Publications by authors named "Paul W Manley"

68Publications

Investigations into the Potential Role of Metabolites on the Anti-Leukemic Activity of Imatinib, Nilotinib and Midostaurin.

Authors:
Paul W Manley

Chimia (Aarau) 2019 Aug;73(7):561-570

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Novartis Pharma AG, CH-4002 Basel;, Email:

View Article and Find Full Text PDF
August 2019

Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its Predominant Metabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy.

Biochemistry 2018 09 13;57(38):5576-5590. Epub 2018 Sep 13.

Oncology Disease Area, Novartis Institutes for Biomedical Research , Novartis International AG , CH-4002 Basel , Switzerland.

View Article and Find Full Text PDF
September 2018

Midostaurin, a Natural Product-Derived Kinase Inhibitor Recently Approved for the Treatment of Hematological Malignancies.

Biochemistry 2018 02 30;57(5):477-478. Epub 2017 Nov 30.

Department of Medical Oncology, Dana Farber Cancer Institute , Boston, Massachusetts 02215, United States.

View Article and Find Full Text PDF
February 2018

Erratum to: Imatinib relaxes the pulmonary venous bed of guinea pigs.

Respir Res 2017 06 19;18(1):121. Epub 2017 Jun 19.

Institute of Pharmacology and Toxicology, Medical Faculty Aachen, RWTH-Aachen, Aachen, Germany.

View Article and Find Full Text PDF
June 2017

Imatinib relaxes the pulmonary venous bed of guinea pigs.

Respir Res 2017 02 8;18(1):32. Epub 2017 Feb 8.

Institute of Pharmacology and Toxicology, Medical Faculty Aachen, RWTH-Aachen, Aachen, Germany.

View Article and Find Full Text PDF
February 2017

Nilotinib is more potent than imatinib for treating plexiform neurofibroma in vitro and in vivo.

PLoS One 2014 23;9(10):e107760. Epub 2014 Oct 23.

Berlin Brandenburg Center for Regenerative Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany; Seoul National University, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul, Republic of Korea.

View Article and Find Full Text PDF
June 2015

Phosphoinositide 3-kinase inhibitors combined with imatinib in patient-derived xenograft models of gastrointestinal stromal tumors: rationale and efficacy.

Clin Cancer Res 2014 Dec 14;20(23):6071-82. Epub 2014 Oct 14.

Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven, Belgium. Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.

View Article and Find Full Text PDF
December 2014

Imaging the intracellular distribution of tyrosine kinase inhibitors in living cells with quantitative hyperspectral stimulated Raman scattering.

Nat Chem 2014 Jul 25;6(7):614-22. Epub 2014 May 25.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

View Article and Find Full Text PDF
July 2014

Effects of Jak2 type 1 inhibitors NVP-BSK805 and NVP-BVB808 on Jak2 mutation-positive and Bcr-Abl-positive cell lines.

Acta Haematol 2014 31;132(1):75-86. Epub 2014 Jan 31.

Medizinische Klinik m.S. Hämatologie und Onkologie, Campus Virchow Klinikum, Charité, Universitätsmedizin Berlin, Berlin, Germany.

View Article and Find Full Text PDF
September 2014