Paul S Mischel

Paul S Mischel

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Paul S Mischel

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Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling.

Cell Metab 2019 Sep 11;30(3):525-538.e8. Epub 2019 Jul 11.

Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742496PMC
September 2019

Acyl-CoA-Binding Protein Fuels Gliomagenesis.

Cell Metab 2019 Aug;30(2):229-230

Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.07.007DOI Listing
August 2019

Extrachromosomal oncogene amplification in tumour pathogenesis and evolution.

Nat Rev Cancer 2019 05;19(5):283-288

Ludwig Institute for Cancer Research, San Diego, La Jolla, CA, USA.

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http://www.nature.com/articles/s41568-019-0128-6
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http://dx.doi.org/10.1038/s41568-019-0128-6DOI Listing
May 2019

Breast cancer treatment and its effects on aging.

J Geriatr Oncol 2019 Mar 2;10(2):346-355. Epub 2018 Aug 2.

Departments of Family Medicine & Public Health, School of Medicine, University of California, San Diego, United States; Department of Internal Medicine, School of Medicine University of California, San Diego, United States; Sam and Rose Stein Institute for Research on Aging, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jgo.2018.07.010DOI Listing
March 2019

Metabolic reprogramming in the pathogenesis of glioma: Update.

Neuropathology 2019 Feb 4;39(1):3-13. Epub 2019 Jan 4.

Department of Pathology, Division of Pathological Neuroscience, Tokyo Women's Medical University, Tokyo, Japan.

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http://doi.wiley.com/10.1111/neup.12535
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http://dx.doi.org/10.1111/neup.12535DOI Listing
February 2019

Exploring the landscape of focal amplifications in cancer using AmpliconArchitect.

Nat Commun 2019 01 23;10(1):392. Epub 2019 Jan 23.

Department of Computer Science and Engineering, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.

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http://www.nature.com/articles/s41467-018-08200-y
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http://dx.doi.org/10.1038/s41467-018-08200-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344493PMC
January 2019

mTOR Complexes as a Nutrient Sensor for Driving Cancer Progression.

Int J Mol Sci 2018 Oct 21;19(10). Epub 2018 Oct 21.

Department of Pathology, Division of Pathological Neuroscience, Tokyo Women's Medical University, Tokyo 162-8666, Japan.

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http://www.mdpi.com/1422-0067/19/10/3267
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http://dx.doi.org/10.3390/ijms19103267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214109PMC
October 2018

Targeting cancer's metabolic co-dependencies: A landscape shaped by genotype and tissue context.

Biochim Biophys Acta Rev Cancer 2018 08 23;1870(1):76-87. Epub 2018 May 23.

Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2018.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193564PMC
August 2018

Targeting epidermal growth factor receptor co-dependent signaling pathways in glioblastoma.

Wiley Interdiscip Rev Syst Biol Med 2018 01 11;10(1). Epub 2017 Sep 11.

Ludwig Institute for Cancer Research, Department of Pathology, Moores Cancer Center, University of California San Diego School of Medicine, La Jolla, CA, USA.

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http://dx.doi.org/10.1002/wsbm.1398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732032PMC
January 2018

Molecular and Genetic Determinants of Glioma Cell Invasion.

Int J Mol Sci 2017 Dec 4;18(12). Epub 2017 Dec 4.

Department of Pathology, Tokyo Women's Medical University, Tokyo 162-8666, Japan.

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http://dx.doi.org/10.3390/ijms18122609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751212PMC
December 2017

mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.

Mol Cell 2017 Jul 22;67(1):128-138.e7. Epub 2017 Jun 22.

Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093 USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093 USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.05.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521991PMC
July 2017

Precision cancer therapy is impacted by oncogene-dependent epigenome remodeling.

NPJ Precis Oncol 2017 20;1(1). Epub 2017 Mar 20.

2Ludwig Institute for Cancer Research, La Jolla, CA 92093 USA.

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http://dx.doi.org/10.1038/s41698-017-0005-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871882PMC
March 2017

Molecular classification of gliomas.

Handb Clin Neurol 2016 ;134:97-120

Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-802997-8.00006-2DOI Listing
December 2016

An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers.

Cancer Cell 2016 Nov 13;30(5):683-693. Epub 2016 Oct 13.

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479636PMC
November 2016

mTORC2 activity in brain cancer: Extracellular nutrients are required to maintain oncogenic signaling.

Bioessays 2016 09 18;38(9):839-44. Epub 2016 Jul 18.

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1002/bies.201600026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501721PMC
September 2016

PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma.

Cancer Res 2016 08 20;76(16):4708-19. Epub 2016 Jun 20.

The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada. RS McLaughlin, Professor and Chairman, University of Toronto, Toronto, Ontario, Canada. Department of Surgery, Hospital for Sick Children, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3079DOI Listing
August 2016

Cancer metabolism as a central driving force of glioma pathogenesis.

Brain Tumor Pathol 2016 Jul 13;33(3):161-8. Epub 2016 Jun 13.

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA, 92093, USA.

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http://dx.doi.org/10.1007/s10014-016-0265-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488809PMC
July 2016

Challenges in identifying cancer genes by analysis of exome sequencing data.

Nat Commun 2016 07 15;7:12096. Epub 2016 Jul 15.

Cancer Cell Map Initiative (CCMI), 9500 Gilman Drive, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/ncomms12096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947162PMC
July 2016

mTORC2 dictates Warburg effect and drug resistance.

Cell Cycle 2014 28;13(7):1053-4. Epub 2014 Feb 28.

Ludwig Institute for Cancer Research; University of California, San Diego; La Jolla, CA USA; Moores Cancer Center; University of California, San Diego; La Jolla, CA USA; Department of Pathology; University of California, San Diego; La Jolla, CA USA.

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http://dx.doi.org/10.4161/cc.28377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013152PMC
May 2016

Old player, new partner: EGFRvIII and cytokine receptor signaling in glioblastoma.

Nat Neurosci 2016 05;19(6):765-7

Department of Pathology and Moores Cancer Center, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1038/nn.4302DOI Listing
May 2016

Single-cell analysis tools for drug discovery and development.

Nat Rev Drug Discov 2016 Mar 16;15(3):204-16. Epub 2015 Dec 16.

Ludwig Institute for Cancer Research San Diego, Department of Pathology and Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/nrd.2015.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883669PMC
March 2016

Metabolic Reprogramming in Brain Cancer: A Coordinated Effort.

Brain Pathol 2015 Nov;25(6):753-4

Ludwig Institute for Cancer Research, San Diego and Department of Pathology, UCSD, San Diego, CA, 92093.

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http://dx.doi.org/10.1111/bpa.12308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096791PMC
November 2015

mTORC2 and Metabolic Reprogramming in GBM: at the Interface of Genetics and Environment.

Brain Pathol 2015 Nov;25(6):755-9

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA.

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http://dx.doi.org/10.1111/bpa.12307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636016PMC
November 2015

EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling.

Mol Cell 2015 Oct 8;60(2):307-18. Epub 2015 Oct 8.

Ludwig Institute for Cancer Research, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609298PMC
October 2015

Shared Intelligence: A Patient-Derived, Deeply Characterized Glioblastoma Cell Line Resource.

EBioMedicine 2015 Oct 24;2(10):1274-5. Epub 2015 Sep 24.

Ludwig Institute for Cancer Research, La Jolla, CA92093, USA ; Department of Pathology and Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92039, USA.

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http://dx.doi.org/10.1016/j.ebiom.2015.09.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634746PMC
October 2015

Significance of filamin A in mTORC2 function in glioblastoma.

Mol Cancer 2015 Jul 2;14:127. Epub 2015 Jul 2.

Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1186/s12943-015-0396-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489161PMC
July 2015

Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance.

Proc Natl Acad Sci U S A 2015 Jul 13;112(30):9406-11. Epub 2015 Jul 13.

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093; Department of Pathology, University of California San Diego, La Jolla, CA 92093

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http://dx.doi.org/10.1073/pnas.1511759112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522814PMC
July 2015

Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma.

Nat Rev Cancer 2015 May 9;15(5):302-10. Epub 2015 Apr 9.

Ludwig Institute for Cancer Research and the Department of Pathology, University of California San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/nrc3918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875778PMC
May 2015

Brain Malignancy Steering Committee clinical trials planning workshop: report from the Targeted Therapies Working Group.

Neuro Oncol 2015 Feb 26;17(2):180-8. Epub 2014 Aug 26.

Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (B.M.A., L.T., K.L.L., P.Y.W.); Mayo Clinic, Rochester, Minnesota (E.G., K.V.B., B.P.O., J.N.S.); The University of Texas M.D. Anderson Cancer Center, Houston, Texas (W.K.A.Y., J.F.D., D.A.B.); St. Jude Children's Research Hospital, Memphis, Tennessee (J.M.B.); University of California, Los Angeles, California (T.F.C.); Memorial Sloan-Kettering Cancer Center, New York, New York (J.T.H., I.K.M.); National Cancer Institute, Bethesda, Maryland (B.M., A.T.-A.); Princess Margaret Cancer Centre, Toronto, Ontario, Canada (W.M.); Henry Ford Hospital, Detroit, Michigan (T.M.); University of California, San Diego, La Jolla, California (P.S.M.); University of California, San Francisco, California (M.D.P.); Johns Hopkins University, Baltimore, Maryland (X.Y.).

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http://dx.doi.org/10.1093/neuonc/nou154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288520PMC
February 2015

A urokinase receptor-Bim signaling axis emerges during EGFR inhibitor resistance in mutant EGFR glioblastoma.

Cancer Res 2015 Jan 28;75(2):394-404. Epub 2014 Nov 28.

Ludwig Institute for Cancer Research, La Jolla, California. Department of Pathology, University of California San Diego, La Jolla, California. The Moores Cancer Center, University of California San Diego, La Jolla, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297573PMC
January 2015

Mutational landscape of gastric adenocarcinoma in Chinese: implications for prognosis and therapy.

Proc Natl Acad Sci U S A 2015 Jan 12;112(4):1107-12. Epub 2015 Jan 12.

Department of Epidemiology and Biostatistics, Department of Pathology, and Department of Gastrointestinal Surgery, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, People's Republic of China;

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http://dx.doi.org/10.1073/pnas.1422640112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313862PMC
January 2015

Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance.

Cancer Biol Med 2014 Dec;11(4):255-63

1 Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA ; 2 Neuro-Oncology Program, University of California, Los Angeles, CA 90095, USA.

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http://www.cancerbiomed.org/index.php/cocr/article/view/823/
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http://dx.doi.org/10.7497/j.issn.2095-3941.2014.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296088PMC
December 2014

Will kinase inhibitors make it as glioblastoma drugs?

Curr Top Microbiol Immunol 2012 ;355:135-69

Department and Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1007/82_2011_178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784987PMC
August 2014

Greater than the sum of its parts: single-nucleus sequencing identifies convergent evolution of independent EGFR mutants in GBM.

Cancer Discov 2014 Aug;4(8):876-8

Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, California; Department of Pathology, University of California, San Diego, La Jolla, California.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521958PMC
August 2014

Protective properties of radio-chemoresistant glioblastoma stem cell clones are associated with metabolic adaptation to reduced glucose dependence.

PLoS One 2013 18;8(11):e80397. Epub 2013 Nov 18.

Department of Surgery/Surgical Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America ; Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080397PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832364PMC
July 2014

mTORC2 in the center of cancer metabolic reprogramming.

Trends Endocrinol Metab 2014 Jul 21;25(7):364-73. Epub 2014 May 21.

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2014.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077930PMC
July 2014

Glioblastoma: from molecular pathology to targeted treatment.

Annu Rev Pathol 2014 5;9:1-25. Epub 2013 Aug 5.

Department of Neurology and Neuro-Oncology Program, University of California, Los Angeles, California 90095; email:

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http://dx.doi.org/10.1146/annurev-pathol-011110-130324DOI Listing
March 2014

When is hub gene selection better than standard meta-analysis?

PLoS One 2013 17;8(4):e61505. Epub 2013 Apr 17.

Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061505PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629234PMC
November 2013

The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas.

Clin Cancer Res 2013 Oct 12;19(20):5722-32. Epub 2013 Sep 12.

Authors' Affiliations: Laboratory of Molecular Pathology, Ludwig Institute for Cancer Research; Moores Cancer Center; University of California San Diego, La Jolla; Celgene Corporation, San Diego; Department of Neurological Surgery and Brain Tumor Research Center, University of California at San Francisco, San Francisco; California Institute of Technology, Pasadena; Henry Singleton Brain Tumor Program; Jonsson Comprehensive Cancer Center; Department of Neurology, David Geffen UCLA School of Medicine; Department of Molecular and Medical Pharmacology; UCLA Medical Scientist Training Program, University of California, Los Angeles, Los Angeles, California; Celgene Corporation, Summit, New Jersey; Department of Radiation Oncology, Ohio State University Comprehensive Cancer Center and Arthur G. James Cancer Hospital, Columbus, Ohio; Department of Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, Verona, Italy; INSERM; Metabolomics Platform, Institut Gustave Roussy, Villejuif; Université Paris Descartes/Sorbonne Paris Cité; Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers; and Pôle de Biologie, Hôpital Européen Georges Pompidou, Paris, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815450PMC
October 2013

Pilot study on "pericytic mimicry" and potential embryonic/stem cell properties of angiotropic melanoma cells interacting with the abluminal vascular surface.

Cancer Microenviron 2013 Apr 29;6(1):19-29. Epub 2012 Dec 29.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles (UCLA) Medical Center, Los Angeles, CA, USA,

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http://dx.doi.org/10.1007/s12307-012-0128-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601217PMC
April 2013

Hypoxia induces a phase transition within a kinase signaling network in cancer cells.

Proc Natl Acad Sci U S A 2013 Apr 25;110(15):E1352-60. Epub 2013 Mar 25.

NanoSystems Biology Cancer Center, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1073/pnas.1303060110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625329PMC
April 2013

Multiple functions of a glioblastoma fusion oncogene.

J Clin Invest 2013 Feb 9;123(2):548-51. Epub 2013 Jan 9.

Ludwig Institute for Cancer Research, UCSD, La Jolla, California, USA.

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http://dx.doi.org/10.1172/JCI67658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561833PMC
February 2013

LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin.

Cancer Cell 2013 Feb 24;23(2):143-58. Epub 2013 Jan 24.

Molecular and Cell Biology Laboratory, Dulbecco Center for Cancer Research, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579627PMC
February 2013

Discovery in context: leveraging multidimensional glioblastoma datasets to identify targetable regulatory networks.

Cancer Discov 2012 Aug;2(8):676-8

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0309DOI Listing
August 2012

Determining PTEN functional status by network component deduced transcription factor activities.

PLoS One 2012 8;7(2):e31053. Epub 2012 Feb 8.

Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031053PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275574PMC
July 2012

HOT models in flux: mitochondrial glucose oxidation fuels glioblastoma growth.

Authors:
Paul S Mischel

Cell Metab 2012 Jun;15(6):789-90

Departments of Pathology and Laboratory Medicine and Molecular and Medical Pharmacology, The David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.cmet.2012.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376384PMC
June 2012

Acridine yellow G blocks glioblastoma growth via dual inhibition of epidermal growth factor receptor and protein kinase C kinases.

J Biol Chem 2012 Feb 3;287(9):6113-27. Epub 2012 Jan 3.

Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1074/jbc.M111.293605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307261PMC
February 2012

Quantification of edema reduction using differential quantitative T2 (DQT2) relaxometry mapping in recurrent glioblastoma treated with bevacizumab.

J Neurooncol 2012 Jan 25;106(1):111-9. Epub 2011 Jun 25.

Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 924 Westwood Blvd., Suite 650, Los Angeles, CA 90095, USA.

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http://link.springer.com/10.1007/s11060-011-0638-x
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http://dx.doi.org/10.1007/s11060-011-0638-xDOI Listing
January 2012

Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells.

Proc Natl Acad Sci U S A 2012 Jan 27;109(2):419-24. Epub 2011 Dec 27.

Nanosystems Biology Cancer Center, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1110865109
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http://dx.doi.org/10.1073/pnas.1110865109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258586PMC
January 2012

Graded functional diffusion map-defined characteristics of apparent diffusion coefficients predict overall survival in recurrent glioblastoma treated with bevacizumab.

Neuro Oncol 2011 Oct 19;13(10):1151-61. Epub 2011 Aug 19.

Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 924 Westwood Blvd., Suite 650, Los Angeles, CA 90024, USA.

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http://dx.doi.org/10.1093/neuonc/nor079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177656PMC
October 2011

Metabolic state of glioma stem cells and nontumorigenic cells.

Proc Natl Acad Sci U S A 2011 Sep 7;108(38):16062-7. Epub 2011 Sep 7.

Department of Radiation Oncology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1073/pnas.1106704108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179043PMC
September 2011

Lost - and found - in translation.

Authors:
Paul S Mischel

J Clin Invest 2011 Aug 1;121(8):3357-9. Epub 2011 Aug 1.

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http://dx.doi.org/10.1172/JCI59686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148756PMC
August 2011

Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway.

Neuro Oncol 2011 Jun 9;13(6):622-34. Epub 2011 May 9.

Department of Neurological Surgery, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1093/neuonc/nor023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107094PMC
June 2011