Publications by authors named "Paul Workman"

100Publications

Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches.

Sci Rep 2020 Sep 29;10(1):16000. Epub 2020 Sep 29.

Division of Cancer Therapeutics, Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-71969-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524759PMC
September 2020

Correction to: Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective.

Authors:
Paul Workman

Adv Exp Med Biol 2020 ;1243:C1-C2

CRUK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-030-40204-4_12DOI Listing
January 2020

Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective.

Authors:
Paul Workman

Adv Exp Med Biol 2020 ;1243:163-179

CRUK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-030-40204-4_11DOI Listing
June 2020

CHK1 Inhibition Is Synthetically Lethal with Loss of B-Family DNA Polymerase Function in Human Lung and Colorectal Cancer Cells.

Cancer Res 2020 04 11;80(8):1735-1747. Epub 2020 Mar 11.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-19-1372DOI Listing
April 2020

The kinase polypharmacology landscape of clinical PARP inhibitors.

Sci Rep 2020 02 17;10(1):2585. Epub 2020 Feb 17.

Department of Data Science, The Institute of Cancer Research, London, SM2 5NG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-59074-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026418PMC
February 2020

From patent to patient: analysing access to innovative cancer drugs.

Drug Discov Today 2020 Sep 29;25(9):1561-1568. Epub 2020 Jan 29.

The Institute of Cancer Research, Old Brompton Road, London, SW7 3RP, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drudis.2020.01.004DOI Listing
September 2020

Public resources for chemical probes: the journey so far and the road ahead.

Future Med Chem 2019 Nov 28. Epub 2019 Nov 28.

The Department of Data Science, The Institute of Cancer Research, London SM2 5NG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/fmc-2019-0231DOI Listing
November 2019

Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release.

Biochem J 2019 09 13;476(18):2521-2543. Epub 2019 Sep 13.

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London SM2 5NG, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BCJ20190383DOI Listing
September 2019

Transforming cancer drug discovery with Big Data and AI.

Expert Opin Drug Discov 2019 11 8;14(11):1089-1095. Epub 2019 Jul 8.

The Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research , London , UK.

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17460441.2019.1
Publisher Site
http://dx.doi.org/10.1080/17460441.2019.1637414DOI Listing
November 2019

Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer.

Oncogene 2019 06 25;38(25):5076-5090. Epub 2019 Mar 25.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-019-0780-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755994PMC
June 2019

Correction to: An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.

Cancer Chemother Pharmacol 2018 Nov;82(5):911-912

Cancer Research UK Centre for Cancer Therapeutics, Haddow Laboratories, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00280-018-3674-9DOI Listing
November 2018

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

Nat Genet 2018 05 16;50(5):682-692. Epub 2018 Apr 16.

The Institute of Cancer Research, London, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41588-018-0086-z
Publisher Site
http://dx.doi.org/10.1038/s41588-018-0086-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372064PMC
May 2018

Oncogenic RAC1 and NRAS drive resistance to endoplasmic reticulum stress through MEK/ERK signalling.

Cell Signal 2018 04 9;44:127-137. Epub 2018 Jan 9.

The Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellsig.2018.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562199PMC
April 2018

Objective, Quantitative, Data-Driven Assessment of Chemical Probes.

Cell Chem Biol 2018 02 14;25(2):194-205.e5. Epub 2017 Dec 14.

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, London SM2 5NG, UK; Department of Data Science, The Institute of Cancer Research, 15 Cotswold Road, London SM2 5NG, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2017.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814752PMC
February 2018

Structure-based drug design: aiming for a perfect fit.

Essays Biochem 2017 11 8;61(5):431-437. Epub 2017 Nov 8.

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London SM2 5NG, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/EBC20170052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869280PMC
November 2017

The role of high expectations of self and social desirability in emotional processing in individuals with irritable bowel syndrome: A qualitative study.

Br J Health Psychol 2017 11 1;22(4):737-762. Epub 2017 Sep 1.

Health Psychology Section, Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjhp.12264DOI Listing
November 2017

RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses.

Br J Cancer 2017 Sep 22;117(7):954-964. Epub 2017 Aug 22.

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/bjc.2017.277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625678PMC
September 2017

In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells.

PLoS One 2017 13;12(7):e0180263. Epub 2017 Jul 13.

Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180263PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509135PMC
September 2017

Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology.

Cancer Cell 2017 07;32(1):9-25

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2017.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511331PMC
July 2017

SiGNet: A signaling network data simulator to enable signaling network inference.

PLoS One 2017 17;12(5):e0177701. Epub 2017 May 17.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177701PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435248PMC
September 2017

How Much Longer Will We Put Up With $100,000 Cancer Drugs?

Cell 2017 02;168(4):579-583

Division of Molecular Carcinogenesis and Cancer Genomics Centre Netherlands, the Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2017.01.034DOI Listing
February 2017

Inhibitors of cyclin-dependent kinases as cancer therapeutics.

Pharmacol Ther 2017 May 5;173:83-105. Epub 2017 Feb 5.

Division of Cancer Therapeutics, The Institute of Cancer Research, London SW7 3RP, United Kingdom; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SW7 3RP, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharmthera.2017.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141011PMC
May 2017

Imaging biomarker roadmap for cancer studies.

Nat Rev Clin Oncol 2017 03 11;14(3):169-186. Epub 2016 Oct 11.

CRUK and EPSRC Cancer Imaging Centre in Cambridge and Manchester, University of Manchester, Manchester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrclinonc.2016.162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378302PMC
March 2017

Polypharmacology in Precision Oncology: Current Applications and Future Prospects.

Curr Pharm Des 2016 ;22(46):6935-6945

Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/openurl/content.php?genre=articl
Publisher Site
http://dx.doi.org/10.2174/1381612822666160923115828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403974PMC
January 2018

Critical parameters in targeted drug development: the pharmacological audit trail.

Semin Oncol 2016 08 14;43(4):436-45. Epub 2016 Jun 14.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.seminoncol.2016.06.001DOI Listing
August 2016

Minimizing bias in target selection by exploiting multidisciplinary Big Data and the protein interactome.

Future Med Chem 2016 09 1;8(14):1711-6. Epub 2016 Sep 1.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/fmc-2016-0133DOI Listing
September 2016

Drug discovery in advanced prostate cancer: translating biology into therapy.

Nat Rev Drug Discov 2016 10 22;15(10):699-718. Epub 2016 Jul 22.

The Institute of Cancer Research, 15 Cotswold Road, London SM2 5NG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrd.2016.120DOI Listing
October 2016

Biopsy-Derived Biomarkers in Phase I Trials: Building Confidence in Drug Development.

J Clin Oncol 2016 07 2;34(20):2431-2. Epub 2016 May 2.

The Institute of Cancer Research, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2016.67.0075DOI Listing
July 2016

Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation.

Mol Cancer Ther 2016 06 5;15(6):1412-24. Epub 2016 Apr 5.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom. Drug Development Unit, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-15-0815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321508PMC
June 2016

Blocking the survival of the nastiest by HSP90 inhibition.

Oncotarget 2016 Jan;7(4):3658-61

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.6971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826159PMC
January 2016

Distinctive Behaviors of Druggable Proteins in Cellular Networks.

PLoS Comput Biol 2015 Dec 23;11(12):e1004597. Epub 2015 Dec 23.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pcbi.1004597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689399PMC
December 2015

Maximizing the Therapeutic Potential of HSP90 Inhibitors.

Mol Cancer Res 2015 Nov 28;13(11):1445-51. Epub 2015 Jul 28.

The Institute of Cancer Research, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1541-7786.MCR-15-0234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645455PMC
November 2015

Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.

Cancer Res 2015 Aug 22;75(16):3340-54. Epub 2015 Jul 22.

Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom. Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.

View Article

Download full-text PDF

Source
http://cancerres.aacrjournals.org/content/early/2015/07/21/0
Web Search
http://cancerres.aacrjournals.org/content/75/16/3340.full.pd
Web Search
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-14-3272DOI Listing
August 2015

Drugging PI3K in cancer: refining targets and therapeutic strategies.

Curr Opin Pharmacol 2015 Aug 25;23:98-107. Epub 2015 Jun 25.

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14714892150006
Publisher Site
http://dx.doi.org/10.1016/j.coph.2015.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728196PMC
August 2015

Chemical biology approaches to target validation in cancer.

Curr Opin Pharmacol 2014 Aug 28;17:87-100. Epub 2014 Aug 28.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coph.2014.07.007DOI Listing
August 2014

Academia and industry: Successes for UK cancer partnership.

Authors:
Paul Workman

Nature 2014 Jun;510(7504):218

The Institute of Cancer Research, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/510218dDOI Listing
June 2014

EML4-ALK fusions: propelling cancer but creating exploitable chaperone dependence.

Cancer Discov 2014 Jun;4(6):642-5

Authors' Affiliation: Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-14-0409DOI Listing
June 2014

E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells.

Proc Natl Acad Sci U S A 2014 May 23;111(18):6834-9. Epub 2014 Apr 23.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1322412111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020071PMC
May 2014

Drugging cancer genomes.

Nat Rev Drug Discov 2013 12;12(12):889-90

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London SM2 5NG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrd4184DOI Listing
December 2013

HSF1 in Translation.

Cancer Cell 2013 Aug;24(2):147-9

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London SM2 5NG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2013.07.017DOI Listing
August 2013

Hsp70 inhibition induces myeloma cell death via the intracellular accumulation of immunoglobulin and the generation of proteotoxic stress.

Cancer Lett 2013 Oct 22;339(1):49-59. Epub 2013 Jul 22.

Haemato-Oncology Research Unit, Division of Molecular Pathology, Cancer Therapeutics and Clinical Studies, The Institute of Cancer Research, London SM2 5NG, UK.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03043835130054
Publisher Site
http://dx.doi.org/10.1016/j.canlet.2013.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778988PMC
October 2013

Genome-based cancer therapeutics: targets, kinase drug resistance and future strategies for precision oncology.

Curr Opin Pharmacol 2013 Aug 28;13(4):486-96. Epub 2013 Jun 28.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14714892130010
Publisher Site
http://dx.doi.org/10.1016/j.coph.2013.06.004DOI Listing
August 2013

MEK1/2 inhibition decreases lactate in BRAF-driven human cancer cells.

Cancer Res 2013 Jul 2;73(13):4039-49. Epub 2013 May 2.

Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research, Sutton, Surrey, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-12-1969DOI Listing
July 2013

Q&A: Paul Workman on big data and large biases.

Authors:
Paul Workman

Cancer Discov 2013 Apr 28;3(4):369. Epub 2013 Mar 28.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-ND2013-006DOI Listing
April 2013

ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.

Nat Chem Biol 2013 May 17;9(5):307-12. Epub 2013 Mar 17.

Medical Research Council Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nchembio.1212
Publisher Site
http://dx.doi.org/10.1038/nchembio.1212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695660PMC
May 2013

Unpicking the combination lock for mutant BRAF and RAS melanomas.

Cancer Discov 2013 Jan;3(1):14-9

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-12-0520DOI Listing
January 2013

Objective assessment of cancer genes for drug discovery.

Nat Rev Drug Discov 2013 01;12(1):35-50

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrd3913DOI Listing
January 2013

Molecular biology: Choose your protein partners.

Nature 2012 Oct;490(7420):351-2

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/490351aDOI Listing
October 2012

Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors.

PLoS One 2012 11;7(9):e44642. Epub 2012 Sep 11.

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044642PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439374PMC
March 2013

Combinatorial drug therapy for cancer in the post-genomic era.

Nat Biotechnol 2012 Jul 10;30(7):679-92. Epub 2012 Jul 10.

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, Sutton, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nbt.2284DOI Listing
July 2012