Publications by authors named "Paul R Reynolds"

92Publications

Regulation of trophoblast cell invasion by Pyruvate Kinase isozyme M2 (PKM2).

Placenta 2020 Oct 15;103:24-32. Epub 2020 Oct 15.

Lung and Placenta Research Laboratory, Brigham Young University, Department of Physiology and Developmental Biology, Provo, UT, USA. Electronic address:

View Article and Find Full Text PDF
October 2020

Cell invasion, RAGE expression, and inflammation in oral squamous cell carcinoma (OSCC) cells exposed to e-cigarette flavoring.

Clin Exp Dent Res 2020 Dec 11;6(6):618-625. Epub 2020 Aug 11.

Lung and Placenta Research Laboratory, Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah, USA.

View Article and Find Full Text PDF
December 2020

Heterozygous IKKβ activation loop mutation results in a complex immunodeficiency syndrome.

J Allergy Clin Immunol 2020 Jun 15. Epub 2020 Jun 15.

National Jewish Health, Immunodeficiency Diagnosis and Treatment Program, Department of Pediatrics, Denver, Colo.

View Article and Find Full Text PDF
June 2020

RAGE and AXL expression following secondhand smoke (SHS) exposure in mice.

Exp Lung Res 2019 Nov - Dec;45(9-10):297-309. Epub 2019 Nov 24.

Lung and Placenta Laboratory, Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah, USA.

View Article and Find Full Text PDF
May 2020

Diesel Exhaust Particle Exposure Compromises Alveolar Macrophage Mitochondrial Bioenergetics.

Int J Mol Sci 2019 Nov 9;20(22). Epub 2019 Nov 9.

Metabolism Research Lab, Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA.

View Article and Find Full Text PDF
November 2019

Differential placental ceramide levels during gestational diabetes mellitus (GDM).

Reprod Biol Endocrinol 2019 Oct 23;17(1):81. Epub 2019 Oct 23.

Department of Physiology and Developmental Biology, Lung and Placenta Research Laboratory, Brigham Young University, 3052 LSB, Provo, UT, 84602, USA.

View Article and Find Full Text PDF
October 2019

Growth arrest-specific protein-6/AXL signaling induces preeclampsia in rats†.

Biol Reprod 2020 02;102(1):199-210

Lung and Placenta Laboratory, Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah, USA.

View Article and Find Full Text PDF
February 2020

A novel ATM mutation associated with elevated atypical lymphocyte populations, hyper-IgM, and cutaneous granulomas.

Clin Immunol 2019 03 9;200:55-63. Epub 2019 Jan 9.

Immunodeficiency Diagnosis and Treatment Program, Department of Pediatrics, National Jewish Health, Denver, CO 80206, United States. Electronic address:

View Article and Find Full Text PDF
March 2019

Gas6 protein induces invasion and reduces inflammatory cytokines in oral squamous cell carcinoma.

J Oral Pathol Med 2018 Sep 19;47(8):748-754. Epub 2018 Jun 19.

Lung and Placenta Research Laboratory, Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT, USA.

View Article and Find Full Text PDF
September 2018

Transgenic up-regulation of Claudin-6 decreases fine diesel particulate matter (DPM)-induced pulmonary inflammation.

Environ Sci Pollut Res Int 2018 Jun 25;25(18):18179-18188. Epub 2018 Apr 25.

Lung and Placenta Research Laboratory, Department of Physiology and Developmental Biology, Brigham Young University, 3054 Life Sciences Building, Provo, UT, 84602, USA.

View Article and Find Full Text PDF
June 2018

The expression profile of Claudin family members in the developing mouse lung and expression alterations resulting from exposure to secondhand smoke (SHS).

Exp Lung Res 2018 02 11;44(1):13-24. Epub 2018 Jan 11.

a Department of Physiology and Developmental Biology, Lung and Placenta Research Laboratory , Brigham Young University , Provo , Utah , USA.

View Article and Find Full Text PDF
February 2018

Dominant-negative loss of function arises from a second, more frequent variant within the SAND domain of autoimmune regulator (AIRE).

J Autoimmun 2018 03 10;88:114-120. Epub 2017 Nov 10.

National Jewish Health, Immunodeficiency Diagnosis and Treatment Program, Department of Pediatrics, 1400 Jackson Street, Denver, CO, 80206, USA. Electronic address:

View Article and Find Full Text PDF
March 2018

Cigarette smoke extract (CSE) induces RAGE-mediated inflammation in the Ca9-22 gingival carcinoma epithelial cell line.

Arch Oral Biol 2017 Aug 31;80:95-100. Epub 2017 Mar 31.

Lung and Placenta Research Laboratory, Brigham Young University, Physiology and Developmental Biology, Provo, UT, USA. Electronic address:

View Article and Find Full Text PDF
August 2017

Plausible Roles for RAGE in Conditions Exacerbated by Direct and Indirect (Secondhand) Smoke Exposure.

Int J Mol Sci 2017 Mar 17;18(3). Epub 2017 Mar 17.

Lung and Placenta Research Laboratory, Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA.

View Article and Find Full Text PDF
March 2017

Caspase dependent and independent mechanisms of apoptosis across gestation in a sheep model of placental insufficiency and intrauterine growth restriction.

Apoptosis 2017 05;22(5):710-718

Lung and Placenta Research Laboratory, Department of Physiology and Developmental Biology, Brigham Young University, 3052 LSB, Provo, UT, 84602, USA.

View Article and Find Full Text PDF
May 2017

Cigarette smoke and decreased oxygen tension inhibit pulmonary claudin-6 expression.

Exp Lung Res 2016 Oct - Dec;42(8-10):440-452. Epub 2016 Dec 16.

a Lung and Placenta Research Laboratory, Department of Physiology and Developmental Biology , Brigham Young University , Provo , Utah , USA.

View Article and Find Full Text PDF
August 2017

Environmental Nontuberculous Mycobacteria in the Hawaiian Islands.

PLoS Negl Trop Dis 2016 Oct 25;10(10):e0005068. Epub 2016 Oct 25.

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States Of America.

View Article and Find Full Text PDF
October 2016

Up-Regulation of Claudin-6 in the Distal Lung Impacts Secondhand Smoke-Induced Inflammation.

Int J Environ Res Public Health 2016 Oct 17;13(10). Epub 2016 Oct 17.

Lung and Placenta Research Laboratory, Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA.

View Article and Find Full Text PDF
October 2016

Decreased activation of placental mTOR family members is associated with the induction of intrauterine growth restriction by secondhand smoke in the mouse.

Cell Tissue Res 2017 02 9;367(2):387-395. Epub 2016 Sep 9.

Lung and Placenta Research Laboratory, Brigham Young University, Physiology and Developmental Biology, Provo, UT, USA.

View Article and Find Full Text PDF
February 2017

Sequence Analysis of Fluoroquinolone Resistance-Associated Genes gyrA and gyrB in Clinical Mycobacterium tuberculosis Isolates from Patients Suspected of Having Multidrug-Resistant Tuberculosis in New Delhi, India.

J Clin Microbiol 2016 09 22;54(9):2298-305. Epub 2016 Jun 22.

Mycobacteriology and Pharmacokinetics Laboratories, National Jewish Health, Denver, Colorado, USA Department of Medicine, National Jewish Health, Denver, Colorado, USA

View Article and Find Full Text PDF
September 2016

The impact of decellularization agents on renal tissue extracellular matrix.

J Biomater Appl 2016 10 16;31(4):521-533. Epub 2016 Jun 16.

Department of Chemical Engineering, Brigham Young University, Provo, UT, USA

View Article and Find Full Text PDF
October 2016

Oral Gingival Cell Cigarette Smoke Exposure Induces Muscle Cell Metabolic Disruption.

Int J Dent 2016 29;2016:2763160. Epub 2016 Feb 29.

Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA.

View Article and Find Full Text PDF
April 2016

Efficient decellularization of whole porcine kidneys improves reseeded cell behavior.

Biomed Mater 2016 Mar 10;11(2):025003. Epub 2016 Mar 10.

Department of Chemical Engineering, 350 CB, Brigham Young University, Provo, UT 84602, USA.

View Article and Find Full Text PDF
March 2016

Differential Receptor for Advanced Glycation End Products Expression in Preeclamptic, Intrauterine Growth Restricted, and Gestational Diabetic Placentas.

Am J Reprod Immunol 2016 Feb 19;75(2):172-80. Epub 2015 Dec 19.

Lung and Placenta Research Laboratory, Physiology and Developmental Biology, Brigham Young University, Provo, UT, USA.

View Article and Find Full Text PDF
February 2016

Hypoxia reduces placental mTOR activation in a hypoxia-induced model of intrauterine growth restriction (IUGR).

Physiol Rep 2015 Dec;3(12)

Lung and Placenta Research Laboratory, , Physiology and Developmental Biology, Brigham Young University, Provo, Utah

View Article and Find Full Text PDF
December 2015

Automation of Pressure Control Improves Whole Porcine Heart Decellularization.

Tissue Eng Part C Methods 2015 Nov 14;21(11):1148-61. Epub 2015 Jul 14.

1 Department of Chemical Engineering, Brigham Young University , Provo, Utah.

View Article and Find Full Text PDF
November 2015

Cardiomyocyte mitochondrial respiration is reduced by receptor for advanced glycation end-product signaling in a ceramide-dependent manner.

Am J Physiol Heart Circ Physiol 2015 Jul 8;309(1):H63-9. Epub 2015 May 8.

Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah; and

View Article and Find Full Text PDF
July 2015

Cigarette smoke increases cardiomyocyte ceramide accumulation and inhibits mitochondrial respiration.

BMC Cardiovasc Disord 2014 Nov 22;14:165. Epub 2014 Nov 22.

Department of Physiology and Developmental Biology and Chemistry, Brigham Young University, Provo, UT 84602, USA.

View Article and Find Full Text PDF
November 2014

Conditionally induced RAGE expression by proximal airway epithelial cells in transgenic mice causes lung inflammation.

Respir Res 2014 Oct 29;15:133. Epub 2014 Oct 29.

Department of Physiology and Developmental Biology, Brigham Young University, 3054 Life Sciences Building, Provo, UT, 84602, USA.

View Article and Find Full Text PDF
October 2014

Mechanistic understanding for the greater sensitivity of monkeys to antisense oligonucleotide-mediated complement activation compared with humans.

J Pharmacol Exp Ther 2014 Dec 9;351(3):709-17. Epub 2014 Oct 9.

Isis Pharmaceuticals, Inc., Carlsbad, California (L.S., A.C., H.Y., S.P.H.); National Jewish Health, Denver, Colorado (A.F.-A., P.R.R., P.C.G.); and University of Texas Health Science Center, Tyler, Texas (M.K.P.).

View Article and Find Full Text PDF
December 2014

Ceramides mediate cigarette smoke-induced metabolic disruption in mice.

Am J Physiol Endocrinol Metab 2014 Nov 30;307(10):E919-27. Epub 2014 Sep 30.

Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah; and

View Article and Find Full Text PDF
November 2014

Acute secondhand smoke-induced pulmonary inflammation is diminished in RAGE knockout mice.

Am J Physiol Lung Cell Mol Physiol 2014 Nov 26;307(10):L758-64. Epub 2014 Sep 26.

Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah

View Article and Find Full Text PDF
November 2014

Genome sequencing of Mycobacterium abscessus isolates from patients in the united states and comparisons to globally diverse clinical strains.

J Clin Microbiol 2014 Oct 23;52(10):3573-82. Epub 2014 Jul 23.

Integrated Center for Genes, Environment, and Health, National Jewish Health, Denver, Colorado, USA Computational Bioscience Program, University of Colorado Denver, School of Medicine, Aurora, Colorado, USA

View Article and Find Full Text PDF
October 2014

Developmental lung expression and transcriptional regulation of claudin-6 by TTF-1, Gata-6, and FoxA2.

Respir Res 2014 Jun 26;15:70. Epub 2014 Jun 26.

Department of Physiology and Developmental Biology, Brigham Young University, 3054 Life Sciences Building, Provo, UT 84602, USA.

View Article and Find Full Text PDF
June 2014

Primary alveolar macrophages exposed to diesel particulate matter increase RAGE expression and activate RAGE signaling.

Cell Tissue Res 2014 Oct 25;358(1):229-38. Epub 2014 May 25.

Department of Physiology and Developmental Biology, Brigham Young University, 3054 Life Sciences Building, Provo, UT, 84602, USA.

View Article and Find Full Text PDF
October 2014

Increased compound heterozygous filaggrin mutations in severe atopic dermatitis in the United States.

J Allergy Clin Immunol Pract 2013 Sep-Oct;1(5):534-6. Epub 2013 Jul 30.

Division of Allergy-Immunology, Department of Pediatrics, National Jewish Health, Denver, Colo. Electronic address:

View Article and Find Full Text PDF
January 2015

Genome Sequence of an Epidemic Isolate of Mycobacterium abscessus subsp. bolletii from Rio de Janeiro, Brazil.

Genome Announc 2013 Aug 15;1(4). Epub 2013 Aug 15.

Integrated Center for Genes, Environment, and Health, National Jewish Health, Denver, Colorado, USA.

View Article and Find Full Text PDF
August 2013

RAGE and tobacco smoke: insights into modeling chronic obstructive pulmonary disease.

Front Physiol 2012 25;3:301. Epub 2012 Jul 25.

Department of Physiology and Developmental Biology, Brigham Young University Provo, UT, USA.

View Article and Find Full Text PDF
October 2012

RAGE signaling by alveolar macrophages influences tobacco smoke-induced inflammation.

Am J Physiol Lung Cell Mol Physiol 2012 Jun 13;302(11):L1192-9. Epub 2012 Apr 13.

Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah 94602, USA.

View Article and Find Full Text PDF
June 2012

Embryonic overexpression of receptors for advanced glycation end-products by alveolar epithelium induces an imbalance between proliferation and apoptosis.

Am J Respir Cell Mol Biol 2012 Jul 16;47(1):60-6. Epub 2012 Feb 16.

Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 94602, USA.

View Article and Find Full Text PDF
July 2012

Up-regulation of receptors for advanced glycation end-products by alveolar epithelium influences cytodifferentiation and causes severe lung hypoplasia.

Am J Respir Cell Mol Biol 2011 Dec 17;45(6):1195-202. Epub 2011 Jun 17.

Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 94602, USA.

View Article and Find Full Text PDF
December 2011

Immunohistochemical detection and regulation of α5 nicotinic acetylcholine receptor (nAChR) subunits by FoxA2 during mouse lung organogenesis.

Respir Res 2011 Jun 17;12:82. Epub 2011 Jun 17.

Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA.

View Article and Find Full Text PDF
June 2011

TTF-1 regulates α5 nicotinic acetylcholine receptor (nAChR) subunits in proximal and distal lung epithelium.

Respir Res 2010 Dec 9;11:175. Epub 2010 Dec 9.

Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA.

View Article and Find Full Text PDF
December 2010

Receptor for advanced glycation end-products signals through Ras during tobacco smoke-induced pulmonary inflammation.

Am J Respir Cell Mol Biol 2011 Aug 3;45(2):411-8. Epub 2010 Dec 3.

Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA.

View Article and Find Full Text PDF
August 2011

Diesel particulate matter induces receptor for advanced glycation end-products (RAGE) expression in pulmonary epithelial cells, and RAGE signaling influences NF-κB-mediated inflammation.

Environ Health Perspect 2011 Mar 18;119(3):332-6. Epub 2010 Nov 18.

Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah 84602, USA.

View Article and Find Full Text PDF
March 2011

Tracheal Basal cells: a facultative progenitor cell pool.

Am J Pathol 2010 Jul 3;177(1):362-76. Epub 2010 Jun 3.

Department of Pediatrics, Division of Cell Biology, National Jewish Health, Denver, Colorado, USA.

View Article and Find Full Text PDF
July 2010

Receptors for advanced glycation end-products targeting protect against hyperoxia-induced lung injury in mice.

Am J Respir Cell Mol Biol 2010 May 18;42(5):545-51. Epub 2009 Jun 18.

Department of Internal Medicine, Pulmonary Division, University of Utah Health Sciences Center, Salt Lake City, Utah, USA.

View Article and Find Full Text PDF
May 2010

RAGE: developmental expression and positive feedback regulation by Egr-1 during cigarette smoke exposure in pulmonary epithelial cells.

Am J Physiol Lung Cell Mol Physiol 2008 Jun 4;294(6):L1094-101. Epub 2008 Apr 4.

Pulmonary Division, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132-2406, USA.

View Article and Find Full Text PDF
June 2008

Stimulation of lung innate immunity protects against lethal pneumococcal pneumonia in mice.

Am J Respir Crit Care Med 2008 Jun 3;177(12):1322-30. Epub 2008 Apr 3.

Department of Pulmonary Medicine, M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4009. USA.

View Article and Find Full Text PDF
June 2008

CCSP regulates cross talk between secretory cells and both ciliated cells and macrophages of the conducting airway.

Am J Physiol Lung Cell Mol Physiol 2007 Jul 23;293(1):L114-23. Epub 2007 Mar 23.

Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.

View Article and Find Full Text PDF
July 2007

Molecular and functional properties of lung SP cells.

Am J Physiol Lung Cell Mol Physiol 2007 Apr 1;292(4):L972-83. Epub 2006 Dec 1.

Center for Lung Regeneration, Department of Environmental and Occupational Health, University of Pittsburgh, USA.

View Article and Find Full Text PDF
April 2007

Avian multiple inositol polyphosphate phosphatase is an active phytase that can be engineered to help ameliorate the planet's "phosphate crisis".

J Biotechnol 2006 Nov 6;126(2):248-59. Epub 2006 Jun 6.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHSS, Research Triangle Park, PO Box 12233, NC 27709, USA.

View Article and Find Full Text PDF
November 2006

Cigarette smoke-induced Egr-1 upregulates proinflammatory cytokines in pulmonary epithelial cells.

Am J Respir Cell Mol Biol 2006 Sep 6;35(3):314-9. Epub 2006 Apr 6.

Department of Internal Medicine, Pulmonary Division, University of Utah Health Sciences Center, Salt Lake City, Utah, USA.

View Article and Find Full Text PDF
September 2006

Temporal-spatial expression and transcriptional regulation of alpha7 nicotinic acetylcholine receptor by thyroid transcription factor-1 and early growth response factor-1 during murine lung development.

J Biol Chem 2005 Sep 20;280(37):32548-54. Epub 2005 Jul 20.

Department of Internal Medicine, Pulmonary Division, University of Utah Health Sciences Center, Salt Lake City, 84132, USA.

View Article and Find Full Text PDF
September 2005

Differential effect of estrogen receptor alpha and beta agonists on the receptor for advanced glycation end product expression in human microvascular endothelial cells.

Biochim Biophys Acta 2005 Sep 12;1745(3):300-9. Epub 2005 Apr 12.

Pulmonary Division, Department of Internal Medicine, University of Utah Health Sciences Center, 30 North 1900 East, Room 4C104 SOM, Salt Lake City, UT 84132-4701, USA.

View Article and Find Full Text PDF
September 2005

Midkine is regulated by hypoxia and causes pulmonary vascular remodeling.

J Biol Chem 2004 Aug 14;279(35):37124-32. Epub 2004 Jun 14.

Divisions of Pulmonary Biology and Human Genetics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.

View Article and Find Full Text PDF
August 2004

Strain-rate sensitive mechanical properties of tendon fascicles from mice with genetically engineered alterations in collagen and decorin.

J Biomech Eng 2004 Apr;126(2):252-7

McKay Orthopaedic Research Laboratory, University of Pennsylvania, 3450 Hamilton Walk, 424 Stemmler Hall, Philadelphia, PA 19104-6081, USA.

View Article and Find Full Text PDF
April 2004

Combination therapy with folic acid and methionine in the prevention of retinoic acid-induced cleft palate in mice.

Birth Defects Res A Clin Mol Teratol 2003 Mar;67(3):168-73

Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah, USA.

View Article and Find Full Text PDF
March 2003

Thyroid transcription factor (TTF) -1 regulates the expression of midkine (MK) during lung morphogenesis.

Dev Dyn 2003 Jun;227(2):227-37

Cincinnati Children's Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229-3039, USA.

View Article and Find Full Text PDF
June 2003

Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways.

Am J Respir Crit Care Med 2002 Dec 1;166(11):1498-509. Epub 2002 Aug 1.

Departments of Environmental and Occupational Health, and Pediatrics, University of Pittsburgh, Pennsylvania 15260, USA.

View Article and Find Full Text PDF
December 2002

A role for the BMP antagonist chordin in endochondral ossification.

J Bone Miner Res 2002 Feb;17(2):293-300

Department of Orthopedics, School of Medicine and Dentistry, University of Rochester, New York, USA.

View Article and Find Full Text PDF
February 2002