Publications by authors named "Paul Richardson"

100Publications

Isatuximab for the treatment of relapsed/refractory multiple myeloma.

Expert Opin Biol Ther 2020 Oct 28. Epub 2020 Oct 28.

Applied Cancer Research and Drug Discovery, Translational Genomics Research Institute, City of Hope Cancer Center , Phoenix, AZ, USA.

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http://dx.doi.org/10.1080/14712598.2021.1841747DOI Listing
October 2020

Letter: Covid-19-re-initiating clinical services for chronic gastrointestinal diseases. How and when?

Aliment Pharmacol Ther 2020 10;52(8):1414-1415

Department of Gastroenterology and Hepatology, Liverpool University Foundation Hospitals NHS Trust, Liverpool, UK.

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http://dx.doi.org/10.1111/apt.16061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537212PMC
October 2020

Melflufen: A Peptide-Drug Conjugate for the Treatment of Multiple Myeloma.

J Clin Med 2020 Sep 27;9(10). Epub 2020 Sep 27.

Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.3390/jcm9103120DOI Listing
September 2020

Overt hepatic encephalopathy: management and prevention of recurrence.

Br J Nurs 2020 Sep;29(Sup17):S14-S17

Consultant Hepatologist, Royal Liverpool University Hospital.

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http://dx.doi.org/10.12968/bjon.2020.29.Sup17.S14DOI Listing
September 2020

Analysis of Time to Complete Response after Defibrotide Initiation in Patients with Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation.

Biol Blood Marrow Transplant 2020 Sep 17. Epub 2020 Sep 17.

Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.bbmt.2020.09.008DOI Listing
September 2020

Melflufen for relapsed and refractory multiple myeloma.

Expert Opin Investig Drugs 2020 Oct 29;29(10):1069-1078. Epub 2020 Sep 29.

Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School , Boston, MA, USA.

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http://dx.doi.org/10.1080/13543784.2020.1808884DOI Listing
October 2020

Synthesis of Fluorinated Alkyl Aryl Ethers by Palladium-Catalyzed C-O Cross-Coupling.

Org Lett 2020 Aug 4;22(16):6573-6577. Epub 2020 Aug 4.

Chemistry Research Laboratory, Oxford University, 12 Mansfield Road, Oxford, OX1 3TA, U.K.

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http://dx.doi.org/10.1021/acs.orglett.0c02347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458480PMC
August 2020

A Barrel-Shaped Metal-Organic Blue-Box Analogue with Photo-/Redox-Switchable Behavior.

Chemistry 2020 Aug 6. Epub 2020 Aug 6.

Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada.

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http://dx.doi.org/10.1002/chem.202003073DOI Listing
August 2020

Proteasome inhibition for the treatment of glioblastoma.

Expert Opin Investig Drugs 2020 Oct 10;29(10):1133-1141. Epub 2020 Aug 10.

Department of Neurology, Brain Tumor Center and Comprehensive Cancer Center Zurich, University Hospital and University of Zurich , Zurich, Switzerland.

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http://dx.doi.org/10.1080/13543784.2020.1803827DOI Listing
October 2020

Incorporation of a nitrogen-rich energetic ligand in a {Yb} complex exhibiting slow relaxation of the magnetisation under an applied field.

Dalton Trans 2020 Aug 23;49(30):10344-10348. Epub 2020 Jul 23.

Department of Chemistry and Biomolecular Sciences, University of Ottawa, ON K1N 6N5, Canada.

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http://dx.doi.org/10.1039/d0dt00696cDOI Listing
August 2020

Alcohol-related brain injury: An unrecognized problem in acute medicine.

Alcohol 2020 Nov 2;88:49-53. Epub 2020 Jun 2.

Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, United Kingdom; Liverpool Centre for Alcohol Research, University of Liverpool, United Kingdom; Gastroenterology and Hepatology, Royal Liverpool University Hospital Trust, Ward 5z Link, United Kingdom.

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http://dx.doi.org/10.1016/j.alcohol.2020.05.005DOI Listing
November 2020

The role of high-dose melphalan with autologous stem-cell transplant in multiple myeloma: is it time for a paradigm shift?

Br J Haematol 2020 Jun 5. Epub 2020 Jun 5.

Department of Medical Oncology, Dana-Farber Cancer Institute, Jerome Lipper Multiple Myeloma Center, Boston, MA, USA.

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http://dx.doi.org/10.1111/bjh.16764DOI Listing
June 2020

Reducing variation in hospital mortality for alcohol-related liver disease in North West England.

Aliment Pharmacol Ther 2020 07 22;52(1):182-195. Epub 2020 May 22.

Department of Health Data Science, Institute of Population Health Sciences, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1111/apt.15781DOI Listing
July 2020

Local biases drive, but do not determine, the perception of illusory trajectories.

Sci Rep 2020 05 8;10(1):7756. Epub 2020 May 8.

Sheffield Hallam University, Sheffield, England.

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http://dx.doi.org/10.1038/s41598-020-64837-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210302PMC
May 2020

Clinical benefit of ixazomib plus lenalidomide-dexamethasone in myeloma patients with non-canonical NF-κB pathway activation.

Eur J Haematol 2020 Sep 1;105(3):274-285. Epub 2020 Jun 1.

Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, USA.

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http://dx.doi.org/10.1111/ejh.13435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497066PMC
September 2020

Cycloisomerization of Olefins in Water.

Angew Chem Int Ed Engl 2020 07 28;59(31):12998-13003. Epub 2020 May 28.

Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1002/anie.202003948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500246PMC
July 2020

Consensus Recommendations for the Clinical Management of Patients With Multiple Myeloma Treated With Selinexor.

Clin Lymphoma Myeloma Leuk 2020 06 7;20(6):351-357. Epub 2020 Mar 7.

Division of Hematology and Oncology, Department of Medicine, Columbia University, New York, NY.

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http://dx.doi.org/10.1016/j.clml.2019.12.026DOI Listing
June 2020

Defibrotide formulations contain (1→3)-β-D-glucan that could influence clinical diagnostic testing.

Bone Marrow Transplant 2020 Oct 30;55(10):2045-2046. Epub 2020 Mar 30.

Department of Pharmacy, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41409-020-0872-yDOI Listing
October 2020

Incidence of Anicteric Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome and Outcomes with Defibrotide following Hematopoietic Cell Transplantation in Adult and Pediatric Patients.

Biol Blood Marrow Transplant 2020 Jul 19;26(7):1342-1349. Epub 2020 Mar 19.

Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.bbmt.2020.03.011DOI Listing
July 2020

Pooled analysis of Day 100 survival for defibrotide-treated patients with hepatic veno-occlusive disease/sinusoidal obstruction syndrome and ventilator or dialysis dependence following haematopoietic cell transplantation.

Br J Haematol 2020 Mar 10. Epub 2020 Mar 10.

Division of Pediatric Oncology, Department of Pediatrics, Perelman School of Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/bjh.16552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497046PMC
March 2020

Veno-occlusive disease/sinusoidal obstruction syndrome in patients with prior gemtuzumab ozogamicin: literature analysis of survival after defibrotide treatment.

Blood Cancer J 2020 03 4;10(3):29. Epub 2020 Mar 4.

Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1038/s41408-020-0286-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055222PMC
March 2020

Controversy in the Use of CD38 Antibody for Treatment of Myeloma: Is High CD38 Expression Good or Bad?

Cells 2020 02 6;9(2). Epub 2020 Feb 6.

Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.3390/cells9020378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072398PMC
February 2020

Isotopically Directed Symmetry Breaking and Enantioenrichment in Attrition-Enhanced Deracemization.

J Am Chem Soc 2020 02 17;142(8):3873-3879. Epub 2020 Feb 17.

Department of Chemistry , Scripps Research Institute , La Jolla , California 92037 , United States.

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http://dx.doi.org/10.1021/jacs.9b11422DOI Listing
February 2020

Selinexor for the treatment of multiple myeloma.

Expert Opin Pharmacother 2020 Mar 19;21(4):399-408. Epub 2020 Jan 19.

Karyopharm Therapeutics, Newton, MA, USA.

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http://dx.doi.org/10.1080/14656566.2019.1707184DOI Listing
March 2020

Randomized Clinical Trial Representativeness and Outcomes in Real-World Patients: Comparison of 6 Hallmark Randomized Clinical Trials of Relapsed/Refractory Multiple Myeloma.

Clin Lymphoma Myeloma Leuk 2020 01 10;20(1):8-17.e16. Epub 2019 Oct 10.

Jerome Lipper Multiple Myeloma Center, Dana Farber Cancer Institute, Boston, MA.

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http://dx.doi.org/10.1016/j.clml.2019.09.625DOI Listing
January 2020

Incidence, Predictors, and Outcomes of Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Reduced-Intensity Allogeneic Hematopoietic Cell Transplantation.

Biol Blood Marrow Transplant 2020 Mar 31;26(3):529-539. Epub 2019 Oct 31.

Department of Medical Oncology, Division of Hematologic Malignancies, Dana-Farber Cancer, Institute, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2019.10.024DOI Listing
March 2020

Pomalidomide in lenalidomide-refractory multiple myeloma: Far from futile.

Br J Haematol 2020 02 30;188(4):483-485. Epub 2019 Sep 30.

Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/bjh.16214DOI Listing
February 2020

Oral Selinexor-Dexamethasone for Triple-Class Refractory Multiple Myeloma.

N Engl J Med 2019 08;381(8):727-738

From the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai (A.C., S.P., S.J.), and New York University Langone Medical Center (D.K.) - both in New York; the Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia (D.T.V.); the School of Medicine, National and Kapodistrian University of Athens, Athens (M.G., M. Dimopoulos); the Winship Cancer Institute, Emory University, Atlanta (A.K.N., S.L.); Massachusetts General Hospital Cancer Center (A.J.Y.), Tufts Medical Center (R.L.C.), and the Dana-Farber Cancer Institute (P.G.R.), Boston, and Karyopharm Therapeutics, Newton (M.G.K., S.S., L.L., S. Tang, C.P., J.-R.S.-M., M.C., H.C., Y.L., J.S.) - all in Massachusetts; Johns Hopkins University, Baltimore (C.A.H.); the University of Nantes, Nantes (P.M.), Hôpital Necker (L.F.), Hôpital Saint-Antoine (M.M.), and La Pitié-Salpêtrière Hospital (S.C.), Paris, University Hospital, Lille (T.F.), Centre Hospitalier Lyon Sud, Pierre-Benite (L.K.), and Centre Hospitalo-Universitaire Vandoeuvre-lès-Nancy, Nancy (A.P.) - all in France; the Mayo Clinic, Rochester, MN (D.D.); the University of Michigan, Ann Arbor (C.C.); the Mayo Clinic of Arizona, Phoenix (A.K.S.); Hackensack University Medical Center, Hackensack, NJ (J.R.); Washington University School of Medicine, St. Louis (R.V.); Lineberger Comprehensive Cancer Center at University of North Carolina-Chapel Hill, Chapel Hill (S. Tuchman); the University of Heidelberg, Heidelberg (M.S.R.), University Medical Center Hamburg-Eppendorf, Hamburg (K.C.W.), the University of Tübingen, Tübingen (K.C.W.), University Hospital Würzburg, Würzburg (M.S.), the University of Freiburg, Freiburg (M.E.), and Gemeinschaftspraxis Hämatologie-Onkologie, Dresden (T.I.) - all in Germany; the University of Leuven, Leuven (M. Delforge), Institut Jules Bordet, Université Libre de Bruxelles, Brussels (N.M.), University Hospital Ghent, Ghent (P.V.), and Centre Hospitalier Universitaire Université Catholique de Louvain Namur, Yvoir (C.D.) - all in Belgium; Vanderbilt University Medical Center, Nashville (R.F.C.); Sylvester Cancer Center, University of Miami, Miami (J.E.H.); the University of Alabama at Birmingham, Birmingham (L.J.C.); Yale School of Medicine, New Haven, CT (T.L.P.); Baylor University Medical Center, Dallas (M.L.); the David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (G.S.); and University Hospital Krems, Karl Landsteiner University of Health Sciences, Krems an der Donau, Austria (K.P.).

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http://www.nejm.org/doi/10.1056/NEJMoa1903455
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http://dx.doi.org/10.1056/NEJMoa1903455DOI Listing
August 2019

Alcohol-related brain injury: Improving identification and management in an acute care setting.

Future Healthc J 2019 Mar;6(Suppl 1):84

Hepatology, Royal Liverpool & Broadgreen University Hospital, Liverpool, UK.

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http://dx.doi.org/10.7861/futurehosp.6-1-s84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616760PMC
March 2019

Controlling cellular distribution of drugs with permeability modifying moieties.

Medchemcomm 2019 Jun 18;10(6):974-984. Epub 2019 Apr 18.

Drug Discovery Science and Technologies , 1 North Waukegan Rd , North Chicago , IL 60064 , USA . Email:

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http://dx.doi.org/10.1039/c8md00412aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595965PMC
June 2019

The association between hepatocellular carcinoma and direct-acting anti-viral treatment in patients with decompensated cirrhosis.

Aliment Pharmacol Ther 2019 07 31;50(2):204-214. Epub 2019 May 31.

NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals, NHS Trust and the University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1111/apt.15296DOI Listing
July 2019

Towards a better understanding of monoclonal gammopathy of renal significance.

Br J Haematol 2019 09 28;186(5):653-654. Epub 2019 May 28.

Department of Medical Oncology, LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA, USA.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjh.15989
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http://dx.doi.org/10.1111/bjh.15989DOI Listing
September 2019

A Clinician's Perspective of Elotuzumab in the Treatment of Relapsed or Refractory Multiple Myeloma.

Clin Adv Hematol Oncol 2019 May;17 Suppl 9(5):2-8

Jerome Lipper Multiple Myeloma Center, Harvard Medical School, Boston, Massachusetts.

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May 2019

Publisher Correction: Systematic review of defibrotide studies in the treatment of veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS).

Bone Marrow Transplant 2019 Dec;54(12):2117-2119

Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1038/s41409-019-0507-3DOI Listing
December 2019

Systematic review of defibrotide studies in the treatment of veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS).

Bone Marrow Transplant 2019 12 25;54(12):1951-1962. Epub 2019 Feb 25.

Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1038/s41409-019-0474-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957462PMC
December 2019

Detection of the adulteration of fresh coconut water via NMR spectroscopy and chemometrics.

Analyst 2019 Feb;144(4):1401-1408

School of Chemistry, Manchester Institute of Biotechnology, 131 Princess Street, University of Manchester, UKM1 7DN.

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http://dx.doi.org/10.1039/c8an01964aDOI Listing
February 2019

Performance of the International Myeloma Working Group myeloma frailty score among patients 75 and older.

J Geriatr Oncol 2019 05 22;10(3):486-489. Epub 2018 Nov 22.

Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA; Center for Leukemia, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18794068183034
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http://dx.doi.org/10.1016/j.jgo.2018.10.010DOI Listing
May 2019

The power of proteasome inhibition in multiple myeloma.

Expert Rev Proteomics 2018 12 14;15(12):1033-1052. Epub 2018 Nov 14.

b Medical Oncology , Dana-Farber Cancer Institute , Boston , MA , USA.

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http://dx.doi.org/10.1080/14789450.2018.1543595DOI Listing
December 2018

Ixazomib for the treatment of multiple myeloma.

Expert Opin Pharmacother 2018 Dec 13;19(17):1949-1968. Epub 2018 Nov 13.

g Hematology & Medical Oncology , Winship Cancer Institute, Emory University , Atlanta , GA , USA.

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https://www.tandfonline.com/doi/full/10.1080/14656566.2018.1
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http://dx.doi.org/10.1080/14656566.2018.1528229DOI Listing
December 2018

Elotuzumab plus Pomalidomide and Dexamethasone for Multiple Myeloma.

N Engl J Med 2018 11;379(19):1811-1822

From the National and Kapodistrian University of Athens, Athens (M.A.D.); Karol Marcinkowski University of Medical Sciences, Poznań (D.D.), and Silesian Medical University, Katowice (S.G.) - both in Poland; University Hospital, Nantes (P.M.), and Centre Hospitalier Universitaire de Poitiers-La Milétrie, Poitiers (X.L.) - both in France; National Hospital Organization Disaster Medical Center (N.T.) and the Japanese Red Cross Medical Center (K.S.), Tokyo, and Ibaraki Prefectural Central Hospital, Kasama (M.H.) - all in Japan; Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal (R.L.); Heidelberg University Hospital, Heidelberg, Germany (M.S.R.); Dana-Farber Cancer Institute, Boston (P.G.R.); Bristol-Myers Squibb, Princeton, NJ (M.P.M., Y.-M.J., S.G.S., M.R., B.R.); and Clínica Universidad de Navarra, Centro de Investigación Médica Aplicada, Instituto de Investigación Sanitaria de Navarra (IDISNA), Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Pamplona, Spain (J.S.-M.).

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http://www.nejm.org/doi/10.1056/NEJMoa1805762
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http://dx.doi.org/10.1056/NEJMoa1805762DOI Listing
November 2018

Synthesis and Investigation of 2,3,5,6-Tetra-(1H-tetrazol-5-yl)pyrazine Based Energetic Materials.

Chempluschem 2018 Nov 9;83(11):984-990. Epub 2018 Oct 9.

Department of Chemistry and Biomolecular Sciences, University of Ottawa, 10 Marie Curie, Ottawa, ON K1N 6N5, Canada.

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http://dx.doi.org/10.1002/cplu.201800414DOI Listing
November 2018