Paul Rutgeerts

Paul Rutgeerts

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Paul Rutgeerts

Publications by authors named "Paul Rutgeerts"

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Immunogenicity of Golimumab and its Clinical Relevance in Patients With Ulcerative Colitis.

Inflamm Bowel Dis 2019 Aug;25(9):1532-1540

Janssen Research & Development, LLC, Spring House, Pennsylvania, USA.

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http://dx.doi.org/10.1093/ibd/izz003DOI Listing
August 2019

Reliability of Endoscopic Evaluation of Postoperative Recurrent Crohn's Disease.

Clin Gastroenterol Hepatol 2019 Aug 29. Epub 2019 Aug 29.

Robarts Clinical Trials, Inc. London, Ontario, Canada; Department of Gastroenterology & Hepatology, Amsterdam UMC, University Medical Center, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.08.046DOI Listing
August 2019

Combination Therapy With Infliximab and Azathioprine Improves Infliximab Pharmacokinetic Features and Efficacy: A Post Hoc Analysis.

Clin Gastroenterol Hepatol 2019 Jul 26;17(8):1525-1532.e1. Epub 2018 Sep 26.

Department of Medicine, Digestive Health Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.

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https://linkinghub.elsevier.com/retrieve/pii/S15423565183102
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http://dx.doi.org/10.1016/j.cgh.2018.09.033DOI Listing
July 2019

No Change in Determining Crohn's Disease Recurrence or Need for Endoscopic or Surgical Intervention With Modification of the Rutgeerts' Scoring System.

Clin Gastroenterol Hepatol 2019 Jul 4;17(8):1643-1645. Epub 2018 Oct 4.

Department of Hepatogastroenterology and Digestive Oncology, Haut-Lévêque Hospital, CHU de Bordeaux, Bordeaux, France. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2018.09.047DOI Listing
July 2019

IM-UNITI: 3 Year Efficacy, Safety, and Immunogenicity of Ustekinumab Treatment of Crohn's Disease.

J Crohns Colitis 2019 Jun 3. Epub 2019 Jun 3.

NIHR Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, UK.

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http://dx.doi.org/10.1093/ecco-jcc/jjz110DOI Listing
June 2019

Difference in Pathomechanism Between Crohn's Disease and Ulcerative Colitis Revealed by Colon Transcriptome.

Inflamm Bowel Dis 2019 03;25(4):722-731

Institute of Digestive Diseases, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

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http://dx.doi.org/10.1093/ibd/izy359DOI Listing
March 2019

Gene Expression Signature for Prediction of Golimumab Response in a Phase 2a Open-Label Trial of Patients With Ulcerative Colitis.

Gastroenterology 2018 10 4;155(4):1008-1011.e8. Epub 2018 Jul 4.

Clinical Development, Gastrointestinal, Immunology, Janssen Research and Development, LLC, Spring House, Pennsylvania (former); Novartis Institutes for Biomedical Research, East Hanover, New Jersey.

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http://dx.doi.org/10.1053/j.gastro.2018.06.077DOI Listing
October 2018

Mucosal Healing and Long-term Outcomes of Patients With Inflammatory Bowel Diseases Receiving Clinic-Based vs Trough Concentration-Based Dosing of Infliximab.

Clin Gastroenterol Hepatol 2018 08 1;16(8):1276-1283.e1. Epub 2017 Dec 1.

Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15423565173141
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http://dx.doi.org/10.1016/j.cgh.2017.11.046DOI Listing
August 2018

Chromoendoscopy versus narrow band imaging in UC: a prospective randomised controlled trial.

Gut 2018 06 11;67(6):1087-1094. Epub 2017 Jul 11.

Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Vlaams Brabant, Belgium.

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http://dx.doi.org/10.1136/gutjnl-2016-313213DOI Listing
June 2018

Effect of vedolizumab (anti-α4β7-integrin) therapy on histological healing and mucosal gene expression in patients with UC.

Gut 2018 01 7;67(1):43-52. Epub 2016 Oct 7.

Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1136/gutjnl-2016-312293DOI Listing
January 2018

Genetic and Transcriptomic Bases of Intestinal Epithelial Barrier Dysfunction in Inflammatory Bowel Disease.

Inflamm Bowel Dis 2017 10;23(10):1718-1729

*Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium; †Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium; ‡Laboratory of Complex Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium; §Gene Expression Unit, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; ‖Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium; and ¶Jessa Hospital, Hasselt, Belgium.

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http://dx.doi.org/10.1097/MIB.0000000000001246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461205PMC
October 2017

Vedolizumab Induces Long-term Mucosal Healing in Patients With Crohn's Disease and Ulcerative Colitis.

J Crohns Colitis 2017 Sep;11(9):1085-1089

Division of Gastroenterology and Hepatology, University Hospital Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1093/ecco-jcc/jjx048DOI Listing
September 2017

The safety of vedolizumab for ulcerative colitis and Crohn's disease.

Gut 2017 05 18;66(5):839-851. Epub 2016 Feb 18.

Department of Medicine, Robarts Clinical Trials, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1136/gutjnl-2015-311079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531223PMC
May 2017

Post-Induction Adalimumab Concentration is Associated with Short-Term Mucosal Healing in Patients with Ulcerative Colitis.

J Crohns Colitis 2017 Jan 11;11(1):53-59. Epub 2016 Jul 11.

KU Leuven, Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders [TARGID], and University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium

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http://dx.doi.org/10.1093/ecco-jcc/jjw122DOI Listing
January 2017

Ustekinumab as Induction and Maintenance Therapy for Crohn's Disease.

N Engl J Med 2016 11;375(20):1946-1960

From Robarts Clinical Trials, Robarts Research Institute, Western University, London, ON (B.G.F.), University of Calgary, Calgary, AB (S.G.), and the Division of Gastroenterology and CEGIIR, University of Alberta, Edmonton (L.A.D.) - all in Canada; University of California, San Diego, La Jolla (W.J.S.), and Cedars-Sinai Medical Center, Los Angeles (S.T.) - both in California; Janssen Research and Development, Spring House (C.G., D.J., Y.L., J.R.F., J.J., L.-L.G., Y.M., O.J.A.), and Janssen Scientific Affairs, Horsham (M.A.B.) - both in Pennsylvania; the Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai (B.E.S., J.-F.C.), and New York University School of Medicine (S.K.) - both in New York; Feinberg School of Medicine, Northwestern University, Chicago (S.B.H.); University Hospitals Leuven, Leuven, Belgium (S.V., P.R.); Stellenbosch University, Stellenbosch, South Africa (W.J.V.); Semmelweis University of Budapest, Budapest, Hungary (Z.T.); the Department of Gastroenterology, Hannover Medical School, Hannover, Germany (U.S.); Atlanta Gastroenterology Specialists, Atlanta (B.A.S.); Hôpital Claude Huriez, Lille, France (P.D.); University of Washington Medical Center, Seattle (S.D.L.); and the Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (E.V.L.).

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http://dx.doi.org/10.1056/NEJMoa1602773DOI Listing
November 2016

Long-Term Outcome of Patients with Ulcerative Colitis and Primary Non-response to Infliximab.

J Crohns Colitis 2016 Sep 28;10(9):1015-23. Epub 2016 Mar 28.

KU Leuven, Translational Research Center for Gastrointestinal Disorders, and University Hospitals Leuven, Department of Gastroenterology, Leuven, Belgium

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http://dx.doi.org/10.1093/ecco-jcc/jjw067DOI Listing
September 2016

Reliability among central readers in the evaluation of endoscopic findings from patients with Crohn's disease.

Gut 2016 07 2;65(7):1119-25. Epub 2015 May 2.

Robarts Clinical Trials, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada Division of Gastroenterology, University of California San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1136/gutjnl-2014-308973DOI Listing
July 2016

Donor Species Richness Determines Faecal Microbiota Transplantation Success in Inflammatory Bowel Disease.

J Crohns Colitis 2016 Apr 29;10(4):387-94. Epub 2015 Oct 29.

KU Leuven, Department of Microbiology and Immunology, Rega Institute, Leuven, Belgium VIB, Center for the Biology of Disease, Leuven, Belgium.

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http://dx.doi.org/10.1093/ecco-jcc/jjv203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946755PMC
April 2016

Infliximab Concentration Thresholds During Induction Therapy Are Associated With Short-term Mucosal Healing in Patients With Ulcerative Colitis.

Clin Gastroenterol Hepatol 2016 Apr 8;14(4):543-9. Epub 2015 Dec 8.

KU Leuven, Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders (TARGID), and University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2015.11.014DOI Listing
April 2016

Genome-Wide Copy Number Variation Scan Identifies Complement Component C4 as Novel Susceptibility Gene for Crohn's Disease.

Inflamm Bowel Dis 2016 Mar;22(3):505-15

*Department of Clinical and Experimental Medicine, TARGID, KU Leuven, Leuven, Belgium; †Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium; ‡iMinds Department of Medical Information Technologies, KU Leuven, Leuven, Belgium; §Department of Human Genetics, KU Leuven, Leuven, Belgium; ‖Department of Gastroenterology, Ghent University Hospital, Gent, Belgium; ¶Erasmus Hospital, Free University of Brussels, Department of Gastroenterology, Brussels, Belgium; **Unit of Animal Genomics, Groupe Interdisciplinaire de Genoproteomique Appliquee (GIGA-R) and Faculty of Veterinary Medicine, University of Liege, Liege, Belgium; ††Division of Gastroenterology, Centre Hospitalier Universitaire, Université de Liege, Liège, Belgium; ‡‡Division of Gastroenterology, UZ Leuven, Leuven, Belgium; and §§Department of Electrical Engineering and Computer Science, Bioinformatics-Statistical Genetics, Montefiore Institute, Universty of Liège, Liège, Belgium.

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http://dx.doi.org/10.1097/MIB.0000000000000623DOI Listing
March 2016

Agreement Between Rectosigmoidoscopy and Colonoscopy Analyses of Disease Activity and Healing in Patients With Ulcerative Colitis.

Gastroenterology 2016 Feb 23;150(2):389-95.e3. Epub 2015 Oct 23.

Hospital Clínic de Barcelona, Institut D'Investigacions Biomédiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain.

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http://dx.doi.org/10.1053/j.gastro.2015.10.016DOI Listing
February 2016

Agreement of site and central readings of ileocolonoscopic scores in Crohn's disease: comparison using data from the EXTEND trial.

Gastrointest Endosc 2016 Jan 30;83(1):188-97.e1-3. Epub 2015 Jul 30.

Global Medical Affairs Gastroenterology, AbbVie Inc., North Chicago, Illinois, USA.

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http://dx.doi.org/10.1016/j.gie.2015.06.018DOI Listing
January 2016

Serum Neutrophil Gelatinase B-associated Lipocalin and Matrix Metalloproteinase-9 Complex as a Surrogate Marker for Mucosal Healing in Patients with Crohn's Disease.

J Crohns Colitis 2015 Dec 7;9(12):1079-87. Epub 2015 Sep 7.

Rega Institute for Medical Research, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium

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http://dx.doi.org/10.1093/ecco-jcc/jjv148DOI Listing
December 2015

Anti-Tumor Necrosis Factor Therapy Restores Peripheral Blood B-cell Subsets and CD40 Expression in Inflammatory Bowel Diseases.

Inflamm Bowel Dis 2015 Dec;21(12):2787-96

*Clinical Immunology Unit, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium; †Division of Gastroenterology, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium; ‡Laboratory of Pediatric Immunology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium; §Department of Bioinformatics-Statistical Genetics, Université of Liège, Liège, Belgium; and ‖Experimental Laboratory Immunology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1097/MIB.0000000000000554DOI Listing
December 2015

Strong Upregulation of AIM2 and IFI16 Inflammasomes in the Mucosa of Patients with Active Inflammatory Bowel Disease.

Inflamm Bowel Dis 2015 Nov;21(11):2673-82

*Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium; †Department of Respiratory Medicine, Maastricht University Medical Centre+, Maastricht University, Maastricht, the Netherlands; ‡IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany; §Gene Expression Unit, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; and ‖Translational Cell & Tissue Research, Department of Imaging & Pathology, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1097/MIB.0000000000000535DOI Listing
November 2015

Central Reading of Endoscopy Endpoints in Inflammatory Bowel Disease Trials.

Inflamm Bowel Dis 2015 Oct;21(10):2475-82

*Gastroenterology Center of Excellence, Quintiles, Durham, North Carolina; †Translational Gastroenterology Unit, Oxford University Hospitals, Oxford, United Kingdom; ‡Robarts Research Institute, Western University, London, ON, Canada; §Division of Gastroenterology, University of California San Diego, San Diego, California; and ||Division of Translational Research in Gastrointestinal Disorders, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1097/MIB.0000000000000470DOI Listing
October 2015

Safety and Efficacy of an Oral Inhibitor of the Purinergic Receptor P2X7 in Adult Patients with Moderately to Severely Active Crohn's Disease: A Randomized Placebo-controlled, Double-blind, Phase IIa Study.

Inflamm Bowel Dis 2015 Oct;21(10):2247-53

*Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; †Icahn School of Medicine at Mount Sinai, New York, New York; ‡Department of Gastroenterology, Catholic University of Leuven, Leuven, Belgium; §Respiratory Projects, Global Medicines Development, AstraZeneca R&D, Alderley Park, United Kingdom; and ‖AstraZeneca R&D Mölndal, Biometrics & Information Sciences, Mölndal, Sweden.

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http://dx.doi.org/10.1097/MIB.0000000000000514DOI Listing
October 2015

Restoration of Foxp3+ Regulatory T-cell Subsets and Foxp3- Type 1 Regulatory-like T Cells in Inflammatory Bowel Diseases During Anti-tumor Necrosis Factor Therapy.

Inflamm Bowel Dis 2015 Oct;21(10):2418-28

*Clinical Immunology Unit, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium; †Division of Gastroenterology, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium; ‡Laboratory of Pediatric Immunology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium; and §Department of Bioinformatics-Statistical Genetics, Université de Liège, Liège, Belgium.

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https://academic.oup.com/ibdjournal/article/21/10/2418-2428/
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http://dx.doi.org/10.1097/MIB.0000000000000509DOI Listing
October 2015

Integrated miRNA and mRNA expression profiling in inflamed colon of patients with ulcerative colitis.

PLoS One 2014 29;9(12):e116117. Epub 2014 Dec 29.

Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium; Gene Expression Unit, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116117PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278881PMC
September 2015

A phase II study of laquinimod in Crohn's disease.

Gut 2015 Aug 3;64(8):1227-35. Epub 2014 Oct 3.

Robarts Research Institute University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1136/gutjnl-2014-307118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515993PMC
August 2015

Long-term outcome of patients with Crohn's disease who discontinued infliximab therapy upon clinical remission.

Clin Gastroenterol Hepatol 2015 Jun 3;13(6):1103-10. Epub 2014 Dec 3.

Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, Katholieke Universiteit Leuven, Leuven, Belgium; Department of Gastroenterology, Universitair ziekenhuis Leuven, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2014.11.026DOI Listing
June 2015

Trough concentrations of infliximab guide dosing for patients with inflammatory bowel disease.

Gastroenterology 2015 Jun 24;148(7):1320-9.e3. Epub 2015 Feb 24.

Department of Gastroenterology, University Hospitals Leuven, KU Leuven-University of Leuven, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.02.031DOI Listing
June 2015

Faecal metabolite profiling identifies medium-chain fatty acids as discriminating compounds in IBD.

Gut 2015 Mar 8;64(3):447-58. Epub 2014 May 8.

Translational Research Center for Gastrointestinal Disorders (TARGID) and Leuven Food Science and Nutrition Research Centre (LFoRCe), University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1136/gutjnl-2013-306423DOI Listing
March 2015

A panel to predict long-term outcome of infliximab therapy for patients with ulcerative colitis.

Clin Gastroenterol Hepatol 2015 Mar 10;13(3):531-8. Epub 2014 Aug 10.

Department of Gastroenterology, University Hospitals Leuven, KU Leuven-University of Leuven, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2014.07.055DOI Listing
March 2015

Change in erythrocyte mean corpuscular volume during combination therapy with azathioprine and infliximab is associated with mucosal healing: a post hoc analysis from SONIC.

Inflamm Bowel Dis 2015 Mar;21(3):606-14

*Division of Gastroenterology, University of California San Diego, La Jolla, California; †Service des Maladie de l'Appareil Digestif et INSERM U991, Centre Hospitalier Universitaire Pontchaillou et université de Rennes 1, Rennes, France; ‡Digestive Disease Associates, Gainesville, Florida; §Department of Medical Affairs, Janssen Biotech Inc., Horsham, Pennsylvania; ‖Department of Gastroenterology, Icahn Medical School at Mount Sinai, New York, New York; ¶Department of Gastroenterology, Academic Medical Center, Amsterdam, the Netherlands; **Imelda ziekenhuis, Bonheiden, Belgium; ††Department of Gastroenterology, Evangelismos Hospital, Athens, Greece; ‡‡Department of Medicine, ShaareZedek Medical Center, Jerusalem, Israel; §§Department of Internal Medicine III, University Vienna, Vienna, Austria; ‖‖Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium; and ¶¶Departments of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1097/MIB.0000000000000302DOI Listing
March 2015

Short-term effect of infliximab is reflected in the clot lysis profile of patients with inflammatory bowel disease: a prospective study.

Inflamm Bowel Dis 2015 Mar;21(3):570-8

*Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven, Leuven, Belgium; †Systems and Modeling Unit, Montefiore Institute, University of Liège, Liège, Belgium; ‡Translational Research in Gastrointestinal Disorders, Department of Gastroenterology, Universitair Ziekenhuis Leuven, Leuven, Belgium; and §Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Universitair Ziekenhuis Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1097/MIB.0000000000000301DOI Listing
March 2015

Inflammation-Induced Downregulation of Butyrate Uptake and Oxidation Is Not Caused by a Reduced Gene Expression.

J Cell Physiol 2015 Feb;230(2):418-26

Translational Research Center for Gastrointestinal Disorders (TARGID) and Leuven Food Science and Nutrition Research Centre (LFoRCe), University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/jcp.24725DOI Listing
February 2015

A rule for determining risk of colorectal cancer in patients with inflammatory bowel disease.

Clin Gastroenterol Hepatol 2015 Jan 17;13(1):148-54.e1. Epub 2014 Jul 17.

Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Heidelberglaan, The Netherlands.

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http://dx.doi.org/10.1016/j.cgh.2014.06.032DOI Listing
January 2015

Role for therapeutic drug monitoring during induction therapy with TNF antagonists in IBD: evolution in the definition and management of primary nonresponse.

Inflamm Bowel Dis 2015 Jan;21(1):182-97

Departments of *Clinical and Experimental Medicine; †Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium; ‡Division of Gastroenterology, University of California San Diego, La Jolla, California; and §Robarts Clinical Trials, Western University, London, ON, Canada.

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http://pdfs.journals.lww.com/ibdjournal/2015/01000/Role_for_
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http://dx.doi.org/10.1097/MIB.0000000000000202DOI Listing
January 2015

Association between serum concentration of infliximab and efficacy in adult patients with ulcerative colitis.

Gastroenterology 2014 Dec 28;147(6):1296-1307.e5. Epub 2014 Aug 28.

Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; McMaster University, Hamilton, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085140107
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http://dx.doi.org/10.1053/j.gastro.2014.08.035DOI Listing
December 2014

Early trough levels and antibodies to infliximab predict safety and success of reinitiation of infliximab therapy.

Clin Gastroenterol Hepatol 2014 Sep 29;12(9):1474-81.e2; quiz e91. Epub 2014 Jan 29.

Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S15423565140014
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http://dx.doi.org/10.1016/j.cgh.2014.01.033DOI Listing
September 2014

A20 controls intestinal homeostasis through cell-specific activities.

Nat Commun 2014 Sep 30;5:5103. Epub 2014 Sep 30.

1] Unit of Molecular Signal Transduction in Inflammation, Inflammation Research Center, VIB, Technologiepark 927, B-9052 Ghent, Belgium [2] Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, B-9052 Ghent, Belgium [3].

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http://dx.doi.org/10.1038/ncomms6103DOI Listing
September 2014

Future directions in inflammatory bowel disease management.

J Crohns Colitis 2014 Aug 16;8(8):726-34. Epub 2014 Apr 16.

Division of Gastroenterology, Department of Internal Medicine, Catholic University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.crohns.2014.02.025DOI Listing
August 2014

Neutrophil gelatinase B-associated lipocalin and matrix metalloproteinase-9 complex as a surrogate serum marker of mucosal healing in ulcerative colitis.

Inflamm Bowel Dis 2014 Jul;20(7):1198-207

*Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium; †Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium; and ‡Montefiore Institute, Electrical Engineering and Computer Science, University of Liège, Liège, Belgium.

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http://dx.doi.org/10.1097/MIB.0000000000000068DOI Listing
July 2014

Comment on 'anti-adhesion therapies and the rule of 3 for rare events'.

Am J Gastroenterol 2014 Jul;109(7):1083-4

Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://dx.doi.org/10.1038/ajg.2014.117DOI Listing
July 2014

Tuberculosis infection following anti-TNF therapy in inflammatory bowel disease, despite negative screening.

J Crohns Colitis 2014 Jun 2;8(6):550-7. Epub 2013 Dec 2.

Department of Gastroenterology, University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.crohns.2013.11.008DOI Listing
June 2014

Republished: Recent advances: personalised use of current Crohn's disease therapeutic options.

Postgrad Med J 2014 Mar;90(1061):144-8

Department of Gastroenterology, University Hospital Leuven, , Leuven, Belgium.

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http://dx.doi.org/10.1136/postgradmedj-2012-303958repDOI Listing
March 2014

Drug safety evaluation of certolizumab pegol.

Expert Opin Drug Saf 2014 Feb 25;13(2):255-66. Epub 2013 Oct 25.

University Hospitals Leuven, Department of Gastroenterology , Herestraat 49, B3000 Leuven , Belgium +32 16 34 42 25 ; +32 16 34 44 19 ;

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http://dx.doi.org/10.1517/14740338.2014.851666DOI Listing
February 2014

Infliximab restores the dysfunctional matrix remodeling protein and growth factor gene expression in patients with inflammatory bowel disease.

Inflamm Bowel Dis 2014 Feb;20(2):339-52

*Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Clinical and Experimental Medicine; †Laboratory of Immunobiology (Rega Institute for Medical Research), Department of Microbiology and Immunology; ‡Translational Cell and Tissue Research, Department of Imaging and Pathology; §Gene Expression Unit, Department of Cellular and Molecular Medicine; and ‖Leuven Food Science and Nutrition Research Centre (LFoRCe), KULeuven, Leuven, Belgium.

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http://dx.doi.org/10.1097/01.MIB.0000438430.15553.90DOI Listing
February 2014

Clinical disease activity, C-reactive protein normalisation and mucosal healing in Crohn's disease in the SONIC trial.

Gut 2014 Jan 23;63(1):88-95. Epub 2013 Aug 23.

Inserm U954 and Department of Hepato-Gastroenterology, University Hospital of Nancy-Brabois, , Vandoeuvre-lès-Nancy, France.

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http://dx.doi.org/10.1136/gutjnl-2013-304984DOI Listing
January 2014

Targeting TNF-α for the treatment of inflammatory bowel disease.

Expert Opin Biol Ther 2014 Jan 11;14(1):75-101. Epub 2013 Nov 11.

University of Leuven, University Hospitals Gasthuisberg, KU Leuven, Department of Gastroenterology , Herestraat 49, O&N1, Box 701, 3000 Leuven , Belgium +3216330277 ; +3216330723 ;

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http://www.tandfonline.com/doi/full/10.1517/14712598.2014.85
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http://dx.doi.org/10.1517/14712598.2014.858695DOI Listing
January 2014

Anxiety is associated with impaired tolerance of colonoscopy preparation in inflammatory bowel disease and controls.

J Crohns Colitis 2013 Dec 9;7(11):e580-7. Epub 2013 May 9.

Department of Gastroenterology, University Hospital Leuven, Leuven, Belgium; Department of Gastroenterology, Royal Victoria Hospital, McGill University Health Center, Montreal, Canada. Electronic address:

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December 2013

Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress.

Autophagy 2013 Dec 14;9(12):2046-55. Epub 2013 Nov 14.

Department of Clinical and Experimental Medicine; Translational Research Center for Gastrointestinal Disorders (TARGID); KU Leuven; Leuven, Belgium.

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http://dx.doi.org/10.4161/auto.26337DOI Listing
December 2013

Recent advances: Personalised use of current Crohn's disease therapeutic options.

Gut 2013 Oct;62(10):1511-5

Department of Gastroenterology, University Hospital Leuven, , Leuven, Belgium.

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http://dx.doi.org/10.1136/gutjnl-2012-303958DOI Listing
October 2013

Correlation between the endoscopic and histologic score in assessing the activity of ulcerative colitis.

Inflamm Bowel Dis 2013 May;19(6):1194-201

Translational Cell & Tissue Research, Department of Imaging and Pathology, University Hospital KU Leuven, Leuven, Belgium.

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https://academic.oup.com/ibdjournal/article/19/6/1194-1201/4
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May 2013

Certolizumab pegol in the treatment of Crohn's disease.

Expert Opin Biol Ther 2013 Apr 4;13(4):595-605. Epub 2013 Mar 4.

University Hospitals Leuven, Department of Gastroenterology, B3000 Leuven, Belgium.

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http://dx.doi.org/10.1517/14712598.2013.777039DOI Listing
April 2013