Paul Savage

Paul Savage

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Paul Savage

Publications by authors named "Paul Savage"

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The effect of the American Joint Committee on Cancer eighth edition on breast cancer staging and prognostication.

Eur J Surg Oncol 2019 Oct 23;45(10):1817-1820. Epub 2019 Mar 23.

Faculty of Medicine, McGill University, Montréal, QC, Canada H4A3T2; Department of Surgery, McGill University, Montréal, QC, Canada H3G1A4; Department of Oncology, McGill University, Montréal, QC, Canada H4A3T2.

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http://dx.doi.org/10.1016/j.ejso.2019.03.027DOI Listing
October 2019

Incidence and predictors of postoperative ileus after loop ileostomy closure: a systematic review and meta-analysis.

Surg Endosc 2019 Aug 17;33(8):2430-2443. Epub 2019 Apr 17.

Center for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, 3755 Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1E2, Canada.

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http://dx.doi.org/10.1007/s00464-019-06794-yDOI Listing
August 2019

High-affinity anti-glycan antibodies: challenges and strategies.

Curr Opin Immunol 2019 Aug 28;59:65-71. Epub 2019 Apr 28.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2019.03.004DOI Listing
August 2019

Determining the necessity of phenyl ring π-character in warfarin.

Bioorg Med Chem Lett 2019 Aug 23;29(15):1954-1956. Epub 2019 May 23.

School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane 4072, Queensland, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.05.039DOI Listing
August 2019

Comparative In Vitro Activities of First and Second-Generation Ceragenins Alone and in Combination with Antibiotics Against Multidrug-Resistant Strains.

Antibiotics (Basel) 2019 Aug 27;8(3). Epub 2019 Aug 27.

Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA.

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http://dx.doi.org/10.3390/antibiotics8030130DOI Listing
August 2019

Effects of ceragenins and conventional antimicrobials on Candida albicans and Staphylococcus aureus mono and multispecies biofilms.

Diagn Microbiol Infect Dis 2019 Jul 11:114863. Epub 2019 Jul 11.

Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA. Electronic address:

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http://dx.doi.org/10.1016/j.diagmicrobio.2019.06.014DOI Listing
July 2019

In vitro activities of antimicrobial peptides and ceragenins against Legionella pneumophila.

J Antibiot (Tokyo) 2019 05 12;72(5):291-297. Epub 2019 Feb 12.

Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, Beyazit, Istanbul, 34116, Turkey.

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http://dx.doi.org/10.1038/s41429-019-0148-1DOI Listing
May 2019

Use of ceragenins as a potential treatment for urinary tract infections.

BMC Infect Dis 2019 May 2;19(1):369. Epub 2019 May 2.

Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystok, Mickiewicza 2c, 15-222, Bialystok, Poland.

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http://dx.doi.org/10.1186/s12879-019-3994-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498624PMC
May 2019

Antifungal susceptibilities, in vitro production of virulence factors and activities of ceragenins against Candida spp. isolated from vulvovaginal candidiasis.

Med Mycol 2019 Apr;57(3):291-299

Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, Beyazit, Istanbul, 34116, Turkey.

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http://dx.doi.org/10.1093/mmy/myy023DOI Listing
April 2019

A natural killer T-cell subset that protects against airway hyperreactivity.

J Allergy Clin Immunol 2019 Feb 29;143(2):565-576.e7. Epub 2018 May 29.

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Mass. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183076
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http://dx.doi.org/10.1016/j.jaci.2018.03.022DOI Listing
February 2019

Cyclooctatetraenes through Valence Isomerization of Cubanes: Scope and Limitations.

Chemistry 2019 Feb 29;25(11):2735-2739. Epub 2019 Jan 29.

School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, 4072, Queensland, Australia.

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http://dx.doi.org/10.1002/chem.201805124DOI Listing
February 2019

Synthesis of the seco-Limonoid BCD Ring System Identifies a Hsp90 Chaperon Machinery (p23) Inhibitor.

Chemistry 2019 Jan 20;25(6):1451-1455. Epub 2018 Dec 20.

School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, 4072, Queensland, Australia.

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http://dx.doi.org/10.1002/chem.201805420DOI Listing
January 2019

Titanium isotopes as a tracer for the plume or island arc affinity of felsic rocks.

Proc Natl Acad Sci U S A 2019 01 3;116(4):1132-1135. Epub 2019 Jan 3.

Institut de Physique du Globe de Paris, Université Paris Diderot, Université Sorbonne Paris Cité, CNRS UMR 7154, 75005 Paris, France.

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http://www.pnas.org/lookup/doi/10.1073/pnas.1809164116
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http://dx.doi.org/10.1073/pnas.1809164116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347677PMC
January 2019

Enantioselective synthesis of (R)-2-cubylglycine including unprecedented rhodium mediated C-H insertion of cubane.

Org Biomol Chem 2019 01;17(5):1067-1070

School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, 4072, Queensland, Australia.

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http://dx.doi.org/10.1039/c8ob02959hDOI Listing
January 2019

First examination of the Lough Neagh European eel (Anguilla anguilla) population for eel virus European, eel virus European X and Anguillid Herpesvirus-1 infection by employing novel molecular techniques.

J Fish Dis 2018 Dec 24;41(12):1783-1791. Epub 2018 Aug 24.

Fish Disease Unit, Veterinary Sciences Division, Agri-Food & Biosciences Institute, Belfast, UK.

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http://dx.doi.org/10.1111/jfd.12885DOI Listing
December 2018

Origin and significance of Si and O isotope heterogeneities in Phanerozoic, Archean, and Hadean zircon.

Proc Natl Acad Sci U S A 2018 10 24;115(41):10287-10292. Epub 2018 Sep 24.

Department of Earth Sciences, University of Oregon, Eugene, OR 97403.

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http://dx.doi.org/10.1073/pnas.1808335115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187114PMC
October 2018

Investigation of the in vitro antifungal and antibiofilm activities of ceragenins CSA-8, CSA-13, CSA-44, CSA-131, and CSA-138 against Candida species.

Diagn Microbiol Infect Dis 2018 Aug 28;91(4):324-330. Epub 2018 Mar 28.

Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA. Electronic address:

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http://dx.doi.org/10.1016/j.diagmicrobio.2018.03.014DOI Listing
August 2018

CSA-90 Promotes Bone Formation and Mitigates Methicillin-resistant Staphylococcus aureus Infection in a Rat Open Fracture Model.

Clin Orthop Relat Res 2018 06;476(6):1311-1323

R. Mills, T. L. Cheng, K. Mikulec, L. Peacock, D. G. Little, A. Schindeler, Orthopedic Research & Biotechnology Unit, The Children's Hospital at Westmead, Sydney, Australia T. L. Cheng, D. Isaacs, D. G. Little, A. Schindeler, Discipline of Paediatrics and Child Health, Faculty of Medicine, University of Sydney, Sydney, NSW, Australia D. Isaacs, Department of Infectious Diseases & Microbiology, Children's Hospital at Westmead, Westmead, NSW, Australia C. Genberg, N8 Medical, Dublin, OH, USA P. B. Savage, Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.

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http://dx.doi.org/10.1097/01.blo.0000533624.79802.e1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263573PMC
June 2018

The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression.

Cell Rep 2018 05;23(5):1476-1490

Montreal Clinical Research Institute (IRCM), Montréal, QC H2W 1R7, Canada; Molecular Biology Programs, Université de Montréal, Montréal, QC H3T 1J4, Canada; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada; Department of Anatomy and Cell Biology, McGill University, Montréal, QC H3A 0C7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.04.019DOI Listing
May 2018

Targeting polyelectrolyte networks in purulent body fluids to modulate bactericidal properties of some antibiotics.

Infect Drug Resist 2018 11;11:77-86. Epub 2018 Jan 11.

Department of Physiology, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.2147/IDR.S145337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768182PMC
January 2018

Stiffening of bacteria cells as a first manifestation of bactericidal attack.

Micron 2017 Oct 27;101:95-102. Epub 2017 Jun 27.

Department of Microbiological and Nanobiomedical Engineering, Medical University of Białystok, Mickiewicza 2C, Białystok, Poland. Electronic address:

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http://dx.doi.org/10.1016/j.micron.2017.06.011DOI Listing
October 2017

Kinetic Benchmarking Reveals the Competence of Prenyl Groups in Ring-Closing Metathesis.

Org Lett 2017 10 21;19(19):5332-5335. Epub 2017 Sep 21.

CSIRO Manufacturing, Private Bag 10, Clayton South VIC 3169, Australia.

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http://dx.doi.org/10.1021/acs.orglett.7b02492DOI Listing
October 2017

A Targetable EGFR-Dependent Tumor-Initiating Program in Breast Cancer.

Cell Rep 2017 Oct;21(5):1140-1149

Department of Human Genetics, McGill University, Montréal, QC H3A 0C7, Canada; McGill University and Genome Québec Innovation Centre, Montréal, QC H3A 1A4, Canada; Center of Innovation in Personalized Medicine, Cancer and Mutagen Unit, King Fahd Center for Medical Research, Department of Biochemistry, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.10.015DOI Listing
October 2017

Susceptibility of Colistin-Resistant, Gram-Negative Bacteria to Antimicrobial Peptides and Ceragenins.

Antimicrob Agents Chemother 2017 08 25;61(8). Epub 2017 Jul 25.

Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA

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http://dx.doi.org/10.1128/AAC.00292-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527650PMC
August 2017

Candidacidal Activity of Selected Ceragenins and Human Cathelicidin LL-37 in Experimental Settings Mimicking Infection Sites.

PLoS One 2016 17;11(6):e0157242. Epub 2016 Jun 17.

Department of Physiology, Pathophysiology and Immunology of Infection, The Faculty of Health Sciences of the Jan Kochanowski University in Kielce, Kielce, Poland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157242PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912103PMC
July 2017

The search for new sporicidal agents for medical use: where are we?

Future Microbiol 2017 07 8;12:735-737. Epub 2017 Jun 8.

Department of Microbiological & Nanobiomedical Engineering, Medical University of Białystok, Białystok, Poland.

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http://dx.doi.org/10.2217/fmb-2017-0069DOI Listing
July 2017

Formulation and candidacidal activity of magnetic nanoparticles coated with cathelicidin LL-37 and ceragenin CSA-13.

Sci Rep 2017 07 4;7(1):4610. Epub 2017 Jul 4.

Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystok, 15-222, Białystok, Poland.

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http://dx.doi.org/10.1038/s41598-017-04653-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496903PMC
July 2017

Antimicrobial ceragenins inhibit biofilms and affect mammalian cell viability and migration .

FEBS Open Bio 2017 07 22;7(7):953-967. Epub 2017 May 22.

Dental and Craniofacial Trauma Research & Tissue Regeneration Directorate United States Army Institute of Surgical Research JBSA Fort Sam Houston TX USA.

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http://dx.doi.org/10.1002/2211-5463.12235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494304PMC
July 2017

Anaerobic bacteria growth in the presence of cathelicidin LL-37 and selected ceragenins delivered as magnetic nanoparticles cargo.

BMC Microbiol 2017 Jul 26;17(1):167. Epub 2017 Jul 26.

Department of Microbiological and Nanobiomedical Engineering, Medical University of Białystok, Mickiewicza 2C, Białystok, Poland.

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http://dx.doi.org/10.1186/s12866-017-1075-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530502PMC
July 2017

Improved proliferation of antigen-specific cytolytic T lymphocytes using a multimodal nanovaccine.

Int J Nanomedicine 2016;11:6103-6121. Epub 2016 Nov 16.

Institute of Imaging Science, Vanderbilt University School of Medicine; Department of Radiology and Radiological Sciences; Vanderbilt Institute of Chemical Biology; Department of Biomedical Engineering; Vanderbilt Ingram Cancer Center; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.

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http://dx.doi.org/10.2147/IJN.S112432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117944PMC
March 2017

Inverse hexagonal and cubic micellar lyotropic liquid crystalline phase behaviour of novel double chain sugar-based amphiphiles.

Colloids Surf B Biointerfaces 2017 Mar 7;151:34-38. Epub 2016 Dec 7.

CSIRO Manufacturing, Bag 10, Clayton South MDC, VIC, 3169, Australia.

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http://dx.doi.org/10.1016/j.colsurfb.2016.12.004DOI Listing
March 2017

Sporicidal activity of ceragenin CSA-13 against Bacillus subtilis.

Sci Rep 2017 03 15;7:44452. Epub 2017 Mar 15.

Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystok, Bialystok, Poland.

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http://dx.doi.org/10.1038/srep44452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353641PMC
March 2017

Core-shell magnetic nanoparticles display synergistic antibacterial effects against and when combined with cathelicidin LL-37 or selected ceragenins.

Int J Nanomedicine 2016;11:5443-5455. Epub 2016 Oct 19.

Department of Microbiological and Nanobiomedical Engineering, Medical University of Białystok; Department of Physiology, Pathophysiology and Immunology of Infections, The Faculty of Health Sciences of the Jan Kochanowski University in Kielce.

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http://dx.doi.org/10.2147/IJN.S113706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077129PMC
February 2017

Discrete TCR Binding Kinetics Control Invariant NKT Cell Selection and Central Priming.

J Immunol 2016 11 19;197(10):3959-3969. Epub 2016 Oct 19.

Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada;

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http://dx.doi.org/10.4049/jimmunol.1601382DOI Listing
November 2016

Phase II Trial of Angiotensin-(1-7) for the Treatment of Patients with Metastatic Sarcoma.

Sarcoma 2016 8;2016:4592768. Epub 2016 Nov 8.

Department of Medicine, Section of Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA; Comprehensive Cancer Center of Wake Forest University, Wake Forest School of Medicine, Winston-Salem, NC, USA; Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1155/2016/4592768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118533PMC
November 2016

Serum calcium, albumin and tumor stage in cutaneous malignant melanoma.

Future Oncol 2016 Oct 16;12(19):2205-14. Epub 2016 Jun 16.

University of North Dakota School of Medicine & Health Sciences, 501 N Columbia Rd Stop 9037, Grand Forks, ND 25202-9037, USA.

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http://dx.doi.org/10.2217/fon-2016-0046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066137PMC
October 2016

Magnetic nanoparticles enhance the anticancer activity of cathelicidin LL-37 peptide against colon cancer cells.

Int J Nanomedicine 2015 4;10:3843-53. Epub 2015 Jun 4.

Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystok, Poland ; Department of Physiology, Pathophysiology and Microbiology of Infections, The Faculty of Health Sciences of the Jan Kochanowski University in Kielce, Kielce, Poland.

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http://dx.doi.org/10.2147/IJN.S76104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461127PMC
August 2016

The processing and presentation of lipids and glycolipids to the immune system.

Immunol Rev 2016 07;272(1):109-19

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1111/imr.12431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916853PMC
July 2016

Species Specific Differences of CD1d Oligomer Loading In Vitro.

PLoS One 2015 24;10(11):e0143449. Epub 2015 Nov 24.

Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143449PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657966PMC
June 2016

Biology and treatment of metastasis of sarcoma to the brain.

Front Biosci (Elite Ed) 2016 Jan 1;8:233-44. Epub 2016 Jan 1.

Department of Pathology, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC, 27157,

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January 2016

Total synthesis of a biotinylated rocaglate: Selective targeting of the translation factors eIF4AI/II.

Bioorg Med Chem Lett 2016 Jan 14;26(2):262-264. Epub 2015 Dec 14.

School of Chemistry, The Bio21 Institute, The University of Melbourne, Melbourne, Victoria 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.12.045DOI Listing
January 2016

Endogenous ligands of natural killer T cells are alpha-linked glycosylceramides.

Mol Immunol 2015 Dec 2;68(2 Pt A):94-7. Epub 2015 Jul 2.

The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2015.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624034PMC
December 2015

CSA-131, a ceragenin active against colistin-resistant Acinetobacter baumannii and Pseudomonas aeruginosa clinical isolates.

Int J Antimicrob Agents 2015 Nov 7;46(5):568-71. Epub 2015 Sep 7.

ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clínic-Universitat de Barcelona, Barcelona, Spain; Department of Clinical Microbiology, CDB, Hospital Clinic, School of Medicine, University of Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2015.08.003DOI Listing
November 2015

Bactericidal Activity of Ceragenin CSA-13 in Cell Culture and in an Animal Model of Peritoneal Infection.

Antimicrob Agents Chemother 2015 Oct 27;59(10):6274-82. Epub 2015 Jul 27.

Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.

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http://dx.doi.org/10.1128/AAC.00653-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576122PMC
October 2015

Bactericidal activities of cathelicidin LL-37 and select cationic lipids against the hypervirulent Pseudomonas aeruginosa strain LESB58.

Antimicrob Agents Chemother 2015 Jul 13;59(7):3808-15. Epub 2015 Apr 13.

Department of Microbiological and Nanobiomedical Engineering, Medical University of Białystok, Białystok, Poland Department of Physiology and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA Department of Physiology, Pathophysiology and Microbiology of Infections, The Faculty of Health Sciences, Jan Kochanowski University, Kielce, Poland

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http://dx.doi.org/10.1128/AAC.00421-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468669PMC
July 2015

Cubane: 50 years later.

Chem Rev 2015 Jul 23;115(14):6719-45. Epub 2015 Jun 23.

∥College of Pharmacy, Western New England University, Springfield, Massachusetts 01119, United States.

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http://dx.doi.org/10.1021/cr500523xDOI Listing
July 2015

The direct α-C(sp(3))-H functionalisation of N-aryl tetrahydroisoquinolines via an iron-catalysed aerobic nitro-Mannich reaction and continuous flow processing.

Chem Commun (Camb) 2015 ;51(2):334-7

CSIRO Manufacturing Flagship, Bayview Avenue, Clayton 3168, Victoria, Australia.

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http://dx.doi.org/10.1039/c4cc07913bDOI Listing
May 2015

Bactericidal activity and biocompatibility of ceragenin-coated magnetic nanoparticles.

J Nanobiotechnology 2015 May 1;13:32. Epub 2015 May 1.

Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystok, Mickiewicza 2c, 15-222, Bialystok, Poland.

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http://dx.doi.org/10.1186/s12951-015-0093-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458011PMC
May 2015

Potential synergy activity of the novel ceragenin, CSA-13, against carbapenem-resistant Acinetobacter baumannii strains isolated from bacteremia patients.

Biomed Res Int 2014 24;2014:710273. Epub 2014 Mar 24.

Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, Beyazit, 34116 Istanbul, Turkey.

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http://dx.doi.org/10.1155/2014/710273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996866PMC
January 2015

Silicon isotopes in angrites and volatile loss in planetesimals.

Proc Natl Acad Sci U S A 2014 Dec 17;111(48):17029-32. Epub 2014 Nov 17.

Université de Brest, Institut Universitaire Européen de la Mer, 29280 Plouzané, France.

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http://dx.doi.org/10.1073/pnas.1418889111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260610PMC
December 2014

Porous double-layer polymer tubing for the potential use in heterogeneous continuous flow reactions.

ACS Appl Mater Interfaces 2014 Dec 4;6(24):22838-46. Epub 2014 Dec 4.

Manufacturing Flagship, CSIRO , Bag 10, Clayton South, Victoria 3169, Australia.

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http://dx.doi.org/10.1021/am5070427DOI Listing
December 2014

Vaccine development: NKT-cell adjuvants in conjugate.

Authors:
Paul B Savage

Nat Chem Biol 2014 Nov;10(11):882-3

Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.

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http://dx.doi.org/10.1038/nchembio.1667DOI Listing
November 2014

Efficacy of ABX196, a new NKT agonist, in prophylactic human vaccination.

Vaccine 2014 Oct 13;32(46):6138-45. Epub 2014 Sep 13.

Abivax, 5 rue Henri Desbruères, 91030 Evry cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2014.08.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233108PMC
October 2014

YAP-induced resistance of cancer cells to antitubulin drugs is modulated by a Hippo-independent pathway.

Cancer Res 2014 Aug 8;74(16):4493-503. Epub 2014 May 8.

Department of Pathology and Molecular Medicine, Queen's University, Kingston;

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2712DOI Listing
August 2014

Ceragenin mediated selectivity of antimicrobial silver nanoparticles.

ACS Appl Mater Interfaces 2014 Aug 11;6(16):13900-8. Epub 2014 Aug 11.

Department of Biological and Agricultural Engineering, Louisiana State University and LSU Agcenter , 149 E. B. Doran Building, Baton Rouge, Louisiana 70803, United States.

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http://dx.doi.org/10.1021/am504640fDOI Listing
August 2014

The search for new amphiphiles: synthesis of a modular, high-throughput library.

Beilstein J Org Chem 2014 10;10:1578-88. Epub 2014 Jul 10.

CSIRO Materials Science and Engineering, Bag 10, Clayton South MDC, VIC 3169, Australia ; School of Applied Sciences, College of Science, Engineering and Health, RMIT University, GPO Box 2476, Melbourne, VIC 3001, Australia.

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http://dx.doi.org/10.3762/bjoc.10.163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142986PMC
August 2014

The SUMO conjugating enzyme Ubc9 is required for inducing and maintaining stem cell pluripotency.

Stem Cells 2014 Apr;32(4):1012-20

The Rosalind & Morris Goodman Cancer Research Center, Montréal, Québec, Canada; Department of Anatomy & Cell Biology, Montréal, Québec, Canada.

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http://doi.wiley.com/10.1002/stem.1600
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April 2014

Maghemite, silver, ceragenin conjugate particles for selective binding and contrast of bacteria.

J Colloid Interface Sci 2014 Jan 27;413:167-74. Epub 2013 Sep 27.

Department of Biological and Agricultural Engineering, Louisiana State University and Agricultural Center, 149 E. B. Doran, Baton Rouge, LA 70803, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jcis.2013.09.016DOI Listing
January 2014

Crystal structure of Vδ1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human γδ T cells.

Immunity 2013 Dec 14;39(6):1032-42. Epub 2013 Nov 14.

Committee on Immunology, University of Chicago, Chicago, IL 60637, USA; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2013.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875342PMC
December 2013

Stimulation of natural killer T cells by glycolipids.

Molecules 2013 Dec 16;18(12):15662-88. Epub 2013 Dec 16.

Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA.

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http://dx.doi.org/10.3390/molecules181215662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018217PMC
December 2013

Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity.

Nat Med 2013 Oct 1;19(10):1297-304. Epub 2013 Sep 1.

1] Division of Immunology and Allergy, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. [2].

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http://dx.doi.org/10.1038/nm.3321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079117PMC
October 2013

Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides.

Proc Natl Acad Sci U S A 2013 Oct 16;110(40):16097-102. Epub 2013 Sep 16.

Institute of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.

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http://dx.doi.org/10.1073/pnas.1303218110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791701PMC
October 2013

Synthesis of fungal glycolipid asperamide B and investigation of its ability to stimulate natural killer T cells.

Org Lett 2013 Oct 10;15(20):5242-5. Epub 2013 Oct 10.

Department of Chemistry and Biochemistry, Brigham Young University , Provo, Utah 84602, United States, and Division of Immunology and Allergy, Children's Hospital, Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/ol4024375DOI Listing
October 2013

Ceragenin CSA-13 induces cell cycle arrest and antiproliferative effects in wild-type and p53 null mutant HCT116 colon cancer cells.

Anticancer Drugs 2013 Sep;24(8):826-34

Laboratory of Animal Microbiology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.

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September 2013

Optimization of ceragenins for prevention of bacterial colonization of hydrogel contact lenses.

Invest Ophthalmol Vis Sci 2013 Sep 17;54(9):6217-23. Epub 2013 Sep 17.

Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah.

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http://dx.doi.org/10.1167/iovs.13-12664DOI Listing
September 2013

Chloroform as a hydrogen atom donor in Barton reductive decarboxylation reactions.

J Org Chem 2013 Jul 24;78(13):6677-87. Epub 2013 Jun 24.

ARC Centre of Excellence for Free-Radical Chemistry and Biotechnology, Research School of Chemistry, Australian National University, Canberra, ACT, Australia.

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http://dx.doi.org/10.1021/jo400927yDOI Listing
July 2013

Sumoylation of Krüppel-like factor 4 inhibits pluripotency induction but promotes adipocyte differentiation.

J Biol Chem 2013 May 20;288(18):12791-804. Epub 2013 Mar 20.

Department of Anatomy and Cell Biology, McGill University Health Center, Montréal, Québec H3A 1A3, Canada.

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http://dx.doi.org/10.1074/jbc.M113.465443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642324PMC
May 2013

Hyperconjugation involving strained carbon-carbon bonds. Application of the variable oxygen probe to ester and ether derivatives of cubylmethanol.

Org Biomol Chem 2013 May 27;11(19):3151-8. Epub 2013 Mar 27.

School of Chemistry and the Bio21 Institute, The University of Melbourne, Australia.

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May 2013

Study of the effect of antimicrobial peptide mimic, CSA-13, on an established biofilm formed by Pseudomonas aeruginosa.

Microbiologyopen 2013 Apr 25;2(2):318-25. Epub 2013 Feb 25.

Laboratoire de Chimie biologique et Médicale et de Microbiologie Pharmaceutique, Faculté de Pharmacie, Université libre de Bruxelles, Brussels, Belgium.

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http://dx.doi.org/10.1002/mbo3.77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633355PMC
April 2013

The molecular basis for recognition of CD1d/α-galactosylceramide by a human non-Vα24 T cell receptor.

PLoS Biol 2012 23;10(10):e1001412. Epub 2012 Oct 23.

Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1001412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479090PMC
March 2013

Synthesis of biotinylated episilvestrol: highly selective targeting of the translation factors eIF4AI/II.

Org Lett 2013 Mar 5;15(6):1406-9. Epub 2013 Mar 5.

School of Chemistry, The Bio21 Institute, The University of Melbourne, Melbourne, Victoria 3010, Australia.

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March 2013

Evaluation of a chiral cubane-based Schiff base ligand in asymmetric catalysis reactions.

Beilstein J Org Chem 2012 22;8:1814-8. Epub 2012 Oct 22.

Department of Chemistry, Biochemistry, and Physics, Niagara University, NY 14109, USA.

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http://dx.doi.org/10.3762/bjoc.8.207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511016PMC
December 2012

Scavenger receptors target glycolipids for natural killer T cell activation.

J Clin Invest 2012 Nov 15;122(11):3943-54. Epub 2012 Oct 15.

Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1172/JCI62267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484437PMC
November 2012

Click-chemistry as a mix-and-match kit for amphiphile synthesis.

ACS Comb Sci 2012 Oct 28;14(10):565-9. Epub 2012 Sep 28.

CSIRO Materials Science and Engineering , Private Bag 10, Clayton South MDC, Vic 3169, Australia.

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October 2012