Publications by authors named "Paul Thornton"

67Publications

An injectable, self-healing and MMP-inhibiting hyaluronic acid gel via iron coordination.

Int J Biol Macromol 2020 Oct 17;165(Pt B):2022-2029. Epub 2020 Oct 17.

School of Dentistry, St. James's University Hospital, University of Leeds, UK; Clothworkers' Centre for Textile Materials Innovation for Healthcare, School of Design, University of Leeds, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ijbiomac.2020.10.079DOI Listing
October 2020

Appraisal and revalidation for UK doctors: the profession should determine any requirements.

Authors:
Paul Thornton

BMJ 2020 10 19;371:m4030. Epub 2020 Oct 19.

Warwick Medical School, Coventry CV4 7HL, UK.

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http://dx.doi.org/10.1136/bmj.m4030DOI Listing
October 2020

The GLOW Study does not light up the true Pediatric Endocrine Society recommendations for management of hypoglycemia in newborns.

J Pediatr 2020 Oct 27;225:279. Epub 2020 Jun 27.

Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Pediatric Endocrinology and Diabetes, Icahn School of Medicine at Mt Sinai, New York, New York.

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http://dx.doi.org/10.1016/j.jpeds.2020.06.070DOI Listing
October 2020

Treatment Threshold for Neonatal Hypoglycemia.

N Engl J Med 2020 06;382(23):2272

Children's Hospital of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1056/NEJMc2004233DOI Listing
June 2020

Covalent polyester colouration by in situ chromophore creation.

Chem Commun (Camb) 2020 Jun 11;56(47):6360-6363. Epub 2020 May 11.

School of Chemistry, University of Leeds, LS2 9JT, UK.

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http://dx.doi.org/10.1039/d0cc00653jDOI Listing
June 2020

Meticulous Doxorubicin Release from pH-Responsive Nanoparticles Entrapped within an Injectable Thermoresponsive Depot.

Chemistry 2020 Oct 18;26(59):13352-13358. Epub 2020 Sep 18.

School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK.

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http://dx.doi.org/10.1002/chem.202000389DOI Listing
October 2020

A redox-responsive hyaluronic acid-based hydrogel for chronic wound management.

J Mater Chem B 2019 12 11;7(47):7494-7501. Epub 2019 Nov 11.

School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK.

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http://dx.doi.org/10.1039/c9tb01683jDOI Listing
December 2019

Current and Emerging Agents for the Treatment of Hypoglycemia in Patients with Congenital Hyperinsulinism.

Paediatr Drugs 2019 Jun;21(3):123-136

Cook Children's Medical Center Congenital Hyperinsulinism Center, Fort Worth, TX, USA.

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http://dx.doi.org/10.1007/s40272-019-00334-wDOI Listing
June 2019

Rate of Serious Adverse Events Associated with Diazoxide Treatment of Patients with Hyperinsulinism.

Horm Res Paediatr 2019 19;91(1):25-32. Epub 2019 Mar 19.

Division of Neonatology, Cook Children's Medical Center, Fort Worth, Texas, USA.

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http://dx.doi.org/10.1159/000497458DOI Listing
November 2019

Dye-Mediated Interactions in Chitosan-Based Polyelectrolyte/Organoclay Hybrids for Enhanced Adsorption of Industrial Dyes.

ACS Appl Mater Interfaces 2019 Mar 13;11(12):11961-11969. Epub 2019 Mar 13.

School of Chemistry , University of Leeds , Leeds LS2 9JT , U.K.

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http://dx.doi.org/10.1021/acsami.9b01648DOI Listing
March 2019

Exploiting poly(α-hydroxy acids) for the acid-mediated release of doxorubicin and reversible inside-out nanoparticle self-assembly.

Nanoscale 2018 Aug 16;10(29):14201-14206. Epub 2018 Jul 16.

School of Chemistry, University of Leeds, Leeds, United Kingdom LS2 9JT, UK.

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http://dx.doi.org/10.1039/c8nr03897jDOI Listing
August 2018

Poly(amino acid)-polyester graft copolymer nanoparticles for the acid-mediated release of doxorubicin.

Chem Commun (Camb) 2017 Aug 19;53(62):8687-8690. Epub 2017 Jul 19.

School of Chemistry, University of Leeds, LS2 9JT, UK.

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http://dx.doi.org/10.1039/c7cc04504bDOI Listing
August 2017

Octreotide use and safety in infants with hyperinsulinism.

Pharmacoepidemiol Drug Saf 2017 01 2;26(1):26-31. Epub 2016 Dec 2.

Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/pds.4144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286465PMC
January 2017

Glucose-bearing biodegradable poly(amino acid) and poly(amino acid)-poly(ester) conjugates for controlled payload release.

Biomater Sci 2016 Nov;4(12):1792-1801

School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK.

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http://dx.doi.org/10.1039/c6bm00535gDOI Listing
November 2016

Neonates at risk for hypoglycemia: associated neurological outcomes.

Authors:
Paul S Thornton

J Pediatr 2016 Mar;170:343-4

Cook Children's Medical Center, Fort Worth, Texas.

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http://dx.doi.org/10.1016/j.jpeds.2015.12.057DOI Listing
March 2016

A vegetable oil-based organogel for use in pH-mediated drug delivery.

Soft Matter 2015 Dec;11(47):9160-7

School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK.

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http://dx.doi.org/10.1039/c5sm02176fDOI Listing
December 2015

Good quality research demands consent.

Authors:
Paul Thornton

BMJ 2015 Aug 11;351:h4314. Epub 2015 Aug 11.

Kenilworth CV8 1PL, UK

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http://dx.doi.org/10.1136/bmj.h4314DOI Listing
August 2015

The formation of biodegradable micelles from a therapeutic initiator for enzyme-mediated drug delivery.

Chem Commun (Camb) 2015 Jan;51(8):1520-3

School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK.

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http://dx.doi.org/10.1039/c4cc08387cDOI Listing
January 2015

A 14-year old girl with reversible hypoglycemic episodes: the role of ASVS.

Pediatr Dev Pathol 2015 Jan-Feb;18(1):80-3. Epub 2014 Dec 1.

1 Department of Pathology and Laboratory, Cook Children's Medical Center, Fort Worth, Texas 76104, USA.

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http://dx.doi.org/10.2350/14-08-1537-CR.1DOI Listing
March 2015

Diversity by divergence: Solution-phase parallel synthesis of a library of N-diversified 1-oxa-7-azaspiro[4.5]decan-2-yl-propanes and -butanes.

ACS Comb Sci 2013 Nov 9;15(11):564-71. Epub 2013 Oct 9.

Center for Chemical Methodologies and Library Development, The University of Kansas , 2034 Becker Drive, Lawrence, Kansas 66047, United States.

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http://dx.doi.org/10.1021/co4001056DOI Listing
November 2013

Synthesis of a family of spirocyclic scaffolds: building blocks for the exploration of chemical space.

J Org Chem 2013 Jul 26;78(13):6529-39. Epub 2013 Jun 26.

Center for Chemical Methodologies and Library Development, The University of Kansas, 2034 Becker Drive, Lawrence, Kansas 66047, USA.

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http://dx.doi.org/10.1021/jo400738bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754844PMC
July 2013

Enzyme-degradable self-assembled hydrogels from polyalanine-modified poly(ethylene glycol) star polymers.

Macromol Rapid Commun 2013 Feb 3;34(3):257-62. Epub 2013 Jan 3.

Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.

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http://dx.doi.org/10.1002/marc.201200649DOI Listing
February 2013

Block copolypeptides prepared by N-carboxyanhydride ring-opening polymerization.

Macromol Rapid Commun 2012 Feb 31;33(4):272-86. Epub 2012 Jan 31.

Laboratory of Polymer Chemistry,Eindhoven University of Technology, Den Dolech 2, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.

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http://dx.doi.org/10.1002/marc.201100730DOI Listing
February 2012

The generation of hydrophilic polypeptide-siloxane conjugates via n-carboxyanhydride polymerisation.

J Mater Sci Mater Med 2012 Jan 30;23(1):37-45. Epub 2011 Nov 30.

School of Chemical Sciences, Dublin City University, Dublin 9, Ireland.

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http://dx.doi.org/10.1007/s10856-011-4503-4DOI Listing
January 2012

Selective formation of angular tricyclic compounds by ruthenium-mediated ring-rearrangement metathesis.

Chem Commun (Camb) 2012 Jan 15;48(2):233-5. Epub 2011 Nov 15.

Department of Chemistry, Dalhousie University, P. O. Box 15000, Halifax, Nova Scotia, Canada B3H 4R2.

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http://dx.doi.org/10.1039/c1cc15452dDOI Listing
January 2012

Selective enzymatic degradation of self-assembled particles from amphiphilic block copolymers obtained by the combination of N-carboxyanhydride and nitroxide-mediated polymerization.

Biomacromolecules 2011 Oct 9;12(10):3761-9. Epub 2011 Sep 9.

Laboratory of Polymer Chemistry, Eindhoven University of Technology, Den Dolech 2, PO Box 513, 5600 MB Eindhoven, The Netherlands.

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http://dx.doi.org/10.1021/bm2010033DOI Listing
October 2011

In situ generation and intramolecular Schmidt reaction of keto azides in a microwave-assisted flow format.

Chemistry 2011 Aug 27;17(35):9595-8. Epub 2011 Jul 27.

Chemical Methodology and Library Development Center, University of Kansas, Delbert M. Shankel Structural Biology Center, Lawrence, KS 66047-3761, USA.

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http://dx.doi.org/10.1002/chem.201100768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382118PMC
August 2011

Application of 6,7-indole aryne cycloaddition and Pd(0)-catalyzed Suzuki-Miyaura and Buchwald-Hartwig cross-coupling reactions for the preparation of annulated indole libraries.

ACS Comb Sci 2011 Sep 30;13(5):443-8. Epub 2011 Jun 30.

Center of Excellence in Chemical Methodologies and Library Development, University of Kansas, Lawrence, 66047, United States.

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http://dx.doi.org/10.1021/co2000289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959986PMC
September 2011

Vinylogous anionic processes in the formation and interconversion of tetracyclic ring systems.

Org Biomol Chem 2011 May 22;9(9):3447-56. Epub 2011 Mar 22.

Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J3.

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http://dx.doi.org/10.1039/c0ob01152eDOI Listing
May 2011

Bio-functionalisation to enzymatically control the solution properties of a self-supporting polymeric material.

Chem Commun (Camb) 2011 Mar 24;47(11):3108-10. Epub 2011 Jan 24.

School of Chemical Sciences, Dublin City University, Dublin 9, Ireland.

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http://xlink.rsc.org/?DOI=c0cc03647a
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http://dx.doi.org/10.1039/c0cc03647aDOI Listing
March 2011

Synthesis of natural products containing the pyrrolic ring.

Nat Prod Rep 2010 Jan 8;27(12):1801-39. Epub 2010 Oct 8.

Process Research and Development, Bristol-Myers Squibb Pharmaceutical Co., One Squibb Drive, New Brunswick, New Jersey 08903, USA.

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http://xlink.rsc.org/?DOI=c0np00014k
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http://dx.doi.org/10.1039/c0np00014kDOI Listing
January 2010

Research initiatives in neonatal hypoglycemia.

J Pediatr 2010 May 20;156(5):862-3; author reply 863. Epub 2010 Mar 20.

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http://dx.doi.org/10.1016/j.jpeds.2010.01.048DOI Listing
May 2010

Highly specific dual enzyme-mediated payload release from peptide-coated silica particles.

J Am Chem Soc 2010 Feb;132(6):2024-8

School of Chemical Sciences, Dublin City University, Dublin 9, Ireland.

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http://dx.doi.org/10.1021/ja9094439DOI Listing
February 2010

Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations.

J Clin Invest 2008 Aug;118(8):2877-86

Division of Endocrinology/Diabetes, The Children's Hospital of Philadelphia, Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1172/JCI35414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441858PMC
August 2008

Enzyme-responsive hydrogel particles for the controlled release of proteins: designing peptide actuators to match payload.

Soft Matter 2008 Mar;4(4):821-827

Manchester Interdisciplinary Biocentre (MIB) and School of Materials, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.

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http://dx.doi.org/10.1039/b714750cDOI Listing
March 2008

Prenatal diagnosis and postnatal management of diffuse congenital hyperinsulinism: a case report.

Fetal Diagn Ther 2006 12;21(6):515-8. Epub 2006 Sep 12.

The Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1159/000095664DOI Listing
January 2007

Reconciling diabetes management and the ketogenic diet in a child with pyruvate dehydrogenase deficiency.

J Child Neurol 2006 May;21(5):436-9

Division of Pediatric Endocrinology, Columbus Children's Hospital, Columbus, Ohio, USA.

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http://dx.doi.org/10.1177/08830738060210051001DOI Listing
May 2006

A Pauson-Khand and ring-expansion approach to the aquariane ring system.

Org Lett 2006 Jul;8(15):3195-8

Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J3.

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http://dx.doi.org/10.1021/ol0609715DOI Listing
July 2006

The diagnosis of ectopic focal hyperinsulinism of infancy with [18F]-dopa positron emission tomography.

J Clin Endocrinol Metab 2006 Aug 9;91(8):2839-42. Epub 2006 May 9.

London Center for Pediatric Endocrinology and Metabolism, Hospital for Children National Health Service Trust, London WC1N 3JH, United Kingdom.

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http://dx.doi.org/10.1210/jc.2006-0455DOI Listing
August 2006

Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism.

J Pediatr 2006 Feb;148(2):207-12

Divisions of Endocrinology and Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.jpeds.2005.10.002DOI Listing
February 2006

Molecular and immunohistochemical analyses of the focal form of congenital hyperinsulinism.

Mod Pathol 2006 Jan;19(1):122-9

Department of Pathology and Laboratory Medicine, The Childrens' Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/modpathol.3800497DOI Listing
January 2006

Enzyme responsive polymer hydrogel beads.

Chem Commun (Camb) 2005 Dec 2(47):5913-5. Epub 2005 Nov 2.

School of Materials, Materials Science Centre, Manchester, UK.

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http://xlink.rsc.org/?DOI=b511005j
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http://dx.doi.org/10.1039/b511005jDOI Listing
December 2005

Effects of hypoglycemia on developmental outcome in children with congenital hyperinsulinism.

J Pediatr Nurs 2005 Apr;20(2):109-18

Department of Endocrinology, The Children's Hospital of Philadephia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.pedn.2004.12.009DOI Listing
April 2005

Genotype-phenotype correlations in children with congenital hyperinsulinism due to recessive mutations of the adenosine triphosphate-sensitive potassium channel genes.

J Clin Endocrinol Metab 2005 Feb 23;90(2):789-94. Epub 2004 Nov 23.

Division of Endocrinology/Diabetes, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1210/jc.2004-1604DOI Listing
February 2005

Congenital hyperinsulinism: intraoperative biopsy interpretation can direct the extent of pancreatectomy.

Am J Surg Pathol 2004 Oct;28(10):1326-35

Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, 5203 34th Street & Civic Center Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1097/01.pas.0000138000.61897.32DOI Listing
October 2004

A multidisciplinary approach to the focal form of congenital hyperinsulinism leads to successful treatment by partial pancreatectomy.

J Pediatr Surg 2004 Mar;39(3):270-5

Department of Surgery, and The Center for Hyperinsulinism, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.jpedsurg.2003.11.019DOI Listing
March 2004

Histopathology of congenital hyperinsulinism: retrospective study with genotype correlations.

Pediatr Dev Pathol 2003 Jul-Aug;6(4):322-33

Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s10024-002-0026-9DOI Listing
May 2004

Confidentiality: consent is not sufficient.

Authors:
Paul Thornton

Br J Gen Pract 2003 Apr;53(489):269-70

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1314567PMC
April 2003

Complete androgen insensitivity syndrome due to X chromosome inversion: a clinical report.

Am J Med Genet A 2003 Jul;120A(3):434-6

Division of Endocrinology, Children's Hospital of Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1002/ajmg.a.20043DOI Listing
July 2003