Paula T Hammond

Paula T Hammond

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Paula T Hammond

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Theranostic Layer-by-Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing.

Angew Chem Int Ed Engl 2020 Feb 7;59(7):2776-2783. Epub 2020 Jan 7.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/anie.201911762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002217PMC
February 2020

Tuning Nanoparticle Interactions with Ovarian Cancer through Layer-by-Layer Modification of Surface Chemistry.

ACS Nano 2020 Feb 10;14(2):2224-2237. Epub 2020 Feb 10.

Koch Institute for Integrative Cancer Research , Massachusetts Institute of Technology , 500 Main Street , Cambridge , Massachusetts 02142 , United States.

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http://dx.doi.org/10.1021/acsnano.9b09213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062411PMC
February 2020

Layer-by-Layer Biomaterials for Drug Delivery.

Annu Rev Biomed Eng 2020 Feb 21. Epub 2020 Feb 21.

School of Engineering and Center for Biomedical Engineering, Brown University, Providence, Rhode Island 02912, USA; email:

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052350DOI Listing
February 2020

Temporal release of a three-component protein subunit vaccine from polymer multilayers.

J Control Release 2020 Jan 20;317:130-141. Epub 2019 Nov 20.

Interdisciplinary Research Group in Infectious Diseases, Singapore-MIT Alliance for Research and Technology, Singapore; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.11.022DOI Listing
January 2020

Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination.

Proc Natl Acad Sci U S A 2019 08 29;116(33):16473-16478. Epub 2019 Jul 29.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1902179116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697788PMC
August 2019

Solution Conditions Tune and Optimize Loading of Therapeutic Polyelectrolytes into Layer-by-Layer Functionalized Liposomes.

ACS Nano 2019 05 18;13(5):5623-5634. Epub 2019 Apr 18.

Koch Institute for Integrative Cancer Research , Massachusetts Institute of Technology , 500 Main Street , Cambridge , Massachusetts 02142 , United States.

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http://dx.doi.org/10.1021/acsnano.9b00792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980385PMC
May 2019

Broad-Spectrum Proteome Editing with an Engineered Bacterial Ubiquitin Ligase Mimic.

ACS Cent Sci 2019 May 10;5(5):852-866. Epub 2019 May 10.

Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, 120 Olin Hall, Ithaca, New York 14853, United States.

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http://dx.doi.org/10.1021/acscentsci.9b00127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535771PMC
May 2019

Microneedle-based intradermal delivery of stabilized dengue virus.

Bioeng Transl Med 2019 May 25;4(2):e10127. Epub 2019 Feb 25.

Infectious Diseases IRG Singapore-MIT Alliance for Research and Technology Singapore.

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http://dx.doi.org/10.1002/btm2.10127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584444PMC
May 2019

Binary Targeting of siRNA to Hematologic Cancer Cells using Layer-by-Layer Nanoparticles.

Adv Funct Mater 2019 May 27;29(20). Epub 2019 Mar 27.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adfm.201900018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910249PMC
May 2019

Deep-tissue optical imaging of near cellular-sized features.

Sci Rep 2019 03 7;9(1):3873. Epub 2019 Mar 7.

Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1038/s41598-019-39502-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405836PMC
March 2019

Green fluorescent proteins engineered for cartilage-targeted drug delivery: Insights for transport into highly charged avascular tissues.

Biomaterials 2018 11 25;183:218-233. Epub 2018 Aug 25.

Department of Biological Engineering, MIT, Cambridge, MA 02139, USA; Department of Mechanical Engineering, MIT, Cambridge, MA 02139, USA; Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2018.08.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141342PMC
November 2018

Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis.

Sci Transl Med 2018 11;10(469)

Koch Institute for Integrative Cancer Research, 500 Main Street, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1126/scitranslmed.aat8800DOI Listing
November 2018

Synthetic Charge-Invertible Polymer for Rapid and Complete Implantation of Layer-by-Layer Microneedle Drug Films for Enhanced Transdermal Vaccination.

ACS Nano 2018 10 4;12(10):10272-10280. Epub 2018 Oct 4.

Koch Institute for Integrative Cancer Research , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

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http://dx.doi.org/10.1021/acsnano.8b05373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501205PMC
October 2018

Rationally Designed Polycationic Carriers for Potent Polymeric siRNA-Mediated Gene Silencing.

ACS Nano 2018 07 28;12(7):6504-6514. Epub 2018 Jun 28.

Koch Institute for Integrative Cancer Research , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

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http://dx.doi.org/10.1021/acsnano.7b08777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152829PMC
July 2018

Efficient Transport Networks in a Dual Electron/Lithium-Conducting Polymeric Composite for Electrochemical Applications.

ACS Appl Mater Interfaces 2018 May 30;10(18):15681-15690. Epub 2018 Apr 30.

Department of Chemical Engineering , Massachusetts Institute of Technology , 77 Massachusetts Avenue , Cambridge , Massachusetts 02139 , United States.

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http://dx.doi.org/10.1021/acsami.8b01519DOI Listing
May 2018

Structurally modulated codelivery of siRNA and Argonaute 2 for enhanced RNA interference.

Proc Natl Acad Sci U S A 2018 03 5;115(12):E2696-E2705. Epub 2018 Feb 5.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1719565115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866582PMC
March 2018

A Combination RNAi-Chemotherapy Layer-by-Layer Nanoparticle for Systemic Targeting of KRAS/P53 with Cisplatin to Treat Non-Small Cell Lung Cancer.

Clin Cancer Res 2017 Dec 14;23(23):7312-7323. Epub 2017 Sep 14.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-2186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712246PMC
December 2017

Catalytic, Conductive Bipolar Membrane Interfaces through Layer-by-Layer Deposition for the Design of Membrane-Integrated Artificial Photosynthesis Systems.

ChemSusChem 2017 11 7;10(22):4599-4609. Epub 2017 Nov 7.

Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/cssc.201701397DOI Listing
November 2017

Polyamine-Mediated Stoichiometric Assembly of Ribonucleoproteins for Enhanced mRNA Delivery.

Angew Chem Int Ed Engl 2017 10 19;56(44):13709-13712. Epub 2017 Sep 19.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/anie.201707466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647255PMC
October 2017

Polymer conjugated retinoids for controlled transdermal delivery.

J Control Release 2017 Sep 6;262:1-9. Epub 2017 Jul 6.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, Cambridge, MA 02139, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2017.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641977PMC
September 2017

Nano Tools Pave the Way to New Solutions in Infectious Disease.

Authors:
Paula T Hammond

ACS Infect Dis 2017 08;3(8):554-558

Department of Chemical Engineering and Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acsinfecdis.7b00104DOI Listing
August 2017

In vitro blood cell viability profiling of polymers used in molecular assembly.

Sci Rep 2017 08 25;7(1):9481. Epub 2017 Aug 25.

School of Chemical Engineering & Materials Science, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.

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http://dx.doi.org/10.1038/s41598-017-10169-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573391PMC
August 2017

Ligand-decorated click polypeptide derived nanoparticles for targeted drug delivery applications.

Nanomedicine 2017 07 2;13(5):1797-1808. Epub 2017 Mar 2.

Department of Chemical Engineering and Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, United States. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2017.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641973PMC
July 2017

A versatile microfluidic device for high throughput production of microparticles and cell microencapsulation.

Lab Chip 2017 06;17(12):2067-2075

Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1039/c6lc01568aDOI Listing
June 2017

Structurally Programmed Assembly of Translation Initiation Nanoplex for Superior mRNA Delivery.

ACS Nano 2017 03 14;11(3):2531-2544. Epub 2017 Feb 14.

Howard Hughes Medical Institute , Chevy Chase, Maryland 20815, United States.

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http://dx.doi.org/10.1021/acsnano.6b08447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629916PMC
March 2017

Engineering nanolayered particles for modular drug delivery.

J Control Release 2016 10 22;240:364-386. Epub 2016 Jan 22.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, Cambridge, MA 02139, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2016.01.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450096PMC
October 2016

Evaluation and Stability of PEDOT Polymer Electrodes for Li-O Batteries.

J Phys Chem Lett 2016 Oct 13;7(19):3770-3775. Epub 2016 Sep 13.

Department of Chemical Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acs.jpclett.6b01986DOI Listing
October 2016

Nano Day: Celebrating the Next Decade of Nanoscience and Nanotechnology.

ACS Nano 2016 Oct 7;10(10):9093-9103. Epub 2016 Oct 7.

Department of Chemistry, University of California, Irvine , Irvine, California 92697-2025, United States.

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http://dx.doi.org/10.1021/acsnano.6b06655DOI Listing
October 2016

Synthetic nanoscale electrostatic particles as growth factor carriers for cartilage repair.

Bioeng Transl Med 2016 Sep 18;1(3):347-356. Epub 2016 Nov 18.

Dept. of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge MA 02139.

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http://dx.doi.org/10.1002/btm2.10043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457159PMC
September 2016

Nanolayered siRNA delivery platforms for local silencing of CTGF reduce cutaneous scar contraction in third-degree burns.

Biomaterials 2016 07 14;95:22-34. Epub 2016 Apr 14.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2016.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518795PMC
July 2016

Engineering Periodic shRNA for Enhanced Silencing Efficacy.

Mol Ther 2016 06 7;24(6):1070-1077. Epub 2016 Apr 7.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1038/mt.2016.69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923333PMC
June 2016

Layer-by-layer assembled fluorescent probes in the second near-infrared window for systemic delivery and detection of ovarian cancer.

Proc Natl Acad Sci U S A 2016 May 25;113(19):5179-84. Epub 2016 Apr 25.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1521175113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868435PMC
May 2016

Designer Dual Therapy Nanolayered Implant Coatings Eradicate Biofilms and Accelerate Bone Tissue Repair.

ACS Nano 2016 04 2;10(4):4441-50. Epub 2016 Mar 2.

Department of Chemical Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acsnano.6b00087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501197PMC
April 2016

Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing In Vivo.

Adv Mater 2016 Mar 23;28(9):1809-17. Epub 2015 Dec 23.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://doi.wiley.com/10.1002/adma.201503565
Publisher Site
http://dx.doi.org/10.1002/adma.201503565DOI Listing
March 2016

A Multi-RNAi Microsponge Platform for Simultaneous Controlled Delivery of Multiple Small Interfering RNAs.

Angew Chem Int Ed Engl 2016 Mar 22;55(10):3347-51. Epub 2015 Dec 22.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/anie.201508978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768639PMC
March 2016

Three-dimensional multilayered fibrous constructs for wound healing applications.

Biomater Sci 2016 Feb;4(2):319-30

Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1039/c5bm00211gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729609PMC
February 2016

Shooting for the Moon: Nanoscale Approaches to Cancer.

Authors:
Paula T Hammond

ACS Nano 2016 Feb;10(2):1711-3

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http://dx.doi.org/10.1021/acsnano.6b01095DOI Listing
February 2016

Highly scalable, closed-loop synthesis of drug-loaded, layer-by-layer nanoparticles.

Adv Funct Mater 2016 Feb 3;26(7):991-1003. Epub 2016 Jan 3.

Koch Institute for Integrative Cancer Research Department of Chemical Engineering Massachusetts Institute of Technology Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adfm.201504385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847955PMC
February 2016

Periodic-shRNA molecules are capable of gene silencing, cytotoxicity and innate immune activation in cancer cells.

Nucleic Acids Res 2016 Jan 23;44(2):545-57. Epub 2015 Dec 23.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

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http://dx.doi.org/10.1093/nar/gkv1488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737167PMC
January 2016

High Throughput Layer-by-Layer Films for Extracting Film Forming Parameters and Modulating Film Interactions with Cells.

ACS Appl Mater Interfaces 2016 Jan 12;8(3):2255-61. Epub 2016 Jan 12.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , 500 Main Street, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acsami.5b11081DOI Listing
January 2016

A Flow Cytometric Clonogenic Assay Reveals the Single-Cell Potency of Doxorubicin.

J Pharm Sci 2015 Dec 7;104(12):4409-4416. Epub 2015 Sep 7.

Department of Chemical Engineering, Massachusetts Institute of Technology; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Department of Biological Engineering, Massachusetts Institute of Technology. Electronic address:

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http://dx.doi.org/10.1002/jps.24631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706798PMC
December 2015

Uncharged Helical Modular Polypeptide Hydrogels for Cellular Scaffolds.

Biomacromolecules 2015 Dec 9;16(12):3774-83. Epub 2015 Nov 9.

Department of Chemical Engineering, ‡Koch Institute for Integrative Cancer Research, §Department of Biological Engineering, and ∥Center for Gynepathology Research, Massachusetts Institute of Technology , Cambridge, Massachusetts United States.

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http://dx.doi.org/10.1021/acs.biomac.5b01076DOI Listing
December 2015

Tumor-Targeted Synergistic Blockade of MAPK and PI3K from a Layer-by-Layer Nanoparticle.

Clin Cancer Res 2015 Oct 1;21(19):4410-9. Epub 2015 Jun 1.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts. Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://clincancerres.aacrjournals.org/content/early/2015/08/
Web Search
http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-15-0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624301PMC
October 2015

Combination Growth Factor Therapy via Electrostatically Assembled Wound Dressings Improves Diabetic Ulcer Healing In Vivo.

Adv Healthc Mater 2015 Oct 13;4(14):2090-2099. Epub 2015 Aug 13.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://doi.wiley.com/10.1002/adhm.201500403
Publisher Site
http://dx.doi.org/10.1002/adhm.201500403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752932PMC
October 2015

Clotting Mimicry from Robust Hemostatic Bandages Based on Self-Assembling Peptides.

ACS Nano 2015 Sep 2;9(9):9394-406. Epub 2015 Sep 2.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acsnano.5b02374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580967PMC
September 2015

Influence of pH and Surface Chemistry on Poly(L-lysine) Adsorption onto Solid Supports Investigated by Quartz Crystal Microbalance with Dissipation Monitoring.

J Phys Chem B 2015 Aug 7;119(33):10554-65. Epub 2015 Aug 7.

†School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798 Singapore.

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http://dx.doi.org/10.1021/acs.jpcb.5b01553DOI Listing
August 2015

Adsorption of hyaluronic acid on solid supports: role of pH and surface chemistry in thin film self-assembly.

J Colloid Interface Sci 2015 Jun 11;448:197-207. Epub 2015 Feb 11.

School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue 639798, Singapore; Centre for Biomimetic Sensor Science, Nanyang Technological University, 50 Nanyang Drive 637553, Singapore; School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive 637459, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jcis.2015.01.060DOI Listing
June 2015

Spray Layer-by-Layer Assembled Clay Composite Thin Films as Selective Layers in Reverse Osmosis Membranes.

ACS Appl Mater Interfaces 2015 Jun 9;7(24):13375-83. Epub 2015 Jun 9.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acsami.5b01879DOI Listing
June 2015

A plug-and-play ratiometric pH-sensing nanoprobe for high-throughput investigation of endosomal escape.

Biomaterials 2015 May 20;51:250-256. Epub 2015 Feb 20.

Chemical Engineering, Koch Institute for Integrative Cancer Research Institute for Soldier Nanotechnologies Massachusetts Institute of Technology.

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http://dx.doi.org/10.1016/j.biomaterials.2015.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387846PMC
May 2015

Regenerating the cell resistance of micromolded PEG hydrogels.

Lab Chip 2015 May;15(9):2073-89

BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology, 3 Science Drive 2, Singapore 117543.

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http://dx.doi.org/10.1039/c4lc01416bDOI Listing
May 2015

Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells.

Adv Mater 2015 Mar 15;27(9):1593-9. Epub 2015 Jan 15.

Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Building 114, 16th Street, Charlestown, MA, 02129, USA; Shriners Hospital for Children, Harvard Medical School, 51 Blossom Street, Boston, MA, 02114, USA; Department of Surgery, Massachusetts General Hospital, Harvard Medical School 55, 55 Fruit Street, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1002/adma.201404677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492283PMC
March 2015

Spray-assisted layer-by-layer assembly on hyaluronic acid scaffolds for skin tissue engineering.

J Biomed Mater Res A 2015 Jan 3;103(1):330-40. Epub 2014 Apr 3.

Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts, 02139; 3B's Research Group, Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909 Caldas das Taipas, Guimarães, Portugal; ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal.

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http://dx.doi.org/10.1002/jbm.a.35178DOI Listing
January 2015

Multilayer transfer printing of electroactive thin film composites.

ACS Appl Mater Interfaces 2014 Nov 14;6(22):20519-23. Epub 2014 Nov 14.

Faculty of Engineering and Natural Sciences, Sabanci University , Istanbul 34956, Turkey.

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http://dx.doi.org/10.1021/am506120eDOI Listing
November 2014

Redox-responsive branched-bottlebrush polymers for in vivo MRI and fluorescence imaging.

Nat Commun 2014 Nov 18;5:5460. Epub 2014 Nov 18.

Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/ncomms6460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269368PMC
November 2014

Layer-by-layer assembled antisense DNA microsponge particles for efficient delivery of cancer therapeutics.

ACS Nano 2014 Oct 14;8(10):9767-80. Epub 2014 Oct 14.

Department of Chemical Engneering and The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/nn502596bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212789PMC
October 2014

Adaptive growth factor delivery from a polyelectrolyte coating promotes synergistic bone tissue repair and reconstruction.

Proc Natl Acad Sci U S A 2014 Sep 18;111(35):12847-52. Epub 2014 Aug 18.

Department of Chemical Engineering and The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1408035111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156697PMC
September 2014

Assembly of viral hydrogels for three-dimensional conducting nanocomposites.

Adv Mater 2014 Aug 30;26(30):5101-7. Epub 2014 Apr 30.

Department of Chemical Engineering, The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adma.201400828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878142PMC
August 2014

Multimonth controlled small molecule release from biodegradable thin films.

Proc Natl Acad Sci U S A 2014 Aug 4;111(33):12175-80. Epub 2014 Aug 4.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;Institute for Soldier Nanotechnologies, Cambridge, MA 02139; andDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139

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http://www.pnas.org/cgi/doi/10.1073/pnas.1323829111
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http://dx.doi.org/10.1073/pnas.1323829111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143022PMC
August 2014

Bimodal tumor-targeting from microenvironment responsive hyaluronan layer-by-layer (LbL) nanoparticles.

ACS Nano 2014 Aug 11;8(8):8374-82. Epub 2014 Aug 11.

Koch Institute for Integrative Cancer Research, ‡Department of Chemical Engineering, and §Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology , 500 Main Street, Cambridge, Massachusetts 02142, United States.

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http://pubs.acs.org/doi/10.1021/nn502861t
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http://dx.doi.org/10.1021/nn502861tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148172PMC
August 2014

A growing place for nano in medicine.

Authors:
Paula T Hammond

ACS Nano 2014 Aug;8(8):7551-2

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http://pubs.acs.org/doi/10.1021/nn504577x
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August 2014

PEG-polypeptide block copolymers as pH-responsive endosome-solubilizing drug nanocarriers.

Mol Pharm 2014 Jul 12;11(7):2420-30. Epub 2014 Jun 12.

Department of Chemical Engineering and Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/mp500162wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096223PMC
July 2014

Capillary flow layer-by-layer: a microfluidic platform for the high-throughput assembly and screening of nanolayered film libraries.

ACS Nano 2014 Jul 22;8(7):6580-9. Epub 2014 May 22.

Department of Chemical Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts, United States.

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http://pubs.acs.org/doi/10.1021/nn501963q
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http://dx.doi.org/10.1021/nn501963qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133994PMC
July 2014

Ordered and kinetically discrete sequential protein release from biodegradable thin films.

Angew Chem Int Ed Engl 2014 Jul 18;53(31):8093-8. Epub 2014 Jun 18.

Koch Institute for Integrative Cancer Research and the Institute for Soldier Nanotechnologies, Massachusetts Institute for Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA); Department of Chemistry, Massachusetts Institute for Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA).

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http://dx.doi.org/10.1002/anie.201403702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387866PMC
July 2014

Osteotropic therapy via targeted layer-by-layer nanoparticles.

Adv Healthc Mater 2014 Jun 9;3(6):867-75. Epub 2013 Oct 9.

The David H. Koch Institute for Integrative Cancer Research, Department of Chemical Engineering Institute for Soldier Nanotechnologies 77 Massachusetts Avenue, Cambridge, MA, 02139.

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http://dx.doi.org/10.1002/adhm.201300465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041853PMC
June 2014

Assembly of a bacteriophage-based template for the organization of materials into nanoporous networks.

Adv Mater 2014 Jun 20;26(21):3398-404. Epub 2014 Mar 20.

Department of Chemical Engineering, The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adma.201305928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043913PMC
June 2014

Multilayer films assembled from naturally-derived materials for controlled protein release.

Biomacromolecules 2014 Jun 30;15(6):2049-57. Epub 2014 May 30.

Departments of Chemistry and §Chemical Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/bm5001839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387870PMC
June 2014

A nanoparticle-based combination chemotherapy delivery system for enhanced tumor killing by dynamic rewiring of signaling pathways.

Sci Signal 2014 May 13;7(325):ra44. Epub 2014 May 13.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Department of Chemical Engineering, MIT, Cambridge, MA 02139, USA. Institute for Soldier Nanotechnologies, MIT, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/scisignal.2005261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138219PMC
May 2014

FRET-enabled biological characterization of polymeric micelles.

Biomaterials 2014 Apr 26;35(11):3489-96. Epub 2014 Jan 26.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, USA; Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, USA. Electronic address: http://web.mit.edu/hammond/lab/

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http://dx.doi.org/10.1016/j.biomaterials.2014.01.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040354PMC
April 2014

Enhanced ex vivo expansion of adult mesenchymal stem cells by fetal mesenchymal stem cell ECM.

Biomaterials 2014 Apr 21;35(13):4046-57. Epub 2014 Feb 21.

BioSystems and Micromechanics Interdisciplinary Group, Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, Singapore 138602, Singapore; Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2014.01.081DOI Listing
April 2014

A convergent synthetic platform for single-nanoparticle combination cancer therapy: ratiometric loading and controlled release of cisplatin, doxorubicin, and camptothecin.

J Am Chem Soc 2014 Apr 11;136(16):5896-9. Epub 2014 Apr 11.

Department of Chemistry, Massachusetts Institute of Technology , 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

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http://pubs.acs.org/doi/10.1021/ja502011g
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105175PMC
April 2014

Tunable staged release of therapeutics from layer-by-layer coatings with clay interlayer barrier.

Biomaterials 2014 Mar 31;35(8):2507-17. Epub 2013 Dec 31.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2013.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951715PMC
March 2014

The influence of transition metal oxides on the kinetics of Li2O2 oxidation in Li-O2 batteries: high activity of chromium oxides.

Phys Chem Chem Phys 2014 Feb;16(6):2297-304

Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://xlink.rsc.org/?DOI=C3CP53330A
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http://dx.doi.org/10.1039/c3cp53330aDOI Listing
February 2014

Vapor-phase polymerization of nanofibrillar poly(3,4-ethylenedioxythiophene) for supercapacitors.

ACS Nano 2014 Feb 3;8(2):1500-10. Epub 2014 Feb 3.

Department of Chemical Engineering and ‡The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/nn405595rDOI Listing
February 2014

Vaccine delivery with microneedle skin patches in nonhuman primates.

Nat Biotechnol 2013 Dec;31(12):1082-5

1] Department of Biological Engineering, MIT, Cambridge, Massachusetts, USA. [2] Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts, USA.

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http://www.nature.com/articles/nbt.2759
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http://dx.doi.org/10.1038/nbt.2759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011140PMC
December 2013

Layer-by-layer nanoparticles for systemic codelivery of an anticancer drug and siRNA for potential triple-negative breast cancer treatment.

ACS Nano 2013 Nov 21;7(11):9571-84. Epub 2013 Oct 21.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Rm 76-553, Cambridge, Massachusetts 02139, United States .

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http://dx.doi.org/10.1021/nn4047925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870477PMC
November 2013

Surface charges and shell crosslinks each play significant roles in mediating degradation, biofouling, cytotoxicity and immunotoxicity for polyphosphoester-based nanoparticles.

Sci Rep 2013 Nov 22;3:3313. Epub 2013 Nov 22.

1] Department of Chemistry, Department of Chemical Engineering, Laboratory for Synthetic-Biologic Interactions, Texas A&M University, P.O. Box 30012, 3255 TAMU, College Station, Texas 77842-3012, United States [2] Department of Pharmaceutics, Faculty of Pharmacy, Assiut Clinical Center of Nanomedicine, Al-Rajhy Liver Hospital, Assiut University, Assiut, Egypt [3].

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http://dx.doi.org/10.1038/srep03313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837308PMC
November 2013

Synthesis of highly stable sub-8 nm TiO2 nanoparticles and their multilayer electrodes of TiO2/MWNT for electrochemical applications.

Nano Lett 2013 Oct 4;13(10):4610-9. Epub 2013 Sep 4.

Department of Chemical Engineering, ‡Department of Mechanical Engineering, §Department of Materials Science and Engineering and ∥Electrochemical Energy Laboratory, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/nl401387sDOI Listing
October 2013