Publications by authors named "Paul Simons"

51Publications

Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology.

Mol Ther 2019 12 27;27(12):2111-2122. Epub 2019 Aug 27.

Laboratory of Molecular Neurobiology, Center for Biomedical Research of La Rioja (CIBIR), Logroño 26006, La Rioja, Spain; Department of Clinical Neuroscience, Institute of Neurology, University College London, London NW3 2PF, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904801PMC
December 2019

Computed Tomography Analysis for Quantification of Displacement of the Distal Fibula in Different Foot Positions With Weightbearing and Sequentially Increased Instability: An Anatomic Cadaveric Study on Syndesmosis.

J Foot Ankle Surg 2019 Jul;58(4):734-738

Surgeon, Department of Foot and Ankle Surgery, Catholic Clinic Mainz, Mainz, Germany; Department of Trauma, Hand and Reconstructive Surgery, University Hospital Jena, Jena, Germany.

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http://dx.doi.org/10.1053/j.jfas.2018.12.013DOI Listing
July 2019

A role for APP in Wnt signalling links synapse loss with β-amyloid production.

Transl Psychiatry 2018 09 20;8(1):179. Epub 2018 Sep 20.

Maurice Wohl Clinical Neuroscience Institute, King's College London, 5 Cutcombe Road, London, SE5 9RT, UK.

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http://dx.doi.org/10.1038/s41398-018-0231-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145937PMC
September 2018

Influence of tibialis posterior muscle activation on foot anatomy under axial loading: A biomechanical CT human cadaveric study.

Foot Ankle Surg 2017 Dec 20;23(4):250-254. Epub 2016 Jul 20.

Catholic Clinic Mainz, Department of Foot and Ankle Surgery, Mainz, Germany; Friedrich-Schiller University Jena, University Hospital Jena, Department of Trauma, Hand and Reconstructive Surgery, Jena, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.fas.2016.07.003DOI Listing
December 2017

[Fractures of the ankle joint in elderly patients].

Unfallchirurg 2017 Nov;120(11):979-992

Klinik für Unfall- und Wiederherstellungschirurgie, Uniklinik RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.

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http://dx.doi.org/10.1007/s00113-017-0423-1DOI Listing
November 2017

[Minimally invasive osteosynthesis after ankle fractures in geriatric patients : Surgical technique with the aid of headless full thread screws].

Unfallchirurg 2017 Nov;120(11):993-999

Klinik für Unfall- und Wiederherstellungschirurgie, Uniklinik RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.

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http://dx.doi.org/10.1007/s00113-017-0422-2DOI Listing
November 2017

Reconstruction of the lateral tibia plateau fracture with a third triangular support screw: A biomechanical study.

J Orthop Translat 2017 Oct 3;11:30-38. Epub 2017 Jan 3.

Department of Trauma, Hand and reconstructive Surgery, University Hospital Jena, Jena, Germany.

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http://dx.doi.org/10.1016/j.jot.2016.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866407PMC
October 2017

The effects of short-term JNK inhibition on the survival and growth of aged sympathetic neurons.

Neurobiol Aging 2016 10 5;46:138-48. Epub 2016 Jul 5.

Genetics Unit and Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, Royal Free Campus, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.06.016DOI Listing
October 2016

Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivo.

Open Biol 2016 Feb;6(2):150202

Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, Royal Free Campus, University College London, Rowland Hill Street, London NW3 2PF, UK

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http://dx.doi.org/10.1098/rsob.150202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772805PMC
February 2016

Lateral soft-tissue release through a medial incision: Anatomic comparison of two techniques.

Foot Ankle Surg 2015 Jun 8;21(2):113-8. Epub 2014 Nov 8.

Institut für Anatomie 1, Friedrich Schiller Universität, Jena, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.fas.2014.10.004DOI Listing
June 2015

Reducing β-amyloid by inhibition of BACE1: how low should you go?

Biol Psychiatry 2015 Apr;77(8):683-4

Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, University College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.biopsych.2015.03.001DOI Listing
April 2015

First Tarsometatarsal Arthrodesis: An Anatomic Evaluation of Dorsomedial Versus Plantar Plating.

J Foot Ankle Surg 2015 Sep-Oct;54(5):787-92. Epub 2015 Mar 4.

Foot and Ankle Surgery, Katholisches Klinikum Mainz, Mainz, Germany.

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http://dx.doi.org/10.1053/j.jfas.2014.12.028DOI Listing
May 2016

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice.

Mov Disord 2014 Oct 11;29(12):1476-85. Epub 2014 Aug 11.

Department of Clinical Neuroscience, Institute of Neurology, University College London, London, United Kingdom.

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http://doi.wiley.com/10.1002/mds.25978
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http://dx.doi.org/10.1002/mds.25978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204174PMC
October 2014

Lapidus arthrodesis plus osteochondral autograft transplantation in the management of hallux rigidus with an elevated first ray.

Foot Ankle Spec 2014 Apr 30;7(2):135-9. Epub 2013 Dec 30.

Department of Foot and Ankle Surgery, Katholisches Klinikum Mainz, Germany (KK, PS).

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http://dx.doi.org/10.1177/1938640013516856DOI Listing
April 2014

Anatomical evaluation of different approaches for tibiotalocalcaneal arthrodesis.

Foot Ankle Int 2014 Feb 11;35(2):163-7. Epub 2013 Dec 11.

Department of Trauma, Hand and Reconstructive Surgery, Friedrich-Schiller-University Jena, Jena, Germany.

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http://dx.doi.org/10.1177/1071100713517095DOI Listing
February 2014

Modified Lapidus arthrodesis with plantar plate and compression screw for treatment of hallux valgus with hypermobility of the first ray: a preliminary report.

Foot Ankle Surg 2013 Dec 3;19(4):239-44. Epub 2013 Jul 3.

Food and Hand Division, Department of Orthopedics, Friedrich-Schiller-University Jena, Waldkrankenhaus "Rudolf Elle" GmbH, Klosterlausnitzer Straße 81, D-07607 Eisenberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.fas.2013.06.003DOI Listing
December 2013

Pathogenetic mechanisms of amyloid A amyloidosis.

Proc Natl Acad Sci U S A 2013 Oct 19;110(40):16115-20. Epub 2013 Aug 19.

Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1306621110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791773PMC
October 2013

Monitoring systemic amyloidosis using MRI measurements of the extracellular volume fraction.

Amyloid 2013 Jun 26;20(2):93-8. Epub 2013 Apr 26.

Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.

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http://dx.doi.org/10.3109/13506129.2013.787984DOI Listing
June 2013

Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein.

Cardiol Res Pract 2012 7;2012:148796. Epub 2012 May 7.

Division of Medicine, UCL Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.

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http://dx.doi.org/10.1155/2012/148796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356902PMC
August 2012

Oligonucleotide-directed gene-editing technology: mechanisms and future prospects.

Expert Opin Biol Ther 2012 Mar 10;12(3):329-42. Epub 2012 Feb 10.

UCL Medical School, Division of Medicine (Upper 3rd Floor), Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.

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http://dx.doi.org/10.1517/14712598.2012.660522DOI Listing
March 2012

Screening for mutations in the phosphatidylinositol 4-kinase 2-alpha gene in autosomal recessive hereditary spastic paraplegia.

Amyotroph Lateral Scler 2011 Mar 30;12(2):148-9. Epub 2010 Dec 30.

UCL Institute of Neurology, University College, London, UK.

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http://dx.doi.org/10.3109/17482968.2010.543689DOI Listing
March 2011

Infant head growth in male siblings of children with and without autism spectrum disorders.

J Neurodev Disord 2010 Mar;2(1):39-46

Departments of Psychiatry and Pediatrics, Washington University, Saint. Louis, Missouri.

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http://dx.doi.org/10.1007/s11689-009-9036-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908031PMC
March 2010

Overexpression of 5-HT2C receptors in forebrain leads to elevated anxiety and hypoactivity.

Eur J Neurosci 2009 Jul 15;30(2):299-306. Epub 2009 Jul 15.

Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, Scotland.

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http://dx.doi.org/10.1111/j.1460-9568.2009.06831.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777260PMC
July 2009

Loss of phosphatidylinositol 4-kinase 2alpha activity causes late onset degeneration of spinal cord axons.

Proc Natl Acad Sci U S A 2009 Jul 6;106(28):11535-9. Epub 2009 Jul 6.

Division of Medicine, Royal Free Centre for Biomedical Science, University College London Medical School, University College London, London NW3 2PF, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0903011106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710652PMC
July 2009

Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system.

Eur J Neurosci 2008 Apr;27(8):2103-14

Centre for Biomedical Sciences, University College London, Hampstead Campus, Rowland Hill Campus, Rowland Hill Street, London NW3 2PF, UK.

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http://dx.doi.org/10.1111/j.1460-9568.2008.06152.xDOI Listing
April 2008

ProNGF, sortilin, and age-related neurodegeneration.

Ann N Y Acad Sci 2007 Nov;1119:208-15

Centre for Biomedical Sciences, University College London, Hampstead Campus, London, UK.

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http://dx.doi.org/10.1196/annals.1404.024DOI Listing
November 2007

The IGF-I splice variant MGF increases progenitor cells in ALS, dystrophic, and normal muscle.

FEBS Lett 2007 Jun 21;581(14):2727-32. Epub 2007 May 21.

Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, University College London, UK.

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http://dx.doi.org/10.1016/j.febslet.2007.05.030DOI Listing
June 2007

The expression and alternative splicing of alpha-neurexins during Xenopus development.

Int J Dev Biol 2006 ;50(1):39-46

School of Pharmacy and Biomedical Sciences, Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, UK.

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http://www.intjdevbiol.com/paper.php?doi=052068zz
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http://dx.doi.org/10.1387/ijdb.052068zzDOI Listing
April 2006

Rates of hospitalisation for influenza, respiratory syncytial virus and human metapneumovirus among infants and young children.

Vaccine 2006 Jan 25;24(1):102-8. Epub 2005 Feb 25.

Infectious Diseases Unit, Leicester Royal Infirmary, Leicester LE1 5WW, UK.

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http://dx.doi.org/10.1016/j.vaccine.2005.02.004DOI Listing
January 2006

Lack of RNA-DNA oligonucleotide (chimeraplast) mutagenic activity in mouse embryos.

Mol Reprod Dev 2005 Jun;71(2):140-4

Department of Anatomy and Developmental Biology, Hampstead Campus, University College London, London, United Kingdom.

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http://dx.doi.org/10.1002/mrd.20250DOI Listing
June 2005

Correction of the neuropathogenic human apolipoprotein E4 (APOE4) gene to APOE3 in vitro using synthetic RNA/DNA oligonucleotides (chimeraplasts).

J Mol Neurosci 2005 ;25(1):95-103

Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, London, UK.

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http://link.springer.com/10.1385/JMN:25:1:095
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http://dx.doi.org/10.1385/JMN:25:1:095DOI Listing
September 2005

Differential spatio-temporal expression of alpha-dystrobrevin-1 during mouse development.

Gene Expr Patterns 2004 Sep;4(5):583-93

Molecular Medicine Group, Institute of Biomedical and Biomolecular Sciences, School of Pharmacy and Biomedical Sciences, St Michael's Building, White Swan Road, Portsmouth PO1 2DT, UK.

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http://dx.doi.org/10.1016/j.modgep.2004.01.015DOI Listing
September 2004

Influenza-related hospitalizations among young children in Leicestershire.

Pediatr Infect Dis J 2003 Oct;22(10 Suppl):S228-30

Infectious Diseases Unit, Leicester Royal Infirmary, Leicester University, Leicester, UK.

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http://pdfs.journals.lww.com/pidj/2003/10001/Influenza_relat
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/01.inf.0000092193.91306.2fDOI Listing
October 2003