Paul Tesar

Paul Tesar

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Paul Tesar

Publications by authors named "Paul Tesar"

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Developing therapeutic strategies to promote myelin repair in multiple sclerosis.

Expert Rev Neurother 2019 Oct 20;19(10):997-1013. Epub 2019 Jun 20.

Mellen Center for MS Treatment and Research, Cleveland Clinic , Cleveland , OH , USA.

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http://dx.doi.org/10.1080/14737175.2019.1632192DOI Listing
October 2019

Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling.

Cell Rep 2019 Jun;27(13):3832-3843.e6

Center for Translational Neuromedicine and Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA; Center for Neuroscience, University of Copenhagen Faculty of Health and Medical Sciences, 2200 Copenhagen N, Denmark; Neuroscience Center, Rigshospitalet, Copenhagen, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193072
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http://dx.doi.org/10.1016/j.celrep.2019.05.088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700735PMC
June 2019

Diverse Chemical Scaffolds Enhance Oligodendrocyte Formation by Inhibiting CYP51, TM7SF2, or EBP.

Cell Chem Biol 2019 Apr 14;26(4):593-599.e4. Epub 2019 Feb 14.

Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474808PMC
April 2019

Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease.

Stem Cell Reports 2018 09 23;11(3):711-726. Epub 2018 Aug 23.

Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135742PMC
September 2018

Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells.

Nat Commun 2018 09 13;9(1):3708. Epub 2018 Sep 13.

Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.

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http://www.nature.com/articles/s41467-018-06102-7
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http://dx.doi.org/10.1038/s41467-018-06102-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137209PMC
September 2018

Drug screening for human genetic diseases using iPSC models.

Hum Mol Genet 2018 08;27(R2):R89-R98

Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

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http://dx.doi.org/10.1093/hmg/ddy186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061782PMC
August 2018

Clemastine fumarate for promotion of optic nerve remyelination.

Lancet 2017 Dec 10;390(10111):2421-2422. Epub 2017 Oct 10.

Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01406736173263
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http://dx.doi.org/10.1016/S0140-6736(17)32639-9DOI Listing
December 2017

iPSC Reprogramming Is Not Just an Open and Shut Case.

Cell Stem Cell 2017 12;21(6):711-712

Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.stem.2017.11.017DOI Listing
December 2017

Lgr5 Marks Post-Mitotic, Lineage Restricted Cerebellar Granule Neurons during Postnatal Development.

PLoS One 2014 10;9(12):e114433. Epub 2014 Dec 10.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114433PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262395PMC
October 2017

Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.

Cell Stem Cell 2017 08 20;21(2):195-208.e6. Epub 2017 Jul 20.

Department of Neurology and Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA; Center for Neuroscience, University of Copenhagen Faculty of Health and Medical Sciences, 2200 Copenhagen N, Denmark; Neuroscience Center, Rigshospitalet, 2100 Copenhagen, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909173023
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http://dx.doi.org/10.1016/j.stem.2017.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576346PMC
August 2017

Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes.

Am J Hum Genet 2017 Apr 30;100(4):617-634. Epub 2017 Mar 30.

Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384098PMC
April 2017

Concise Review: Stem Cell-Based Treatment of Pelizaeus-Merzbacher Disease.

Stem Cells 2017 02 23;35(2):311-315. Epub 2016 Nov 23.

Center for Basic and Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/stem.2530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314962PMC
February 2017

Using iPSC-derived human DA neurons from opioid-dependent subjects to study dopamine dynamics.

Brain Behav 2016 08 25;6(8):e00491. Epub 2016 May 25.

Department of Neurological Surgery Case Western Reserve University Cleveland Ohio 44106.

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http://dx.doi.org/10.1002/brb3.491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884574PMC
August 2016

Depletion of Olig2 in oligodendrocyte progenitor cells infected by Theiler's murine encephalomyelitis virus.

J Neurovirol 2016 06 2;22(3):336-48. Epub 2015 Dec 2.

Department of Biology, The University of Tampa, Tampa, FL, USA.

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http://dx.doi.org/10.1007/s13365-015-0402-7DOI Listing
June 2016

Lower Dopamine D2 Receptor Expression Levels in Human Dopaminergic Neurons Derived From Opioid-Dependent iPSCs.

Am J Psychiatry 2016 Apr;173(4):429-31

From the Departments of Neurological Surgery and of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland; the Intramural Research Program, Clinical Trials Treatment Branch, the Clinical Pharmacology and Therapeutics Research Branch, and the Cellular Neurobiology Branch, NIDA, Baltimore; and the Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Mass.

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http://dx.doi.org/10.1176/appi.ajp.2015.15121545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298893PMC
April 2016

Snapshots of Pluripotency.

Authors:
Paul J Tesar

Stem Cell Reports 2016 Feb 28;6(2):163-7. Epub 2016 Jan 28.

Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750095PMC
February 2016

Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.

Nature 2015 Jun 20;522(7555):216-20. Epub 2015 Apr 20.

1] Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA [2] Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1038/nature14335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528969PMC
June 2015

Epigenomic comparison reveals activation of "seed" enhancers during transition from naive to primed pluripotency.

Cell Stem Cell 2014 Jun;14(6):854-63

Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; National Center for Regenerative Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address:

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http://www.cell.com/cell-stem-cell/pdf/S1934-5909(14)00192-1
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http://www.cell.com/cms/attachment/2024866441/2044539278/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S193459091400192
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http://dx.doi.org/10.1016/j.stem.2014.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149284PMC
June 2014

Generation and characterization of epiblast stem cells from blastocyst-stage mouse embryos.

Methods Mol Biol 2013 ;1074:1-13

Department of Genetics and Genome Sciences, Case Western Reserve, University School of Medicine, Cleveland, OH, USA.

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http://dx.doi.org/10.1007/978-1-62703-628-3_1DOI Listing
March 2014

Derivation of naive human embryonic stem cells.

Proc Natl Acad Sci U S A 2014 Mar 12;111(12):4484-9. Epub 2014 Mar 12.

Institute for Stem Cell and Regenerative Medicine, Departments of Comparative Medicine, Biology, and Biochemistry, and Divisions of Hematology, Metabolism, Endocrinology and Nutrition, and Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195.

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http://dx.doi.org/10.1073/pnas.1319738111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970494PMC
March 2014

NPTX1 regulates neural lineage specification from human pluripotent stem cells.

Cell Rep 2014 Feb 13;6(4):724-36. Epub 2014 Feb 13.

The Neural Stem Cell Institute, 1 Discovery Drive, Rensselaer, NY 12144, USA; Department of Biomedical Sciences, University at Albany, New York State University of New York, Albany, NY 12201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.01.026DOI Listing
February 2014

Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis.

BMC Genet 2013 Jun 17;14:54. Epub 2013 Jun 17.

Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland OH 44106, USA.

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http://dx.doi.org/10.1186/1471-2156-14-54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693958PMC
June 2013

Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells.

Nat Biotechnol 2013 May 14;31(5):426-33. Epub 2013 Apr 14.

Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1038/nbt.2561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678540PMC
May 2013

StemCellDB: the human pluripotent stem cell database at the National Institutes of Health.

Stem Cell Res 2013 Jan 26;10(1):57-66. Epub 2012 Sep 26.

NIH Stem Cell Unit, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.scr.2012.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590800PMC
January 2013

Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells.

Development 2012 Nov 19;139(21):3926-37. Epub 2012 Sep 19.

Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan.

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http://dev.biologists.org/cgi/doi/10.1242/dev.085936
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http://dx.doi.org/10.1242/dev.085936DOI Listing
November 2012

DNA and chromatin modification networks distinguish stem cell pluripotent ground states.

Mol Cell Proteomics 2012 Oct 22;11(10):1036-47. Epub 2012 Jul 22.

Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.

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http://www.mcponline.org/lookup/doi/10.1074/mcp.M111.011114
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http://dx.doi.org/10.1074/mcp.M111.011114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494154PMC
October 2012

Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability.

Proc Natl Acad Sci U S A 2012 Oct 24;109(41):E2766-73. Epub 2012 Aug 24.

Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1073/pnas.1207169109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478648PMC
October 2012

Accessing naïve human pluripotency.

Curr Opin Genet Dev 2012 Jun 29;22(3):272-82. Epub 2012 Mar 29.

Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children's Hospital Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.gde.2012.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171054PMC
June 2012

Stem cells: Cloning advance calls for careful regulation.

Nature 2011 Oct 5;478(7367):36-7. Epub 2011 Oct 5.

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http://dx.doi.org/10.1038/478036cDOI Listing
October 2011

Tracking down the human myelinating cell.

Nat Biotechnol 2011 Oct 13;29(10):881-3. Epub 2011 Oct 13.

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http://dx.doi.org/10.1038/nbt.2004DOI Listing
October 2011

Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells.

Nat Methods 2011 Sep 25;8(11):957-62. Epub 2011 Sep 25.

Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1038/nmeth.1712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400969PMC
September 2011

Epigenetic signatures distinguish multiple classes of enhancers with distinct cellular functions.

Genome Res 2011 Aug 1;21(8):1273-83. Epub 2011 Jun 1.

Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1101/gr.122382.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149494PMC
August 2011

Isolation of epiblast stem cells from preimplantation mouse embryos.

Cell Stem Cell 2011 Mar;8(3):318-25

Department of Genetics & Center for Stem Cell and Regenerative Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1016/j.stem.2011.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073125PMC
March 2011

Isolation and maintenance of mouse epiblast stem cells.

Methods Mol Biol 2010 ;636:25-44

Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/978-1-60761-691-7_2DOI Listing
June 2010

ELF5-enforced transcriptional networks define an epigenetically regulated trophoblast stem cell compartment in the human placenta.

Hum Mol Genet 2010 Jun 30;19(12):2456-67. Epub 2010 Mar 30.

Laboratory for Developmental Genetics & Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddq128DOI Listing
June 2010

Epiblast stem cells contribute new insight into pluripotency and gastrulation.

Dev Growth Differ 2010 Apr 7;52(3):293-301. Epub 2010 Mar 7.

Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://doi.wiley.com/10.1111/j.1440-169X.2010.01171.x
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http://dx.doi.org/10.1111/j.1440-169X.2010.01171.xDOI Listing
April 2010

Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells.

Cell Stem Cell 2010 Mar;6(3):215-26

Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, D-48149 Münster, Germany.

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http://dx.doi.org/10.1016/j.stem.2010.01.003DOI Listing
March 2010

Genetic factors on mouse chromosome 18 affecting susceptibility to testicular germ cell tumors and permissiveness to embryonic stem cell derivation.

Cancer Res 2009 Dec 24;69(23):9112-7. Epub 2009 Nov 24.

Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-3342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375044PMC
December 2009

The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells.

Cell 2008 Oct;135(3):449-61

Harvard Stem Cell Institute, Massachusetts General Hospital, Center for Regenerative Medicine, CPZN - 4256, 185 Cambridge Street, Boston, MA 02114, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740801116
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http://dx.doi.org/10.1016/j.cell.2008.08.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767270PMC
October 2008

New cell lines from mouse epiblast share defining features with human embryonic stem cells.

Nature 2007 Jul 27;448(7150):196-9. Epub 2007 Jun 27.

Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nature05972DOI Listing
July 2007

Characterizing medullary and human mesenchymal stem cell-derived adipocytes.

J Cell Physiol 2006 Jun;207(3):722-8

Department of Biology, Skeletal Research Center, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1002/jcp.20617DOI Listing
June 2006

Derivation of germ-line-competent embryonic stem cell lines from preblastocyst mouse embryos.

Authors:
Paul J Tesar

Proc Natl Acad Sci U S A 2005 Jun 25;102(23):8239-44. Epub 2005 May 25.

Mammalian Development Laboratory, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0503231102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1149445PMC
June 2005

The validity and heritability of self-report osteoarthritis in an Australian older twin sample.

Twin Res 2002 Apr;5(2):98-106

Psychiatry Department, University of Queensland and Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia..

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http://journals.cambridge.org/abstract_S1369052300002488
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http://dx.doi.org/10.1375/1369052022965DOI Listing
April 2002