Pedro M Nieto

Pedro M Nieto

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Pedro M Nieto

Pedro M Nieto

Publications by authors named "Pedro M Nieto"

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Synthesis of (1→3) Thiodisaccharides of GlcNAc and the Serendipitous Formation of 2,3-Dideoxy-(1→2)-thiodisaccharides through a Vinyl Azide Intermediate.

J Org Chem 2020 Jan 19;85(2):306-317. Epub 2019 Dec 19.

Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires , Ciudad Universitaria , Pabellón 2, C1428EGA Buenos Aires , Argentina.

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http://dx.doi.org/10.1021/acs.joc.9b01883DOI Listing
January 2020

Synthesis of a Fluorous-Tagged Hexasaccharide and Interaction with Growth Factors Using Sugar-Coated Microplates.

Molecules 2019 Apr 22;24(8). Epub 2019 Apr 22.

Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), cicCartuja, CSIC and Universidad de Sevilla, Americo Vespucio, 49, 41092 Sevilla, Spain.

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http://dx.doi.org/10.3390/molecules24081591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515340PMC
April 2019

Unexpected loss of stereoselectivity in glycosylation reactions during the synthesis of chondroitin sulfate oligosaccharides.

Beilstein J Org Chem 2019 15;15:137-144. Epub 2019 Jan 15.

Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), cicCartuja, CSIC and Universidad de Sevilla, Americo Vespucio, 49, 41092 Sevilla, Spain.

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http://dx.doi.org/10.3762/bjoc.15.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350880PMC
January 2019

The Use of NMR to Study Transient Carbohydrate-Protein Interactions.

Authors:
Pedro M Nieto

Front Mol Biosci 2018 11;5:33. Epub 2018 Apr 11.

Glycosystems Laboratory, Instituto de Investigaciones Científicas, cicCartuja, CSIC/USE, Seville, Spain.

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http://dx.doi.org/10.3389/fmolb.2018.00033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904382PMC
April 2018

Fluorous-tag assisted synthesis of a glycosaminoglycan mimetic tetrasaccharide as a high-affinity FGF-2 and midkine ligand.

Bioorg Med Chem 2018 03 3;26(5):1076-1085. Epub 2018 Feb 3.

Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), cicCartuja, CSIC and Universidad de Sevilla, Americo Vespucio, 49, 41092 Sevilla, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2018.01.022DOI Listing
March 2018

Glycodendrimers as Chondroitin Sulfate Mimetics: Synthesis and Binding to Growth Factor Midkine.

Chemistry 2017 Aug 3;23(47):11338-11345. Epub 2017 Aug 3.

Instituto de Investigaciones Químicas (IIQ), CSIC- Universidad de Sevilla, Américo Vespucio 49, 41092, Seville, Spain.

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http://doi.wiley.com/10.1002/chem.201701890
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http://dx.doi.org/10.1002/chem.201701890DOI Listing
August 2017

Interactions between a Heparin Trisaccharide Library and FGF-1 Analyzed by NMR Methods.

Int J Mol Sci 2017 Jun 17;18(6). Epub 2017 Jun 17.

Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), Centro de Investigaciones Científicas Isla de La Cartuja, CSIC and Universidad de Sevilla, Américo Vespucio, 49, 41092 Sevilla, Spain.

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http://dx.doi.org/10.3390/ijms18061293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486114PMC
June 2017

Chondroitin Sulfate Tetrasaccharides: Synthesis, Three-Dimensional Structure and Interaction with Midkine.

Chemistry 2016 Feb 19;22(7):2356-69. Epub 2016 Jan 19.

Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), cicCartuja, CSIC and Universidad de Sevilla, Americo Vespucio, 49, 41092, Sevilla, Spain.

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http://dx.doi.org/10.1002/chem.201504440DOI Listing
February 2016

Structures of glycans bound to receptors from saturation transfer difference (STD) NMR spectroscopy: quantitative analysis by using CORCEMA-ST.

Methods Mol Biol 2015 ;1273:475-87

Andalusian Centre for Nanomedicine and Biotechnology (BIONAND), C/Severo Ochoa 35, Parque Tecnológico de Andalucía, 29590, Campanillas, Málaga, Spain.

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http://dx.doi.org/10.1007/978-1-4939-2343-4_28DOI Listing
November 2015

Mimicking Tyrosine Phosphorylation in Human Cytochrome c by the Evolved tRNA Synthetase Technique.

Chemistry 2015 Oct 21;21(42):15004-12. Epub 2015 Aug 21.

IBVF - cicCartuja, Universidad de Sevilla - CSIC, Avenida Américo Vespucio 49, Sevilla 41092 (Spain).

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http://dx.doi.org/10.1002/chem.201502019DOI Listing
October 2015

Langerin-heparin interaction: two binding sites for small and large ligands as revealed by a combination of NMR spectroscopy and cross-linking mapping experiments.

J Am Chem Soc 2015 Apr 23;137(12):4100-10. Epub 2015 Mar 23.

†Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), Centro de Investigaciones Científicas Isla de La Cartuja, CSIC and Universidad de Sevilla, Américo Vespucio, 49, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1021/ja511529xDOI Listing
April 2015

Importance of the polarity of the glycosaminoglycan chain on the interaction with FGF-1.

Glycobiology 2014 Nov 11;24(11):1004-9. Epub 2014 Jul 11.

Instituto de Investigaciones Químicas, CSIC, Américo Vespucio, 49, Sevilla 41092, Spain

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http://dx.doi.org/10.1093/glycob/cwu071DOI Listing
November 2014

Synthesis of hyaluronic acid oligosaccharides and exploration of a fluorous-assisted approach.

Carbohydr Res 2014 Jul 20;394:17-25. Epub 2014 May 20.

Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), Centro de Investigaciones Científicas Isla de La Cartuja, CSIC and Universidad de Sevilla, Americo Vespucio, 49, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1016/j.carres.2014.05.007DOI Listing
July 2014

A STD-NMR study of the interaction of the Anabaena ferredoxin-NADP+ reductase with the coenzyme.

Molecules 2014 Jan 7;19(1):672-85. Epub 2014 Jan 7.

Instituto de Investigaciones Químicas, CSIC, Americo Vespucio, 49, Sevilla 41092, Spain.

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http://www.mdpi.com/1420-3049/19/1/672
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http://dx.doi.org/10.3390/molecules19010672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272016PMC
January 2014

3D structure of a heparin mimetic analogue of a FGF-1 activator. A NMR and molecular modelling study.

Org Biomol Chem 2013 Dec 31;11(47):8269-75. Epub 2013 Oct 31.

Lab. of Glycosystems, Dept. Bioorganic Chemistry, Instituto de Investigaciones Químicas, cicCartuja, CSIC/US, C/Americo Vespucio, 49 Sevilla 41092, Spain.

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http://dx.doi.org/10.1039/c3ob41789aDOI Listing
December 2013

Conformations of the iduronate ring in short heparin fragments described by time-averaged distance restrained molecular dynamics.

Glycobiology 2013 Nov 31;23(11):1220-9. Epub 2013 Jul 31.

Glycosystems Laboratory, Instituto de Investigaciones Quimicas, CSIC - US, Americo Vespucio, 49, E-41092 Sevilla, Spain.

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http://glycob.oxfordjournals.org/content/early/2013/08/22/gl
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http://www.glycob.oxfordjournals.org/cgi/doi/10.1093/glycob/
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http://dx.doi.org/10.1093/glycob/cwt058DOI Listing
November 2013

Synthesis of chondroitin/dermatan sulfate-like oligosaccharides and evaluation of their protein affinity by fluorescence polarization.

Org Biomol Chem 2013 Jun 17;11(21):3510-25. Epub 2013 Apr 17.

Glycosystems Laboratory, Instituto de Investigaciones Químicas, Centro de Investigaciones Científicas Isla de La Cartuja, CSIC and Universidad de Sevilla, Americo Vespucio, 49, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1039/c3ob40306hDOI Listing
June 2013

Insights into the glycosaminoglycan-mediated cytotoxic mechanism of eosinophil cationic protein revealed by NMR.

ACS Chem Biol 2013 Jan 9;8(1):144-51. Epub 2012 Oct 9.

Departamento de Química Física Biológica, Instituto de Química Física Rocasolano, CSIC, Madrid, Spain.

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http://dx.doi.org/10.1021/cb300386vDOI Listing
January 2013

Effect of the substituents of the neighboring ring in the conformational equilibrium of iduronate in heparin-like trisaccharides.

Chemistry 2012 Dec 9;18(51):16319-31. Epub 2012 Nov 9.

Glycosystems Laboratory, Instituto de Investigaciones Quimicas, CSIC-US, Americo Vespucio, 49, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1002/chem.201202770DOI Listing
December 2012

sp2-Iminosugar O-, S-, and N-glycosides as conformational mimics of α-linked disaccharides; implications for glycosidase inhibition.

Chemistry 2012 Jul 4;18(27):8527-39. Epub 2012 Jun 4.

Instituto de Investigaciones Químicas (IIQ), CSIC-Universidad de Sevilla, Avda. Americo Vespucio 49, 41092, Sevilla, Spain.

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http://doi.wiley.com/10.1002/chem.201200279
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http://dx.doi.org/10.1002/chem.201200279DOI Listing
July 2012

Synthesis of amine-functionalized heparin oligosaccharides for the investigation of carbohydrate-protein interactions in microtiter plates.

Org Biomol Chem 2012 Mar 31;10(10):2146-63. Epub 2012 Jan 31.

Glycosystems Laboratory, Instituto de Investigaciones Químicas, Centro de Investigaciones Científicas Isla de La Cartuja, CSIC and Universidad de Sevilla, Américo Vespucio, 49, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1039/c2ob06607fDOI Listing
March 2012

A non-damaging method to analyze the configuration and dynamics of nitrotyrosines in proteins.

Chemistry 2012 Mar 29;18(13):3872-8. Epub 2012 Feb 29.

Instituto de Bioquímica Vegetal y Fotosíntesis, Centro de Investigaciones Científicas Isla de la Cartuja, Universidad de Sevilla-C.S.I.C. Avda. Américo Vespucio, 49, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1002/chem.201103413DOI Listing
March 2012

STD-NMR: application to transient interactions between biomolecules-a quantitative approach.

Eur Biophys J 2011 Dec 24;40(12):1357-69. Epub 2011 Sep 24.

Instituto de Investigaciones Químicas, CSIC - US, Sevilla, Spain.

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http://dx.doi.org/10.1007/s00249-011-0749-5DOI Listing
December 2011

Insights into molecular recognition of Lewis(X) mimics by DC-SIGN using NMR and molecular modelling.

Org Biomol Chem 2011 Oct 10;9(22):7705-12. Epub 2011 Oct 10.

Glycosystems Laboratory, Instituto de Investigaciones Químicas, CSIC-US, AmericoVespucio, 49 41092 Sevilla, Spain.

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http://dx.doi.org/10.1039/c1ob05938fDOI Listing
October 2011

Conformational selection of the AGA*IA(M) heparin pentasaccharide when bound to the fibroblast growth factor receptor.

Chemistry 2011 Sep 25;17(40):11204-9. Epub 2011 Aug 25.

Chemical and Physical Biology, Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.

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http://dx.doi.org/10.1002/chem.201101000DOI Listing
September 2011

Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation.

Biochim Biophys Acta 2010 Jun-Jul;1797(6-7):981-93. Epub 2010 Mar 20.

Instituto de Bioquímica Vegetal y Fotosíntesis, Universidad de Sevilla-CSIC, Avda. Americo Vespucio 49, Sevilla 41092, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S000527281000115
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http://dx.doi.org/10.1016/j.bbabio.2010.03.009DOI Listing
January 2011

Ligand-receptor binding affinities from saturation transfer difference (STD) NMR spectroscopy: the binding isotherm of STD initial growth rates.

Chemistry 2010 Jul;16(26):7803-12

Department of Bioorganic Chemistry, Instituto de Investigaciones Químicas (CSIC-US), Américo Vespucio 49, 41092, Sevilla, Spain.

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http://doi.wiley.com/10.1002/chem.200903528
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http://dx.doi.org/10.1002/chem.200903528DOI Listing
July 2010

Exploration of the use of an acylsulfonamide safety-catch linker for the polymer-supported synthesis of hyaluronic acid oligosaccharides.

Carbohydr Res 2010 Mar 4;345(5):565-71. Epub 2010 Jan 4.

Instituto de Investigaciones Químicas, Centro de Investigaciones Científicas Isla de La Cartuja, CSIC -US, Americo Vespucio, 49, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1016/j.carres.2009.12.021DOI Listing
March 2010

Mutants of the Arabidopsis thaliana cation/H+ antiporter AtNHX1 conferring increased salt tolerance in yeast: the endosome/prevacuolar compartment is a target for salt toxicity.

J Biol Chem 2009 May 23;284(21):14276-85. Epub 2009 Mar 23.

Instituto de Recursos Naturales y Agrobiología, Consejo Superior de Investigaciones Científicas (IRNASE-CSIC), Avda. Reina Mercedes 10, Seville 41012, Spain.

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http://dx.doi.org/10.1074/jbc.M806203200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682876PMC
May 2009

Experimental measurement of carbohydrate-aromatic stacking in water by using a dangling-ended DNA model system.

Chemistry 2008 ;14(26):7828-35

Department of Bioorganic Chemistry, Instituto de Investigaciones Químicas, CSIC-Universidad de Sevilla, Sevilla, Spain.

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http://dx.doi.org/10.1002/chem.200800335DOI Listing
October 2008

Saturation transfer difference (STD) NMR spectroscopy characterization of dual binding mode of a mannose disaccharide to DC-SIGN.

Chembiochem 2008 Sep;9(14):2225-7

Grupo de Carbohidratos, Instituto de Investigaciones Químicas, CSIC-Universidad de Sevilla, Américo Vespucio 49, 41092 Seville, Spain.

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http://dx.doi.org/10.1002/cbic.200800361DOI Listing
September 2008

Docking, synthesis, and NMR studies of mannosyl trisaccharide ligands for DC-SIGN lectin.

Org Biomol Chem 2008 Aug 5;6(15):2743-54. Epub 2008 Jun 5.

Grupo de Carbohidratos, Instituto de Investigaciones Químicas, CSIC, Universidad de Sevilla, Américo Vespucio 49, Seville, Spain.

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http://dx.doi.org/10.1039/b802144aDOI Listing
August 2008

Synthesis of novel DC-SIGN ligands with an alpha-fucosylamide anchor.

Chembiochem 2008 Aug;9(12):1921-30

Dipartimento di Chimica Organica e Industriale and CISI, Università di Milano, via Venezian 21, 20133 Milano, Italy.

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http://dx.doi.org/10.1002/cbic.200800139DOI Listing
August 2008

1,2-Mannobioside mimic: synthesis, DC-SIGN interaction by NMR and docking, and antiviral activity.

ChemMedChem 2007 Jul;2(7):1030-6

Departamento de Química Bioorgánica, Instituto de Investigaciones Químicas, CSIC, Américo Vespucio 49, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1002/cmdc.200700047DOI Listing
July 2007

Structure and dynamics of the conserved protein GPI anchor core inserted into detergent micelles.

Glycobiology 2006 Oct 14;16(10):969-80. Epub 2006 Jun 14.

Grupo de Carbohidratos, Instituto de Investigaciones Químicas, CSIC, Isla de la Cartuja, Seville, Spain.

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http://dx.doi.org/10.1093/glycob/cwl015DOI Listing
October 2006

Backbone dynamics of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue, by 15N NMR relaxation methods.

J Biomol NMR 2006 Aug 29;35(4):225-39. Epub 2006 Jul 29.

Departamento de Estructura y Función de Proteínas, Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu, 9, 28006, Madrid, Spain.

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http://link.springer.com/10.1007/s10858-006-9024-y
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http://dx.doi.org/10.1007/s10858-006-9024-yDOI Listing
August 2006

Dynamic properties of biologically active synthetic heparin-like hexasaccharides.

Glycobiology 2005 Oct 15;15(10):1008-15. Epub 2005 Jun 15.

Grupo de Carbohidratos, Instituto de Investigaciones Químicas, CSIC, Américo Vespucio 49, Isla de la Cartuja, 41092 Sevilla, Spain.

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http://academic.oup.com/glycob/article/15/10/1008/693730/Dyn
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http://dx.doi.org/10.1093/glycob/cwi091DOI Listing
October 2005

Conformational flexibility of a synthetic glycosylaminoglycan bound to a fibroblast growth factor. FGF-1 recognizes both the (1)C(4) and (2)S(O) conformations of a bioactive heparin-like hexasaccharide.

J Am Chem Soc 2005 Apr;127(16):5778-9

Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain, Instituto de Investigaciones Químicas, CSIC, Américo Vespucio s/n, Sevilla, Spain.

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http://dx.doi.org/10.1021/ja043363yDOI Listing
April 2005

NMR analysis of the transient complex between membrane photosystem I and soluble cytochrome c6.

J Biol Chem 2005 Mar 16;280(9):7925-31. Epub 2004 Dec 16.

Instituto de Bioquímica Vegetal y Fotosíntesis, Universidad de Sevilla y Consejo de Investigaciones Científicas, Américo Vespucio, Spain.

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http://dx.doi.org/10.1074/jbc.M412422200DOI Listing
March 2005

Gender dimorphism and altitudinal variation of secondary compounds in leaves of the gynodioecious shrub Daphne laureola.

J Chem Ecol 2005 Jan;31(1):139-50

Estación Biológica de Doñana, Consejo Superior de Investigaciones Científicas, Apdo. 1056, E-41080 Sevilla, Spain.

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http://dx.doi.org/10.1007/s10886-005-0980-6DOI Listing
January 2005

The heparin-Ca(2+) interaction: the influence of the O-sulfation pattern on binding.

Carbohydr Res 2004 Apr;339(5):975-83

Grupo de Carbohidratos, Instituto de Investigaciones Químicas, CSIC, Américo Vespucio s/n, Isla de la Cartuja, 41092 Seville, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S000862150400011
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http://dx.doi.org/10.1016/j.carres.2003.12.023DOI Listing
April 2004

Glycodendritic structures based on Boltorn hyperbranched polymers and their interactions with Lens culinaris lectin.

Bioconjug Chem 2003 Jul-Aug;14(4):817-23

Grupo de Carbohidratos, Instituto de Investigaciones Químicas, CSIC, Isla de la Cartuja, Américo Vespucio s/n, E-41092 Sevilla, Spain.

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http://pubs.acs.org/doi/abs/10.1021/bc034008k
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http://dx.doi.org/10.1021/bc034008kDOI Listing
March 2004

The activation of fibroblast growth factors (FGFs) by glycosaminoglycans: influence of the sulfation pattern on the biological activity of FGF-1.

Chembiochem 2004 Jan;5(1):55-61

Grupo de Carbohidratos, Instituto de Investigaciones Químicas, CSIC, Américo Vespucios s/n, Isla de la Cartuja, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1002/cbic.200300696DOI Listing
January 2004

A molecular dynamics description of the conformational flexibility of the L-iduronate ring in glycosaminoglycans.

Chem Commun (Camb) 2003 Jul(13):1512-3

Grupo de Carbohidratos, Instituto de Investigaciones Químicas, CSIC, Americo Vespucio s/n E-41092 Sevilla, Spain.

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http://dx.doi.org/10.1039/b303386bDOI Listing
July 2003

Synthesis and structural study of two new heparin-like hexasaccharides.

Org Biomol Chem 2003 Jul;1(13):2253-66

Grupo de Carbohidratos, Instituto de Investigaciones Químicas, CSIC, Américo Vespucio s/n, Isla de la Cartuja, 41092 Sevilla, Spain.

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http://dx.doi.org/10.1039/b303115bDOI Listing
July 2003