Publications by authors named "Pedro Jaen"

92 Publications

Subclinical Liver Disease is Associated with Subclinical Atherosclerosis in Psoriasis: Results from Two Observational Studies.

J Invest Dermatol 2021 Jul 19. Epub 2021 Jul 19.

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address:

Psoriasis is associated with a higher risk of liver diseases. We investigated the impact of hepatic steatosis (European cohort) and hepatic inflammation (United States cohort) on subclinical atherosclerosis. In the European cohort (n=76 psoriasis participants and 76 controls), non-alcoholic fatty liver disease (NAFLD), assessed by the sonographic hepatorenal index (SHRI), was more prevalent in psoriasis than controls (61% vs 45%; p=.04). Psoriasis participants with NAFLD had a higher prevalence of subclinical atherosclerosis (ultrasonographic presence of plaque in femoral or carotid arteries) than psoriasis without NAFLD (61% vs 23%; p=.006) and controls with NAFLD (61% vs 32%; p<.05). SHRI was a determinant of subclinical atherosclerosis in psoriasis (OR, 3.5; p=.01). In the United States cohort, (n=162 psoriasis participants who underwent positron emission tomography and coronary CT angiography), those with high hepatic F-FDG uptake had higher noncalcified (1.3 (0.49 mm) vs 1.0 (0.40 mm)), fibrofatty (0.23 (0.15 mm) vs 0.11 (0.087 mm)), and lipid rich necrotic core (4.3 (2.3 mm) vs 3.0 (1.7 mm)) coronary burden (all p<.001,). Hepatic F-FDG uptake associated with noncalcified (β=0.28; p<.001), fibrofatty (β=0.49; p<.001) and lipid rich necrotic core (β=0.28; p=.003) burden. These results demonstrate the downstream cardiovascular effects of subclinical liver disease in psoriasis.
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http://dx.doi.org/10.1016/j.jid.2021.05.034DOI Listing
July 2021

Impact of Biological Agents on Imaging and Biomarkers of Cardiovascular Disease in Patients with Psoriasis: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials.

J Invest Dermatol 2021 Apr 21. Epub 2021 Apr 21.

Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address:

Background: The effect of biologics on the risk for cardiovascular disease in patients with psoriasis is still unclear despite their widespread use.

Objective: The objective of this study was to examine the impact of licensed biological therapies on imaging and biomarkers of cardiovascular disease risk in patients with psoriasis by a systematic review and meta-analysis of placebo-controlled trials.

Methods: A comprehensive search of studies published before 1 June 2020 was performed in Medline-Ovid, EMBASE, and CENTRAL using a predefined strategy to identify relevant articles.

Results: Five studies were included for the final examination, and two studies were included in the meta-analysis. We did not find a significant reduction in aortic vascular inflammation in patients treated with adalimumab compared with those who received placebo at weeks 12-16. There was no beneficial effect on imaging biomarkers (aortic vascular inflammation or flow-mediated dilatation) of cardiovascular disease risk in patients exposed to biological therapies (adalimumab and secukinumab) compared with those exposed to placebo, except for ustekinumab showing a reduction in aortic vascular inflammation at week 12 but not at week 52 after the open-label extension period. The strongest reduction in blood-based cardiometabolic risk biomarkers was observed with adalimumab (CRP, TNF-α, IL-6, and GlycA) and phototherapy (CRP and IL-6) compared with that observed with placebo.

Conclusions: Randomized controlled trials show that ustekinumab reduces aortic vascular inflammation and that TNF-α inhibitors and phototherapy reduce CRP and IL-6. These surrogate marker findings require randomized controlled trials evaluating cardiovascular events to inform clinical practice.
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http://dx.doi.org/10.1016/j.jid.2021.03.024DOI Listing
April 2021

Underperformance of clinical risk scores in identifying imaging-based high cardiovascular risk in psoriasis: results from two observational cohorts.

Eur J Prev Cardiol 2020 Nov 9. Epub 2020 Nov 9.

Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Clinical Research Center, Room 5-5140, Bethesda, MD 20892, USA.

Aims: We aimed to evaluate whether traditional risk scores [short-term, 'psoriasis-modified' (multiplied by 1.5) and lifetime] were able to capture high cardiovascular disease (CVD) risk as defined by the presence of atherosclerotic plaques in coronary, femoral, or carotid arteries in psoriasis.

Methods And Results: We used two prospectives obseravational cohorts. European cohort: femoral and carotid atherosclerotic plaques were evaluated by ultrasound in 73 psoriasis patients. Lifetime CVD risk (LTCVR) was evaluated with QRISK-LT; short-term CVD risk was evaluated with SCORE and psoriasis-modified SCORE. American cohort: 165 patients underwent coronary computed tomography angiography to assess presence of coronary plaques. LTCVR was evaluated with atherosclerotic cardiovascular disease (ASCVD-LT) lifetime; short-term CVD risk was evaluated with ASCVD and psoriasis-modified ASCVD. European cohort: subclinical atherosclerosis was present in 51% of patients. QRISK-LT identified 64% of patients with atherosclerosis missing a high proportion (35%) with atheroma plaque (P < 0.05). The percentage of patients with atherosclerosis identified by QRISK-LT was significantly higher than those detected by SCORE (0%) and modified SCORE (10%). American cohort: subclinical atherosclerosis was present in 54% of patients. ASCVD-LT captured 54% of patients with coronary plaques missing a high proportion (46%) with coronary plaque (P < 0.05). The percentage of patients with atheroma plaques detected with ASCVD and modified ASCVD were only 20% and 45%, respectively.

Conclusions: Application of lifetime, short-term and 'psoriasis-modified' risk scores did not accurately capture psoriasis patients at high CVD risk.
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http://dx.doi.org/10.1093/eurjpc/zwaa033DOI Listing
November 2020

Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis.

Nature 2021 01 16;589(7842):448-455. Epub 2020 Dec 16.

Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles (ULB), Brussels, Belgium.

FAT1, which encodes a protocadherin, is one of the most frequently mutated genes in human cancers. However, the role and the molecular mechanisms by which FAT1 mutations control tumour initiation and progression are poorly understood. Here, using mouse models of skin squamous cell carcinoma and lung tumours, we found that deletion of Fat1 accelerates tumour initiation and malignant progression and promotes a hybrid epithelial-to-mesenchymal transition (EMT) phenotype. We also found this hybrid EMT state in FAT1-mutated human squamous cell carcinomas. Skin squamous cell carcinomas in which Fat1 was deleted presented increased tumour stemness and spontaneous metastasis. We performed transcriptional and chromatin profiling combined with proteomic analyses and mechanistic studies, which revealed that loss of function of FAT1 activates a CAMK2-CD44-SRC axis that promotes YAP1 nuclear translocation and ZEB1 expression that stimulates the mesenchymal state. This loss of function also inactivates EZH2, promoting SOX2 expression, which sustains the epithelial state. Our comprehensive analysis identified drug resistance and vulnerabilities in FAT1-deficient tumours, which have important implications for cancer therapy. Our studies reveal that, in mouse and human squamous cell carcinoma, loss of function of FAT1 promotes tumour initiation, progression, invasiveness, stemness and metastasis through the induction of a hybrid EMT state.
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http://dx.doi.org/10.1038/s41586-020-03046-1DOI Listing
January 2021

In vitro characterization and clinical use of platelet-rich plasma-derived Endoret-Gel as an autologous treatment for atrophic scars.

J Cosmet Dermatol 2020 Jul 11;19(7):1607-1613. Epub 2019 Nov 11.

BTI Biotechnology Institute, Vitoria, Spain.

Background: Normal healing process becomes severely dysregulated in pathophysiological conditions such as inflammation, infection or underlaying diseases. These scenarios hamper the standard healing pattern and dermal fibrotic tissue develops.

Objective: In the present study a novel three-dimensional formulation (Endoret-Gel) based on plasma rich in growth factors technology (Endoret-PRGF) has been assessed for atrophic scar management.

Materials And Methods: Microstructure analysis, growth factor content, and projection capacity of both formulations (Endoret-Gel and Endoret-PRGF) was assessed. Additionally, a clinical evaluation of Endoret-Gel treatment was also performed in a case of an extense atrophic scar.

Results: Endoret-Gel presented high molecular weight plasmatic proteins that formed solid thermal aggregates enclosed by a stable fibrin network. This formulation has a higher cutaneous projection capacity compared with Endoret-PRGF. Both formulations presented a high load of bioactive proteins such as EGF, PDGF-AB, and IGF-I being higher in liquid Endoret-PRGF. Clinical results evidenced that infiltrations of Endoret-Gel derived in an early volumetric disposal that was maintained for several months. The treatment provided and immediate soft tissue augmentation and scar amelioration effect that was translated into a noticeable clinical improvement of the injury. No side effects or adverse events were reported during ten-month follow-up period.

Conclusion: These preliminary findings suggest that Endoret-Gel may act not only as a temporary volumizer but also as soft tissue stimulator that might be used as a monotherapy for scar management.
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http://dx.doi.org/10.1111/jocd.13212DOI Listing
July 2020

Platelet rich plasma for the management of hair loss: Better alone or in combination?

J Cosmet Dermatol 2019 Apr 14;18(2):483-486. Epub 2018 Jun 14.

Centro Dermatológico Estético, Alicante, Spain.

Platelet-rich plasma (PRP) and autologous protein-based treatments have recently emerged as a potential therapeutic approach for hair loss-related disorders including androgenetic alopecia and alopecia areata. The safety and efficacy of repeated intradermal injections of PRP has proved to promote hair growth in a number of randomized clinical trials. Biologically active proteins and cytokines released upon platelet activation have shown to induce folliculogenesis and activate the anagen growing phase of dormant bulbs. Interestingly, further studies have revealed that combining PRP with other hair loss-related products may enhance the final performance of the treatment. These synergistic approaches include Food and Drug Administration (FDA) approved drugs such as finasteride or minoxidil, bioactive macromolecules and cell-based therapies. Here, recent research involving alone or combined therapy with platelet-rich plasma for the management of hair loss-related disorders are outlined and future prospects are discussed.
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http://dx.doi.org/10.1111/jocd.12683DOI Listing
April 2019

A novel personalized 3D injectable protein scaffold for regenerative medicine.

J Mater Sci Mater Med 2017 Dec 14;29(1). Epub 2017 Dec 14.

Foundation Eduardo Anitua, Vitoria, Spain.

Biomaterials should be designed to closely resemble the characteristics and functions of the native extracellular matrix to provide mechanical support and signals to direct biological events. Here we have developed a novel injectable plasma rich in growth factors (PRGF-Endoret)-based formulation that combines a thermal-denaturation step of plasma with an autologous fibrin crosslinking. Rheological and mechanical properties were evaluated. Additionally, the microstructure and biological capacity of the biomaterial was also characterized. This novel formulation exhibited ideal mechanical properties and a gel-like behavior with the ability to progressively release its growth factor load over time. The results also suggested that the novel injectable formulation is non-cytotoxic, biocompatible and suitable for cell ingrowth as it is deduced from the fibroblast proliferation within the scaffold. Finally, stimulation of both cell proliferation and matrix proteins synthesis demonstrated the regenerative potential of this autologous protein based injectable scaffold.
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http://dx.doi.org/10.1007/s10856-017-6012-6DOI Listing
December 2017

Treatment of recalcitrant adult alopecia areata universalis with oral azathioprine.

J Am Acad Dermatol 2016 May;74(5):1007-8

Dermatology Service, Trichology Unit, Ramon y Cajal Hospital, Madrid, Spain; Trichology Unit, Grupo Pedro Jaén Clinic, Madrid, Spain.

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http://dx.doi.org/10.1016/j.jaad.2015.12.055DOI Listing
May 2016

Pulse corticosteroid therapy with oral dexamethasone for the treatment of adult alopecia totalis and universalis.

J Am Acad Dermatol 2016 May;74(5):1005-7

Dermatology Service, Trichology Unit, Ramon y Cajal Hospital, Madrid, Spain; Trichology Unit, Grupo Pedro Jaén Clinic, Madrid, Spain.

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http://dx.doi.org/10.1016/j.jaad.2015.12.026DOI Listing
May 2016

Plasma Rich in Growth Factors Enhances Wound Healing and Protects from Photo-oxidative Stress in Dermal Fibroblasts and 3D Skin Models.

Curr Pharm Biotechnol 2016 ;17(6):556-70

Background: Optimal skin repair has been a desired goal for many researchers. Recently, plasma rich in growth factors (PRGF) has gained importance in dermatology proving it is beneficial effects in wound healing and cutaneous regeneration.

Objective: The anti-fibrotic, pro-contractile and photo-protective effect of PRGF on dermal fibroblasts and 3D skin models has been evaluated.

Method: The effect against TGFβ1 induced myofibroblast differentiation was tested. Cell contractile activity over collagen gel matrices was analyzed and the effect against UV derived photo-oxidative stress was assessed. The effectiveness of PRGF obtained from young aged and middle aged donors was compared. Furthermore, 3D organotypic skin explants were used as human skin models with the aim of analyzing ex vivo cutaneous preventive and regenerative photo-protection after UV exposure.

Results: TGFβ1 induced myofibroblast levels decreased significantly after treatment with PRGF while the contractile activity increased compared to the control group. After UV irradiation, cell survival was promoted while apoptotic and ROS levels were noticeably reduced. Photo-exposed 3D explants showed higher levels of metabolic activity and lower levels of necrosis, cell damage, irritation and ROS formation when treated with PRGF. The histological integrity and connective tissue fibers showed lower signals of photodamage among PRGF injected skin models. No significant differences for the assessed biological outcomes were observed when PRGF obtained from young aged and middle aged donors were compared.

Conclusion: These findings suggest that this autologous approach might be useful for antifibrotic wound healing and provide an effective protection against sun derived photo-oxidative stress regardless the age of the patient.
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http://dx.doi.org/10.2174/1389201017666160301104139DOI Listing
December 2016

Depression of the frontal veins: A new clinical sign of frontal fibrosing alopecia.

J Am Acad Dermatol 2015 Jun;72(6):1087-8

Ramón y Cajal Hospital, Dermatology Service, Madrid, Spain; Trichology Unit, Grupo Pedro Jaén Clinic, Madrid, Spain.

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http://dx.doi.org/10.1016/j.jaad.2015.02.1129DOI Listing
June 2015

Isolation and characterization of PDT-resistant cancer cells.

Photochem Photobiol Sci 2015 Aug 5;14(8):1378-89. Epub 2015 Mar 5.

Department of Biology, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco 28049, Madrid, Spain.

Even though the efficacy of photodynamic therapy (PDT) for treating premalignant and malignant lesions has been demonstrated, resistant tumor cells to this therapy occasionally appear. Here, we describe the published methods to isolate resistant cancer cells to PDT and propose new procedures that may be used, as laboratory models allow a better understanding of resistance mechanisms. For this purpose, the treatment conditions, the photosensitizer (PS) or pro-drug, the cell line and the final selection - clonal of total population - must be taken into account. In general, high and repeated treatment doses are used. The resistant cell population characterization may include cell morphology, response to PDT, expression of death proteins or survival related genes and cell proliferation analysis. In addition, in vivo models such as the resistant cell transplantation to mice, allow evaluating tumorigenicity and aggressiveness, leading to the determination of the in vivo resistance. Summarizing, in order to improve clinical results, cellular models can help understand PDT-resistance mechanisms in vivo and in vitro.
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http://dx.doi.org/10.1039/c4pp00448eDOI Listing
August 2015

Assessment of the efficacy and tolerance of a new combination of retinoids and depigmenting agents in the treatment of melasma.

J Cosmet Dermatol 2014 Dec;13(4):261-8

Dermatology Department, University Hospital Ramón y Cajal Hospital, Madrid, Spain.

Background: Melasma is a dermatosis with significant repercussions on patients' quality of life, and there is currently no standard treatment. Hydroquinone is deemed the treatment of choice, but its safety has been questioned in certain cases.

Aims: To determine the efficacy and safety of a new combination of retinoids in the improvement of melasma.

Patients/methods: Prospective, double-blind, vehicle-controlled, and randomized study in 30 patients with melasma. The product was applied on one side of the face and the vehicle on the other, twice daily during 3 months. Standardized photographs were taken using RBX technology on the three visits (basal, at one and a half months and at 3 months). The main variable to determine the efficacy was the improvement of the hemifacial Melasma Area Severity Index (MASI). Other variables were determined such as improvement perceived by the investigator, improvement perceived by the patient, impact on quality of life or side effects.

Results: The MASI improvement at 3 months of treatment was significant on the treated side vs. the vehicle side, reaching an improvement of 70%, which is comparable to the percentage of improvement described with hydroquinone. No notable side effects were detected, in spite of a significant percentage of patients included in the study citing a history that could be compatible with sensitive skin.

Conclusions: This new combination of retinoids and depigmenting agents proved to be effective and safe in the treatment of melasma.
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http://dx.doi.org/10.1111/jocd.12110DOI Listing
December 2014

The effect of pulsed dye laser on high-risk basal cell carcinomas with response control by Mohs micrographic surgery.

Lasers Med Sci 2015 Sep 31;30(7):2009-14. Epub 2014 Oct 31.

Department of Dermatology, Ramón y Cajal University Hospital, Madrid, Spain,

Several reports have shown the effectiveness of pulsed dye laser (PDL) for the treatment of basal cell carcinoma (BCC). Most studies have focused on low-risk BCCs, but an important limitation has been the lack of histologic confirmation of the treatment results. The aim of this study was to assess the effectiveness of PDL in high-risk BCCs with complete histologic evaluation with Mohs micrographic surgery (MMS). Seven patients with high-risk BCCs located on the face were included. All tumors were treated with three sessions of PDL (595 nm) at 4-week intervals. The tumor and 4 mm of peripheral skin were treated with two stacked pulses with a 1-s delay, a fluence of 15 J/cm(2), a pulse duration of 2 ms, and a spot size of 7 mm. MMS was performed at least 1 month after the last PDL session including excisional tumor debulking prior to the first stage of MMS for standard histologic evaluation. Apparent complete clinical response was achieved in five of seven patients. MMS was finally performed in six patients, and clear margins were achieved after one stage of MMS. The histologic evaluation of the tumor debulking specimens showed complete clearance in four of six cases. One patient who did not undergo MMS showed a recurrence after 14 months. This is the first pilot study that demonstrates that PDL can be effective for the treatment of high-risk BCCs. Until further scientific evidence is available, treatment of high-risk BCCs should include histologic confirmation of clearance.
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http://dx.doi.org/10.1007/s10103-014-1686-1DOI Listing
September 2015

Eosinophilic fasciitis/generalized morphea overlap successfully treated with azathioprine.

Int J Dermatol 2014 Nov 2;53(11):1386-8. Epub 2014 Apr 2.

Department of Dermatology, Ramón y Cajal Hospital, Madrid, Spain.

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http://dx.doi.org/10.1111/j.1365-4632.2012.05741.xDOI Listing
November 2014

Necrobiosis lipoidica.

Aust Fam Physician 2014 Mar;43(3):129-30

MD, is a dermatologist, Department of Dermatology, Ramon Y Cajal University Hospital, Madrid, Spain.

Background: Necrobiosis lipoidica presents with a distinctive appearance making it an important clinical diagnosis.

Objective: To describe a case of necrobiosis lipoidica in a patient with type 1 diabetes mellitus, and to discuss differential diagnoses and management.

Discussion: Necrobiosis lipoidica is most commonly found on the shins, presenting as a well-defined plaque. Management is challenging and options are discussed. Avoiding ulceration is a key concern.
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March 2014

Frontal fibrosing alopecia: a multicenter review of 355 patients.

J Am Acad Dermatol 2014 Apr 5;70(4):670-678. Epub 2014 Feb 5.

Hospital Dermatology Service, Virgen Macarena Hospital, Sevilla, Spain.

Background: To our knowledge, there are no large multicenter studies concerning frontal fibrosing alopecia (FFA) that could give clues about its pathogenesis and best treatment.

Objective: We sought to describe the epidemiology, comorbidities, clinical presentation, diagnostic findings, and therapeutic choices in a large series of patients with FFA.

Methods: This retrospective multicenter study included patients given the diagnosis of FFA. Clinical severity was classified based on the recession of the frontotemporal hairline.

Results: In all, 355 patients (343 women [49 premenopausal] and 12 men) with a mean age of 61 years (range 23-86) were included. Early menopause was detected in 49 patients (14%), whereas 46 (13%) had undergone hysterectomy. Severe FFA was observed in 131 patients (37%). Independent factors associated with severe FFA after multivariate analysis were: eyelash loss, facial papules, and body hair involvement. Eyebrow loss as the initial clinical presentation was associated with mild forms. Antiandrogens such as finasteride and dutasteride were used in 111 patients (31%), with improvement in 52 (47%) and stabilization in 59 (53%).

Limitations: The retrospective design is a limitation.

Conclusions: Eyelash loss, facial papules, and body hair involvement were associated with severe FFA. Antiandrogens were the most useful treatment.
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http://dx.doi.org/10.1016/j.jaad.2013.12.003DOI Listing
April 2014

Photodynamic therapy for necrobiosis lipoidica is an unpredictable option: three cases with different results.

Int J Dermatol 2013 Dec;52(12):1589-90

Department of Dermatology, University Ramón y Cajal Hospital, Madrid, Spain.

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http://dx.doi.org/10.1111/j.1365-4632.2012.5474.xDOI Listing
December 2013

The clinical picture: chronic itch on the upper back, with pain.

Cleve Clin J Med 2013 Sep;80(9):550-2

Department of Dermatology, Ramón y Cajal Hospital, Madrid, Spain.

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http://dx.doi.org/10.3949/ccjm.80a.12135DOI Listing
September 2013

Patchy hair loss on the pubis--a case study.

Aust Fam Physician 2013 Jul;42(7):487-9

Department of Dermatology, Ramon y Cajal University Hospital, Madrid, Spain.

A female, aged 17 years and with a history of anorexia nervosa, presented with a 3 month history of a large, irregular area of hair loss over the pubis. Physical examination revealed scattered short hairs of varying length, follicular hyperkeratosis and hyperpigmentation throughout the area of alopecia (Figure 1a). A magnified view revealed decreased hair density, broken hairs with different shaft lengths, short vellous hairs and signs of recent haemorrhage (Figure 1b). The remainder of the hairs appeared normal, and her nails did not show any pathological changes. The hair-pull test was negative. Potassium hydroxide (KOH) examination and fungal culture were negative. Biochemical studies, abdominal X-ray and ultrasonography were normal.
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July 2013

Congenital plaque-like glomangioma treated successfully with dual wavelength pulsed-dye and neodymium:yttrium-aluminum-garnet laser.

Photodermatol Photoimmunol Photomed 2013 Aug;29(4):212-4

Department of Dermatology, Ramon y Cajal University Hospital, University of Alcalá, Madrid, Spain.

Glomovenous malformations are disseminated variants of cutaneous glomus tumors. These malformations are subdivided into regional or localized, disseminated, and congenital plaque-like forms. The congenital plaque-like form is the rarest variant. Most treatment modalities have been disappointing in the treatment of large glomangiomas, leading to high recurrence rates. We report a case of a 34-year-old man with a congenital plaque-like glomangioma on his left arm and forearm treated successfully with sequential pulsed-dye neodymium yttrium aluminum garnet laser.
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http://dx.doi.org/10.1111/phpp.12036DOI Listing
August 2013

Vitiligo in 2 patients receiving vemurafenib for metastatic melanoma.

J Am Acad Dermatol 2013 Jul;69(1):e28-9

Hospital Ramón y Cajal, Servicio de Dermatología, Madrid, Spain.

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http://dx.doi.org/10.1016/j.jaad.2013.01.012DOI Listing
July 2013

Perforating dermatosis in a patient receiving azathioprine.

Indian J Dermatol 2013 Mar;58(2):158

Department of Dermatology, Ramón y Cajal Hospital, Madrid, Spain.

Azathioprine (AZA) is an imidazole derivative of mercaptopurine. It antagonizes purine metabolism, and it may inhibit synthesis of DNA, RNA, and proteins. The 6-thioguanine nucleotides appear to mediate the majority of AZAs immunosuppressive and toxic effects. While cutaneous adverse side-effects are not uncommon, perforating dermatosis has not been reported in association to AZA. We speculate that immunological disorders induced by AZA in susceptible individuals could be related to perforating dermatosis.
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http://dx.doi.org/10.4103/0019-5154.108077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657234PMC
March 2013

Unknown: congenital linear whitish papules in a 3-year-old boy.

Dermatol Online J 2013 Mar 15;19(3). Epub 2013 Mar 15.

Department of Dermatology, Ramón y Cajal University Hospital, Madrid, Spain.

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March 2013

Chronic itch on the back associated with disc hernia--a case study.

Aust Fam Physician 2013 Mar;42(3):131-2

Department of Dermatology, Ramon y Cajal University Hospital, Madrid, Spain.

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March 2013

Pretibial erythematous plaque in a young male.

Aust Fam Physician 2013 Jan-Feb;42(1-2):45-7

Department of Dermatology, Ramon y Cajal University Hospital, Madrid, Spain.

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December 2013

[Panitumumab-induced trichomegaly].

Med Clin (Barc) 2013 Apr 11;140(8):e15. Epub 2013 Mar 11.

Departamento de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, España.

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http://dx.doi.org/10.1016/j.medcli.2013.01.006DOI Listing
April 2013

Odynophagia, peripheral facial nerve paralysis, mucocutaneous lesions.

Cleve Clin J Med 2013 Feb;80(2):76-7

Department of Dermatology, Ramón y Cajal University Hospital, Madrid, Spain.

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http://dx.doi.org/10.3949/ccjm.80a.12098DOI Listing
February 2013
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