Publications by authors named "Paulette Bioulac-Sage"

100Publications

Long-term Evolution of Hepatocellular Adenomas at MRI Follow-up.

Radiology 2021 Jan 10;298(1):E57-E58. Epub 2020 Nov 10.

CHU de Bordeaux, Department of Radiology, Université de Bordeaux, F-33000 Bordeaux, France.

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January 2021

Corrigendum to: "BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA" [J Hepatol (2020) 1-13].

J Hepatol 2020 Jul 29;73(1):225-226. Epub 2020 Apr 29.

Centre de Recherche des Cordeliers, Sorbonne Université, Inserm, Université de Paris, F-75006 Paris, France; Functional Genomics of Solid Tumors laboratory, équipe labellisée Ligue Nationale contre le Cancer, Labex OncoImmunology, F-75006, Paris, France; Hôpital Européen Georges Pompidou, APHP, F-75015 Paris, France. Electronic address:

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July 2020

Innervation of the proximal human biliary tree.

Virchows Arch 2020 Sep 28;477(3):385-392. Epub 2020 Jan 28.

Department of Pathology, New York University School of Medicine, New York, NY, USA.

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September 2020

BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA.

J Hepatol 2020 May 18;72(5):924-936. Epub 2019 Dec 18.

Centre de Recherche des Cordeliers, Sorbonne Université, Inserm, Université de Paris, F-75006 Paris, France; Functional Genomics of Solid Tumors laboratory, équipe labellisée Ligue Nationale contre le Cancer, Labex OncoImmunology, F-75006, Paris, France; Hôpital Européen Georges Pompidou, APHP, F-75015 Paris, France. Electronic address:

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May 2020

Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response.

Gastroenterology 2019 09 4;157(3):760-776. Epub 2019 May 4.

Centre de Recherche des Cordeliers, Sorbonne Université, Inserm, UMRS-1138, F-75006 Paris, France; Functional Genomics of Solid Tumors, USPC, Université Paris Descartes, Université Paris Diderot, Université Paris 13, Labex Immuno-Oncology, équipe labellisée Ligue Contre le Cancer, F-75000 Paris, France. Electronic address:

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September 2019

Unclassified hepatocellular adenoma expressing ASS1 associated with inflammatory hepatocellular adenomas.

Clin Res Hepatol Gastroenterol 2019 10 30;43(5):e63-e67. Epub 2019 Apr 30.

Inserm, UMR1053 Bordeaux research in translational oncology, BaRITOn, université de Bordeaux, 33076 Bordeaux, France; Pathology department, Pellegrin Hospital, CHU de Bordeaux, 33076 Bordeaux France.

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October 2019

Porto-sinusoidal vascular disease: proposal and description of a novel entity.

Lancet Gastroenterol Hepatol 2019 05;4(5):399-411

Barcelona Hepatic Hemodynamic Lab, Liver Unit, Hospital Clinic de Barcelona, University of Barcelona, Barcelona, Spain; CIBER Hepatic and Digestive Diseases, Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

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May 2019

Repeat surgery in HNF1alpha-inactivated adenomatosis.

Clin Res Hepatol Gastroenterol 2019 08 20;43(4):460-467. Epub 2019 Mar 20.

Inserm, UMR1053 Bordeaux research in translational oncology, université de Bordeaux, Bariton, 33076 Bordeaux, France.

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August 2019

New MRI features improve subtype classification of hepatocellular adenoma.

Eur Radiol 2019 May 6;29(5):2436-2447. Epub 2018 Dec 6.

CHU de Bordeaux, Service d'imagerie diagnostique et interventionnelle, Hôpital Haut-Lévêque, F-33604, Pessac, France.

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May 2019

Snapshot summary of diagnosis and management of hepatocellular adenoma subtypes.

Clin Res Hepatol Gastroenterol 2019 02 10;43(1):12-19. Epub 2018 Sep 10.

Inserm, UMR1053 Bordeaux research in translational oncology, BaRITOn, université de Bordeaux, 33076 Bordeaux, France.

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February 2019

A difficult case of β-catenin-mutated hepatocellular adenoma: a lesson for diagnosis.

Histopathology 2019 01 6;74(2):355-357. Epub 2018 Dec 6.

Inserm, UMR1053 Bordeaux Research in Translational Oncology, BaRITOn, Université de Bordeaux, Bordeaux, France.

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January 2019

Collision of hepatocellular nodules in vascular livers: A medical challenge.

Clin Res Hepatol Gastroenterol 2018 10 23;42(5):e83-e85. Epub 2018 Aug 23.

Department of pathology, hôpital Pellegrin, CHU de Bordeaux, 33076, Bordeaux, France; U1053, université de Bordeaux, 33076, Bordeaux, France. Electronic address:

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October 2018

Hepatocellular nodules in vascular liver diseases.

Virchows Arch 2018 Jul 26;473(1):33-44. Epub 2018 May 26.

Inserm, UMR1053 Bordeaux Research In Translational Oncology, BaRITOn, F-33000 Bordeaux, Université de Bordeaux, 33076, Bordeaux, France.

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July 2018

Vascular liver lesions: contemporary views on long-recognized entities.

Virchows Arch 2018 07 14;473(1):1-2. Epub 2018 Mar 14.

Inserm, UMR1053 Bordeaux Research in Translational Oncology, BaRITOn, F-33000 Bordeaux, Université de Bordeaux, 33076, Bordeaux, France.

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July 2018

Reply.

Hepatology 2017 12 6;66(6):2093-2094. Epub 2017 Nov 6.

Inserm UMR-1162 "Functional Genomics of Solid Tumors" Equipe labellisée Ligue Contre le Cancer, Paris, France.

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December 2017

Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification.

J Hepatol 2017 10 19;67(4):727-738. Epub 2017 May 19.

Inserm, UMR-1162, Functional Genomics of Solid Tumors, Equipe Labellisée Ligue Contre le Cancer, Université Paris Descartes, Université Paris Diderot, Université Paris 13, F-75010, France; Assistance Publique-Hôpitaux de Paris, Department of Oncology, Hôpital Européen Georges Pompidou, Paris, France. Electronic address:

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October 2017

Hepatocellular Adenomas: Morphology and Genomics.

Gastroenterol Clin North Am 2017 06;46(2):253-272

Inserm U 1053, Université Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux, France.

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June 2017

Proliferation Markers Are Associated with MET Expression in Hepatocellular Carcinoma and Predict Tivantinib Sensitivity .

Clin Cancer Res 2017 Aug 28;23(15):4364-4375. Epub 2017 Feb 28.

Inserm UMR-1162, Génomique Fonctionnelle des Tumeurs Solides, Université Paris Descartes, Université Paris Diderot, Université Paris 13, Labex Immuno-Oncology, Paris, France.

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August 2017

Hepatocellular adenoma: Classification, variants and clinical relevance.

Semin Diagn Pathol 2017 Mar 20;34(2):112-125. Epub 2016 Dec 20.

Inserm U 1053, Université Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux, France. Electronic address:

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March 2017

CYP1A2 is a predictor of HCC recurrence in HCV-related chronic liver disease: A retrospective multicentric validation study.

Dig Liver Dis 2017 Apr 16;49(4):434-439. Epub 2016 Dec 16.

Humanitas Clinical and Research Center, Pathology Unit, Rozzano, Milano, Italy; Humanitas University, Department of Biomedical Sciences, Rozzano, Milano, Italy. Electronic address:

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April 2017

Germline and somatic DICER1 mutations in familial and sporadic liver tumors.

J Hepatol 2017 04 22;66(4):734-742. Epub 2016 Dec 22.

INSERM, Unité Mixte de Recherche (UMR) 1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue contre le Cancer, Paris, France; Université Paris Descartes, Labex Immuno-Oncology, Sorbonne Paris Cité, Paris, France; Université Paris 13, Sorbonne Paris Cité, Unité de Formation et de Recherche (UFR) Santé, Médecine, Biologie Humaine (SMBH), Bobigny, France; Université Paris Diderot, Institut Universitaire d'Hématologie, Paris, France; AP-HP, Hôpital Européen Georges Pompidou, Paris, France. Electronic address:

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April 2017

Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation.

Gastroenterology 2017 03 7;152(4):880-894.e6. Epub 2016 Dec 7.

Unité Mixte de Recherche 1162, Génomique Fonctionnelle des Tumeurs Solides, Institut National de la Santé et de la Recherche Médicale, Université Paris Descartes, Université Paris Diderot, Paris, France; Assistance Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Département d'Oncologie, Paris, France. Electronic address:

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March 2017

TGF-β1 promotes linear invadosome formation in hepatocellular carcinoma cells, through DDR1 up-regulation and collagen I cross-linking.

Eur J Cell Biol 2016 Nov 4;95(11):503-512. Epub 2016 Oct 4.

INSERM, U1053 Bordeaux Research In Translational Oncology, BaRITOn, F-33000 Bordeaux, France; Univ. Bordeaux, U1053 Bordeaux Research In Translational Oncology, BaRITOn, F-33000 Bordeaux, France. Electronic address:

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November 2016

Simultaneous occurrence of focal nodular hyperplasia and HNF1A-inactivated hepatocellular adenoma: a collision tumor simulating a composite FNH-HCA.

Am J Surg Pathol 2015 Sep;39(9):1296-300

*James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA †Inserm U1053, Université de Bordeaux ‡Pathology Department, Pellegrin Hospital, CHU Bordeaux, Bordeaux, France.

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September 2015

Hepatocellular nodules expressing markers of hepatocellular adenomas in Budd-Chiari syndrome and other rare hepatic vascular disorders.

J Hepatol 2015 Nov 25;63(5):1173-80. Epub 2015 Jun 25.

Inserm, UMR 1053, Université de Bordeaux, Bordeaux F-33076, France; Department of Pathology, Pellegrin Hospital, Centre Hospitalier Universitaire Bordeaux, F-33076, France. Electronic address:

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November 2015

Hepatocellular adenoma management: advances but still a long way to go.

Hepat Oncol 2015 Apr 15;2(2):171-180. Epub 2015 May 15.

Inserm, UMR-1053, Université de Bordeaux, 33076 Bordeaux, France.

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April 2015

BRAF V600E mutational status in bile duct adenomas and hamartomas.

Histopathology 2015 Oct 31;67(4):562-7. Epub 2015 Mar 31.

Department of Pathology, Assistance Publique-Hôpitaux de Paris, CHU Henri Mondor, Créteil, France.

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October 2015

Hepatocellular adenoma management: call for shared guidelines and multidisciplinary approach.

Clin Res Hepatol Gastroenterol 2015 Apr 26;39(2):180-7. Epub 2014 Nov 26.

Inserm UMR 1053, université de Bordeaux, 146, rue Léo-Saignat, 33076 Bordeaux cedex, France. Electronic address:

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April 2015

Malignant transformation of hepatocellular adenoma.

Hepat Oncol 2014 Oct 11;1(4):421-431. Epub 2014 Dec 11.

Institut National de la Santé et de la Recherche Médicale (Inserm) 1053, Université de Bordeaux, Bordeaux, France.

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October 2014

Pictures of focal nodular hyperplasia and hepatocellular adenomas.

World J Hepatol 2014 Aug;6(8):580-95

Christine Sempoux, Service d'Anatomie Pathologique, Cliniques universitaires Saint Luc, Université catholique de Louvain, 1200 Brussels, Belgium.

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August 2014

Integrative quantitative proteomics unveils proteostasis imbalance in human hepatocellular carcinoma developed on nonfibrotic livers.

Mol Cell Proteomics 2014 Dec 15;13(12):3473-83. Epub 2014 Sep 15.

§Université de Bordeaux, Bordeaux, France; ¶INSERM, UMR-U1053, Team ≪ Endoplasmic Reticulum Stress and Cancer ≫, Bordeaux, France. ‖BMYscreen, Bordeaux, France; Centre Régional de Lutte Contre le Cancer Eugène Marquis, 35000 Rennes, France

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December 2014

Glutamine synthetase interpretation in hepatocellular adenoma.

Virchows Arch 2014 Oct 13;465(4):495-6. Epub 2014 Sep 13.

Inserm, UMR-1053, Université de Bordeaux 2, 33076, Bordeaux, France,

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October 2014

Telomerase reverse transcriptase promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis.

Hepatology 2014 Dec 27;60(6):1983-92. Epub 2014 Oct 27.

Inserm, UMR-1162, Génomique fonctionnelle des Tumeurs solides, IUH, Paris, France; Université Paris Descartes, Labex Immuno-Oncology, Sorbonne Paris Cité, Faculté de Médecine, Paris, France; Université Paris 13, Sorbonne Paris Cité, UFR SMBH, Bobigny, France; Université Paris Diderot, Paris, France; APHP, Hôpitaux Universitaires Paris-Seine Saint-Denis, Site Jean Verdier, Pôle d'Activité Cancérologique Spécialisée, Service d'Hépatologie, Bondy, France.

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December 2014

Integration of tumour and viral genomic characterizations in HBV-related hepatocellular carcinomas.

Gut 2015 May 9;64(5):820-9. Epub 2014 Jun 9.

Inserm, UMR-674, Génomique fonctionnelle des tumeurs solides, IUH, Paris, France Université Paris Descartes, Labex Immuno-oncology, Sorbonne Paris Cité, Faculté de Médecine, Paris, France Hopital Europeen Georges Pompidou, Paris, France.

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May 2015

Polycystic ovary syndrome as a rare association with inflammatory hepatocellular adenoma: a case report.

Clin Res Hepatol Gastroenterol 2014 Dec 30;38(6):e107-10. Epub 2014 Jun 30.

Inserm U1053, Bordeaux University, Bordeaux, France; Department of Pathology, CHU de Bordeaux, Hôpital Pellegrin, Bordeaux, France.

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December 2014

Congenital hepatic fibrosis with multiple HNF1α hepatocellular adenomas.

Clin Res Hepatol Gastroenterol 2014 Dec 26;38(6):e115-6. Epub 2014 Jun 26.

GREF/Inserm U1053, université de Bordeaux, 33076 Bordeaux, France. Electronic address:

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December 2014

Characterization of a novel PXR isoform with potential dominant-negative properties.

J Hepatol 2014 Sep 2;61(3):609-16. Epub 2014 May 2.

Centre National de la Recherche Scientifique, UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France; Université Montpellier 1 et 2, UMR5203, Montpellier, France. Electronic address:

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September 2014

Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation.

Cancer Cell 2014 Apr;25(4):428-41

INSERM, UMR-1162, Génomique fonctionnelle des tumeurs solides, IUH, 75010 Paris, France; Labex Immuno-oncology, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, 75006 Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, 75015 Paris, France. Electronic address:

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April 2014

BRAF V600E mutations in bile duct adenomas.

Hepatology 2015 Jan 19;61(1):403-5. Epub 2014 May 19.

Assistance Publique-Hôpitaux de Paris, Department of Pathology, Créteil, France; Université Paris-Est Créteil, Faculté de Médecine, Créteil, France; Inserm U955, Institut Mondor de Recherche Biomédicale, Créteil, France.

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January 2015

Immunohistochemical pitfalls in the diagnosis of focal nodular hyperplasia and inflammatory hepatocellular adenoma.

Clin Res Hepatol Gastroenterol 2014 Jun 10;38(3):245-9. Epub 2014 Feb 10.

Inserm U1053, Université Bordeaux Segalen, 33076 Bordeaux cedex, France.

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June 2014

Smoothelin, a new marker to determine the origin of liver fibrogenic cells.

World J Gastroenterol 2013 Dec;19(48):9343-50

Sébastien Lepreux, CHU Bordeaux, Hôpital Pellegrin, Service d'Anatomie Pathologique, F-33076 Bordeaux, France.

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December 2013

ALDH3A1 is overexpressed in a subset of hepatocellular carcinoma characterised by activation of the Wnt/ß-catenin pathway.

Virchows Arch 2014 Jan 26;464(1):53-60. Epub 2013 Nov 26.

Inserm, UMR-674, Génomique fonctionnelle des tumeurs solides, Institut Universitaire d'Hematologie, 27 rue Juliette Dodu, Paris, 75010, France.

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January 2014

Coexistence of inflammatory hepatocellular adenomas with HNF1α-inactivated adenomas: is there an association?

Histopathology 2014 May 24;64(6):890-5. Epub 2014 Jan 24.

Service de Pathologie, Hôpital Pellegrin, CHU Bordeaux, Bordeaux, France; Inserm U1053, Université Bordeaux Segalen, Bordeaux, France.

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May 2014

Hepatocellular adenomatosis: what should the term stand for!

Clin Res Hepatol Gastroenterol 2014 Apr 11;38(2):132-6. Epub 2013 Oct 11.

Inserm U1053, Université Victor-Segalen, 33076 Bordeaux, France. Electronic address:

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April 2014

Changes in the management of benign liver tumors.

Clin Res Hepatol Gastroenterol 2013 Nov 12;37(5):444-6. Epub 2013 Aug 12.

Service de Pathologie, Inserm U1053, Université Bordeaux Segalen, Hôpital Pèllegrin, 33076 Bordeaux cedex, France. Electronic address:

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November 2013

Benign hepatocellular nodules: what have we learned using the patho-molecular classification.

Clin Res Hepatol Gastroenterol 2013 Sep 19;37(4):322-7. Epub 2013 Jul 19.

Service d'Anatomie Pathologique, Cliniques universitaires Saint-Luc, Université catholique de Louvain, 1200 Brussels, Belgium.

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September 2013

Benign hepatocellular tumors: a multidisciplinary approach.

Int J Hepatol 2013 28;2013:153693. Epub 2013 May 28.

Pathology Department, CHU Bordeaux and Inserm U1053, Université Bordeaux 2, 33076 Bordeaux, France.

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June 2013

Hepatocellular carcinoma treated by sorafenib with complete radiological response according to mRECIST criteria: could we stop the treatment? About four cases.

Acta Oncol 2014 Mar 29;53(3):420-3. Epub 2013 May 29.

Department of Gastroenterology and Hepatology, Saint-André Hospital, University Hospital of Bordeaux and Victor Segalen University , Bordeaux , France.

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March 2014

Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context.

Int J Hepatol 2013 18;2013:253261. Epub 2013 Apr 18.

Service d'Anatomie Pathologique, Hôpital Pellegrin, CHU Bordeaux, 33076 Bordeaux, France ; U1053 Université Bordeaux 2, 33076 Bordeaux, France.

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May 2013

A hepatocellular carcinoma 5-gene score associated with survival of patients after liver resection.

Gastroenterology 2013 Jul 6;145(1):176-187. Epub 2013 Apr 6.

Inserm, UMR-674, Génomique Fonctionnelle des Tumeurs Solides, IUH, Paris, France; Université Paris Descartes, Labex Immuno-Oncology, Sorbonne Paris Cité, Faculté de Médecine, Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France. Electronic address:

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July 2013

Value and limits of routine histology alone or combined with glutamine synthetase immunostaining in the diagnosis of hepatocellular adenoma subtypes on surgical specimens.

Int J Hepatol 2013 19;2013:417323. Epub 2013 Feb 19.

Service d'Anatomie Pathologique, Hôpital Pellegrin, CHU Bordeaux, Place Amélie Raba Léon, 33075 Bordeaux Cedex, France ; Inserm U1053 Université Bordeaux Segalen, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France.

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March 2013

Hepatocellular benign tumors-from molecular classification to personalized clinical care.

Gastroenterology 2013 May 26;144(5):888-902. Epub 2013 Feb 26.

INSERM, UMR-674, Génomique Fonctionnelle des Tumeurs Solides, IUH, Paris, France.

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May 2013

Evaluation of liver tumors using acoustic radiation force impulse elastography and correlation with histologic data.

J Ultrasound Med 2013 Jan;32(1):121-30

Department of Radiology, Saint Andre Hospital, Centre Hospitalier Universitaire de Bordeaux, 1 rue Jean Burguet, 33075 Bordeaux, France.

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January 2013

Hepatocellular adenomas associated with hepatic granulomas: experience in five cases.

Case Rep Gastroenterol 2012 Sep 30;6(3):677-83. Epub 2012 Oct 30.

Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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September 2012