Pedro Melgar-Lesmes

Pedro Melgar-Lesmes

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Pedro Melgar-Lesmes

Pedro Melgar-Lesmes

Publications by authors named "Pedro Melgar-Lesmes"

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20Publications

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Graphene-Dendrimer Nanostars for Targeted Macrophage Overexpression of Metalloproteinase 9 and Hepatic Fibrosis Precision Therapy.

Nano Lett 2018 Aug 16. Epub 2018 Aug 16.

Department of Biomedicine, School of Medicine , University of Barcelona , 143 Casanova , 08036 Barcelona , Spain.

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August 2018

Chondroitin Sulphate Attenuates Atherosclerosis in ApoE Knockout Mice Involving Cellular Regulation of the Inflammatory Response.

Thromb Haemost 2018 Jul 6;118(7):1329-1339. Epub 2018 Jun 6.

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States.

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July 2018

Optimizing Glutaraldehyde-Fixed Tissue Heart Valves with Chondroitin Sulfate Hydrogel for Endothelialization and Shielding against Deterioration.

Biomacromolecules 2018 Apr 20;19(4):1234-1244. Epub 2018 Mar 20.

Massachusetts Institute of Technology, Institute for Medical Engineering and Science , Cambridge , Massachusetts 02139 , United States.

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April 2018

A small population of liver endothelial cells undergoes endothelial-to-mesenchymal transition in response to chronic liver injury.

Am J Physiol Gastrointest Liver Physiol 2017 Nov 10;313(5):G492-G504. Epub 2017 Aug 10.

Biochemistry and Molecular Genetics Department, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain;

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November 2017

Implantation of healthy matrix-embedded endothelial cells rescues dysfunctional endothelium and ischaemic tissue in liver engraftment.

Gut 2017 07 5;66(7):1297-1305. Epub 2016 Feb 5.

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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July 2017

Pulsatility and high shear stress deteriorate barrier phenotype in brain microvascular endothelium.

J Cereb Blood Flow Metab 2017 Jul 1;37(7):2614-2625. Epub 2016 Jan 1.

1 Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.

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July 2017

Treatment with chondroitin sulfate to modulate inflammation and atherogenesis in obesity.

Atherosclerosis 2016 Feb 13;245:82-7. Epub 2015 Dec 13.

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA; Bioengineering Department, Institut Químic de Sarrià, Ramon Llull Univ, Barcelona, Spain.

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February 2016

Monocyte-endothelial cell interactions in the regulation of vascular sprouting and liver regeneration in mouse.

J Hepatol 2015 Oct 27;63(4):917-25. Epub 2015 May 27.

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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October 2015

Factors involved in extracellular matrix turnover in human derived cardiomyocytes.

Cell Physiol Biochem 2013 11;32(5):1125-36. Epub 2013 Nov 11.

Service of Biochemistry and Molecular Genetics, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

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August 2014

Extent of flow recirculation governs expression of atherosclerotic and thrombotic biomarkers in arterial bifurcations.

Cardiovasc Res 2014 Jul 19;103(1):37-46. Epub 2014 May 19.

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA Department of Biological Engineering, IQS School of Engineering, URL, Barcelona, Spain.

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July 2014

Quantifying the bioadhesive properties of surface-modified polyurethane-urea nanoparticles in the vascular network.

Colloids Surf B Biointerfaces 2014 Jun 18;118:280-8. Epub 2014 Apr 18.

Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Barcelona, Av Joan XXIII s/n, 08028 Barcelona, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Barcelona, Spain. Electronic address:

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June 2014

Polyurethane and polyurea nanoparticles based on polyoxyethylene castor oil derivative surfactant suitable for endovascular applications.

Int J Pharm 2014 Jan 23;461(1-2):1-13. Epub 2013 Nov 23.

Departament de Farmàcia i Tecnologia Farmacèutica, Facultat de Farmàcia, Universitat de Barcelona, Av Joan XXIII s/n, 08028 Barcelona, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Barcelona, Spain. Electronic address:

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January 2014

Hypoxia and proinflammatory factors upregulate apelin receptor expression in human stellate cells and hepatocytes.

Gut 2011 Oct 29;60(10):1404-11. Epub 2011 Mar 29.

Service of Biochemistry and Molecular Genetics, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

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October 2011

Apelin mediates the induction of profibrogenic genes in human hepatic stellate cells.

Endocrinology 2010 Nov 15;151(11):5306-14. Epub 2010 Sep 15.

Service of Biochemistry and Molecular Genetics, Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain.

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November 2010

The hepatic apelin system: a new therapeutic target for liver disease.

Hepatology 2008 Oct;48(4):1193-201

Biochemistry and Molecular Genetics Service, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Hospital Clínic, University of Barcelona, Barcelona, Spain.

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October 2008

Ascites from cirrhotic patients induces angiogenesis through the phosphoinositide 3-kinase/Akt signaling pathway.

J Hepatol 2005 Jul 12;43(1):85-91. Epub 2005 Apr 12.

Hormonal Laboratory, Hospital Clínic and Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Villarroel 170 Barcelona 08036, Spain.

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July 2005