Publications by authors named "Pedro Torres-Ayuso"

13Publications

The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells.

Authors:
Van T Hoang Katherine Nyswaner Pedro Torres-Ayuso John Brognard

J Biol Chem 2020 06 30;295(25):8470-8479. Epub 2020 Apr 30.

Laboratory of Cell and Developmental Signaling, National Cancer Institute, Frederick, Maryland, USA

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June 2020

Combing the Cancer Genome for Novel Kinase Drivers and New Therapeutic Targets.

Authors:
Pedro Torres-Ayuso John Brognard

Cancers (Basel) 2019 Dec 7;11(12). Epub 2019 Dec 7.

Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

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December 2019

Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors.

Authors:
Isabel Merida Javier Arranz-Nicolás Pedro Torres-Ayuso Antonia Ávila-Flores

Handb Exp Pharmacol 2020 ;259:133-162

Department of Immunology and Oncology, National Center of Biotechnology (CNB-CSIC), Madrid, Spain.

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August 2020

Shipping Out MEK Inhibitor Resistance with SHP2 Inhibitors.

Authors:
Pedro Torres-Ayuso John Brognard

Cancer Discov 2018 10;8(10):1210-1212

Signaling Networks in Cancer Section, Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, Frederick, Maryland.

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October 2018

Signaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations: a case report for a cancer of unknown primary origin.

Authors:
Pedro Torres-Ayuso Sudhakar Sahoo Garry Ashton Elvira An Nicole Simms Melanie Galvin Hui Sun Leong Kristopher K Frese Kathryn Simpson Natalie Cook Andrew Hughes Crispin J Miller Richard Marais Caroline Dive Matthew G Krebs John Brognard

NPJ Genom Med 2018 20;3:15. Epub 2018 Jun 20.

1Signalling Networks in Cancer Group, Cancer Research UK, Manchester Institute, University of Manchester, Manchester, M20 4BX UK.

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June 2018

Survival of Head and Neck Cancer Cells Relies upon LZK Kinase-Mediated Stabilization of Mutant p53.

Authors:
Zoe C Edwards Eleanor W Trotter Pedro Torres-Ayuso Phil Chapman Henry M Wood Katherine Nyswaner John Brognard

Cancer Res 2017 09 31;77(18):4961-4972. Epub 2017 Jul 31.

Signalling Networks in Cancer Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom.

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September 2017

Diacylglycerol kinases in cancer.

Authors:
Isabel Mérida Pedro Torres-Ayuso Antonia Ávila-Flores Javier Arranz-Nicolás Elena Andrada María Tello-Lafoz Rosa Liébana Raquel Arcos

Adv Biol Regul 2017 Jan 23;63:22-31. Epub 2016 Sep 23.

Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB-CSIC), E-28049, Madrid, Spain.

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January 2017

Somatically mutated ABL1 is an actionable and essential NSCLC survival gene.

Authors:
Ewelina Testoni Natalie L Stephenson Pedro Torres-Ayuso Anna A Marusiak Eleanor W Trotter Andrew Hudson Cassandra L Hodgkinson Christopher J Morrow Caroline Dive John Brognard

EMBO Mol Med 2016 Feb;8(2):105-16

Signalling Networks in Cancer Group, Cancer Research UK Manchester Institute The University of Manchester, Manchester, UK

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February 2016

Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src.

Authors:
Pedro Torres-Ayuso Manuel Daza-Martín Jorge Martín-Pérez Antonia Ávila-Flores Isabel Mérida

Oncotarget 2014 Oct;5(20):9710-26

Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Madrid, Spain.

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October 2014

A Blk-p190RhoGAP signaling module downstream of activated Gα13 functionally opposes CXCL12-stimulated RhoA activation and cell invasion.

Authors:
Rubén A Bartolomé Marta Díaz-Martínez Georgina P Coló Nohemí Arellano-Sánchez Pedro Torres-Ayuso Jan Willem Kleinovink Isabel Mérida Joaquin Teixidó

Cell Signal 2014 Nov 13;26(11):2551-61. Epub 2014 Jul 13.

Department of Cellular and Molecular Medicine, Centro de Investigaciones Biológicas (CSIC), 28040 Madrid, Spain. Electronic address:

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November 2014

FoxO-dependent regulation of diacylglycerol kinase α gene expression.

Authors:
Mónica Martínez-Moreno Job García-Liévana Denise Soutar Pedro Torres-Ayuso Elena Andrada Xiao-Ping Zhong Gary A Koretzky Isabel Mérida Antonia Ávila-Flores

Mol Cell Biol 2012 Oct 13;32(20):4168-80. Epub 2012 Aug 13.

Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, Madrid, Spain.

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October 2012

Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse.

Authors:
Severine I Gharbi Esther Rincón Antonia Avila-Flores Pedro Torres-Ayuso María Almena María Angeles Cobos Juan Pablo Albar Isabel Mérida

Mol Biol Cell 2011 Nov 21;22(22):4406-14. Epub 2011 Sep 21.

Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, E-28049 Madrid, Spain.

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November 2011

Diacylglycerol kinase alpha, from negative modulation of T cell activation to control of cancer progression.

Authors:
Isabel Mérida Antonia Avila-Flores Job García Ernesto Merino María Almena Pedro Torres-Ayuso

Adv Enzyme Regul 2009 ;49(1):174-88

Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Darwin 3, Campus de Cantoblanco, E-28049 Madrid, Spain.

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September 2009