Paul P Van Veldhoven

Paul P Van Veldhoven

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Paul P Van Veldhoven

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Deciphering the potential involvement of PXMP2 and PEX11B in hydrogen peroxide permeation across the peroxisomal membrane reveals a role for PEX11B in protein sorting.

Biochim Biophys Acta Biomembr 2019 Oct 24;1861(10):182991. Epub 2019 May 24.

Laboratory of Lipid Biochemistry and Protein Interactions, Department of Cellular and Molecular Medicine, KU Leuven - University of Leuven, Herestraat 49, box 601, B-3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2019.05.013DOI Listing
October 2019

Leukodystrophy caused by plasmalogen deficiency rescued by glyceryl 1-myristyl ether treatment.

Brain Pathol 2019 09 20;29(5):622-639. Epub 2019 Feb 20.

Neurolipid Biology, Instituto de Investigação e Inovação em Saúde - i3S, Instituto de Biologia Molecular e Celular - IBMC e Universidade do Porto, Porto, Portugal.

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http://dx.doi.org/10.1111/bpa.12710DOI Listing
September 2019

Distinct Mechanisms for Visual and Motor-Related Astrocyte Responses in Mouse Visual Cortex.

Curr Biol 2019 Sep 5;29(18):3120-3127.e5. Epub 2019 Sep 5.

VIB Center for Brain and Disease Research, Herestraat 49-Box 602, 3000 Leuven, Belgium; KU Leuven, Department of Neuroscience and Leuven Brain Institute, Herestraat 49-Box 1021, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2019.07.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859477PMC
September 2019

Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones.

Crit Care 2019 Jul 1;23(1):236. Epub 2019 Jul 1.

Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1186/s13054-019-2506-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600878PMC
July 2019

Differential distribution of peroxisomal proteins points to specific roles of peroxisomes in the murine retina.

Mol Cell Biochem 2019 Jun 2;456(1-2):53-62. Epub 2019 Jan 2.

Department of Pharmaceutical and Pharmacological Sciences, Cell Metabolism, KU Leuven -University of Leuven, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1007/s11010-018-3489-3DOI Listing
June 2019

Functional peroxisomes are required for β-cell integrity in mice.

Mol Metab 2019 04 8;22:71-83. Epub 2019 Feb 8.

KU Leuven - University of Leuven, Department of Pharmaceutical and Pharmacological Sciences, Laboratory of Cell Metabolism, B-3000, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437690PMC
April 2019

Peroxisomes as Modulators of Cellular Protein Thiol Oxidation: A New Model System.

Antioxid Redox Signal 2019 01 14;30(1):22-39. Epub 2017 Jul 14.

1 Laboratory of Lipid Biochemistry and Protein Interactions, Department of Cellular and Molecular Medicine, KU Leuven-University of Leuven , Leuven, Belgium .

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http://dx.doi.org/10.1089/ars.2017.6997DOI Listing
January 2019

Mitochondrial disruption in peroxisome deficient cells is hepatocyte selective but is not mediated by common hepatic peroxisomal metabolites.

Mitochondrion 2018 03 1;39:51-59. Epub 2017 Sep 1.

KU Leuven - University of Leuven, Department of Pharmaceutical and Pharmacological Sciences, Laboratory of Cell Metabolism, B-3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2017.08.013DOI Listing
March 2018

Lipid homeostasis and inflammatory activation are disturbed in classically activated macrophages with peroxisomal β-oxidation deficiency.

Immunology 2018 03 26;153(3):342-356. Epub 2017 Oct 26.

Department of Clinical and Experimental Medicine, Translational Research Centre for Gastrointestinal Disorders (TARGID), KU Leuven - University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/imm.12844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795189PMC
March 2018

Cholesterol-Lowering Gene Therapy Counteracts the Development of Non-ischemic Cardiomyopathy in Mice.

Mol Ther 2017 11 1;25(11):2513-2525. Epub 2017 Aug 1.

Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, Catholic University of Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2017.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675591PMC
November 2017

Peroxisomal 2-Hydroxyacyl-CoA Lyase Is Involved in Endogenous Biosynthesis of Heptadecanoic Acid.

Molecules 2017 10 13;22(10). Epub 2017 Oct 13.

NIHR BRC Core Metabolomics and Lipidomics Laboratory, University of Cambridge, Pathology building Level 4, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.3390/molecules22101718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151664PMC
October 2017

Phytol-induced pathology in 2-hydroxyacyl-CoA lyase (HACL1) deficient mice. Evidence for a second non-HACL1-related lyase.

Biochim Biophys Acta Mol Cell Biol Lipids 2017 Sep 17;1862(9):972-990. Epub 2017 Jun 17.

LIPIT, Department of Cellular and Molecular Medicine, KU Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2017.06.004DOI Listing
September 2017

Coconut Oil Aggravates Pressure Overload-Induced Cardiomyopathy without Inducing Obesity, Systemic Insulin Resistance, or Cardiac Steatosis.

Int J Mol Sci 2017 07 18;18(7). Epub 2017 Jul 18.

Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, Catholic University of Leuven, Leuven 3000, Belgium.

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http://dx.doi.org/10.3390/ijms18071565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536053PMC
July 2017

Differential activities of peroxisomes along the mouse intestinal epithelium.

Cell Biochem Funct 2017 Apr 29;35(3):144-155. Epub 2017 Mar 29.

Lipid Biochemistry and Protein Interactions (LIPIT), KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/cbf.3255DOI Listing
April 2017

Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts.

Autophagy 2015 ;11(8):1326-40

a Laboratory of Lipid Biochemistry and Protein Interactions; Department of Cellular and Molecular Medicine; University of Leuven - KU Leuven ; Leuven , Belgium.

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http://dx.doi.org/10.1080/15548627.2015.1061846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590649PMC
June 2016

Hepatic dysfunction in peroxisomal disorders.

Biochim Biophys Acta 2016 May 9;1863(5):956-70. Epub 2015 Oct 9.

Laboratory for Lipid Biochemistry and Protein Interactions, Department of Cellular and Molecular Medicine, KU Leuven, B-3000 Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01674889150034
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http://dx.doi.org/10.1016/j.bbamcr.2015.09.035DOI Listing
May 2016

Bifunctional Sphingosine for Cell-Based Analysis of Protein-Sphingolipid Interactions.

ACS Chem Biol 2016 Jan 25;11(1):222-30. Epub 2015 Nov 25.

European Molecular Biology Laboratory , Cell Biology and Biophysics Unit, Meyerhofstr. 1, 69117 Heidelberg, Germany.

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http://dx.doi.org/10.1021/acschembio.5b00810DOI Listing
January 2016

Intellectual disability, muscle weakness and characteristic face in three siblings: A newly described recessive syndrome mapping to 3p24.3-p25.3.

Am J Med Genet A 2015 Nov 20;167A(11):2508-15. Epub 2015 Jul 20.

Department of Pediatrics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/ajmg.a.37248DOI Listing
November 2015

The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid.

Steroids 2015 Jul 7;99(Pt B):172-7. Epub 2015 Mar 7.

College of Medicine, Grove Building, Swansea University, Singleton Park, Swansea SA2 8PP, UK. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2015.02.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503871PMC
July 2015

Redox interplay between mitochondria and peroxisomes.

Front Cell Dev Biol 2015 27;3:35. Epub 2015 May 27.

Laboratory of Lipid Biochemistry and Protein Interactions, Department of Cellular and Molecular Medicine, KU Leuven - University of Leuven Leuven, Belgium.

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http://www.frontiersin.org/Mitochondrial_Research/10.3389/fc
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http://dx.doi.org/10.3389/fcell.2015.00035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444963PMC
June 2015

Hematopoietic stem/progenitor cells directly contribute to arteriosclerotic progression via integrin β2.

Stem Cells 2015 Apr;33(4):1230-40

Beijing Key Laboratory of Diabetes Prevention and Research, Department of Endocrinology, Lu He Hospital, Capital Medical University, Beijing, People's Republic of China.

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http://dx.doi.org/10.1002/stem.1939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409030PMC
April 2015

Mitochondria in peroxisome-deficient hepatocytes exhibit impaired respiration, depleted DNA, and PGC-1α independent proliferation.

Biochim Biophys Acta 2015 Feb 20;1853(2):285-98. Epub 2014 Nov 20.

KU Leuven - University of Leuven, Department of Pharmaceutical and Pharmacological Sciences, Laboratory of Cell Metabolism, B-3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2014.11.017DOI Listing
February 2015

Glial β-oxidation regulates Drosophila energy metabolism.

Sci Rep 2015 Jan 15;5:7805. Epub 2015 Jan 15.

1] VIB Center for the Biology of Disease, Leuven and Center for Human Genetics, KU Leuven, Leuven, Belgium [2] Centro Biología Molecular "Severo Ochoa" CSIC-UAM, Madrid, Spain.

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http://www.nature.com/articles/srep07805
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http://dx.doi.org/10.1038/srep07805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295106PMC
January 2015

Regulation of high-density lipoprotein on hematopoietic stem/progenitor cells in atherosclerosis requires scavenger receptor type BI expression.

Arterioscler Thromb Vasc Biol 2014 Sep 26;34(9):1900-9. Epub 2014 Jun 26.

From the Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University, Beijing, China (M.G., G.L.); Beijing Key Laboratory of Diabetes Research and Care, LuHe Hospital, Capital University, Peking, China (D.Z.); Interdepartmental Stem Cell Institute (S.S., K.E., C.M.V., Y.F.) and Laboratory of Lipid Biochemistry and Protein Interactions, Department of Cellular and Molecular Medicine (P.P.V.V.), Katholieke Universiteit Leuven, Leuven, Belgium; and Section on Molecular Medicine, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC (M.G.S.-T.).

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http://dx.doi.org/10.1161/ATVBAHA.114.304006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140992PMC
September 2014

Aging, age-related diseases and peroxisomes.

Subcell Biochem 2013 ;69:45-65

Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 601, B-3000, Leuven, Belgium,

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http://dx.doi.org/10.1007/978-94-007-6889-5_3DOI Listing
August 2014

Acyl-CoA thioesterase 9 (ACOT9) in mouse may provide a novel link between fatty acid and amino acid metabolism in mitochondria.

Cell Mol Life Sci 2014 Mar 18;71(5):933-48. Epub 2013 Jul 18.

Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet, C1-74, Karolinska University Hospital, SE-141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00018-013-1422-1DOI Listing
March 2014

Central nervous system pathology in MFP2 deficiency: insights from general and conditional knockout mouse models.

Biochimie 2014 Mar 19;98:119-26. Epub 2013 Aug 19.

Laboratory for Cell Metabolism, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven B-3000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2013.08.009DOI Listing
March 2014

RP-HPLC-fluorescence analysis of aliphatic aldehydes: application to aldehyde-generating enzymes HACL1 and SGPL1.

J Lipid Res 2014 Mar 9;55(3):573-82. Epub 2013 Dec 9.

Department Cellular and Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1194/jlr.D044230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934741PMC
March 2014

PEX5, the shuttling import receptor for peroxisomal matrix proteins, is a redox-sensitive protein.

Traffic 2014 Jan 31;15(1):94-103. Epub 2013 Oct 31.

Laboratory of Lipid Biochemistry and Protein Interactions, Department of Cellular and Molecular Medicine, KU, Leuven, Belgium.

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http://doi.wiley.com/10.1111/tra.12129
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http://dx.doi.org/10.1111/tra.12129DOI Listing
January 2014

Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cells.

Free Radic Biol Med 2013 Dec 27;65:882-894. Epub 2013 Aug 27.

Laboratory of Lipid Biochemistry and Protein Interactions, Katholieke Universiteit Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2013.08.173DOI Listing
December 2013

Peroxisome deficient invertebrate and vertebrate animal models.

Front Physiol 2013 Nov 22;4:335. Epub 2013 Nov 22.

LIPIT, Department Cellular and Molecular Medicine, KU Leuven Leuven, Belgium.

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http://journal.frontiersin.org/article/10.3389/fphys.2013.00
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http://dx.doi.org/10.3389/fphys.2013.00335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837297PMC
November 2013

Peroxisome deficient aP2-Pex5 knockout mice display impaired white adipocyte and muscle function concomitant with reduced adrenergic tone.

Mol Genet Metab 2012 Dec 22;107(4):735-47. Epub 2012 Oct 22.

Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.ymgme.2012.10.015DOI Listing
December 2012

Mouse models for peroxisome biogenesis defects and β-oxidation enzyme deficiencies.

Biochim Biophys Acta 2012 Sep 14;1822(9):1489-500. Epub 2012 Mar 14.

Department of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.bbadis.2012.03.003DOI Listing
September 2012

A Nonradioactive Fluorimetric SPE-Based Ceramide Kinase Assay Using NBD-C(6)-Ceramide.

J Lipids 2012 26;2012:404513. Epub 2012 Jul 26.

Department Cellular and Molecular Medicine, Katholieke Universiteit Leuven, Campus Gasthuisberg O&N1, LIPIT, Herestraat, Box 601, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1155/2012/404513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412103PMC
August 2012

Alterations in phosphatidylethanolamine levels affect the generation of Aβ.

Aging Cell 2012 Feb 28;11(1):63-72. Epub 2011 Nov 28.

Center for Human Genetics, Leuven Institute for Neurodegenerative diseases, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/j.1474-9726.2011.00760.xDOI Listing
February 2012

Determination of sphingosine-1-phosphate lyase activity by gas chromatography coupled to electron impact mass spectrometry.

Chem Phys Lipids 2012 Feb 12;165(2):225-31. Epub 2012 Jan 12.

Dept. of Biomedicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC), Spanish National Research Council (CSIC), Barcelona, Spain.

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http://dx.doi.org/10.1016/j.chemphyslip.2012.01.001DOI Listing
February 2012

Identification of a novel PEX14 mutation in Zellweger syndrome.

BMJ Case Rep 2009 23;2009. Epub 2009 Jan 23.

K.U.Leuven, Moleculaire Celbiologie, Campust Gasthuisberg ON1, Herestraat 49 box 601, Leuven, 3000, Belgium.

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http://dx.doi.org/10.1136/bcr.07.2008.0503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027610PMC
November 2011

Mitochondrial targeting of peroxiredoxin 5 is preserved from annelids to mammals but is absent in pig Sus scrofa domesticus.

Mitochondrion 2011 Nov 8;11(6):973-81. Epub 2011 Jul 8.

Université catholique de Louvain, Institut des Sciences de la Vie, 4-5 place Croix du Sud, B-1348 Louvain-la-Neuve, Belgium.

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http://dx.doi.org/10.1016/j.mito.2011.06.013DOI Listing
November 2011

Role of thiamine pyrophosphate in oligomerisation, functioning and import of peroxisomal 2-hydroxyacyl-CoA lyase.

Biochim Biophys Acta 2011 Oct 25;1814(10):1226-33. Epub 2011 Jun 25.

Department of Molecular Cell Biology, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.bbapap.2011.06.007DOI Listing
October 2011

Hepatosteatosis in peroxisome deficient liver despite increased β-oxidation capacity and impaired lipogenesis.

Biochimie 2011 Oct 5;93(10):1828-38. Epub 2011 Jul 5.

Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, K.U.Leuven, B-3000 Leuven, Belgium.

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http://linkinghub.elsevier.com/retrieve/pii/S030090841100243
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http://dx.doi.org/10.1016/j.biochi.2011.06.034DOI Listing
October 2011

Thapsigargin affinity purification of intracellular P(2A)-type Ca(2+) ATPases.

Biochim Biophys Acta 2011 May 4;1813(5):1118-27. Epub 2011 Jan 4.

Laboratory of Cellular Transport Systems; Department of Molecular Cell Biology, Campus Gasthuisberg O.&N.1, K.U. Leuven, Herestraat 49, bus 802, B-3000 Leuven, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S01674889100033
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http://dx.doi.org/10.1016/j.bbamcr.2010.12.020DOI Listing
May 2011

Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk.

Mol Biol Cell 2011 May 3;22(9):1440-51. Epub 2011 Mar 3.

Laboratory of Lipid Biochemistry and Protein Interactions, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1091/mbc.E10-11-0919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084667PMC
May 2011

Identification and characterization of new long chain acyl-CoA dehydrogenases.

Mol Genet Metab 2011 Apr 17;102(4):418-29. Epub 2010 Dec 17.

Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/j.ymgme.2010.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073726PMC
April 2011

Sphingomyelin upregulation in mature neurons contributes to TrkB activity by Rac1 endocytosis.

J Cell Sci 2011 Apr;124(Pt 8):1308-15

VIB, Department of Developmental Molecular Genetics and KULeuven Department of Human Genetics, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1242/jcs.078766DOI Listing
April 2011

Training in the fasted state improves glucose tolerance during fat-rich diet.

J Physiol 2010 Nov;588(Pt 21):4289-302

Research Centre for Exercise and Health, Department of Biomedical Kinesiology, K.U. Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1113/jphysiol.2010.196493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002457PMC
November 2010

Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism.

J Lipid Res 2010 Oct 17;51(10):2863-95. Epub 2010 Jun 17.

Katholieke Universiteit Leuven, Department of Molecular Cell Biology, LIPIT, Campus Gasthuisberg, Herestraat, Leuven, Belgium.

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http://dx.doi.org/10.1194/jlr.R005959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936746PMC
October 2010

Identification of a substrate-binding site in a peroxisomal beta-oxidation enzyme by photoaffinity labeling with a novel palmitoyl derivative.

J Biol Chem 2010 Aug 21;285(34):26315-25. Epub 2010 Jun 21.

Department of Biological Chemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.1074/jbc.M110.104547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924054PMC
August 2010

Gender affects liver desaturase expression in a rat model of n-3 fatty acid repletion.

J Nutr Biochem 2010 Mar 20;21(3):180-7. Epub 2009 Jan 20.

Unit of Lipid Nutrition and Regulation of Brain Functions, NuRéLiCe, UR909, INRA, F 78352 Jouy-en-Josas, France.

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http://dx.doi.org/10.1016/j.jnutbio.2008.10.008DOI Listing
March 2010

Enhanced Ca2+ storage in sphingosine-1-phosphate lyase-deficient fibroblasts.

Cell Signal 2010 Mar;22(3):476-83

Institut für Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe-Universität, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.cellsig.2009.11.001DOI Listing
March 2010

Peroxisome dynamics in cultured mammalian cells.

Traffic 2009 Nov 4;10(11):1722-33. Epub 2009 Aug 4.

Katholieke Universiteit Leuven, Faculteit Geneeskunde, Departement Moleculaire Celbiologie, LIPIT, Campus Gasthuisberg (O&N 1), Leuven, Belgium.

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http://dx.doi.org/10.1111/j.1600-0854.2009.00970.xDOI Listing
November 2009

Discontinued postnatal thymocyte development in sphingosine 1-phosphate-lyase-deficient mice.

J Immunol 2009 Oct 11;183(7):4292-301. Epub 2009 Sep 11.

Institute for Immunology, Hannover Medical School, Hanover 30625, Germany.

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http://dx.doi.org/10.4049/jimmunol.0901724DOI Listing
October 2009

Subcellular origin of sphingosine 1-phosphate is essential for its toxic effect in lyase-deficient neurons.

J Biol Chem 2009 Apr 27;284(17):11346-53. Epub 2009 Feb 27.

Kekulé-Institute, Life and Medical Sciences Membrane Biology and Lipid Biochemistry, University of Bonn, D-53121 Bonn, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M807336200
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http://dx.doi.org/10.1074/jbc.M807336200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670140PMC
April 2009

Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity.

Chembiochem 2009 Mar;10(5):820-2

Department of Biomedicinal Chemistry, Institut de Química Avançada de Catalunya, CSIC, Jordi Girona 18, 08034 Barcelona, Spain.

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http://dx.doi.org/10.1002/cbic.200800809DOI Listing
March 2009

Coordinate induction of PPAR alpha and SREBP2 in multifunctional protein 2 deficient mice.

Biochim Biophys Acta 2008 Nov-Dec;1781(11-12):694-702. Epub 2008 Aug 12.

Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, K.U. Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.bbalip.2008.07.010DOI Listing
February 2009

Degradation of very long chain dicarboxylic polyunsaturated fatty acids in mouse hepatocytes, a peroxisomal process.

Biochim Biophys Acta 2008 Aug 19;1781(8):400-5. Epub 2008 Jun 19.

Laboratory of Lipid Biochemistry and Protein Interactions, Department of Molecular Cell Biology, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.bbalip.2008.06.004DOI Listing
August 2008

S1P-lyase independent clearance of extracellular sphingosine 1-phosphate after dephosphorylation and cellular uptake.

J Cell Biochem 2008 Jun;104(3):756-72

Institute for Immunology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hanover, Germany.

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June 2008

Comparison of the PTS1- and Rab8b-binding properties of Pex5p and Pex5Rp/TRIP8b.

Biochim Biophys Acta 2008 May 29;1783(5):864-73. Epub 2008 Feb 29.

Katholieke Universiteit Leuven, Campus Gasthuisberg (O&N 1), Departement Moleculaire Celbiologie, LIPIT, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.bbamcr.2008.02.013DOI Listing
May 2008

Anomalous surface distribution of glycosyl phosphatidyl inositol-anchored proteins in neurons lacking acid sphingomyelinase.

Mol Biol Cell 2008 Feb 21;19(2):509-22. Epub 2007 Nov 21.

Cavalieri Ottolenghi Scientific Institute, Universita degli Studi di Torino, A.O. San Luigi Gonzaga, Regione Gonzole 10, 10043 Orbassano (Torino), Italy.

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http://dx.doi.org/10.1091/mbc.e07-05-0439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2230584PMC
February 2008

Ceramide-dependent release of ceramide kinase from cultured cells.

Biochem Biophys Res Commun 2007 Dec 4;364(1):169-74. Epub 2007 Oct 4.

Katholieke Universiteit Leuven, Faculteit Geneeskunde, Departement Moleculaire Celbiologie, LIPIT, Campus Gasthuisberg, Herestraat, Box 601, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.bbrc.2007.09.117DOI Listing
December 2007

Beta-oxidation in hepatocyte cultures from mice with peroxisomal gene knockouts.

Biochem Biophys Res Commun 2007 Jun 9;357(3):718-23. Epub 2007 Apr 9.

Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.bbrc.2007.03.198DOI Listing
June 2007

Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation.

J Biol Chem 2007 Jun 5;282(26):18777-85. Epub 2007 May 5.

Laboratory for Experimental Medicine and Endocrinology, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1074/jbc.M611763200DOI Listing
June 2007

Presence of thiamine pyrophosphate in mammalian peroxisomes.

BMC Biochem 2007 Jun 27;8:10. Epub 2007 Jun 27.

Department of Molecular Cell Biology, Division of Pharmacology, LIPIT, Katholieke Universiteit Leuven, O&N1, Leuven, Belgium.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913525PMC
June 2007

On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase.

Biol Chem 2007 Mar;388(3):315-24

Katholieke Universiteit Leuven, Departement Moleculaire Celbiologie, Afdeling Farmacologie, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1515/BC.2007.035DOI Listing
March 2007

Generalised and conditional inactivation of Pex genes in mice.

Biochim Biophys Acta 2006 Dec 25;1763(12):1785-93. Epub 2006 Aug 25.

Laboratory for Cell Metabolism, Campus Gasthuisberg Onderwijs en Navorsing II, bus 823 Herestraat 49 B-3000, Department of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Leuven, Belgium.

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December 2006

Peroxisomal multifunctional protein-2: the enzyme, the patients and the knockout mouse model.

Biochim Biophys Acta 2006 Sep 5;1761(9):973-94. Epub 2006 May 5.

Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Campus Gasthuisberg, Onderwijs en Navorsing II, bus 823, Herestraat 49, B-3000 Leuven, Belgium.

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September 2006

Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility in mice.

Endocrinology 2006 May 16;147(5):2228-36. Epub 2006 Feb 16.

Laboratory of Clinical Chemistry, Faculty of Pharmacy, Katholieke Universiteit, Leuven, Belgium.

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http://dx.doi.org/10.1210/en.2005-1571DOI Listing
May 2006

Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies.

J Lipid Res 2006 Feb 3;47(2):268-83. Epub 2005 Nov 3.

Katholieke Universiteit Leuven, Faculteit Geneeskunde, Departement Moleculaire Celbiologie, Afdeling Farmacologie, Leuven, Belgium.

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http://dx.doi.org/10.1194/jlr.M500321-JLR200DOI Listing
February 2006

Developmental changes of bile acid composition and conjugation in L- and D-bifunctional protein single and double knockout mice.

J Biol Chem 2005 May 15;280(19):18658-66. Epub 2005 Mar 15.

Academic Medical Center, Laboratory of Genetic Metabolic Diseases, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M414311200DOI Listing
May 2005

Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38-dependent manner.

Mol Cancer Res 2005 May;3(5):287-96

Division of Biological Sciences, University of Missouri, 303 Tucker Hall, Columbia, MO 65211-7400, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-04-0197DOI Listing
May 2005

Absence of peroxisomes in mouse hepatocytes causes mitochondrial and ER abnormalities.

Hepatology 2005 Apr;41(4):868-78

Laboratory of Clinical Chemistry, K. U. Leuven, B 3000 Leuven, Belgium.

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http://dx.doi.org/10.1002/hep.20628DOI Listing
April 2005

N-acyl migration in ceramides.

J Lipid Res 2005 Apr 16;46(4):812-6. Epub 2005 Jan 16.

Katholieke Universiteit Leuven, Faculteit Geneeskunde, Departement Moleculaire Celbiologie, Afdeling Farmacologie, Leuven, Belgium.

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http://dx.doi.org/10.1194/jlr.D400034-JLR200DOI Listing
April 2005