Paul Workman

Paul Workman

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Paul Workman

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Transforming cancer drug discovery with Big Data and AI.

Expert Opin Drug Discov 2019 Nov 8;14(11):1089-1095. Epub 2019 Jul 8.

The Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research , London , UK.

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https://www.tandfonline.com/doi/full/10.1080/17460441.2019.1
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http://dx.doi.org/10.1080/17460441.2019.1637414DOI Listing
November 2019

Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release.

Biochem J 2019 Sep 13;476(18):2521-2543. Epub 2019 Sep 13.

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London SM2 5NG, U.K.

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http://dx.doi.org/10.1042/BCJ20190383DOI Listing
September 2019

Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer.

Oncogene 2019 Jun 25;38(25):5076-5090. Epub 2019 Mar 25.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK.

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http://dx.doi.org/10.1038/s41388-019-0780-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755994PMC
June 2019

Correction to: An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.

Cancer Chemother Pharmacol 2018 Nov;82(5):911-912

Cancer Research UK Centre for Cancer Therapeutics, Haddow Laboratories, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.

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http://dx.doi.org/10.1007/s00280-018-3674-9DOI Listing
November 2018

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

Nat Genet 2018 05 16;50(5):682-692. Epub 2018 Apr 16.

The Institute of Cancer Research, London, UK.

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http://www.nature.com/articles/s41588-018-0086-z
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http://dx.doi.org/10.1038/s41588-018-0086-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372064PMC
May 2018

Oncogenic RAC1 and NRAS drive resistance to endoplasmic reticulum stress through MEK/ERK signalling.

Cell Signal 2018 04 9;44:127-137. Epub 2018 Jan 9.

The Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, UK.

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http://dx.doi.org/10.1016/j.cellsig.2018.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562199PMC
April 2018

Objective, Quantitative, Data-Driven Assessment of Chemical Probes.

Cell Chem Biol 2018 02 14;25(2):194-205.e5. Epub 2017 Dec 14.

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, London SM2 5NG, UK; Department of Data Science, The Institute of Cancer Research, 15 Cotswold Road, London SM2 5NG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814752PMC
February 2018

Polypharmacology in Precision Oncology: Current Applications and Future Prospects.

Curr Pharm Des 2016 ;22(46):6935-6945

Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.

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http://www.eurekaselect.com/openurl/content.php?genre=articl
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http://dx.doi.org/10.2174/1381612822666160923115828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403974PMC
January 2018

The role of high expectations of self and social desirability in emotional processing in individuals with irritable bowel syndrome: A qualitative study.

Br J Health Psychol 2017 11 1;22(4):737-762. Epub 2017 Sep 1.

Health Psychology Section, Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.

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http://dx.doi.org/10.1111/bjhp.12264DOI Listing
November 2017

Structure-based drug design: aiming for a perfect fit.

Essays Biochem 2017 11 8;61(5):431-437. Epub 2017 Nov 8.

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London SM2 5NG, U.K.

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http://dx.doi.org/10.1042/EBC20170052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869280PMC
November 2017

SiGNet: A signaling network data simulator to enable signaling network inference.

PLoS One 2017 17;12(5):e0177701. Epub 2017 May 17.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177701PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435248PMC
September 2017

In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells.

PLoS One 2017 13;12(7):e0180263. Epub 2017 Jul 13.

Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180263PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509135PMC
September 2017

RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses.

Br J Cancer 2017 Sep 22;117(7):954-964. Epub 2017 Aug 22.

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/bjc.2017.277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625678PMC
September 2017

Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology.

Cancer Cell 2017 07;32(1):9-25

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511331PMC
July 2017

Inhibitors of cyclin-dependent kinases as cancer therapeutics.

Pharmacol Ther 2017 May 5;173:83-105. Epub 2017 Feb 5.

Division of Cancer Therapeutics, The Institute of Cancer Research, London SW7 3RP, United Kingdom; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SW7 3RP, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2017.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141011PMC
May 2017

Imaging biomarker roadmap for cancer studies.

Nat Rev Clin Oncol 2017 03 11;14(3):169-186. Epub 2016 Oct 11.

CRUK and EPSRC Cancer Imaging Centre in Cambridge and Manchester, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/nrclinonc.2016.162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378302PMC
March 2017

How Much Longer Will We Put Up With $100,000 Cancer Drugs?

Cell 2017 02;168(4):579-583

Division of Molecular Carcinogenesis and Cancer Genomics Centre Netherlands, the Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.01.034DOI Listing
February 2017

Drug discovery in advanced prostate cancer: translating biology into therapy.

Nat Rev Drug Discov 2016 10 22;15(10):699-718. Epub 2016 Jul 22.

The Institute of Cancer Research, 15 Cotswold Road, London SM2 5NG, UK.

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http://dx.doi.org/10.1038/nrd.2016.120DOI Listing
October 2016

Minimizing bias in target selection by exploiting multidisciplinary Big Data and the protein interactome.

Future Med Chem 2016 09 1;8(14):1711-6. Epub 2016 Sep 1.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK.

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http://dx.doi.org/10.4155/fmc-2016-0133DOI Listing
September 2016

Critical parameters in targeted drug development: the pharmacological audit trail.

Semin Oncol 2016 08 14;43(4):436-45. Epub 2016 Jun 14.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK. Electronic address:

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http://dx.doi.org/10.1053/j.seminoncol.2016.06.001DOI Listing
August 2016

Biopsy-Derived Biomarkers in Phase I Trials: Building Confidence in Drug Development.

J Clin Oncol 2016 07 2;34(20):2431-2. Epub 2016 May 2.

The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2016.67.0075DOI Listing
July 2016

Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation.

Mol Cancer Ther 2016 06 5;15(6):1412-24. Epub 2016 Apr 5.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom. Drug Development Unit, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321508PMC
June 2016

Blocking the survival of the nastiest by HSP90 inhibition.

Oncotarget 2016 Jan;7(4):3658-61

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.18632/oncotarget.6971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826159PMC
January 2016

Distinctive Behaviors of Druggable Proteins in Cellular Networks.

PLoS Comput Biol 2015 Dec 23;11(12):e1004597. Epub 2015 Dec 23.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1004597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689399PMC
December 2015

Maximizing the Therapeutic Potential of HSP90 Inhibitors.

Mol Cancer Res 2015 Nov 28;13(11):1445-51. Epub 2015 Jul 28.

The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645455PMC
November 2015

Drugging PI3K in cancer: refining targets and therapeutic strategies.

Curr Opin Pharmacol 2015 Aug 25;23:98-107. Epub 2015 Jun 25.

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14714892150006
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http://dx.doi.org/10.1016/j.coph.2015.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728196PMC
August 2015

Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.

Cancer Res 2015 Aug 22;75(16):3340-54. Epub 2015 Jul 22.

Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom. Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.

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http://cancerres.aacrjournals.org/content/early/2015/07/21/0
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http://cancerres.aacrjournals.org/content/75/16/3340.full.pd
Web Search
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-14-3272DOI Listing
August 2015

Chemical biology approaches to target validation in cancer.

Curr Opin Pharmacol 2014 Aug 28;17:87-100. Epub 2014 Aug 28.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2014.07.007DOI Listing
August 2014

EML4-ALK fusions: propelling cancer but creating exploitable chaperone dependence.

Cancer Discov 2014 Jun;4(6):642-5

Authors' Affiliation: Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom

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http://dx.doi.org/10.1158/2159-8290.CD-14-0409DOI Listing
June 2014

Academia and industry: Successes for UK cancer partnership.

Authors:
Paul Workman

Nature 2014 Jun;510(7504):218

The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/510218dDOI Listing
June 2014

E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells.

Proc Natl Acad Sci U S A 2014 May 23;111(18):6834-9. Epub 2014 Apr 23.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, UK.

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http://dx.doi.org/10.1073/pnas.1322412111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020071PMC
May 2014

Drugging cancer genomes.

Nat Rev Drug Discov 2013 12;12(12):889-90

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London SM2 5NG, UK.

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http://dx.doi.org/10.1038/nrd4184DOI Listing
December 2013

Hsp70 inhibition induces myeloma cell death via the intracellular accumulation of immunoglobulin and the generation of proteotoxic stress.

Cancer Lett 2013 Oct 22;339(1):49-59. Epub 2013 Jul 22.

Haemato-Oncology Research Unit, Division of Molecular Pathology, Cancer Therapeutics and Clinical Studies, The Institute of Cancer Research, London SM2 5NG, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S03043835130054
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http://dx.doi.org/10.1016/j.canlet.2013.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778988PMC
October 2013

Genome-based cancer therapeutics: targets, kinase drug resistance and future strategies for precision oncology.

Curr Opin Pharmacol 2013 Aug 28;13(4):486-96. Epub 2013 Jun 28.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S14714892130010
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http://dx.doi.org/10.1016/j.coph.2013.06.004DOI Listing
August 2013

HSF1 in Translation.

Cancer Cell 2013 Aug;24(2):147-9

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London SM2 5NG, UK.

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http://dx.doi.org/10.1016/j.ccr.2013.07.017DOI Listing
August 2013

MEK1/2 inhibition decreases lactate in BRAF-driven human cancer cells.

Cancer Res 2013 Jul 2;73(13):4039-49. Epub 2013 May 2.

Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research, Sutton, Surrey, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1969DOI Listing
July 2013

ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.

Nat Chem Biol 2013 May 17;9(5):307-12. Epub 2013 Mar 17.

Medical Research Council Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.

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http://www.nature.com/articles/nchembio.1212
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http://dx.doi.org/10.1038/nchembio.1212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695660PMC
May 2013

Q&A: Paul Workman on big data and large biases.

Authors:
Paul Workman

Cancer Discov 2013 Apr 28;3(4):369. Epub 2013 Mar 28.

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http://dx.doi.org/10.1158/2159-8290.CD-ND2013-006DOI Listing
April 2013

Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors.

PLoS One 2012 11;7(9):e44642. Epub 2012 Sep 11.

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044642PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439374PMC
March 2013

Objective assessment of cancer genes for drug discovery.

Nat Rev Drug Discov 2013 01;12(1):35-50

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/nrd3913DOI Listing
January 2013

Unpicking the combination lock for mutant BRAF and RAS melanomas.

Cancer Discov 2013 Jan;3(1):14-9

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0520DOI Listing
January 2013

Molecular biology: Choose your protein partners.

Nature 2012 Oct;490(7420):351-2

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http://dx.doi.org/10.1038/490351aDOI Listing
October 2012

Small-molecule inhibitors of the protein methyltransferase SET7/9 identified in a high-throughput screen.

J Biomol Screen 2012 Sep 5;17(8):1102-9. Epub 2012 Jul 5.

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, Sutton, UK.

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http://dx.doi.org/10.1177/1087057112452137DOI Listing
September 2012

The association of PI3 kinase signaling and chemoresistance in advanced ovarian cancer.

Mol Cancer Ther 2012 Jul 3;11(7):1609-17. Epub 2012 May 3.

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutic, The Institute of Cancer Research, Sutton,United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-11-0996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630857PMC
July 2012

Combinatorial drug therapy for cancer in the post-genomic era.

Nat Biotechnol 2012 Jul 10;30(7):679-92. Epub 2012 Jul 10.

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, Sutton, UK.

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http://dx.doi.org/10.1038/nbt.2284DOI Listing
July 2012

Exploiting the cancer genome: strategies for the discovery and clinical development of targeted molecular therapeutics.

Annu Rev Pharmacol Toxicol 2012 ;52:549-73

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey SM2 5NG, United Kingdom.

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http://www.annualreviews.org/doi/10.1146/annurev-pharmtox-01
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http://dx.doi.org/10.1146/annurev-pharmtox-010611-134532DOI Listing
May 2012

Sensitization of (colon) cancer cells to death receptor related therapies: a report from the FP6-ONCODEATH research consortium.

Cancer Biol Ther 2012 May 1;13(7):458-66. Epub 2012 May 1.

Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece.

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http://dx.doi.org/10.4161/cbt.19600DOI Listing
May 2012

The expanding proteome of the molecular chaperone HSP90.

Cell Cycle 2012 Apr 1;11(7):1301-8. Epub 2012 Apr 1.

Signal Transduction and Molecular Pharmacology Team, Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, UK.

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http://dx.doi.org/10.4161/cc.19722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350876PMC
April 2012

Discovery of small molecule cancer drugs: successes, challenges and opportunities.

Mol Oncol 2012 Apr 3;6(2):155-76. Epub 2012 Mar 3.

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.

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http://doi.wiley.com/10.1016/j.molonc.2012.02.004
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http://dx.doi.org/10.1016/j.molonc.2012.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476506PMC
April 2012

Personalized medicine: patient-predictive panel power.

Cancer Cell 2012 Apr;21(4):455-8

Signal Transduction and Molecular Pharmacology Team, Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, Sutton, UK.

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http://dx.doi.org/10.1016/j.ccr.2012.03.030DOI Listing
April 2012

HSP90 inhibition: two-pronged exploitation of cancer dependencies.

Drug Discov Today 2012 Mar 30;17(5-6):242-52. Epub 2011 Dec 30.

Signal Transduction and Molecular Pharmacology Team, Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, UK.

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http://dx.doi.org/10.1016/j.drudis.2011.12.021DOI Listing
March 2012