Publications by authors named "Paul S Mischel"

100Publications

Same Script, Different Cast: Different Cell Origins Shape Molecular Features and Therapeutic Response in Glioblastoma.

Cancer Cell 2020 Sep;38(3):311-313

Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA; Moores Cancer Center, University of California at San Diego, La Jolla, CA, USA; Department of Pathology, University of California at San Diego, La Jolla, CA, USA; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA. Electronic address:

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September 2020

Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM.

Mol Cancer Res 2020 08 4;18(8):1142-1152. Epub 2020 May 4.

Division of Pathological Neuroscience, Department of Pathology, Tokyo Women's Medical University, Tokyo, Japan.

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August 2020

Codependency of Metabolism and Epigenetics Drives Cancer Progression: A Review.

Acta Histochem Cytochem 2020 Feb 26;53(1):1-10. Epub 2020 Feb 26.

Department of Pathology, Division of Pathological Neuroscience, Tokyo Women's Medical University, Tokyo 162-8666, Japan.

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February 2020

mTOR complex 2 is an integrator of cancer metabolism and epigenetics.

Cancer Lett 2020 05 5;478:1-7. Epub 2020 Mar 5.

Department of Pathology, Division of Pathological Neuroscience, Tokyo Women's Medical University, Tokyo, 162-8666, Japan.

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May 2020

Altered cellular metabolism in gliomas - an emerging landscape of actionable co-dependency targets.

Nat Rev Cancer 2020 01 5;20(1):57-70. Epub 2019 Dec 5.

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA, USA.

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January 2020

Acyl-CoA-Binding Protein Fuels Gliomagenesis.

Cell Metab 2019 08;30(2):229-230

Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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August 2019

Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling.

Cell Metab 2019 09 11;30(3):525-538.e8. Epub 2019 Jul 11.

Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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September 2019

Extrachromosomal oncogene amplification in tumour pathogenesis and evolution.

Nat Rev Cancer 2019 05;19(5):283-288

Ludwig Institute for Cancer Research, San Diego, La Jolla, CA, USA.

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May 2019

Exploring the landscape of focal amplifications in cancer using AmpliconArchitect.

Nat Commun 2019 01 23;10(1):392. Epub 2019 Jan 23.

Department of Computer Science and Engineering, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.

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January 2019

Metabolic reprogramming in the pathogenesis of glioma: Update.

Neuropathology 2019 Feb 4;39(1):3-13. Epub 2019 Jan 4.

Department of Pathology, Division of Pathological Neuroscience, Tokyo Women's Medical University, Tokyo, Japan.

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February 2019

mTOR Complexes as a Nutrient Sensor for Driving Cancer Progression.

Int J Mol Sci 2018 Oct 21;19(10). Epub 2018 Oct 21.

Department of Pathology, Division of Pathological Neuroscience, Tokyo Women's Medical University, Tokyo 162-8666, Japan.

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October 2018

Breast cancer treatment and its effects on aging.

J Geriatr Oncol 2019 03 2;10(2):346-355. Epub 2018 Aug 2.

Departments of Family Medicine & Public Health, School of Medicine, University of California, San Diego, United States; Department of Internal Medicine, School of Medicine University of California, San Diego, United States; Sam and Rose Stein Institute for Research on Aging, United States. Electronic address:

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March 2019

Targeting cancer's metabolic co-dependencies: A landscape shaped by genotype and tissue context.

Biochim Biophys Acta Rev Cancer 2018 08 23;1870(1):76-87. Epub 2018 May 23.

Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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August 2018

ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer.

Nucleic Acids Res 2018 04;46(7):3309-3325

Computer Science and Engineering, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA.

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April 2018

Molecular and Genetic Determinants of Glioma Cell Invasion.

Int J Mol Sci 2017 Dec 4;18(12). Epub 2017 Dec 4.

Department of Pathology, Tokyo Women's Medical University, Tokyo 162-8666, Japan.

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December 2017

Targeting epidermal growth factor receptor co-dependent signaling pathways in glioblastoma.

Wiley Interdiscip Rev Syst Biol Med 2018 01 11;10(1). Epub 2017 Sep 11.

Ludwig Institute for Cancer Research, Department of Pathology, Moores Cancer Center, University of California San Diego School of Medicine, La Jolla, CA, USA.

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January 2018

mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.

Mol Cell 2017 Jul 22;67(1):128-138.e7. Epub 2017 Jun 22.

Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093 USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093 USA. Electronic address:

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July 2017

Precision cancer therapy is impacted by oncogene-dependent epigenome remodeling.

NPJ Precis Oncol 2017 20;1(1). Epub 2017 Mar 20.

2Ludwig Institute for Cancer Research, La Jolla, CA 92093 USA.

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March 2017

An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers.

Cancer Cell 2016 Nov 13;30(5):683-693. Epub 2016 Oct 13.

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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November 2016

mTORC2 activity in brain cancer: Extracellular nutrients are required to maintain oncogenic signaling.

Bioessays 2016 09 18;38(9):839-44. Epub 2016 Jul 18.

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA, USA.

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September 2016

Challenges in identifying cancer genes by analysis of exome sequencing data.

Nat Commun 2016 07 15;7:12096. Epub 2016 Jul 15.

Cancer Cell Map Initiative (CCMI), 9500 Gilman Drive, La Jolla, California 92093, USA.

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July 2016

PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma.

Cancer Res 2016 08 20;76(16):4708-19. Epub 2016 Jun 20.

The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada. RS McLaughlin, Professor and Chairman, University of Toronto, Toronto, Ontario, Canada. Department of Surgery, Hospital for Sick Children, Ontario, Canada.

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August 2016

Cancer metabolism as a central driving force of glioma pathogenesis.

Brain Tumor Pathol 2016 Jul 13;33(3):161-8. Epub 2016 Jun 13.

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA, 92093, USA.

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July 2016

Old player, new partner: EGFRvIII and cytokine receptor signaling in glioblastoma.

Nat Neurosci 2016 05;19(6):765-7

Department of Pathology and Moores Cancer Center, University of California, San Diego, La Jolla, California, USA.

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May 2016

Molecular classification of gliomas.

Handb Clin Neurol 2016 ;134:97-120

Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany. Electronic address:

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December 2016

Single-cell analysis tools for drug discovery and development.

Nat Rev Drug Discov 2016 Mar 16;15(3):204-16. Epub 2015 Dec 16.

Ludwig Institute for Cancer Research San Diego, Department of Pathology and Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.

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March 2016

Shared Intelligence: A Patient-Derived, Deeply Characterized Glioblastoma Cell Line Resource.

EBioMedicine 2015 Oct 24;2(10):1274-5. Epub 2015 Sep 24.

Ludwig Institute for Cancer Research, La Jolla, CA92093, USA ; Department of Pathology and Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92039, USA.

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October 2015

mTORC2 and Metabolic Reprogramming in GBM: at the Interface of Genetics and Environment.

Brain Pathol 2015 Nov;25(6):755-9

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA.

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November 2015

Metabolic Reprogramming in Brain Cancer: A Coordinated Effort.

Brain Pathol 2015 Nov;25(6):753-4

Ludwig Institute for Cancer Research, San Diego and Department of Pathology, UCSD, San Diego, CA, 92093.

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November 2015

EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling.

Mol Cell 2015 Oct 8;60(2):307-18. Epub 2015 Oct 8.

Ludwig Institute for Cancer Research, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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October 2015

Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance.

Proc Natl Acad Sci U S A 2015 Jul 13;112(30):9406-11. Epub 2015 Jul 13.

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093; Department of Pathology, University of California San Diego, La Jolla, CA 92093

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July 2015

Significance of filamin A in mTORC2 function in glioblastoma.

Mol Cancer 2015 Jul 2;14:127. Epub 2015 Jul 2.

Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA, 90095, USA.

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July 2015

Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma.

Nat Rev Cancer 2015 May 9;15(5):302-10. Epub 2015 Apr 9.

Ludwig Institute for Cancer Research and the Department of Pathology, University of California San Diego, La Jolla, California 92093, USA.

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May 2015

Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance.

Cancer Biol Med 2014 Dec;11(4):255-63

1 Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA ; 2 Neuro-Oncology Program, University of California, Los Angeles, CA 90095, USA.

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December 2014

Mutational landscape of gastric adenocarcinoma in Chinese: implications for prognosis and therapy.

Proc Natl Acad Sci U S A 2015 Jan 12;112(4):1107-12. Epub 2015 Jan 12.

Department of Epidemiology and Biostatistics, Department of Pathology, and Department of Gastrointestinal Surgery, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, People's Republic of China;

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January 2015

A urokinase receptor-Bim signaling axis emerges during EGFR inhibitor resistance in mutant EGFR glioblastoma.

Cancer Res 2015 Jan 28;75(2):394-404. Epub 2014 Nov 28.

Ludwig Institute for Cancer Research, La Jolla, California. Department of Pathology, University of California San Diego, La Jolla, California. The Moores Cancer Center, University of California San Diego, La Jolla, California.

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January 2015

Tumor-suppressive miR148a is silenced by CpG island hypermethylation in IDH1-mutant gliomas.

Clin Cancer Res 2014 Nov 15;20(22):5808-22. Epub 2014 Sep 15.

Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.

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November 2014

Brain Malignancy Steering Committee clinical trials planning workshop: report from the Targeted Therapies Working Group.

Neuro Oncol 2015 Feb 26;17(2):180-8. Epub 2014 Aug 26.

Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (B.M.A., L.T., K.L.L., P.Y.W.); Mayo Clinic, Rochester, Minnesota (E.G., K.V.B., B.P.O., J.N.S.); The University of Texas M.D. Anderson Cancer Center, Houston, Texas (W.K.A.Y., J.F.D., D.A.B.); St. Jude Children's Research Hospital, Memphis, Tennessee (J.M.B.); University of California, Los Angeles, California (T.F.C.); Memorial Sloan-Kettering Cancer Center, New York, New York (J.T.H., I.K.M.); National Cancer Institute, Bethesda, Maryland (B.M., A.T.-A.); Princess Margaret Cancer Centre, Toronto, Ontario, Canada (W.M.); Henry Ford Hospital, Detroit, Michigan (T.M.); University of California, San Diego, La Jolla, California (P.S.M.); University of California, San Francisco, California (M.D.P.); Johns Hopkins University, Baltimore, Maryland (X.Y.).

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February 2015

Greater than the sum of its parts: single-nucleus sequencing identifies convergent evolution of independent EGFR mutants in GBM.

Cancer Discov 2014 Aug;4(8):876-8

Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, California; Department of Pathology, University of California, San Diego, La Jolla, California.

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August 2014

mTORC2 in the center of cancer metabolic reprogramming.

Trends Endocrinol Metab 2014 Jul 21;25(7):364-73. Epub 2014 May 21.

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA. Electronic address:

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July 2014

mTORC2 dictates Warburg effect and drug resistance.

Cell Cycle 2014 28;13(7):1053-4. Epub 2014 Feb 28.

Ludwig Institute for Cancer Research; University of California, San Diego; La Jolla, CA USA; Moores Cancer Center; University of California, San Diego; La Jolla, CA USA; Department of Pathology; University of California, San Diego; La Jolla, CA USA.

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May 2016

Protective properties of radio-chemoresistant glioblastoma stem cell clones are associated with metabolic adaptation to reduced glucose dependence.

PLoS One 2013 18;8(11):e80397. Epub 2013 Nov 18.

Department of Surgery/Surgical Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America ; Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

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July 2014

The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas.

Clin Cancer Res 2013 Oct 12;19(20):5722-32. Epub 2013 Sep 12.

Authors' Affiliations: Laboratory of Molecular Pathology, Ludwig Institute for Cancer Research; Moores Cancer Center; University of California San Diego, La Jolla; Celgene Corporation, San Diego; Department of Neurological Surgery and Brain Tumor Research Center, University of California at San Francisco, San Francisco; California Institute of Technology, Pasadena; Henry Singleton Brain Tumor Program; Jonsson Comprehensive Cancer Center; Department of Neurology, David Geffen UCLA School of Medicine; Department of Molecular and Medical Pharmacology; UCLA Medical Scientist Training Program, University of California, Los Angeles, Los Angeles, California; Celgene Corporation, Summit, New Jersey; Department of Radiation Oncology, Ohio State University Comprehensive Cancer Center and Arthur G. James Cancer Hospital, Columbus, Ohio; Department of Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, Verona, Italy; INSERM; Metabolomics Platform, Institut Gustave Roussy, Villejuif; Université Paris Descartes/Sorbonne Paris Cité; Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers; and Pôle de Biologie, Hôpital Européen Georges Pompidou, Paris, France.

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October 2013

Glioblastoma: from molecular pathology to targeted treatment.

Annu Rev Pathol 2014 5;9:1-25. Epub 2013 Aug 5.

Department of Neurology and Neuro-Oncology Program, University of California, Los Angeles, California 90095; email:

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March 2014

EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer.

Cell Metab 2013 Jun 23;17(6):1000-1008. Epub 2013 May 23.

Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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June 2013

When is hub gene selection better than standard meta-analysis?

PLoS One 2013 17;8(4):e61505. Epub 2013 Apr 17.

Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America.

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November 2013

On the role of 25-hydroxycholesterol synthesis by glioblastoma cell lines. Implications for chemotactic monocyte recruitment.

Exp Cell Res 2013 Jul 26;319(12):1828-1838. Epub 2013 Mar 26.

Institute of Molecular Biology and Biochemistry, Medical University of Graz, Harrachgasse 21, Graz 8010, Austria. Electronic address:

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July 2013

Hypoxia induces a phase transition within a kinase signaling network in cancer cells.

Proc Natl Acad Sci U S A 2013 Apr 25;110(15):E1352-60. Epub 2013 Mar 25.

NanoSystems Biology Cancer Center, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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April 2013

A tale of two approaches: complementary mechanisms of cytotoxic and targeted therapy resistance may inform next-generation cancer treatments.

Carcinogenesis 2013 Apr 1;34(4):725-38. Epub 2013 Mar 1.

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093-0660, USA.

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April 2013

LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin.

Cancer Cell 2013 Feb 24;23(2):143-58. Epub 2013 Jan 24.

Molecular and Cell Biology Laboratory, Dulbecco Center for Cancer Research, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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February 2013

Multiple functions of a glioblastoma fusion oncogene.

J Clin Invest 2013 Feb 9;123(2):548-51. Epub 2013 Jan 9.

Ludwig Institute for Cancer Research, UCSD, La Jolla, California, USA.

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February 2013

Pilot study on "pericytic mimicry" and potential embryonic/stem cell properties of angiotropic melanoma cells interacting with the abluminal vascular surface.

Cancer Microenviron 2013 Apr 29;6(1):19-29. Epub 2012 Dec 29.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles (UCLA) Medical Center, Los Angeles, CA, USA,

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April 2013

Discovery in context: leveraging multidimensional glioblastoma datasets to identify targetable regulatory networks.

Cancer Discov 2012 Aug;2(8):676-8

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California, USA.

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August 2012

HOT models in flux: mitochondrial glucose oxidation fuels glioblastoma growth.

Authors:
Paul S Mischel

Cell Metab 2012 Jun;15(6):789-90

Departments of Pathology and Laboratory Medicine and Molecular and Medical Pharmacology, The David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.

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June 2012

Determining PTEN functional status by network component deduced transcription factor activities.

PLoS One 2012 8;7(2):e31053. Epub 2012 Feb 8.

Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America.

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July 2012

Acridine yellow G blocks glioblastoma growth via dual inhibition of epidermal growth factor receptor and protein kinase C kinases.

J Biol Chem 2012 Feb 3;287(9):6113-27. Epub 2012 Jan 3.

Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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February 2012

Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells.

Proc Natl Acad Sci U S A 2012 Jan 27;109(2):419-24. Epub 2011 Dec 27.

Nanosystems Biology Cancer Center, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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January 2012

Reversing melanoma cross-resistance to BRAF and MEK inhibitors by co-targeting the AKT/mTOR pathway.

PLoS One 2011 14;6(12):e28973. Epub 2011 Dec 14.

Department of Medicine, Division of Hematology/Oncology, University of California Los Angeles, Los Angeles, California, United States of America.

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August 2012