clinical Trial and Research, National Taiwan University College of Medicine, Taipei 112, Taiwan Graduate Institute of Molecular Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 112, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561392PMC
July 2015

Development of risk scoring system for stratifying population for hepatocellular carcinoma screening.

Hepatology 2015 Jun 13;61(6):1934-44. Epub 2015 Apr 13.

1nstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1002/hep.27610DOI Listing
June 2015

Feedback regulation of IFN-α/β signaling by Axl receptor tyrosine kinase modulates HBV immunity.

Eur J Immunol 2015 Jun 15;45(6):1696-705. Epub 2015 May 15.

Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1002/eji.201445239DOI Listing
June 2015

Contribution of adiponectin and its type 1 receptor to age-related hearing impairment.

Neurobiol Aging 2015 Jun 5;36(6):2085-93. Epub 2015 Mar 5.

Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan; Department of Otolaryngology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.02.030DOI Listing
June 2015

Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition.

Proc Natl Acad Sci U S A 2015 Jun 26;112(23):7243-8. Epub 2015 May 26.

Graduate Institute of Clinical Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hepatitis Research Center, Genomics Research Center, Academia Sinica, Nankang, Taipei 11529, Taiwan

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http://www.pnas.org/lookup/doi/10.1073/pnas.1507499112
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466718PMC
June 2015

Advanced hepatic fibrosis and steatosis are associated with persistent alanine aminotransferase elevation in chronic hepatitis C patients negative for hepatitis C virus RNA during pegylated interferon plus ribavirin therapy.

J Infect Dis 2015 May 11;211(9):1429-36. Epub 2014 Nov 11.

Department of Internal Medicine Hepatitis Research Center, National Taiwan University Hospital Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine.

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http://dx.doi.org/10.1093/infdis/jiu630DOI Listing
May 2015

Predicting Hepatitis B Virus (HBV) Surface Antigen Seroclearance in HBV e Antigen-Negative Patients With Chronic Hepatitis B: External Validation of a Scoring System.

J Infect Dis 2015 May 27;211(10):1566-73. Epub 2014 Nov 27.

Division of Gastroenterology and Hepatology, Department of Internal Medicine Hepatitis Research Center Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine.

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May 2015

Tumor necrosis factor-alpha blockage therapy impairs hepatitis B viral clearance and enhances T-cell exhaustion in a mouse model.

Cell Mol Immunol 2015 May 9;12(3):317-25. Epub 2015 Feb 9.

1] Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan, China [2] Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, China.

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http://www.nature.com/articles/cmi201501
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654324PMC
May 2015

Comparison of Abbott RealTime HCV Genotype II with Versant line probe assay 2.0 for hepatitis C virus genotyping.

J Clin Microbiol 2015 May 4;53(5):1754-7. Epub 2015 Mar 4.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan

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http://dx.doi.org/10.1128/JCM.03548-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400777PMC
May 2015

New insights into the evolutionary rate of hepatitis B virus at different biological scales.

J Virol 2015 Apr 14;89(7):3512-22. Epub 2015 Jan 14.

Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan Genomics Research Center, Academia Sinica, Taipei, Taiwan.

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http://dx.doi.org/10.1128/JVI.03131-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403390PMC
April 2015

Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota.

Proc Natl Acad Sci U S A 2015 Feb 2;112(7):2175-80. Epub 2015 Feb 2.

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan; Genomics Research Center, Academia Sinica, Taipei 115, Taiwan

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http://dx.doi.org/10.1073/pnas.1424775112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343154PMC
February 2015

Linifanib versus Sorafenib in patients with advanced hepatocellular carcinoma: results of a randomized phase III trial.

J Clin Oncol 2015 Jan 8;33(2):172-9. Epub 2014 Dec 8.

Calin Cainap, Institute of Oncology, Cluj-Napoca, Romania; Shukui Qin, Chinese People's Liberation Army Cancer Center, Bayi Hospital, Beijing; Hongming Pan, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou; Ying Cheng, Tumor Hospital of Jilin Province, Changchun, People's Republic of China; Wen-Tsung Huang, Chi Mei Medical Center, Liouying; Pei-Jer Chen, National Taiwan University Hospital, Taipei, Taiwan, Republic of China; Ik Joo Chung, Chonnam National University, Hwasun Hospital, Hwasun, Jeollonam-do; Yoon-Koo Kang, Asan Medical Center, University of Ulsan, Seoul, Republic of Korea; Masatoshi Kudo, Kinki University, Osaka, Japan; Han-Chong Toh, National Cancer Centre, Singapore, Singapore; Vera Gorbunova, Russian Academy of Medical Sciences, Moscow, Russia; Ferry A.L.M. Eskens, Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands; Jiang Qian, Mark D. McKee, Justin L. Ricker, Dawn M. Carlson, AbbVie, North Chicago, IL; Saied El-Nowiem, Alexandria University, Alexandria, Egypt.

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http://dx.doi.org/10.1200/JCO.2013.54.3298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279237PMC
January 2015

Clinical significance of circulating miR-122 in patients with dual chronic hepatitis B and C virus infection.

Hepatol Int 2015 Jan 18;9(1):35-42. Epub 2014 Nov 18.

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, 1 Chang-Te Street, Taipei, 10002, Taiwan.

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http://dx.doi.org/10.1007/s12072-014-9591-zDOI Listing
January 2015