Paul S Aisen

Paul S Aisen

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Paul S Aisen

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Frequency and longitudinal clinical outcomes of Alzheimer's AT(N) biomarker profiles: A longitudinal study.

Alzheimers Dement 2019 Aug 6. Epub 2019 Aug 6.

Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA; Department of Radiology, University of California, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, CA, USA; Department of Psychiatry, University of California, San Francisco, CA, USA; Department of Neurology, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/j.jalz.2019.05.006DOI Listing
August 2019

The relative efficiency of time-to-progression and continuous measures of cognition in presymptomatic Alzheimer's disease.

Alzheimers Dement (N Y) 2019 18;5:308-318. Epub 2019 Jul 18.

Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego, CA, USA.

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http://dx.doi.org/10.1016/j.trci.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656701PMC
July 2019

Predicting the course of Alzheimer's progression.

Brain Inform 2019 Jun 28;6(1). Epub 2019 Jun 28.

Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego, USA.

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http://dx.doi.org/10.1186/s40708-019-0099-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598897PMC
June 2019

Randomized Trial of Verubecestat for Prodromal Alzheimer's Disease.

N Engl J Med 2019 Apr;380(15):1408-1420

From Merck, Kenilworth, NJ (M.F.E., J.K., T.V., Y. Mukai, Y.Z., W.L., C.F., E.M., L.H.M., Y. Mo, C.S., D.M.); the University of Southern California, San Diego (P.S.A.); Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas (J.L.C.); Banner Alzheimer's Institute, Phoenix, AZ (P.N.T.); Gerontopole, INSERM Unité 1027, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France (B.V.); Yale University School of Medicine, New Haven, CT (C.H.D.); and the Research Center and Memory Clínic, Fundació Alzheimer Centre Educacional, Institut Català de Neurociènces Aplicades-Universitat Internacional de Catalunya, Barcelona, and the Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid - both in Spain (M.B.).

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http://dx.doi.org/10.1056/NEJMoa1812840DOI Listing
April 2019

Alzheimer's Disease Clinical Trials: Moving Toward Successful Prevention.

CNS Drugs 2019 Feb;33(2):99-106

Alzheimer's Therapeutic Research Institute (ATRI), Keck School of Medicine, University of Southern California, 9860 Mesa Rim Road, San Diego, CA, 92121, USA.

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http://dx.doi.org/10.1007/s40263-018-0598-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367028PMC
February 2019

Estimating the Evolution of Disease in the Parkinson's Progression Markers Initiative.

Neurodegener Dis 2018 8;18(4):173-190. Epub 2018 Aug 8.

Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA.

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http://dx.doi.org/10.1159/000488780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314496PMC
January 2019

Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement 2019 01 13;15(1):106-152. Epub 2018 Oct 13.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Alzheimer's Disease Core Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Udall Parkinson's Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jalz.2018.08.005DOI Listing
January 2019

Unsuccessful trials of therapies for Alzheimer's disease.

Lancet 2019 01;393(10166):29

Institute of Neurology, Dementia Research Centre, University College London, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/S0140-6736(18)31896-8DOI Listing
January 2019

Automated and manual hippocampal segmentation techniques: Comparison of results, reproducibility and clinical applicability.

Neuroimage Clin 2019 14;21:101574. Epub 2018 Oct 14.

Department of Neurology, Indiana University, Indianapolis, IN, USA; Department of Radiological Sciences, Indiana University, Indianapolis, IN, USA; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nicl.2018.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413347PMC
October 2018

Bayesian latent time joint mixed-effects model of progression in the Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement (Amst) 2018 29;10:657-668. Epub 2018 Aug 29.

Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego, CA, USA.

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http://dx.doi.org/10.1016/j.dadm.2018.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234901PMC
August 2018

Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer's Disease.

N Engl J Med 2018 05;378(18):1691-1703

From Merck Research Laboratories, Merck, Kenilworth, NJ (M.F.E., J.K., C.S., Y. Mukai, T.V., C.F., E.M., L.H.M., Y. Mo, D.M.); Banner Alzheimer's Institute, Phoenix, AZ (P.N.T.); University of Southern California, San Diego (P.S.A.); Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas (J.L.C.); Gerontopole, INSERM Unité 1027, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France (B.V.); and Leuven Institute of Neuroscience and Disease, Alzheimer Research Center, and the Laboratory for Cognitive Neurology, Department of Neurosciences, Katholieke Universiteit Leuven, and Neurology, University Hospitals - both in Leuven, Belgium (R.V.).

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http://dx.doi.org/10.1056/NEJMoa1706441DOI Listing
May 2018

Deleterious Effect of Butyrylcholinesterase K-Variant in Donepezil Treatment of Mild Cognitive Impairment.

J Alzheimers Dis 2017 ;56(1):229-237

Indiana University School of Medicine, Indiana Alzheimer's Disease Center, Indianapolis, IN, USA.

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http://dx.doi.org/10.3233/JAD-160562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534361PMC
February 2018

Author response: A phase 3 trial of IV immunoglobulin for Alzheimer disease.

Authors:
Paul S Aisen

Neurology 2018 01;90(3):145

(San Diego).

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http://dx.doi.org/10.1212/WNL.0000000000004821DOI Listing
January 2018

Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease.

Neurobiol Aging 2017 Dec 18;60:92-103. Epub 2017 Aug 18.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774672PMC
December 2017

Elevated Brain Amyloid in Cognitively Normal Individuals-Reply.

JAMA 2017 10;318(14):1393-1394

Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California.

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http://dx.doi.org/10.1001/jama.2017.12962DOI Listing
October 2017

Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated amyloid β.

Alzheimers Dement 2017 Sep 28;13(9):1004-1012. Epub 2017 Feb 28.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2017.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573651PMC
September 2017

On the path to 2025: understanding the Alzheimer's disease continuum.

Alzheimers Res Ther 2017 Aug 9;9(1):60. Epub 2017 Aug 9.

Institute for Memory and Alzheimer's Disease (IM2A) and ICM, Salpêtrière University Hospital, Paris University (UPMC), Paris, France.

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http://dx.doi.org/10.1186/s13195-017-0283-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549378PMC
August 2017

Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons.

JAMA 2017 06;317(22):2305-2316

Alzheimer's Therapeutic Research Institute, Department of Neurology, University of Southern California, San Diego.

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http://dx.doi.org/10.1001/jama.2017.6669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736301PMC
June 2017

The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement.

Alzheimers Dement 2017 May 5;13(5):561-571. Epub 2016 Dec 5.

Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Alzheimer's Disease Core Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Udall Parkinson's Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jalz.2016.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536850PMC
May 2017

Association between tau deposition and antecedent amyloid-β accumulation rates in normal and early symptomatic individuals.

Brain 2017 May;140(5):1499-1512

Department of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1093/brain/awx046DOI Listing
May 2017

A phase 3 trial of IV immunoglobulin for Alzheimer disease.

Neurology 2017 May 5;88(18):1768-1775. Epub 2017 Apr 5.

From Weill Cornell Medicine (N.R.R., P.S.), New York, NY; University of California (R.G.T., R.A.R., J.B.B.), San Diego; University of Southern California (M.S.R., R.R., P.S.A.), Los Angeles; Yale University (C.H.v.D.), New Haven, CT; Mayo Clinic (C.R.J., D.S.K.), Rochester, MN; Mount Sinai School of Medicine (M.S.), New York, NY; and Baxalta (D.M.G., S.F.), Bannockburn, IL.

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http://dx.doi.org/10.1212/WNL.0000000000003904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409846PMC
May 2017

Randomized controlled trials in mild cognitive impairment: Sources of variability.

Neurology 2017 May 5;88(18):1751-1758. Epub 2017 Apr 5.

From the Department of Neurology (R.C.P.), Mayo Clinic College of Medicine, Rochester, MN; Department of Neurosciences (R.G.T.), University of California, San Diego, La Jolla; University of Southern California (P.S.A.), Los Angeles; Eli Lilly and Company (R.C.M.), Indianapolis, IN; Division of Medical & Scientific Relations (M.C.C.), Alzheimer's Association, Chicago, IL; and Johns Hopkins School of Medicine (M.S.A.), Baltimore, MD. R.C.M. is currently with Global Alzheimer's Platform Foundation, Washington, DC.

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http://dx.doi.org/10.1212/WNL.0000000000003907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409843PMC
May 2017

Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials.

Alzheimers Dement 2017 Apr 22;13(4):e1-e85. Epub 2017 Mar 22.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Alzheimer's Disease Core Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Udall Parkinson's Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jalz.2016.11.007DOI Listing
April 2017

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease.

J Neuroinflammation 2017 01 3;14(1). Epub 2017 Jan 3.

Alzheimer's Disease Cooperative Study (ADCS), Department of Neurosciences, University of California, La Jolla, San Diego, CA, USA.

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http://dx.doi.org/10.1186/s12974-016-0779-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234138PMC
January 2017

Cross-validation of optimized composites for preclinical Alzheimer's disease.

Alzheimers Dement (N Y) 2017 Jan;3(1):123-129

Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, CA, USA.

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http://dx.doi.org/10.1016/j.trci.2016.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527287PMC
January 2017

Cognitive and functional changes associated with Aβ pathology and the progression to mild cognitive impairment.

Neurobiol Aging 2016 12 26;48:172-181. Epub 2016 Aug 26.

Clinical Memory Research Unit, Faculty of Medicine, Lund University, Lund, Sweden; Memory Clinic, Skåne University Hospital, Lund University, Lund, Sweden; Department of Neurology, Skåne University Hospital, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.08.017DOI Listing
December 2016

Drug development in Alzheimer's disease: the path to 2025.

Alzheimers Res Ther 2016 09 20;8:39. Epub 2016 Sep 20.

Department of Neurology & Alzheimer Center, VU University Medical Center, Amsterdam, Netherlands.

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http://dx.doi.org/10.1186/s13195-016-0207-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028936PMC
September 2016

Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults.

JAMA Neurol 2016 06;73(6):721-32

Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indiana University Health Neuroscience Center, Indianapolis2Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis.

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http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam
Publisher Site
http://dx.doi.org/10.1001/jamaneurol.2016.0580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029278PMC
June 2016

The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer's disease.

Alzheimers Res Ther 2016 06 30;8:25. Epub 2016 Jun 30.

Department of Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1186/s13195-016-0194-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928349PMC
June 2016

Longitudinal decline in mild-to-moderate Alzheimer's disease: Analyses of placebo data from clinical trials.

Alzheimers Dement 2016 05 23;12(5):598-603. Epub 2016 Feb 23.

Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2016.01.002DOI Listing
May 2016

Accelerating rates of cognitive decline and imaging markers associated with β-amyloid pathology.

Neurology 2016 05 15;86(20):1887-96. Epub 2016 Apr 15.

From the Center for Imaging of Neurodegenerative Diseases (P.S.I., R.S.M., R.L.N., D.T., M.W.W.), Department of Veterans Affairs Medical Center, San Francisco; Departments of Radiology and Biomedical Imaging (P.S.I., D.T., M.W.W.) and Psychiatry (R.S.M.), University of California, San Francisco; Clinical Memory Research Unit, Faculty of Medicine (P.S.I., N.M.), Lund University; Memory Clinic (N.M.) and Department of Neurology (N.M.), Skåne University Hospital, Lund University; MedTech West and the Department of Clinical Neuroscience and Rehabilitation (M.S.), University of Gothenburg, Sweden; Department of Neurology (M.C.D., P.S.A.), Keck School of Medicine, University of Southern California, Los Angeles; Helen Wills Neuroscience Institute (W.J.J.), University of California, Berkeley; and Life Sciences Division (M.S., W.J.J.), Lawrence Berkeley National Laboratory, Berkeley CA.

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http://dx.doi.org/10.1212/WNL.0000000000002683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873684PMC
May 2016

Vitamin E in aging persons with Down syndrome: A randomized, placebo-controlled clinical trial.

Neurology 2016 May 4;86(22):2071-6. Epub 2016 May 4.

From the Department of Psychiatry (M.S.), Alzheimer Disease Research Center, Icahn School of Medicine at Mount Sinai, New York; James J. Peters VAMC (M.S.), Bronx, NY; Alzheimer's Therapeutic Research Institute (P.S.A.), University of Southern California, San Diego; Data Coordinating Center (H.F.A.), New York State Psychiatric Institute; Department of Psychiatry (H.F.A.) and Division of Biostatistics (W.-Y.T.), Columbia University College of Physicians and Surgeons, New York, NY; Department of Neurology (F.L.), McLean Hospital, Belmont; Harvard Medical School (F.L.), Boston, MA; and Center for Aging Studies (A.J.D.), George Jervis Clinic, New York State Institute for Basic Research in Developmental Disabilities, Staten Island.

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http://dx.doi.org/10.1212/WNL.0000000000002714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891209PMC
May 2016

Chronic Depressive Symptomatology in Mild Cognitive Impairment Is Associated with Frontal Atrophy Rate which Hastens Conversion to Alzheimer Dementia.

Am J Geriatr Psychiatry 2016 Feb 30;24(2):126-35. Epub 2015 Mar 30.

Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, CA; Department of Psychiatry, University of California San Francisco, San Francisco, CA. Electronic address:

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http://dx.doi.org/10.1016/j.jagp.2015.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973623PMC
February 2016

APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern.

Alzheimers Dement 2015 Dec 7;11(12):1417-1429. Epub 2015 May 7.

Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2015.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637003PMC
December 2015

The transitional association between β-amyloid pathology and regional brain atrophy.

Alzheimers Dement 2015 Oct 9;11(10):1171-9. Epub 2014 Dec 9.

Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/j.jalz.2014.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461550PMC
October 2015

GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP.

Brain 2015 Oct 11;138(Pt 10):3076-88. Epub 2015 Aug 11.

1 Centre for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA 1 Centre for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA 4 Indiana Alzheimer Disease Centre, Indiana University School of Medicine, Indianapolis, IN 46202, USA 5 Centre for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA

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http://dx.doi.org/10.1093/brain/awv231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671479PMC
October 2015

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease.

Neurology 2015 Oct 11;85(16):1383-91. Epub 2015 Sep 11.

From the Department of Neurology (R.S.T., B.A.R.), Georgetown University, Washington, DC; the Department of Neurosciences (R.G.T., J.B.B., R.A.R., R.R., P.S.A.), University of California, San Diego, La Jolla; the Department of Internal Medicine (S.C.), Wake Forest University, Winston-Salem, NC; the Departments of Psychiatry, Neurology, and Neurobiology (C.H.v.D.), Yale University, New Haven, CT; and the Clinical Biotechnology Research Institute (J.M.), Roper St. Francis Healthcare, Charleston, SC.

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http://www.neurology.org/content/early/2015/09/11/WNL.000000
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http://www.neurology.org/content/early/2015/09/11/WNL.000000
Web Search
http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000203
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000002035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626244PMC
October 2015

The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome.

Front Behav Neurosci 2015 14;9:239. Epub 2015 Sep 14.

Alzheimer's Disease Cooperative Study, Department of Neurosciences, UC San Diego School of Medicine, University of California, San Diego La Jolla, CA, USA.

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http://dx.doi.org/10.3389/fnbeh.2015.00239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568340PMC
October 2015

Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials.

Alzheimers Dement 2015 Sep 7;11(9):1069-79. Epub 2014 Oct 7.

Alzheimer's Disease Cooperative Study, Department of Neurosciences, University of California San Diego, School of Medicine, San Diego, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2014.07.156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387108PMC
September 2015

Prevention of sporadic Alzheimer's disease: lessons learned from clinical trials and future directions.

Lancet Neurol 2015 Sep 23;14(9):926-944. Epub 2015 Jul 23.

Inserm UMR1027, F-31073, Toulouse, France; University Toulouse III, Toulouse, France; Department of Geriatric Medicine, CHU Toulouse, Toulouse, France.

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http://dx.doi.org/10.1016/S1474-4422(15)00153-2DOI Listing
September 2015

Alzheimer's Disease Neuroimaging Initiative 2 Clinical Core: Progress and plans.

Alzheimers Dement 2015 Jul;11(7):734-9

Departments of Radiology and Biomedical Imaging, Medicine, Psychiatry and Neurology, University of California San Francisco, San Fransisco, CA, USA.

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http://dx.doi.org/10.1016/j.jalz.2015.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643840PMC
July 2015

The Alzheimer's Disease Neuroimaging Initiative 2 Biomarker Core: A review of progress and plans.

Alzheimers Dement 2015 Jul;11(7):772-91

Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Neurodegenerative Disease Research, Institute on Aging, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2015.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127404PMC
July 2015

Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014.

Alzheimers Dement 2015 Jul;11(7):865-84

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Alzheimer's Disease Core Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Udall Parkinson's Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jalz.2015.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659407PMC
July 2015

2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception.

Alzheimers Dement 2015 Jun;11(6):e1-120

Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Alzheimer's Disease Core Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Udall Parkinson's Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jalz.2014.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469297PMC
June 2015

Biomarkers and cognitive endpoints to optimize trials in Alzheimer's disease.

Ann Clin Transl Neurol 2015 May 21;2(5):534-47. Epub 2015 Mar 21.

Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases San Francisco, California ; Department of Radiology and Biomedical Imaging, University of California San Francisco, California.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435707PMC
May 2015

Brain structure and function as mediators of the effects of amyloid on memory.

Neurology 2015 Mar 13;84(11):1136-44. Epub 2015 Feb 13.

From the Department of Veterans Affairs Medical Center (N.M., P.S.I., S.M., M.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA; Clinical Neurochemistry Laboratory (N.M.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Department of Radiology and Biomedical Imaging (N.M., P.S.I., M.W.), University of California, San Francisco; Alzheimer's Disease Cooperative Study (P.S.A.), Department of Neurosciences, University of California, San Diego, La Jolla; Helen Wills Neuroscience Institute and School of Public Health (W.J.), University of California, Berkeley; and Department of Psychiatry (S.M.), University of California, San Francisco.

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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000137
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http://dx.doi.org/10.1212/WNL.0000000000001375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371407PMC
March 2015

Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment.

Neurobiol Aging 2015 Jan 1;36(1):273-82. Epub 2014 Aug 1.

Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA; Department of Radiology and Biomedical Imaging, University of California, CA, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.07.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832349PMC
January 2015

The preclinical Alzheimer cognitive composite: measuring amyloid-related decline.

JAMA Neurol 2014 Aug;71(8):961-70

Alzheimer's Disease Cooperative Study, Department of Neurosciences, University of California, San Diego, La Jolla.

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http://dx.doi.org/10.1001/jamaneurol.2014.803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439182PMC
August 2014

Developing dementia prevention trials: baseline report of the Home-Based Assessment study.

Alzheimer Dis Assoc Disord 2013 Oct-Dec;27(4):356-62

*Mount Sinai School of Medicine §New York University Langone Medical Center, New York †James J Peters VA Medical Center, Bronx, NY ‡University of California (UCSD), San Diego, La Jolla, CA ∥Oregon Health & Science University ¶Portland VAMC, Portland, OR #Center for Psychological Consultation, Madison, WI **University of Arkansas for Medical Sciences, Little Rock, AR.

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http://dx.doi.org/10.1097/WAD.0b013e3182769c05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943465PMC
July 2014

Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis.

Neurology 2014 Jul 13;83(3):253-60. Epub 2014 Jun 13.

From the Departments of Neurology (D.C.R., J.C.M., R.J.B.), Biostatistics (C.X.), and Psychiatry (A.G.), Washington University School of Medicine, St. Louis, MO; Neurologische Klinik Ludwig-Maximilians-Universität Munich and German Center for Neurodegenerative Diseases (A.D.), Munich, Germany; Department of Neurosciences (P.S.A.), University of California San Diego; Mental Health Research Institute (C.L.M.), University of Melbourne, Australia; Grupo de Neurociencias de Antioquia (N.A.-B., F.L., S.M.), Universidad de Antioquia, Medellín, Colombia; Department of Neurology (E.M.), University of Pittsburgh, PA; Department of Neurology (T.B.), University of Washington, Seattle; Banner Alzheimer's Institute (J.B.S.L., E.M.R., P.N.T.), Phoenix, AZ; Neuroscience Research Australia and University of New South Wales (P.R.S.), Sydney, Australia; Edith Cowan University (R.M.), Western Australia; Easton Center for Alzheimer's Disease Research at UCLA (J.M.R.), Los Angeles, CA; Department of Neurology (R.P.M.), Columbia University, New York, NY; Queen Square Institute of Neurology (N.C.F.), University College London; Department of Neurology (S.S.), Warren Alpert Medical School, Brown University, Providence, RI; and Center for Alzheimer Research and Treatment (R.S.), Brigham and Women's Hospital and Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000000596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117367PMC
July 2014

Serum brain-derived neurotrophic factor and the risk for dementia.

Authors:
Paul S Aisen

JAMA 2014 Apr 23-30;311(16):1684-5

Department of Neurosciences, University of California, San Diego, La Jolla.

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May 2014

Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: a long-range point of view beyond 2020.

Biochem Pharmacol 2014 Apr 22;88(4):426-49. Epub 2013 Nov 22.

Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Département de Neurologie, Hôpital de la Pitié Salpêtrière, Paris, France; Université Pierre et Marie Curie, Paris, France.

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http://dx.doi.org/10.1016/j.bcp.2013.11.009DOI Listing
April 2014

Clinical trial of an inhibitor of RAGE-Aβ interactions in Alzheimer disease.

Neurology 2014 Apr 2;82(17):1536-42. Epub 2014 Apr 2.

From the Department of Neurosciences (D.G., R.G.T., P.S.A.), University of California, San Diego; Pfizer Global Research & Development (J.B., J.Y.M., J.W.K.), Cambridge, MA; Banner Sun Health Research Institute (M.N.S.), Sun City; University of Arizona (M.N.S.), Tucson; and the Department of Psychiatry (C.v.D.), Yale University, New Haven, CT.

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http://dx.doi.org/10.1212/WNL.0000000000000364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011464PMC
April 2014

Neuropsychiatric symptoms and regional neocortical atrophy in mild cognitive impairment and Alzheimer's disease.

Am J Alzheimers Dis Other Demen 2014 Mar 27;29(2):159-65. Epub 2013 Oct 27.

1Department of Neurosciences, University of California, San Diego, CA, USA.

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http://dx.doi.org/10.1177/1533317513507373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351414PMC
March 2014

Association of plasma and cortical amyloid beta is modulated by APOE ε4 status.

Alzheimers Dement 2014 Jan 26;10(1):e9-e18. Epub 2013 Mar 26.

Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2013.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750076PMC
January 2014

Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease.

N Engl J Med 2014 Jan;370(4):311-21

From the Alzheimer's Disease and Memory Disorders Center, Department of Neurology, Baylor College of Medicine, Houston (R.S.D.); Alzheimer's Disease Cooperative Study, Department of Family and Preventive Medicine (R.G.T., R.R., X.S.), and the Department of Neurosciences (R.G.T., R.R., P.S.A., R.M.), University of California at San Diego, San Diego; Indiana Alzheimer Disease Center, Indiana University (M.F.), and Eli Lilly (E.S., H.L.-S., R.M.) - both in Indianapolis; the Department of Neuropathology, School of Medicine, and the Department of Neuropathology and Neuroscience, School of Pharmacological Science, University of Tokyo, Tokyo (T.I.); Gerontopole, Unité Mixte de Recherche 1027, Centre Hospitalier Universitaire Toulouse, Toulouse, France (B.V.); the Department of Medical Ethics and Health Policy, University of Pennsylvania, Philadelphia (S.J.); and the Center for Human Experimental Therapeutics, University of Rochester Medical Center, Rochester, NY (K.K.).

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http://dx.doi.org/10.1056/NEJMoa1312889DOI Listing
January 2014

Detecting When "Quality of Life" Has Been "Enhanced": Estimating Change in Quality of Life Ratings.

Open J Philos 2013 Nov;3(4A):24-31

Department of Neurology, University of California, San Diego, USA.

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http://dx.doi.org/10.4236/ojpp.2013.34A005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514524PMC
November 2013

Focal hemosiderin deposits and β-amyloid load in the ADNI cohort.

Alzheimers Dement 2013 Oct 30;9(5 Suppl):S116-23. Epub 2013 Jan 30.

Department of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2012.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770782PMC
October 2013

Semagacestat for treatment of Alzheimer's disease.

N Engl J Med 2013 10;369(17):1661

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http://dx.doi.org/10.1056/NEJMc1310845DOI Listing
October 2013

The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment.

Am J Geriatr Psychiatry 2013 Sep 6;21(9):906-14. Epub 2013 Feb 6.

Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, San Francisco, CA; Department of Psychiatry, University of California, San Francisco, CA. Electronic address:

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http://dx.doi.org/10.1016/j.jagp.2013.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548455PMC
September 2013

Age and apolipoprotein E genotype influence rate of cognitive decline in nondemented elderly.

Neuropsychology 2013 Jul;27(4):391-401

Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0948, USA.

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http://dx.doi.org/10.1037/a0032707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831285PMC
July 2013

A phase 3 trial of semagacestat for treatment of Alzheimer's disease.

N Engl J Med 2013 Jul;369(4):341-50

Alzheimer's Disease and Memory Disorders Center, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1056/NEJMoa1210951DOI Listing
July 2013

Moving towards early clinical trials for amyloid-targeted therapy in Alzheimer's disease.

Nat Rev Drug Discov 2013 Apr 15;12(4):324. Epub 2013 Mar 15.

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http://dx.doi.org/10.1038/nrd3842-c1DOI Listing
April 2013

Health-related resource use and costs in elderly adults with and without mild cognitive impairment.

J Am Geriatr Soc 2013 Mar 15;61(3):396-402. Epub 2013 Feb 15.

Department of Geriatrics and Palliative Medicine, Alzheimer Disease Research Center, Bronx, NY 10468, USA.

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http://dx.doi.org/10.1111/jgs.12132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928966PMC
March 2013

Amyloid deposition, hypometabolism, and longitudinal cognitive decline.

Ann Neurol 2012 Oct;72(4):578-86

Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, CA 94720-3190, USA.

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http://dx.doi.org/10.1002/ana.23650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786871PMC
October 2012

Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network.

Clin Investig (Lond) 2012 Oct;2(10):975-984

Departments of Neurology and of Pathology and Immunology, and the Programs in Physical Therapy and Occupational Therapy, Washington University, St. Louis, MO (JCM). Other authors' affiliations are as follows: the Departments of Neurology (RB, AF, DH, VB, AO, KM, NS), Biostatistics (CX), Psychiatry (AG), Radiology (TB, DM), and Pathology and Immunology (NC), Washington University School of Medicine, St. Louis; University College London Institute of Neurology, London (MR); the Department of Neurosciences, University of California, San Diego, La Jolla (PA); the Department of Pathology and Laboratory Medicine (BG) and the Center for Bioethics (KQ), Indiana University School of Medicine, Indianapolis; the Departments of Psychiatry (WK) and Neurology (WK, EM), University of Pittsburgh School of Medicine, Pittsburgh; the Centre of Excellence for Alzheimer's Disease Research and Care, Edith Cowan University, Joondalup, WA (RM), the Mental Health Research Institute, University of Melbourne, Melbourne, VIC (CM), and Neuroscience Research Australia and the School of Medical Sciences, University of New South Wales, Sydney (PS) - all in Australia; the Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Department of Neurology, Columbia University College of Physicians and Surgeons, New York (RM); the Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles (JR); the Center for Alzheimer Research and Treatment and the Department of Neurology, Brigham and Women's Hospital, Massachusetts General Hospital, and Harvard Medical School (RS) - all in Boston; the Department of Neurology and the Memory and Aging Program, Butler Hospital, Warren Alpert Medical School of Brown University, Providence, RI (SS); and the Departments of Medicine, Radiology, and Psychiatry, University of California San Francisco (MW).

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http://dx.doi.org/10.4155/cli.12.93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489185PMC
October 2012

Amyloid-β--associated clinical decline occurs only in the presence of elevated P-tau.

Arch Neurol 2012 Jun;69(6):709-13

Department of Radiology, University of California–San Diego, 8950 Villa La Jolla Dr, Ste C101, La Jolla, CA 92037-0841, USA.

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http://dx.doi.org/10.1001/archneurol.2011.3354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423526PMC
June 2012

Considerations in the design of clinical trials for cognitive aging.

J Gerontol A Biol Sci Med Sci 2012 Jun 9;67(7):766-72. Epub 2012 May 9.

Banner Alzheimer's Institute, Banner Research, Translational Genomics Research Institute, University of Arizona College of Medicine, and Arizona Alzheimer's Consortium, Phoenix AZ 85006, USA.

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http://dx.doi.org/10.1093/gerona/gls124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391068PMC
June 2012