Publications by authors named "Paul W Noble"

100Publications

Alveolar Epithelial Type II Cells as Drivers of Lung Fibrosis in Idiopathic Pulmonary Fibrosis.

Int J Mol Sci 2020 Mar 25;21(7). Epub 2020 Mar 25.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.3390/ijms21072269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177323PMC
March 2020

Pirfenidone in patients with idiopathic pulmonary fibrosis and more advanced lung function impairment.

Respir Med 2019 07 24;153:44-51. Epub 2019 Apr 24.

Department of Medicine, Cedars-Sinai Medical Center, 87000 Beverly Boulevard, Los Angeles, CA, 90048, USA. Electronic address:

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http://dx.doi.org/10.1016/j.rmed.2019.04.016DOI Listing
July 2019

Effect of pirfenidone in patients with more advanced idiopathic pulmonary fibrosis.

Respir Res 2019 Mar 12;20(1):55. Epub 2019 Mar 12.

Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA.

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http://dx.doi.org/10.1186/s12931-019-1021-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416878PMC
March 2019

PD-L1 on invasive fibroblasts drives fibrosis in a humanized model of idiopathic pulmonary fibrosis.

JCI Insight 2019 03 21;4(6). Epub 2019 Mar 21.

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

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http://insight.jci.org/articles/view/125326
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http://dx.doi.org/10.1172/jci.insight.125326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482997PMC
March 2019

Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis.

Cell Rep 2018 03;22(13):3625-3640

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908225PMC
March 2018

An Open-Label Study of the Long-Term Safety of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis (RECAP).

Respiration 2017 13;94(5):408-415. Epub 2017 Sep 13.

Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1159/000479976DOI Listing
July 2018

MicroRNA-29c Prevents Pulmonary Fibrosis by Regulating Epithelial Cell Renewal and Apoptosis.

Am J Respir Cell Mol Biol 2017 12;57(6):721-732

1 Department of Medicine, Division of Pulmonary and Critical Care Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1165/rcmb.2017-0133OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765420PMC
December 2017

miR-323a-3p regulates lung fibrosis by targeting multiple profibrotic pathways.

JCI Insight 2016 12 8;1(20):e90301. Epub 2016 Dec 8.

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

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http://dx.doi.org/10.1172/jci.insight.90301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135276PMC
December 2016

Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis.

Matrix Biol 2016 09 15;55:35-48. Epub 2016 Mar 15.

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2016.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383204PMC
September 2016

Pirfenidone Initiates a New Era in the Treatment of Idiopathic Pulmonary Fibrosis.

Annu Rev Med 2016 4;67:487-95. Epub 2015 Nov 4.

Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048; email: ,

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http://dx.doi.org/10.1146/annurev-med-120214-013614DOI Listing
October 2016

Hyaluronan as a therapeutic target in human diseases.

Adv Drug Deliv Rev 2016 Feb 2;97:186-203. Epub 2015 Nov 2.

Department of Medicine and Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2015.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753080PMC
February 2016

Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice.

J Exp Med 2015 Feb 12;212(2):235-52. Epub 2015 Jan 12.

State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China

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http://dx.doi.org/10.1084/jem.20121878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322044PMC
February 2015

Analysis of lung function and survival in RECAP: An open-label extension study of pirfenidone in patients with idiopathic pulmonary fibrosis.

Sarcoidosis Vasc Diffuse Lung Dis 2014 Oct 20;31(3):198-205. Epub 2014 Oct 20.

Ruhrlandklinik, University Hospital, University Duisburg-Essen, Essen, Germany.

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October 2014

Familial and sporadic idiopathic pulmonary fibrosis: making the diagnosis from peripheral blood.

BMC Genomics 2014 Oct 16;15:902. Epub 2014 Oct 16.

Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University Medical Center, 1313 21st Avenue South, 1105 Oxford House, Nashville, TN, USA.

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http://dx.doi.org/10.1186/1471-2164-15-902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288625PMC
October 2014

Treatments for idiopathic pulmonary fibrosis.

N Engl J Med 2014 08;371(8):783-4

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http://dx.doi.org/10.1056/NEJMc1407776DOI Listing
August 2014

A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis.

N Engl J Med 2014 May 18;370(22):2083-92. Epub 2014 May 18.

From the University of California, San Francisco, San Francisco (T.E.K.), InterMune, Brisbane (W.Z.B., E.A.F., E.G., D.K.), and Cedars-Sinai Medical Center, Los Angeles (P.W.N.) - all in California; Neumocare, Clínica San Borja, Lima, Peru (S.C.-B.); Alfred Hospital, Melbourne, VIC (I.G.), and Prince Charles Hospital, Brisbane, QLD (P.M.H.) - both in Australia; University of Miami Miller School of Medicine, Miami (M.K.G.); Vanderbilt University Medical Center, Nashville (L.L.); Columbia University Medical Center, New York (D.J.L.); Inova Fairfax Hospital, Falls Church, VA (S.D.N.); Paulista School of Medicine, Federal University of São Paulo, São Paulo (C.A.P.); Medical University of South Carolina, Charleston (S.A.S.); Atlantic Health System-Overlook Medical Center, Summit, NJ (R.S.); and National Jewish Health, Denver (J.J.S.).

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http://dx.doi.org/10.1056/NEJMoa1402582DOI Listing
May 2014

Cellular mechanisms of tissue fibrosis. 7. New insights into the cellular mechanisms of pulmonary fibrosis.

Am J Physiol Cell Physiol 2014 Jun 16;306(11):C987-96. Epub 2014 Apr 16.

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California

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http://dx.doi.org/10.1152/ajpcell.00321.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422352PMC
June 2014

Type 2 alveolar cells are stem cells in adult lung.

J Clin Invest 2013 Jul 10;123(7):3025-36. Epub 2013 Jun 10.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.

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http://dx.doi.org/10.1172/JCI68782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696553PMC
July 2013

β-Arrestins in the immune system.

Prog Mol Biol Transl Sci 2013 ;118:359-93

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.

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http://dx.doi.org/10.1016/B978-0-12-394440-5.00014-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467910PMC
March 2014

Pulmonary fibrosis: patterns and perpetrators.

J Clin Invest 2012 Aug 1;122(8):2756-62. Epub 2012 Aug 1.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.

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http://dx.doi.org/10.1172/JCI60323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408732PMC
August 2012

Take a deep breath: pulmonary research inspires.

Authors:
Paul W Noble

J Clin Invest 2012 Aug 1;122(8):2722-3. Epub 2012 Aug 1.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

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http://dx.doi.org/10.1172/JCI65404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408760PMC
August 2012

Idiopathic pulmonary fibrosis: lung function is a clinically meaningful endpoint for phase III trials.

Am J Respir Crit Care Med 2012 Oct 12;186(8):712-5. Epub 2012 Jul 12.

Respiratory Medicine, Imperial College, London, UK.

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http://dx.doi.org/10.1164/rccm.201206-1010PPDOI Listing
October 2012

MicroRNA-127 inhibits lung inflammation by targeting IgG Fcγ receptor I.

J Immunol 2012 Mar 27;188(5):2437-44. Epub 2012 Jan 27.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1101070
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http://dx.doi.org/10.4049/jimmunol.1101070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288289PMC
March 2012

A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury.

Am J Physiol Lung Cell Mol Physiol 2012 May 27;302(9):L933-40. Epub 2012 Jan 27.

Division of Pulmonary,Department of Medicine, Duke Univ. School of Medicine, Durham, NC 27710, USA.

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http://www.physiology.org/doi/10.1152/ajplung.00256.2011
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http://dx.doi.org/10.1152/ajplung.00256.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362164PMC
May 2012

Surfactant protein-D regulates effector cell function and fibrotic lung remodeling in response to bleomycin injury.

Am J Respir Crit Care Med 2012 Mar 28;185(5):525-36. Epub 2011 Dec 28.

Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA.

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http://dx.doi.org/10.1164/rccm.201103-0561OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297103PMC
March 2012

Long-term exposure of chemokine CXCL10 causes bronchiolitis-like inflammation.

Am J Respir Cell Mol Biol 2012 May 8;46(5):592-8. Epub 2011 Dec 8.

Division of Pulmonary, Duke University School of Medicine, 106 Research Drive, Durham, NC 27710, USA.

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http://dx.doi.org/10.1165/rcmb.2011-0116OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359901PMC
May 2012

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition.

Proc Natl Acad Sci U S A 2011 Dec 28;108(52):E1475-83. Epub 2011 Nov 28.

Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1073/pnas.1117988108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248478PMC
December 2011

Role of CD44 in the organization of keratinocyte pericellular hyaluronan.

Histochem Cell Biol 2012 Jan 10;137(1):107-20. Epub 2011 Nov 10.

Department of Anatomy, Institute of Biomedicine, University of Eastern Finland, P.O.B. 1627, 70211 Kuopio, Finland.

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http://dx.doi.org/10.1007/s00418-011-0883-2DOI Listing
January 2012

Efficacy of a tyrosine kinase inhibitor in idiopathic pulmonary fibrosis.

N Engl J Med 2011 Sep;365(12):1079-87

Center for Rare Lung Diseases, University of Modena and Reggio Emilia, Policlinico Hospital, Modena, Italy.

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http://dx.doi.org/10.1056/NEJMoa1103690DOI Listing
September 2011

Bayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principle.

BMC Med Genomics 2011 Oct 5;4:70. Epub 2011 Oct 5.

Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA.

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http://dx.doi.org/10.1186/1755-8794-4-70DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199230PMC
October 2011

Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44.

J Exp Med 2011 Jul 27;208(7):1459-71. Epub 2011 Jun 27.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

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http://dx.doi.org/10.1084/jem.20102510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135364PMC
July 2011

Role of hyaluronan and hyaluronan-binding proteins in human asthma.

J Allergy Clin Immunol 2011 Aug 13;128(2):403-411.e3. Epub 2011 May 13.

Division of Pulmonary, Allergy and Critical Care Medicine, Duke University School of Medicine, Durham, NC, USA.

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http://dx.doi.org/10.1016/j.jaci.2011.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149736PMC
August 2011

Airway fibroblasts in asthma manifest an invasive phenotype.

Am J Respir Crit Care Med 2011 Jun 25;183(12):1625-32. Epub 2011 Mar 25.

Department of Medicine, Duke University Medical Center, 201 MSRB 1, Research Drive, Box 2641, Durham, NC 27710, USA.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.201009-1452O
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http://dx.doi.org/10.1164/rccm.201009-1452OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136991PMC
June 2011

Extracorporeal membrane oxygenation for severe refractory respiratory failure secondary to 2009 H1N1 influenza A.

Respir Care 2011 Jul 21;56(7):941-6. Epub 2011 Feb 21.

Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.4187/respcare.01066DOI Listing
July 2011

Recruited exudative macrophages selectively produce CXCL10 after noninfectious lung injury.

Am J Respir Cell Mol Biol 2011 Oct 17;45(4):781-8. Epub 2011 Feb 17.

Department of Medicine, Duke University Medical Center, Durham, NC, USA.

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http://www.atsjournals.org/doi/abs/10.1165/rcmb.2010-0471OC
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http://dx.doi.org/10.1165/rcmb.2010-0471OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208617PMC
October 2011

Comprehensive microRNA analysis in bleomycin-induced pulmonary fibrosis identifies multiple sites of molecular regulation.

Physiol Genomics 2011 May 25;43(9):479-87. Epub 2011 Jan 25.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA.

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http://www.physiology.org/doi/10.1152/physiolgenomics.00222.
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http://dx.doi.org/10.1152/physiolgenomics.00222.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110895PMC
May 2011

Hyaluronan as an immune regulator in human diseases.

Physiol Rev 2011 Jan;91(1):221-64

Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA.

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http://www.physiology.org/doi/10.1152/physrev.00052.2009
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http://dx.doi.org/10.1152/physrev.00052.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051404PMC
January 2011

CD44 deficiency is associated with increased bacterial clearance but enhanced lung inflammation during Gram-negative pneumonia.

Am J Pathol 2010 Nov 23;177(5):2483-94. Epub 2010 Sep 23.

Center for Infection and Immunity Amsterdam, Department of Pathology, Academic Medical Center, Meibergdreef 9, Room G2-130, 1105 AZ Amsterdam, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S000294401060299
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http://dx.doi.org/10.2353/ajpath.2010.100562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966805PMC
November 2010

Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4.

J Clin Invest 2010 Jun 17;120(6):2049-57. Epub 2010 May 17.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1172/JCI38644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877927PMC
June 2010

Regulation of non-infectious lung injury, inflammation, and repair by the extracellular matrix glycosaminoglycan hyaluronan.

Anat Rec (Hoboken) 2010 Jun;293(6):982-5

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.

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http://doi.wiley.com/10.1002/ar.21102
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http://dx.doi.org/10.1002/ar.21102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877145PMC
June 2010

The role of surfactant protein A in bleomycin-induced acute lung injury.

Am J Respir Crit Care Med 2010 Jun 18;181(12):1336-44. Epub 2010 Feb 18.

Department of Cell Biology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.

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http://dx.doi.org/10.1164/rccm.200907-1002OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894409PMC
June 2010

Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice.

J Biol Chem 2009 Apr 21;284(17):11309-17. Epub 2009 Jan 21.

NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1074/jbc.M802400200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670136PMC
April 2009

Idiopathic pulmonary fibrosis.

Orphanet J Rare Dis 2008 Mar 26;3. Epub 2008 Mar 26.

Department of Medicine, Division of Pulmonary, Allergy and Critical Care, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://ojrd.biomedcentral.com/articles/10.1186/1750-1172-3-8
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http://dx.doi.org/10.1186/1750-1172-3-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2330030PMC
March 2008

Hyaluronan in tissue injury and repair.

Annu Rev Cell Dev Biol 2007 ;23:435-61

Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

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http://www.annualreviews.org/doi/10.1146/annurev.cellbio.23.
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http://dx.doi.org/10.1146/annurev.cellbio.23.090506.123337DOI Listing
December 2007

CD44 is a negative regulator of acute pulmonary inflammation and lipopolysaccharide-TLR signaling in mouse macrophages.

J Immunol 2007 Feb;178(4):2469-75

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

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http://dx.doi.org/10.4049/jimmunol.178.4.2469DOI Listing
February 2007

Idiopathic pulmonary fibrosis and pulmonary hypertension: connecting the dots.

Am J Respir Crit Care Med 2007 May 25;175(9):875-80. Epub 2007 Jan 25.

Medical Director, Advanced Lung Disease and Transplant Program, INOVA Heart & Vascular Institute, INOVA Fairfax Hospital, Falls Church, VA 22042, USA.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.200608-1153C
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http://dx.doi.org/10.1164/rccm.200608-1153CCDOI Listing
May 2007

Patient experiences with pulmonary fibrosis.

Respir Med 2007 Jun 14;101(6):1350-4. Epub 2006 Nov 14.

Department of Medicine, San Francisco General Hospital, University of California-San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA.

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http://dx.doi.org/10.1016/j.rmed.2006.10.002DOI Listing
June 2007

The role of Toll-like receptors in non-infectious lung injury.

Cell Res 2006 Aug;16(8):693-701

Department of Medicine, Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://www.nature.com/articles/7310085
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http://dx.doi.org/10.1038/sj.cr.7310085DOI Listing
August 2006

Matrix regulation of lung injury, inflammation, and repair: the role of innate immunity.

Proc Am Thorac Soc 2006 Jul;3(5):401-4

Pulmonary and Critical Care Medicine, Yale University School of Medicine, TAC S441C, PO Box 208057, 333 Cedar Street, New Haven, CT 06520, USA.

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http://pats.atsjournals.org/cgi/doi/10.1513/pats.200604-097A
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http://dx.doi.org/10.1513/pats.200604-097AWDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658702PMC
July 2006

Idiopathic pulmonary fibrosis: natural history and prognosis.

Authors:
Paul W Noble

Clin Chest Med 2006 Mar;27(1 Suppl 1):S11-6, v

Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, 441-C CAB, 333 Cedar Street, New Haven, CT 06520-8057, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S027252310500088
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http://dx.doi.org/10.1016/j.ccm.2005.08.003DOI Listing
March 2006