Paul R Montellano

Paul R Ortiz de Montellano

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Paul R Montellano

Paul R Ortiz de Montellano

Publications by authors named "Paul R Ortiz de Montellano"

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1PubMed Central Citations

Acetylenes: cytochrome P450 oxidation and mechanism-based enzyme inactivation.

Drug Metab Rev 2019 05 7;51(2):162-177. Epub 2019 Jul 7.

Department of Pharmaceutical Chemistry, University of California , San Francisco , CA , USA.

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http://dx.doi.org/10.1080/03602532.2019.1632891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699906PMC
May 2019

Xanthates: Metabolism by Flavoprotein-Containing Monooxygenases and Antimycobacterial Activity.

Drug Metab Dispos 2018 08 18;46(8):1091-1095. Epub 2018 May 18.

Department of Drug Toxicology, Institute of Neurobiology (S.G.Y., T.D.S.), and Institute of Microbiology (V.V.V.), Bulgarian Academy of Sciences, Sofia, Bulgaria; and Department of Pharmaceutical Chemistry, University of California, San Francisco, California (P.R.O.M.).

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http://dmd.aspetjournals.org/lookup/doi/10.1124/dmd.118.0819
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http://dx.doi.org/10.1124/dmd.118.081984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034259PMC
August 2018

Potential drug targets in the Mycobacterium tuberculosis cytochrome P450 system.

J Inorg Biochem 2018 03 12;180:235-245. Epub 2018 Jan 12.

Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jinorgbio.2018.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801126PMC
March 2018

1-Aminobenzotriazole: A Mechanism-Based Cytochrome P450 Inhibitor and Probe of Cytochrome P450 Biology.

Med Chem (Los Angeles) 2018 31;8(3). Epub 2018 Mar 31.

Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.4172/2161-0444.1000495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137267PMC
March 2018

A New Step in the Treatment of Sickle Cell Disease.

Biochemistry 2018 02 27;57(5):470-471. Epub 2017 Nov 27.

University of California, San Francisco , San Francisco, California 94158-2517, United States.

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http://dx.doi.org/10.1021/acs.biochem.7b00785DOI Listing
February 2018

Crystal structures of the CO and NOBound DosS GAF-A domain and implications for DosS signaling in Mycobacterium tuberculosis.

Arch Biochem Biophys 2016 Dec 8;612:1-8. Epub 2016 Oct 8.

Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143, United States. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2016.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121028PMC
December 2016

Distal Hydrogen-bonding Interactions in Ligand Sensing and Signaling by Mycobacterium tuberculosis DosS.

J Biol Chem 2016 07 27;291(31):16100-11. Epub 2016 May 27.

From the Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, California 94158-2517 and

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http://www.jbc.org/lookup/doi/10.1074/jbc.M116.724815
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http://dx.doi.org/10.1074/jbc.M116.724815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965560PMC
July 2016

Catalytic Activities of Tumor-Specific Human Cytochrome P450 CYP2W1 Toward Endogenous Substrates.

Drug Metab Dispos 2016 May 2;44(5):771-80. Epub 2016 Mar 2.

Department of Pharmaceutical Chemistry, University of California, San Francisco (Y.Z., P.R.O.M.) and Department of Entomology and Cancer Center, University of California, Davis, CA (D.W., J.Y., B.D.H.)

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http://dx.doi.org/10.1124/dmd.116.069633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851306PMC
May 2016

Cholesterol Analogs with Degradation-resistant Alkyl Side Chains Are Effective Mycobacterium tuberculosis Growth Inhibitors.

J Biol Chem 2016 Apr 1;291(14):7325-33. Epub 2016 Feb 1.

From the Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158-2517 and

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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.708172
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http://dx.doi.org/10.1074/jbc.M115.708172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817165PMC
April 2016

Cytochrome P450 125A4, the Third Cholesterol C-26 Hydroxylase from Mycobacterium smegmatis.

Biochemistry 2015 Nov 11;54(46):6909-16. Epub 2015 Nov 11.

Department of Pharmaceutical Chemistry, University of California , San Francisco, California 94158-2517, United States.

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http://dx.doi.org/10.1021/acs.biochem.5b01029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660985PMC
November 2015

Heme and I.

J Biol Chem 2015 Sep 20;290(36):21833-44. Epub 2015 Jul 20.

From the Department of Pharmaceutical Chemistry, University of California, San Francisco, California 91158-2517

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http://dx.doi.org/10.1074/jbc.X115.680066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571939PMC
September 2015

Analysis of cytochrome P450 CYP119 ligand-dependent conformational dynamics by two-dimensional NMR and X-ray crystallography.

J Biol Chem 2015 Apr 10;290(16):10000-17. Epub 2015 Feb 10.

From the Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, California 94158,

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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.627935
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http://dx.doi.org/10.1074/jbc.M114.627935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400317PMC
April 2015

Cholesterol ester oxidation by mycobacterial cytochrome P450.

J Biol Chem 2014 Oct 10;289(44):30417-25. Epub 2014 Sep 10.

From the Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158-2517

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http://www.jbc.org/content/289/44/30417.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.602771
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http://dx.doi.org/10.1074/jbc.M114.602771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215225PMC
October 2014

Carbon-carbon bond cleavage in activation of the prodrug nabumetone.

Drug Metab Dispos 2014 May 28;42(5):828-38. Epub 2014 Feb 28.

Department of Pharmaceutical Chemistry, University of California, San Francisco, California (F.V., H.P., P.R.O.M.); Department of Chemistry, University of Queensland, St. Lucia, Brisbane, Australia (S.N.A.Z., V.L.C., J.J.D.V.); and Department of Biological Sciences, Konkuk University, Seoul, Korea (H.P.).

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http://dx.doi.org/10.1124/dmd.114.056903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989788PMC
May 2014

Specificity determinants of CYP1B1 estradiol hydroxylation.

Mol Pharmacol 2013 Sep 2;84(3):451-8. Epub 2013 Jul 2.

Department of Pharmaceutical Chemistry, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.1124/mol.113.087700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876821PMC
September 2013

A highly conserved mycobacterial cholesterol catabolic pathway.

Environ Microbiol 2013 Aug 14;15(8):2342-59. Epub 2013 Mar 14.

Department of Environmental Biology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.

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http://dx.doi.org/10.1111/1462-2920.12108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706556PMC
August 2013

Conserved cysteine residues provide a protein-protein interaction surface in dual oxidase (DUOX) proteins.

J Biol Chem 2013 Mar 28;288(10):7147-57. Epub 2013 Jan 28.

Laboratory of Molecular Pharmacology of the Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.414797
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http://dx.doi.org/10.1074/jbc.M112.414797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591624PMC
March 2013

Cytochrome P450-activated prodrugs.

Future Med Chem 2013 Feb;5(2):213-28

Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, CA 94158-2517, USA.

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http://dx.doi.org/10.4155/fmc.12.197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697796PMC
February 2013

The DosS-DosT/DosR Mycobacterial Sensor System.

Biosensors (Basel) 2013 ;3(3):259-282

Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, CA 94158, USA;

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http://dx.doi.org/10.3390/bios3030259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082495PMC
January 2013

Role of cysteine residues in heme binding to human heme oxygenase-2 elucidated by two-dimensional NMR spectroscopy.

J Biol Chem 2012 Oct 24;287(42):35181-91. Epub 2012 Aug 24.

Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, California 94158-2517, USA.

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http://dx.doi.org/10.1074/jbc.M112.378042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471713PMC
October 2012

Covalent attachment of heme to the protein moiety in an insect E75 nitric oxide sensor.

Biochemistry 2012 Sep 4;51(37):7403-16. Epub 2012 Sep 4.

Departamento de Bioquímica y Biología Molecular I, Universidad Complutense, 28040 Madrid, Spain.

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http://dx.doi.org/10.1021/bi300848xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448046PMC
September 2012

Proximal ligand electron donation and reactivity of the cytochrome P450 ferric-peroxo anion.

J Am Chem Soc 2012 Apr 4;134(15):6673-84. Epub 2012 Apr 4.

Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, California 94158-2517, USA.

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http://dx.doi.org/10.1021/ja211499qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329582PMC
April 2012

Photosystem I from plants as a bacterial cytochrome P450 surrogate electron donor: terminal hydroxylation of branched hydrocarbon chains.

Biotechnol Lett 2012 Feb 8;34(2):239-45. Epub 2011 Oct 8.

Plant Biochemistry Laboratory, Department of Plant Biology and Biotechnology, University of Copenhagen, 40 Thorvaldsensvej, 1871, Copenhagen, Frederiksberg C, Denmark.

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http://dx.doi.org/10.1007/s10529-011-0768-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671864PMC
February 2012

Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.

Trends Microbiol 2011 Nov 15;19(11):530-9. Epub 2011 Sep 15.

Department of Pharmaceutical Chemistry, University of California at San Francisco, Genentech Hall, N572D, 600 16th Street, San Francisco, CA 94158-2517, USA.

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http://dx.doi.org/10.1016/j.tim.2011.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205253PMC
November 2011

Structural stability and heme binding potential of the truncated human dual oxidase 2 (DUOX2) peroxidase domain.

Arch Biochem Biophys 2011 Aug 17;512(2):197-203. Epub 2011 Jun 17.

Department of Pharmaceutical Chemistry, University of California, San Francisco, United States.

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http://dx.doi.org/10.1016/j.abb.2011.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139011PMC
August 2011

Bioactivation of antituberculosis thioamide and thiourea prodrugs by bacterial and mammalian flavin monooxygenases.

Chem Biol Interact 2011 Jun 21;192(1-2):21-5. Epub 2010 Sep 21.

Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, CA 94158-2517, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00092797100056
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http://dx.doi.org/10.1016/j.cbi.2010.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033498PMC
June 2011

Active-site residues move independently from the rest of the protein in a 200 ns molecular dynamics simulation of cytochrome P450 CYP119.

Arch Biochem Biophys 2011 May 26;509(2):127-32. Epub 2011 Feb 26.

Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158-2517, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00039861110008
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http://dx.doi.org/10.1016/j.abb.2011.02.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085956PMC
May 2011

A novel intermediate in the reaction of seleno CYP119 with m-chloroperbenzoic acid.

Biochemistry 2011 Apr 22;50(14):3014-24. Epub 2011 Mar 22.

Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158-2517, United States.

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http://dx.doi.org/10.1021/bi101728yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071435PMC
April 2011

Structural control of cytochrome P450-catalyzed ω-hydroxylation.

Arch Biochem Biophys 2011 Mar 19;507(1):86-94. Epub 2010 Aug 19.

Department of Pharmaceutical Chemistry, University of California-San Francisco, CA 94158-2517, United States.

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http://dx.doi.org/10.1016/j.abb.2010.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997901PMC
March 2011

Rearrangement reactions catalyzed by cytochrome P450s.

Arch Biochem Biophys 2011 Mar 29;507(1):95-110. Epub 2010 Oct 29.

Department of Pharmaceutical Chemistry, University of California-San Francisco, CA 94158-2517, USA.

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http://dx.doi.org/10.1016/j.abb.2010.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039701PMC
March 2011

Nitric oxide dioxygenation reaction in DevS and the initial response to nitric oxide in Mycobacterium tuberculosis.

Biochemistry 2011 Feb 20;50(6):1023-8. Epub 2011 Jan 20.

Division of Environmental and Biomolecular Systems, Oregon Health and Science University, 20000 Northwest Walker Road, Beaverton, Oregon 97006-8921, United States.

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http://dx.doi.org/10.1021/bi1015315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079480PMC
February 2011

Reverse type I inhibitor of Mycobacterium tuberculosis CYP125A1.

Bioorg Med Chem Lett 2011 Jan 5;21(1):332-7. Epub 2010 Nov 5.

Department of Pharmaceutical Chemistry and Sandler Center for Drug Discovery, University of California, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1016/j.bmcl.2010.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011832PMC
January 2011

Perturbed heme binding is responsible for the blistering phenotype associated with mutations in the Caenorhabditis elegans dual oxidase 1 (DUOX1) peroxidase domain.

J Biol Chem 2010 Dec 14;285(52):40991-1000. Epub 2010 Oct 14.

Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94518-2517, USA.

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http://dx.doi.org/10.1074/jbc.M110.170902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003398PMC
December 2010

Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.

J Biol Chem 2010 Nov 15;285(47):36352-60. Epub 2010 Sep 15.

Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1074/jbc.M110.161117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978563PMC
November 2010

Efficient hypoxic activation of the anticancer agent AQ4N by CYP2S1 and CYP2W1.

Mol Pharmacol 2010 Sep 21;78(3):497-502. Epub 2010 Jun 21.

Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158-2517, USA.

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http://dx.doi.org/10.1124/mol.110.065045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939484PMC
September 2010

Two-dimensional NMR and all-atom molecular dynamics of cytochrome P450 CYP119 reveal hidden conformational substates.

J Biol Chem 2010 Mar 22;285(13):9594-603. Epub 2010 Jan 22.

Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158-2517, USA.

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http://dx.doi.org/10.1074/jbc.M109.087593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843209PMC
March 2010

Hydrocarbon hydroxylation by cytochrome P450 enzymes.

Chem Rev 2010 Feb;110(2):932-48

Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, California 94158-2517, USA.

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http://dx.doi.org/10.1021/cr9002193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820140PMC
February 2010

The Mycobacterium tuberculosis cytochrome P450 system.

Arch Biochem Biophys 2010 Jan 25;493(1):82-95. Epub 2009 Jul 25.

Department of Pharmaceutical Chemistry, University of California San Francisco, 600 16th Street, San Francisco, CA 94158-2517, USA.

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http://dx.doi.org/10.1016/j.abb.2009.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812603PMC
January 2010

Calculated and experimental spin state of seleno cytochrome P450.

Angew Chem Int Ed Engl 2009 ;48(39):7193-5

Department of Pharmaceutical Chemistry, University of California, 600 16th street, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1002/anie.200901485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848667PMC
January 2010

Biochemical and structural characterization of CYP124: a methyl-branched lipid omega-hydroxylase from Mycobacterium tuberculosis.

Proc Natl Acad Sci U S A 2009 Dec 20;106(49):20687-92. Epub 2009 Nov 20.

Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158-2517, USA.

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http://dx.doi.org/10.1073/pnas.0907398106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791619PMC
December 2009

Tricistronic overexpression of cytochrome P450cam, putidaredoxin, and putidaredoxin reductase provides a useful cell-based catalytic system.

Biotechnol Lett 2009 Sep 21;31(9):1427-31. Epub 2009 May 21.

Department of Biological Sciences, Konkuk University, 1 Hwayang-dong, Gwangjn-gu, Seoul 143-701, Korea.

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http://dx.doi.org/10.1007/s10529-009-0016-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844094PMC
September 2009

Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines.

J Biol Chem 2009 Sep 15;284(37):25211-9. Epub 2009 Jul 15.

Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1074/jbc.M109.017632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757224PMC
September 2009

Isocyanides inhibit human heme oxygenases at the verdoheme stage.

Biochemistry 2009 Sep;48(37):8920-8

Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, California 94158-2517, USA.

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http://dx.doi.org/10.1021/bi9011258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857669PMC
September 2009

Caenorhabditis elegans and human dual oxidase 1 (DUOX1) "peroxidase" domains: insights into heme binding and catalytic activity.

J Biol Chem 2009 Jul 21;284(28):18634-43. Epub 2009 May 21.

Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1074/jbc.M109.013581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707201PMC
July 2009

Spin scavenging analysis of myoglobin protein-centered radicals using stable nitroxide radicals: characterization of oxoammonium cation-induced modifications.

Chem Res Toxicol 2009 Jun;22(6):1034-49

Laboratories of Pharmacology and Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1021/tx9000094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862229PMC
June 2009

DevS oxy complex stability identifies this heme protein as a gas sensor in Mycobacterium tuberculosis dormancy.

Biochemistry 2009 Jun;48(25):5839-48

Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, California 94158-2517, USA.

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http://dx.doi.org/10.1021/bi802309yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756985PMC
June 2009

Covalent heme attachment to the protein in human heme oxygenase-1 with selenocysteine replacing the His25 proximal iron ligand.

J Inorg Biochem 2009 Mar 19;103(3):316-25. Epub 2008 Nov 19.

Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, CA 94158-2517, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S01620134080027
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http://dx.doi.org/10.1016/j.jinorgbio.2008.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762215PMC
March 2009

Cooperative effects on radical recombination in CYP3A4-catalyzed oxidation of the radical clock beta-thujone.

Chembiochem 2009 Mar;10(4):650-3

Department of Pharmaceutical Chemistry, University of California-San Francisco, 600 16th Street, San Francisco, CA 94158-2517, USA.

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http://dx.doi.org/10.1002/cbic.200800772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709176PMC
March 2009

Reaction of Mycobacterium tuberculosis cytochrome P450 enzymes with nitric oxide.

Biochemistry 2009 Feb;48(5):863-72

Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, California 94158-2517, USA.

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http://dx.doi.org/10.1021/bi801595tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681326PMC
February 2009

Human flavin-containing monooxygenase 2.1 catalyzes oxygenation of the antitubercular drugs thiacetazone and ethionamide.

Drug Metab Dispos 2009 Jan 23;37(1):178-86. Epub 2008 Oct 23.

Department of Structural and Molecular Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.108.024158
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http://dx.doi.org/10.1124/dmd.108.024158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683658PMC
January 2009

A distal tyrosine residue is required for ligand discrimination in DevS from Mycobacterium tuberculosis.

Biochemistry 2008 Nov;47(47):12532-9

Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, 20000 NW Walker Road, Beaverton, Oregon 97006-8921, USA.

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http://dx.doi.org/10.1021/bi801234wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666047PMC
November 2008

2.3 A X-ray structure of the heme-bound GAF domain of sensory histidine kinase DosT of Mycobacterium tuberculosis.

Biochemistry 2008 Nov;47(47):12523-31

Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, California 94158-2517, USA.

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http://dx.doi.org/10.1021/bi8012356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645934PMC
November 2008

Mechanism and role of covalent heme binding in the CYP4 family of P450 enzymes and the mammalian peroxidases.

Drug Metab Rev 2008 ;40(3):405-26

Department of Pharmaceutical Chemistry, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.1080/03602530802186439DOI Listing
September 2008

Reductive heme-dependent activation of the n-oxide prodrug AQ4N by nitric oxide synthase.

J Med Chem 2008 Aug 6;51(16):5118-20. Epub 2008 Aug 6.

Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, California 94158-2517, USA.

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http://dx.doi.org/10.1021/jm800496sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730118PMC
August 2008

Efficient catalytic turnover of cytochrome P450(cam) is supported by a T252N mutation.

Arch Biochem Biophys 2008 Jun 10;474(1):150-6. Epub 2008 Mar 10.

Department of Pharmaceutical Chemistry, University of California, San Francisco, Genentech Hall, N572D, 600 16th Street, San Francisco, CA 94158-2517, USA.

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http://dx.doi.org/10.1016/j.abb.2008.02.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577879PMC
June 2008

Selenolate complexes of CYP101 and the heme-bound hHO-1/H25A proximal cavity mutant.

Inorg Chem 2008 May 1;47(9):3480-2. Epub 2008 Apr 1.

Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158-2517, USA.

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http://dx.doi.org/10.1021/ic800148aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727152PMC
May 2008

Mycobacterium tuberculosis CYP130: crystal structure, biophysical characterization, and interactions with antifungal azole drugs.

J Biol Chem 2008 Feb 18;283(8):5069-80. Epub 2007 Dec 18.

Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1074/jbc.M708734200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958778PMC
February 2008

Crystal structure and properties of CYP231A2 from the thermoacidophilic archaeon Picrophilus torridus.

Biochemistry 2008 Feb 16;47(7):2071-9. Epub 2008 Jan 16.

Departments of Molecular Biology and Biochemistry, Chemistry, and Pharmaceutical Sciences, University of California, Irvine, California 92697-3900, USA.

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February 2008

Implication for using heme methyl hyperfine shifts as indicators of heme seating as related to stereoselectivity in the catabolism of heme by heme oxygenase: in-plane heme versus axial his rotation.

Biochemistry 2008 Jan 14;47(1):421-30. Epub 2007 Dec 14.

Department of Chemistry, University of California, Davis, California 95616, USA.

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http://dx.doi.org/10.1021/bi7017333DOI Listing
January 2008

Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides.

Bioorg Med Chem 2007 Nov 15;15(21):6649-58. Epub 2007 Aug 15.

Applied Technology Group, Incyte Corporation, Experimental Station, Wilmington, DE 19880, USA.

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http://dx.doi.org/10.1016/j.bmc.2007.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2020492PMC
November 2007

Functional expression and characterization of cytochrome P450 52A21 from Candida albicans.

Arch Biochem Biophys 2007 Aug 16;464(2):213-20. Epub 2007 Mar 16.

Department of Pharmaceutical Chemistry, University of California, San Francisco, Genentech Hall, N572D, 600 16th Street, San Francisco, CA 94158-2517, USA.

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http://dx.doi.org/10.1016/j.abb.2007.02.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1993549PMC
August 2007

Interdomain interactions within the two-component heme-based sensor DevS from Mycobacterium tuberculosis.

Biochemistry 2007 Aug 3;46(34):9728-36. Epub 2007 Aug 3.

Department of Environmental & Biomolecular Systems, OGI School of Science and Engineering, Oregon Health & Science University, 20,000 NW Walker Road, Beaverton, Oregon 97006-8921, USA.

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http://dx.doi.org/10.1021/bi7008695DOI Listing
August 2007

Arthromyces ramosus peroxidase produces two chlorinating species.

Biochem Biophys Res Commun 2007 Apr 9;355(2):581-6. Epub 2007 Feb 9.

Department of Pharmaceutical Chemistry, University of California-San Francisco, 600 16th Street, San Francisco, CA 94158-2517, USA.

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http://dx.doi.org/10.1016/j.bbrc.2007.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852486PMC
April 2007

DevS, a heme-containing two-component oxygen sensor of Mycobacterium tuberculosis.

Biochemistry 2007 Apr 20;46(14):4250-60. Epub 2007 Mar 20.

Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, California 94158-2517, USA.

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http://dx.doi.org/10.1021/bi602422pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518089PMC
April 2007

Radical energies and the regiochemistry of addition to heme groups. Methylperoxy and nitrite radical additions to the heme of horseradish peroxidase.

J Am Chem Soc 2007 Feb 24;129(6):1663-72. Epub 2007 Jan 24.

Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, California 94158-2517, USA.

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http://dx.doi.org/10.1021/ja067067sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526285PMC
February 2007

Motexafin gadolinium-induced cell death correlates with heme oxygenase-1 expression and inhibition of P450 reductase-dependent activities.

Mol Pharmacol 2007 Jan 3;71(1):193-200. Epub 2006 Oct 3.

Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th St., San Francisco, CA 94143-2280, USA.

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http://dx.doi.org/10.1124/mol.106.028407DOI Listing
January 2007

The diagnostic substrate bicyclohexane reveals a radical mechanism for bacterial cytochrome P450 in whole cells.

Angew Chem Int Ed Engl 2006 Dec;45(48):8192-4

Department of Chemistry, Bates College, Lewiston, ME 04240, USA.

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http://dx.doi.org/10.1002/anie.200603282DOI Listing
December 2006

Fungal heme oxygenases: Functional expression and characterization of Hmx1 from Saccharomyces cerevisiae and CaHmx1 from Candida albicans.

Biochemistry 2006 Dec;45(49):14772-80

Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158-2517, USA.

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http://dx.doi.org/10.1021/bi061429rDOI Listing
December 2006

Mechanism of O2 activation by cytochrome P450cam studied by isotope effects and transient state kinetics.

Biochemistry 2006 Dec;45(51):15793-806

Department of Chemistry, University of California, Berkeley, California 94720-1460, USA.

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http://dx.doi.org/10.1021/bi061726wDOI Listing
December 2006

Cytochrome P450 active site plasticity: attenuation of imidazole binding in cytochrome P450(cam) by an L244A mutation.

Protein Eng Des Sel 2006 Nov 30;19(11):491-6. Epub 2006 Aug 30.

Department of Pharmaceutical Chemistry, University of California 600 16th Street, San Francisco, CA 94158-2517, USA.

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http://dx.doi.org/10.1093/protein/gzl035DOI Listing
November 2006

Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis.

J Med Chem 2006 Oct;49(21):6308-23

Department of Pharmaceutical Chemistry, University of California, 600 16 Street, San Francisco, California 94158-2517, USA.

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http://dx.doi.org/10.1021/jm060715yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517584PMC
October 2006

CYP4 isoform specificity in the omega-hydroxylation of phytanic acid, a potential route to elimination of the causative agent of Refsum's disease.

J Pharmacol Exp Ther 2006 Aug 17;318(2):835-9. Epub 2006 May 17.

Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143-2280, USA.

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http://dx.doi.org/10.1124/jpet.106.104976DOI Listing
August 2006

Role of heme-protein covalent bonds in mammalian peroxidases. Protection of the heme by a single engineered heme-protein link in horseradish peroxidase.

J Biol Chem 2006 Jul 1;281(28):18983-8. Epub 2006 May 1.

Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1074/jbc.M602307200DOI Listing
July 2006

Oxidative activation of thiacetazone by the Mycobacterium tuberculosis flavin monooxygenase EtaA and human FMO1 and FMO3.

Chem Res Toxicol 2006 Mar;19(3):443-9

Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, California 94143-2280, USA.

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http://pubs.acs.org/doi/abs/10.1021/tx050328b
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533439PMC
March 2006

Heme-protein covalent bonds in peroxidases and resistance to heme modification during halide oxidation.

Arch Biochem Biophys 2006 Feb 5;446(1):77-83. Epub 2005 Dec 5.

Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, CA 94143-2280, USA.

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http://dx.doi.org/10.1016/j.abb.2005.11.011DOI Listing
February 2006

Solution NMR study of environmental effects on substrate seating in human heme oxygenase: influence of polypeptide truncation, substrate modification and axial ligand.

J Inorg Biochem 2006 Jan 6;100(1):97-107. Epub 2005 Dec 6.

Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, United States.

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http://dx.doi.org/10.1016/j.jinorgbio.2005.08.010DOI Listing
January 2006

Alteration of the regiospecificity of human heme oxygenase-1 by unseating of the heme but not disruption of the distal hydrogen bonding network.

Biochemistry 2006 Jan;45(1):61-73

Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, California 94143-2280, USA.

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http://dx.doi.org/10.1021/bi051645kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2507887PMC
January 2006

Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes.

Biochemistry 2006 Jan;45(2):533-42

Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, California 94143-2280, USA.

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http://dx.doi.org/10.1021/bi051840zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566308PMC
January 2006

Thermophilic cytochrome P450 enzymes.

Biochem Biophys Res Commun 2005 Dec 22;338(1):437-45. Epub 2005 Aug 22.

Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, CA 94143-2280, USA.

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http://dx.doi.org/10.1016/j.bbrc.2005.08.093DOI Listing
December 2005

Autocatalytic modification of the prosthetic heme of horseradish but not lactoperoxidase by thiocyanate oxidation products. A role for heme-protein covalent cross-linking.

J Am Chem Soc 2005 Nov;127(45):15871-9

Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, California 94143-2280, USA.

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http://pubs.acs.org/doi/abs/10.1021/ja054084t
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November 2005

Role of the Met-Tyr-Trp cross-link in Mycobacterium tuberculosis catalase-peroxidase (KatG) as revealed by KatG(M255I).

Biochemistry 2005 Nov;44(46):15093-105

Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143-2280, USA.

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http://dx.doi.org/10.1021/bi051463qDOI Listing
November 2005

Correlation between isoniazid resistance and superoxide reactivity in mycobacterium tuberculosis KatG.

J Am Chem Soc 2005 Sep;127(38):13428-42

Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143-2280, USA.

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http://dx.doi.org/10.1021/ja054366tDOI Listing
September 2005

The Met-Tyr-Trp cross-link in Mycobacterium tuberculosis catalase-peroxidase (KatG): autocatalytic formation and effect on enzyme catalysis and spectroscopic properties.

J Biol Chem 2005 Jun 18;280(24):22651-63. Epub 2005 Apr 18.

Department of Pharmaceutical Chemistry, University of California, San Francisco, 94143, USA.

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http://dx.doi.org/10.1074/jbc.M502486200DOI Listing
June 2005

Identification of the myoglobin tyrosyl radical by immuno-spin trapping and its dimerization.

Free Radic Biol Med 2005 Apr;38(7):969-76

Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, MD F0-01, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2004.12.031DOI Listing
April 2005

Cyclopropyl containing fatty acids as mechanistic probes for cytochromes P450.

J Org Chem 2005 Apr;70(7):2455-69

Department of Chemistry, University of Queensland, St. Lucia, Brisbane, Australia 4072.

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http://dx.doi.org/10.1021/jo047985dDOI Listing
April 2005

Prosthetic heme modification during halide ion oxidation. Demonstration of chloride oxidation by horseradish peroxidase.

J Am Chem Soc 2005 Apr;127(15):5345-53

Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, California 94143-2280, USA.

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http://dx.doi.org/10.1021/ja050278xDOI Listing
April 2005

Crystal structures of the G139A, G139A-NO and G143H mutants of human heme oxygenase-1. A finely tuned hydrogen-bonding network controls oxygenase versus peroxidase activity.

J Biol Inorg Chem 2005 Mar 3;10(2):138-46. Epub 2005 Feb 3.

Department of Molecular Biology and Biochemistry, University of California, Irvine, 92697-3900, USA.

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http://dx.doi.org/10.1007/s00775-004-0620-6DOI Listing
March 2005

The P450cam G248E mutant covalently binds its prosthetic heme group.

Biochemistry 2005 Mar;44(10):4091-9

Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143-0446, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi047686i
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March 2005

The Sulfolobus solfataricus electron donor partners of thermophilic CYP119: an unusual non-NAD(P)H-dependent cytochrome P450 system.

Arch Biochem Biophys 2005 Feb;434(1):169-77

Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, CA 94143-2280, USA.

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http://dx.doi.org/10.1016/j.abb.2004.10.022DOI Listing
February 2005

Protein kinase Akt/PKB phosphorylates heme oxygenase-1 in vitro and in vivo.

FEBS Lett 2004 Dec;578(1-2):90-4

Instituto de Investigaciones Biomedicas A. Sols UAM-CSIC and Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, Arzobispo Morcillo 4, Madrid 28029, Spain.

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http://dx.doi.org/10.1016/j.febslet.2004.10.077DOI Listing
December 2004