Publications by authors named "Pei-Chien Tsai"

100Publications

Rapid determination of remdesivir (SARS-CoV-2 drug) in human plasma for therapeutic drug monitoring in COVID-19-Patients.

Process Biochem 2021 Mar 25;102:150-156. Epub 2020 Dec 25.

Innovative Green Product Synthesis and Renewable Environment Development Research Group, Faculty of Environment and Labour Safety, Ton Duc Thang University, Ho Chi Minh City, Viet Nam.

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March 2021

Investigating CAG/CAA trinucleotide repeat expansions in a Taiwanese cohort with ALS.

Amyotroph Lateral Scler Frontotemporal Degener 2020 Dec 30:1-6. Epub 2020 Dec 30.

Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan.

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December 2020

Various potential techniques to reduce the water footprint of microalgal biomass production for biofuel-A review.

Sci Total Environ 2020 Dec 13;749:142218. Epub 2020 Sep 13.

School of Civil and Environmental Engineering, Yonsei University, Seoul 03722, Republic of Korea. Electronic address:

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December 2020

Low-cost disposable Poly(ethyleneimine)-Functionalized Carbon Nanofibers Coated Cellulose Paper as efficient solid phase extraction sorbent material for the extraction of Parahydroxybenzoates from environmental waters.

Chemosphere 2020 Dec 11;267:129274. Epub 2020 Dec 11.

Department of Medicinal and Applied Chemistry, Kaohsiung Medical University (KMU), Kaohsiung City, 807, Taiwan; Research Center for Environmental Medicine, Kaohsiung Medical University (KMU), Kaohsiung City, 807, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital (KMUH), Kaohsiung City, 807, Taiwan; Department of Chemistry, National Sun Yat-sen University (NSYSU), Kaohsiung City, 807, Taiwan. Electronic address:

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December 2020

Significant down-regulation of GHR expression as a new unfavorable prognostic factor in HCV-related hepatocellular carcinoma revealed.

Clin Mol Hepatol 2020 Dec 14. Epub 2020 Dec 14.

Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Taiwan.

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December 2020

Role of hepatitis D virus in persistent alanine aminotransferase abnormality among chronic hepatitis B patients treated with nucleotide/nucleoside analogues.

J Formos Med Assoc 2021 Jan 24;120(1 Pt 2):303-310. Epub 2020 Oct 24.

Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Faculty of Internal Medicine and Hepatitis Research Center, School of Medicine, College of Medicine, and Center for Cancer Research and Liquid Biopsy, Kaohsiung Medical University, Kaohsiung, Taiwan; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan; Center for Intelligent Drug Systems and Smart Bio-devices (IDS(2)B) and Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan; Center for Lipid Science and Aging Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

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January 2021

Rapid progressive ALS in a patient with a loss-of-function mutation.

Neurol Genet 2020 Oct 6;6(5):e503. Epub 2020 Aug 6.

Department of Neurology (K.-Y.J., Y.-C. Liao, Y.-C. Lee), Taipei Veterans General Hospital; Department of Neurology (K.-Y.J., Y.-C. Liao, Y.-C. Lee), Brain Research Center (Y.-C. Liao, Y.-C. Lee), and Center for Systems and Synthetic Biology (Y.-S.T.), National Yang-Ming University, Taipei; and Department of Life Sciences (P.-C.T.), National Chung Hsing University, Taichung, Taiwan.

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October 2020

Clusters of Circulating let-7 Family Tumor Suppressors Are Associated with Clinical Characteristics of Chronic Hepatitis C.

Int J Mol Sci 2020 Jul 13;21(14). Epub 2020 Jul 13.

Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

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July 2020

Hand-onset weakness is a common feature of ALS patients with a NEK1 loss-of-function variant.

Ann Clin Transl Neurol 2020 06 27;7(6):965-971. Epub 2020 May 27.

Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.

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June 2020

Silver nanoparticles in dye effluent treatment: A review on synthesis, treatment methods, mechanisms, photocatalytic degradation, toxic effects and mitigation of toxicity.

J Photochem Photobiol B 2020 Apr 21;205:111823. Epub 2020 Feb 21.

Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung City 807, Taiwan; Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung City 807, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung City 807, Taiwan. Electronic address:

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April 2020

Hepatitis B-related outcomes following direct-acting antiviral therapy in Taiwanese patients with chronic HBV/HCV co-infection.

J Hepatol 2020 Jul 14;73(1):62-71. Epub 2020 Feb 14.

Hepatitis Center and Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; School of Medicine and Hepatitis Research Center, College of Medicine Center for Cancer Research and Center for Liquid Biopsy, Kaohsiung Medical University, Kaohsiung, Taiwan; Center for Intelligent Drug Systems and Smart Bio-devices (IDS(2)B) and Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan. Electronic address:

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July 2020

Heritability of skewed X-inactivation in female twins is tissue-specific and associated with age.

Nat Commun 2019 11 25;10(1):5339. Epub 2019 Nov 25.

Department of Twin Research & Genetic Epidemiology, King's College London, London, SE1 7EH, UK.

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November 2019

Enhancement of biofuel production by microalgae using cement flue gas as substrate.

Environ Sci Pollut Res Int 2020 May 11;27(15):17571-17586. Epub 2019 Sep 11.

Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No. 100, Shiquan 1st Road, Sanmin District, Kaohsiung City, 807, Taiwan.

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May 2020

Investigating PUM1 mutations in a Taiwanese cohort with cerebellar ataxia.

Parkinsonism Relat Disord 2019 09 7;66:220-223. Epub 2019 Aug 7.

Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Neurology, National Yang-Ming University School of Medicine, Taipei, Taiwan; Brain Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan. Electronic address:

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September 2019

Improvement of hyperuricemia in chronic hepatitis C patients receiving directly acting antiviral agents.

J Gastroenterol Hepatol 2020 Mar 10;35(3):473-481. Epub 2019 Sep 10.

Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

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March 2020

CoMutPlotter: a web tool for visual summary of mutations in cancer cohorts.

BMC Med Genomics 2019 07 11;12(Suppl 5):99. Epub 2019 Jul 11.

Department of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan.

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July 2019

Risk stratification of non-alcoholic fatty liver disease across body mass index in a community basis.

J Formos Med Assoc 2020 Jan 2;119(1 Pt 1):89-96. Epub 2019 Apr 2.

Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Electronic address:

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January 2020

Epigenetic findings in periodontitis in UK twins: a cross-sectional study.

Clin Epigenetics 2019 02 13;11(1):27. Epub 2019 Feb 13.

Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK.

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February 2019

Genetic analysis of ANXA11 variants in a Han Chinese cohort with amyotrophic lateral sclerosis in Taiwan.

Neurobiol Aging 2018 12 10;72:188.e1-188.e2. Epub 2018 Jul 10.

Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Neurology, National Yang-Ming University School of Medicine, Taipei, Taiwan; Brain Research Center, National Yang-Ming University, Taipei, Taiwan. Electronic address:

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December 2018

A real world cost effectiveness analysis of interferon-based therapy for HCV naïve super-responders.

J Chin Med Assoc 2018 Aug 1;81(8):670-675. Epub 2018 Jun 1.

Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC; Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; College of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan, ROC; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan, ROC. Electronic address:

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August 2018

The IL-6/STAT3 pathway upregulates microRNA-125b expression in hepatitis C virus infection.

Oncotarget 2018 Feb 10;9(13):11291-11302. Epub 2018 Jan 10.

Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

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February 2018

Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort.

Hum Mol Genet 2018 02;27(4):732-741

Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Campus, SE1 7EH London, UK.

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February 2018

Impact of tumor size on the prognosis of hepatocellular carcinoma in patients who underwent liver resection.

J Chin Med Assoc 2018 02 6;81(2):155-163. Epub 2017 Dec 6.

Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; Department of General Surgery, Changhua Christian Hospital, Changhua, Taiwan, ROC. Electronic address:

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February 2018

Clinical and Molecular Characterization of PMP22 point mutations in Taiwanese patients with Inherited Neuropathy.

Sci Rep 2017 11 10;7(1):15363. Epub 2017 Nov 10.

Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

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November 2017

Investigating CCNF mutations in a Taiwanese cohort with amyotrophic lateral sclerosis.

Neurobiol Aging 2018 02 9;62:243.e1-243.e6. Epub 2017 Oct 9.

Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Neurology, National Yang-Ming University School of Medicine, Taipei, Taiwan; Brain Research Center, National Yang-Ming University, Taipei, Taiwan. Electronic address:

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February 2018

Reply to "cost effectiveness of hepatitis C treatments: Need for a comprehensive evaluation".

Kaohsiung J Med Sci 2017 11 13;33(11):586. Epub 2017 Jul 13.

Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

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November 2017

Identification of groups with poor cost-effectiveness of peginterferon plus ribavirin for naïve hepatitis C patients with a real-world cohort and database.

Medicine (Baltimore) 2017 Jun;96(22):e6984

Hepatobiliary Division, Department of Internal Medicine, and Hepatitis Center, Kaohsiung Medical University Hospital Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.

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June 2017

Unmasking adrenoleukodystrophy in a cohort of cerebellar ataxia.

PLoS One 2017 8;12(5):e0177296. Epub 2017 May 8.

Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan.

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September 2017

Identification of treatment-experienced hepatitis C patients with poor cost-effectiveness of pegylated interferon plus ribavirin from a real-world cohort.

J Formos Med Assoc 2018 Jan 4;117(1):54-62. Epub 2017 Apr 4.

Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan. Electronic address:

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January 2018

Corrigendum to "Genetics Variants and Serum Levels of MHC Class I Chain-related A in Predicting Hepatocellular Carcinoma Development in Chronic Hepatitis C Patients Post Antiviral Treatment" [EBioMedicine 15 (2017) 81-89].

EBioMedicine 2017 03 1;17:237. Epub 2017 Mar 1.

Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Faculty of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Institute of Biomedical Sciences, National Sun Yat-Sen University, Taiwan; Liver Center, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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March 2017

A real-world impact of cost-effectiveness of pegylated interferon/ribavarin regimens on treatment-naïve chronic hepatitis C patients in Taiwan.

Kaohsiung J Med Sci 2017 Jan 18;33(1):44-49. Epub 2016 Nov 18.

Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

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January 2017

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.

Authors:
Simone Wahl Alexander Drong Benjamin Lehne Marie Loh William R Scott Sonja Kunze Pei-Chien Tsai Janina S Ried Weihua Zhang Youwen Yang Sili Tan Giovanni Fiorito Lude Franke Simonetta Guarrera Silva Kasela Jennifer Kriebel Rebecca C Richmond Marco Adamo Uzma Afzal Mika Ala-Korpela Benedetta Albetti Ole Ammerpohl Jane F Apperley Marian Beekman Pier Alberto Bertazzi S Lucas Black Christine Blancher Marc-Jan Bonder Mario Brosch Maren Carstensen-Kirberg Anton J M de Craen Simon de Lusignan Abbas Dehghan Mohamed Elkalaawy Krista Fischer Oscar H Franco Tom R Gaunt Jochen Hampe Majid Hashemi Aaron Isaacs Andrew Jenkinson Sujeet Jha Norihiro Kato Vittorio Krogh Michael Laffan Christa Meisinger Thomas Meitinger Zuan Yu Mok Valeria Motta Hong Kiat Ng Zacharoula Nikolakopoulou Georgios Nteliopoulos Salvatore Panico Natalia Pervjakova Holger Prokisch Wolfgang Rathmann Michael Roden Federica Rota Michelle Ann Rozario Johanna K Sandling Clemens Schafmayer Katharina Schramm Reiner Siebert P Eline Slagboom Pasi Soininen Lisette Stolk Konstantin Strauch E-Shyong Tai Letizia Tarantini Barbara Thorand Ettje F Tigchelaar Rosario Tumino Andre G Uitterlinden Cornelia van Duijn Joyce B J van Meurs Paolo Vineis Ananda Rajitha Wickremasinghe Cisca Wijmenga Tsun-Po Yang Wei Yuan Alexandra Zhernakova Rachel L Batterham George Davey Smith Panos Deloukas Bastiaan T Heijmans Christian Herder Albert Hofman Cecilia M Lindgren Lili Milani Pim van der Harst Annette Peters Thomas Illig Caroline L Relton Melanie Waldenberger Marjo-Riitta Järvelin Valentina Bollati Richie Soong Tim D Spector James Scott Mark I McCarthy Paul Elliott Jordana T Bell Giuseppe Matullo Christian Gieger Jaspal S Kooner Harald Grallert John C Chambers

Nature 2017 01 21;541(7635):81-86. Epub 2016 Dec 21.

Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.

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January 2017

Genetics Variants and Serum Levels of MHC Class I Chain-related A in Predicting Hepatocellular Carcinoma Development in Chronic Hepatitis C Patients Post Antiviral Treatment.

EBioMedicine 2017 02 1;15:81-89. Epub 2016 Dec 1.

Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Faculty of Internal Medicine, School of Medicine,College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Institute of Biomedical Sciences, National Sun Yat-Sen University, Taiwan; Liver Center, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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February 2017

Exploring the molecular basis of age-related disease comorbidities using a multi-omics graphical model.

Sci Rep 2016 11 25;6:37646. Epub 2016 Nov 25.

Department of Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom.

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November 2016

Clinical and biophysical characterization of 19 mutations.

Ann Clin Transl Neurol 2016 11 1;3(11):854-865. Epub 2016 Sep 1.

Department of Neurology Taipei Veterans General Hospital Taipei 11217 Taiwan; Department of Neurology National Yang-Ming University School of Medicine Taipei 11221 Taiwan; Brain Research Center National Yang-Ming University Taipei 11221 Taiwan.

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November 2016

Unexpected early tumor recurrence in patients with hepatitis C virus-related hepatocellular carcinoma undergoing interferon-free therapy: Issue of the interval between HCC treatment and antiviral therapy.

J Hepatol 2017 02 10;66(2):464. Epub 2016 Nov 10.

Hepatobiliary Division, Department of Internal Medicine, and Hepatitis Center Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Faculty of Internal Medicine and Hepatitis Research Center, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Liver Center, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States. Electronic address:

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February 2017

Pretreatment glucose status determines HCC development in HCV patients with mild liver disease after curative antiviral therapy.

Medicine (Baltimore) 2016 Jul;95(27):e4157

Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan Department of Occupational Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan Faculty of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan Health Management Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan Institute of Biomedical Sciences, National Sun Yat-Sen University.

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July 2016

Spinocerebellar ataxia type 36 in the Han Chinese.

Neurol Genet 2016 Jun 12;2(3):e68. Epub 2016 Apr 12.

Department of Neurology (Y.-C. Lee, C.-T.H., G.-T.L., Y.-C. Liao, B.-W.S.), Taipei Veterans General Hospital, Taiwan; Department of Neurology (Y.-C. Lee, P.-C.T., Y.-C. Liao, B.-W.S.), Institute of Clinical Medicine (Y.-C.G.), and Brain Research Center (Y.-C. Lee, P.-C.T., B.-W.S.), National Yang-Ming University School of Medicine, Taipei, Taiwan; Department of Neurology (Y.-C.G.), and School of Medicine (Y.-C.G.), College of Medicine, China Medical University, Taichung, Taiwan.

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June 2016

Epigenetic associations of type 2 diabetes and BMI in an Arab population.

Clin Epigenetics 2016 28;8:13. Epub 2016 Jan 28.

Bioinformatics Core, Weill Cornell Medical College in Qatar, Qatar Foundation-Education City, PO Box 24144, Doha, Qatar.

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April 2016

Mutational analysis of TBK1 in Taiwanese patients with amyotrophic lateral sclerosis.

Neurobiol Aging 2016 Apr 5;40:191.e11-191.e16. Epub 2016 Jan 5.

Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Neurology, National Yang-Ming University School of Medicine, Taipei, Taiwan; Brain Research Center, National Yang-Ming University, Taipei, Taiwan. Electronic address:

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April 2016

Taiwan cobra cardiotoxin III suppresses EGF/EGFR-mediated epithelial-to-mesenchymal transition and invasion of human breast cancer MDA-MB-231 cells.

Toxicon 2016 Mar 14;111:108-20. Epub 2016 Jan 14.

Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address:

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March 2016

Genetic and environmental impacts on DNA methylation levels in twins.

Epigenomics 2016 Jan 18;8(1):105-17. Epub 2015 Dec 18.

Department of Twin Research & Genetic Epidemiology, King's College, London, UK.

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January 2016

DNA Methylation Changes in the IGF1R Gene in Birth Weight Discordant Adult Monozygotic Twins.

Twin Res Hum Genet 2015 Dec 13;18(6):635-46. Epub 2015 Nov 13.

Department of Twin Research & Genetic Epidemiology,King's College London,London,UK.

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December 2015

MicroRNA let-7g cooperates with interferon/ribavirin to repress hepatitis C virus replication.

J Mol Med (Berl) 2016 Mar 21;94(3):311-20. Epub 2015 Oct 21.

Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, No. 100, Tzyou 1st Road, Kaohsiung, 807, Taiwan.

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March 2016

Integrated multiomics approach identifies calcium and integrin-binding protein-2 as a novel gene for pulse wave velocity.

J Hypertens 2016 Jan;34(1):79-87

aDepartment of Twin Research and Genetic Epidemiology, King's College London bNIHR Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust cDepartment of Clinical Pharmacology, King's College London dThe Institute of Cancer Research, London, UK eCardiovascular Engineering, Inc, Norwood, Massachusetts, USA.

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January 2016

Cardiotoxin III Inhibits Hepatocyte Growth Factor-Induced Epithelial-Mesenchymal Transition and Suppresses Invasion of MDA-MB-231 Cells.

J Biochem Mol Toxicol 2016 Jan 17;30(1):12-21. Epub 2015 Aug 17.

Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.

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January 2016

Two Novel De Novo GARS Mutations Cause Early-Onset Axonal Charcot-Marie-Tooth Disease.

PLoS One 2015 5;10(8):e0133423. Epub 2015 Aug 5.

Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Neurology, National Yang-Ming University School of Medicine, Taipei, Taiwan; Brain Research Center, National Yang-Ming University, Taipei, Taiwan.

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May 2016

The tertiary prevention of hepatocellular carcinoma in chronic hepatitis C patients.

J Gastroenterol Hepatol 2015 Dec;30(12):1768-74

Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

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December 2015

Power and sample size estimation for epigenome-wide association scans to detect differential DNA methylation.

Int J Epidemiol 2015 08 13;44(4):1429-1441. Epub 2015 May 13.

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK

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August 2015

coMET: visualisation of regional epigenome-wide association scan results and DNA co-methylation patterns.

BMC Bioinformatics 2015 Apr 28;16:131. Epub 2015 Apr 28.

Department of Twin Research and Genetic Epidemiology, St Thomas' Hospital Campus, King's College London, Westminster Bridge Road, London, UK.

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April 2015

Huge gap between clinical efficacy and community effectiveness in the treatment of chronic hepatitis C: a nationwide survey in Taiwan.

Medicine (Baltimore) 2015 Apr;94(13):e690

From the Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital (Ming-Lung Yu, Ming-Lun Yeh, P-CT, J-FH, C-FH, P-CL, Y-HL, M-YH, Z-YL, S-CC, C-YD, W-LC, W-YC); Faculty of Internal Medicine, College of Medicine, and Graduate Institute of Clinical Medicine, and Center for Infectious Disease and Cancer Research, Kaohsiung Medical University (Ming-Lung Yu, J-FH, C-FH, M-HH, Z-YL, S-CC, C-YD, W-LC); Institute of Biomedical Sciences, National Sun Yat-Sen University (Ming-Lung Yu); Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University (C-IH, N-JH); Department of Occupational Medicine, Kaohsiung Municipal Ta-Tung Hospital (C-FH); Department of Preventive Medicine, Kaohsiung Medical University Hospital (M-HH); Department of Occupational Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University (W-YL); and Taiwan Liver Research Foundation, Kaohsiung, Taiwan (W-YC).

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April 2015

Mutational analysis of MATR3 in Taiwanese patients with amyotrophic lateral sclerosis.

Neurobiol Aging 2015 May 14;36(5):2005.e1-4. Epub 2015 Feb 14.

Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Neurology, National Yang-Ming University School of Medicine, Taipei, Taiwan; Brain Research Center, National Yang-Ming University, Taipei, Taiwan. Electronic address:

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May 2015

Mortality after exposure to polychlorinated biphenyls and polychlorinated dibenzofurans: a meta-analysis of two highly exposed cohorts.

Int J Cancer 2015 Sep 16;137(6):1427-32. Epub 2015 Mar 16.

Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University (NTU), Taipei, Taiwan.

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September 2015

C9ORF72 repeat expansion is not a significant cause of late onset cerebellar ataxia syndrome.

J Neurol Sci 2014 Dec 6;347(1-2):322-4. Epub 2014 Nov 6.

Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Neurology, National Yang-Ming University School of Medicine, Taipei, Taiwan; Brain Research Center, National Yang-Ming University, Taipei, Taiwan. Electronic address:

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December 2014

Obesity accelerates epigenetic aging of human liver.

Proc Natl Acad Sci U S A 2014 Oct 13;111(43):15538-43. Epub 2014 Oct 13.

Medical Department 1, University Hospital Dresden, Technical University Dresden, 01307 Dresden, Germany;

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October 2014

Spinocerebellar ataxia 35: novel mutations in TGM6 with clinical and genetic characterization.

Neurology 2014 Oct 24;83(17):1554-61. Epub 2014 Sep 24.

From the Institute of Clinical Medicine (Y.-C.G.), National Yang-Ming University, Taipei; Department of Neurology (Y.-C. Liao, P.-C.T., Y.-C. Lee, B.-W.S.) and Brain Research Center (P.-C.T., Y.-C. Lee, B.-W.S.), National Yang-Ming University School of Medicine, Taipei; Neuroscience Laboratory (Y.-C.G.), Department of Neurology, China Medical University Hospital, Taichung; School of Medicine (Y.-C.G.), College of Medicine, China Medical University, Taichung; Department of Neurology (J.-J.L.), Chushang Show-Chwan Hospital, Nantou; Department of Neurology (J.-J.L.), Chung-Shan Medical University Hospital, Taichung; and Department of Neurology (Y.-C. Liao, P.-C.T., Y.-C. Lee, B.-W.S.), Taipei Veterans General Hospital, Taiwan.

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October 2014

The association between DNA copy number aberrations at chromosome 5q22 and gastric cancer.

PLoS One 2014 11;9(9):e106624. Epub 2014 Sep 11.

Department of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Division of Gastrointestinal and General Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

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May 2015

Epigenome-wide DNA methylation in hearing ability: new mechanisms for an old problem.

PLoS One 2014 3;9(9):e105729. Epub 2014 Sep 3.

Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.

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May 2015

A novel TFG mutation causes Charcot-Marie-Tooth disease type 2 and impairs TFG function.

Neurology 2014 Sep 6;83(10):903-12. Epub 2014 Aug 6.

From the Departments of Neurology (P.-C.T., K.-P.L., Y.-C. Liao, Y.-T.L., B.-W.S., Y.-C. Lee) and Radiology (H.-T.W.), Taipei Veterans General Hospital; Department of Neurology (K.-P.L., Y.-C. Liao, Y.-T.L., B.-W.S., Y.-C. Lee), Brain Research Center (P.-C.T., L.-S.K., M.-J.F., B.-W.S., Y.-C. Lee), Institute of Biomedical Informatics (Y.-H.H.), Center or Systems and Synthetic Biology (Y.-H.H., Y.-S.T.), Department of Life Sciences and Institute of Genome Sciences (L.-S.K., M.-J.F.), Genome Research Center (T.-T.L., L.-S.K.), and Institute of Neuroscience (B.-W.S.), National Yang-Ming University, Taipei; Neuroscience Laboratory (Y.-C.G.), Department of Neurology, China Medical University Hospital, Taichung; School of Medicine (Y.-C.G.), College of Medicine, China Medical University, Taichung; and Institute of Cellular and System Medicine (S.-F.Y.), National Health Research Institutes, Zhunan, Taiwan.

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September 2014

Cardiotoxin III suppresses hepatocyte growth factor-stimulated migration and invasion of MDA-MB-231 cells.

Cell Biochem Funct 2014 Aug 26;32(6):485-95. Epub 2014 Jun 26.

Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan.

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August 2014

Extensive molecular genetic survey of Taiwanese patients with amyotrophic lateral sclerosis.

Neurobiol Aging 2014 Oct 11;35(10):2423.e1-6. Epub 2014 May 11.

Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Neurology, National Yang-Ming University School of Medicine, Taipei, Taiwan; Brain Research Center, National Yang-Ming University, Taipei, Taiwan. Electronic address:

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October 2014

Baseline gamma-glutamyl transferase levels strongly correlate with hepatocellular carcinoma development in non-cirrhotic patients with successful hepatitis C virus eradication.

J Hepatol 2014 Jul 5;61(1):67-74. Epub 2014 Mar 5.

Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Faculty of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

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July 2014

Critical residues of class II PHA synthase for expanding the substrate specificity and enhancing the biosynthesis of polyhydroxyalkanoate.

Enzyme Microb Technol 2014 Mar 16;56:60-6. Epub 2014 Jan 16.

Department of Agricultural Chemistry, National Taiwan University, Taipei 10617, Taiwan. Electronic address:

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March 2014

Naphtho[1,2-b]furan-4,5-dione inhibits MDA-MB-231 cell migration and invasion by suppressing Src-mediated signaling pathways.

Mol Cell Biochem 2014 Feb 26;387(1-2):101-11. Epub 2013 Oct 26.

Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.

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February 2014