Publications by authors named "Pedram Nazari"

7 Publications

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Ocular muscle metastasis as the initial presentation of a malignant pheochromocytoma: A unique case.

Clin Case Rep 2020 Sep 28;8(9):1689-1692. Epub 2020 May 28.

Cancer Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran.

In this paper, we discuss a unique manifestation of malignant pheochromocytoma, which presented with ocular pain. The histopathological study pointed to a possible pheochromocytoma origin. Subsequently, the patient underwent thorough imaging and paraclinical evaluations, which confirmed the diagnosis of pheochromocytoma.
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http://dx.doi.org/10.1002/ccr3.2990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495871PMC
September 2020

The Efficacy and Safety of Modified Docetaxel, Cisplatin, and 5-Fluorouracil Vs. Epirubicin, Oxaliplatin, and Capecitabine Regimen in the Advanced Gastric Cancer: A Randomized Controlled Clinical Trial.

Asian Pac J Cancer Prev 2020 Mar 1;21(3):727-732. Epub 2020 Mar 1.

Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Introduction: One of the major challenges of advanced gastric cancer treatment is the lack of a standard regimen for patients. However, several clinical trials have shown that modified docetaxel, cisplatin, and 5-fluorouracil (m-DCF) and epirubicin, oxaliplatin, and capecitabine (EOX) regimens are superior to other regimens.

Methods: This randomized, single-center clinical trial was performed on 40 patients with advanced gastric cancer. The first group received the m-DCF regimen as follows: docetaxel (40 mg/m2) on the first day; cisplatin (40 mg/m2) on the first and second days; and 5-fluorouracil (400 mg/m2) from the first to fourth day. The second group received the EOX regimen, including epirubicin (50 mg/m2) and oxaliplatin (130 mg/m2) i.v on the first day and capecitabine at a twice-daily dose of 625 mg/m2 p.o for 21 days. Treatment was applied every three weeks for a total of eight cycles in both groups. In each group, the overall and progression-free survival rates and toxicity were assessed.

Results: A total of 40 patients were enrolled in this study (21 samples in the m-DCF group and 19 samples in the EOX group), 62.5% of whom were male. The median survival rate was 14.00 (95% CI: 11.82-16.18) months in the m-DCF group and 15.00 (95% CI: 9.56-20.43) months in the EOX group; however, differences between the groups were not significant. The progression-free survival rate was higher in the EOX group, although there was no significant difference between the two groups. Also, there was no significant difference regarding the side effects (e.g., toxicity) or need for supportive care between the groups.

Conclusion: It seems that both m-DCF and EOX regimens are similar in terms of survival and toxicity and are recommended as first-line treatment for advanced gastric cancer with respect to the patient's status.
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http://dx.doi.org/10.31557/APJCP.2020.21.3.727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437336PMC
March 2020

How can someone's entire skin change color?

Clin Case Rep 2019 Dec 24;7(12):2581-2582. Epub 2019 Oct 24.

Cancer Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran.

One of the most important differential diagnoses that not to be missed in patients with hyperpigmentation changes in the skin is Addison's. The diagnosis of the disease is relatively difficult, and its misdiagnosis leads to dangerous morbidity and even mortality. It confirms by cosyntropin test.
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http://dx.doi.org/10.1002/ccr3.2505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935622PMC
December 2019

The Effects of Exposure to Low Frequency Electromagnetic Fields in the Treatment of Migraine Headache: A Cohort Study.

Electron Physician 2016 Dec 25;8(12):3445-3449. Epub 2016 Dec 25.

Medical Student, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Introduction: Findings have indicated that increased usage of mobile phones may be concomitant with higher rate of headache attacks due to the low radiofrequency electromagnetic fields (RF-EMF). The aim of this study was to determine the effects of low RF-EMF on the treatment outcome in migraine patients.

Methods: This cohort study was performed on 114 migraine patients referred to the Neurology Clinic of Golestan Hospital in Ahvaz, Southwest Iran, from September 2014 to March 2015. Patients with migraine were interviewed using a standardized questionnaire exploring mobile phones, Wi-Fi devices and fixed-line telephone use as RF-EMF sources. After 3 months, we determined patients' response to treatment. Generalized estimating equation (GEE) tests were carried out to analyze data, using SPSS version 17.

Results: Out of 114 individuals who participated, 82 (71.9%) were female and 32 (28.1%) cases were male. The number and severity of migraine headaches were correlated significantly with an increased use of mobile phones during day and Wi-Fi per week (p<0.05). The usage of fixed-line telephones had no significant relationship with the study variables (p>0.05).

Conclusion: It is recommended that the patients with migraine headache limit mobile phone use and instead, use the fixed-line telephone for their daily telecommunications.
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http://dx.doi.org/10.19082/3445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279981PMC
December 2016

Prevalence of Congenital Heart Disease: A Single Center Experience in Southwestern of Iran.

Glob J Health Sci 2016 10 1;8(10):56421. Epub 2016 Oct 1.

Medical Student Research Committee and Social Determinant of Health Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Congenital heart disease (CHD) refers to complex abnormalities that affect the structure or function of the heart due to embryonic defects. There is little accurate statistical data about prevalence, incidence and frequency in many developing countries such as Iran. The aim of this study was to evaluate the frequency of CHD in patients who were referred to the Department of Pediatric Cardiology in a large single-center in Southwestern of Iran.

Methods: This is a retrospective, cross-sectional study. Patients with various cardiac malformations were each investigated separately. A check list was used to collect information. It was comprised of three parts; demographic characteristics, Patient's birth details and maternal data.

Results: The frequency of ventricular septal defect (VSD), atrial septal defect (ASD) and tetralogy of fallot (TOF) were 125 (28.47%), 48 (10.93%) and 41(9.3%) respectively. Family history was reported in 26(11.1%) cases. Down syndrome, skeletal anomaly and hematological anomaly were the most common co-anomalies. Parental consanguinity was 48.7%.

Conclusions: Present study showed that VSD was the most common CHD subtype followed by family history, familial marriage, extra cardiac anomalies (ECAs), birth weight, and maternal concomitant disease. But there was a controversial relationship between birth order and drug history in CHD.
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http://dx.doi.org/10.5539/gjhs.v8n10p288DOI Listing
October 2016

In Vitro Activity of Cordia myxa Mucilage Extract Against Leishmania major and L. infantum Promastigotes.

Jundishapur J Microbiol 2015 Mar 21;8(3):e19640. Epub 2015 Mar 21.

Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.

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http://dx.doi.org/10.5812/jjm.19640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386074PMC
March 2015