Paul P Tak

Paul P Tak

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Therapeutic options for targeting inflammatory osteoarthritis pain.

Nat Rev Rheumatol 2019 Jun;15(6):355-363

Department of Clinical Immunology & Rheumatology, Academic Medical Centre, Amsterdam University Medical Centre, Amsterdam, Netherlands.

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http://www.nature.com/articles/s41584-019-0221-y
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http://dx.doi.org/10.1038/s41584-019-0221-yDOI Listing
June 2019

Non-response to rituximab therapy in rheumatoid arthritis is associated with incomplete disruption of the B cell receptor repertoire.

Ann Rheum Dis 2019 Jun 19. Epub 2019 Jun 19.

Amsterdam Rheumatology and Immunology Center (ARC) | Department of Clinical Immunology and Rheumatology, Amsterdam UMC, location AMC, University of Amsterdam, Amsterdam, The Netherlands

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http://dx.doi.org/10.1136/annrheumdis-2018-214898DOI Listing
June 2019

Effects of B-cell directed therapy on the preclinical stage of rheumatoid arthritis: the PRAIRI study.

Ann Rheum Dis 2019 Feb 1;78(2):179-185. Epub 2018 Dec 1.

Department of Clinical immunology and Rheumatology, Amsterdam Rheumatology and Immunology Center, Amsterdam University Medical Centre, Amsterdam, The Netherlands

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2017-21276
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http://dx.doi.org/10.1136/annrheumdis-2017-212763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352407PMC
February 2019

Physician's Global Assessment in Psoriatic Arthritis: A Multicenter GRAPPA Study.

J Rheumatol 2018 Aug 15;45(9):1256-1262. Epub 2018 Jun 15.

From the Department of Medical Sciences, Policlinico of the University of Cagliari; Rheumatology Unit, and Department of Public Health, University of Cagliari, Cagliari; Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Matera; Rheumatology Research Unit, Department of Clinical and Experimental Medicine, University "Federico II," Naples; Department of Rheumatology, ASST Gaetano Pini-Centro Traumatologico Ortopedico (CTO), Milan; Rheumatology Unit, Azienda USL-IRCCS di Reggio Emilia and Università di Modena e Reggio Emilia, Modena and Reggio Emilia; Dipartimento di Medicina e Scienze della Salute, Università degli Studi del Molise, Campobasso, Italy; University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada; Academic Medical Center/University of Amsterdam; Amsterdam Rheumatology and Immunology Center Reade, Amsterdam, the Netherlands; Rehabilitation Teaching and Research Unit, Department of Medicine, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand; Medizinische Klinik III mit Poliklinik, Friedrich-Alexander-Universität Erlangen-Nuernberg, Erlangen, Germany; Sector of Dermatology, HUCFF School of Medicine, Federal University of Rio de Janeiro and Sector of Dermatology, HUPE School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Spondyloarthritis Program, Johns Hopkins University, School of Medicine, Baltimore, Maryland; Swedish Medical Centre and University of Washington School of Medicine, Seattle, Washington, USA; Department of Rheumatology, Semmelweis University, Budapest, Hungary; Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.3899/jrheum.171183DOI Listing
August 2018

Class 3 semaphorins modulate the invasive capacity of rheumatoid arthritis fibroblast-like synoviocytes.

Rheumatology (Oxford) 2018 05;57(5):909-920

Department of Experimental Immunology and Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology and Immunology Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/rheumatology/kex511DOI Listing
May 2018

Impaired lymph node stromal cell function during the earliest phases of rheumatoid arthritis.

Arthritis Res Ther 2018 02 26;20(1):35. Epub 2018 Feb 26.

Amsterdam Rheumatology & immunology Centre (ARC), Department of Clinical Immunology and Rheumatology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105, AZ, the Netherlands.

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https://arthritis-research.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13075-018-1529-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828373PMC
February 2018

Distinctive expression of T cell guiding molecules in human autoimmune lymph node stromal cells upon TLR3 triggering.

Sci Rep 2018 01 29;8(1):1736. Epub 2018 Jan 29.

Amsterdam Rheumatology & immunology Center (ARC), Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41598-018-19951-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789053PMC
January 2018

Sirukumab for rheumatoid arthritis: the phase III SIRROUND-D study.

Ann Rheum Dis 2017 Dec 30;76(12):2001-2008. Epub 2017 Aug 30.

GlaxoSmithKline Research and Development, Stevenage, Hertfordshire, UK.

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http://dx.doi.org/10.1136/annrheumdis-2017-211328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705845PMC
December 2017

Synovial tissue research: a state-of-the-art review.

Nat Rev Rheumatol 2017 08 13;13(8):463-475. Epub 2017 Jul 13.

Department of Clinical Immunology &Rheumatology, Amsterdam Rheumatology and Immunology Centre, Academic Medical Centre, University of Amsterdam, Room F4-105, POBox 22700, 1100 DE, Amsterdam, Netherlands.

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http://dx.doi.org/10.1038/nrrheum.2017.115DOI Listing
August 2017

Insight into the Endocrine System and the Immune System: A Review of the Inflammatory Role of Prolactin in Rheumatoid Arthritis and Psoriatic Arthritis.

Front Immunol 2017 23;8:720. Epub 2017 Jun 23.

Laboratory of Translational Immunology, Department of Rheumatology and Clinical Immunology, University Medical Center, Utrecht, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2017.00720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481306PMC
June 2017

Synovial IL-21/TNF-producing CD4 T cells induce joint destruction in rheumatoid arthritis by inducing matrix metalloproteinase production by fibroblast-like synoviocytes.

J Leukoc Biol 2017 03 12;101(3):775-783. Epub 2016 Oct 12.

Department of Immunology, Imperial College London, Hammersmith Campus, London, United Kingdom.

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http://dx.doi.org/10.1189/jlb.5A0516-217RRDOI Listing
March 2017

Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes.

Ann Rheum Dis 2017 Jan 25;76(1):277-285. Epub 2016 Jul 25.

Department of Experimental Immunology and Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2015-209064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264225PMC
January 2017

Lymph node biopsy analysis reveals an altered immunoregulatory balance already during the at-risk phase of autoantibody positive rheumatoid arthritis.

Eur J Immunol 2016 12 12;46(12):2812-2821. Epub 2016 Oct 12.

Amsterdam Rheumatology and Immunology Center (ARC), Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/eji.201646393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157721PMC
December 2016

Epigenetic drug discovery: breaking through the immune barrier.

Nat Rev Drug Discov 2016 12 21;15(12):835-853. Epub 2016 Oct 21.

Epinova Epigenetics Discovery Performance Unit, Immuno-Inflammation Therapy Area, GlaxoSmithKline, Medicines Research Centre, Stevenage SG1 2NY, UK.

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http://dx.doi.org/10.1038/nrd.2016.185DOI Listing
December 2016

Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases.

Nat Rev Drug Discov 2016 12;16(1):53-70

GlaxoSmithKline, Medicines Research Centre, Stevenage SG1 2NY, UK.

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http://dx.doi.org/10.1038/nrd.2016.231DOI Listing
December 2016

Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Nat Commun 2016 10 10;7:13205. Epub 2016 Oct 10.

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http://dx.doi.org/10.1038/ncomms13205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062501PMC
October 2016

Reduced CLEC9A expression in synovial tissue of psoriatic arthritis patients after adalimumab therapy.

Rheumatology (Oxford) 2016 09 13;55(9):1575-84. Epub 2016 May 13.

Clinical Immunology and Rheumatology Department Experimental Immunology Department

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http://dx.doi.org/10.1093/rheumatology/kew204DOI Listing
September 2016

Intracellular delivery of poly(I:C) induces apoptosis of fibroblast-like synoviocytes via an unknown dsRNA sensor.

Biochem Biophys Res Commun 2016 08 22;477(3):343-9. Epub 2016 Jun 22.

Departments of Experimental Immunology and Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.06.104DOI Listing
August 2016

Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Nat Commun 2016 08 23;7:12460. Epub 2016 Aug 23.

Sage Bionetworks, Seattle, Washington 98115, USA.

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http://dx.doi.org/10.1038/ncomms12460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996969PMC
August 2016

Smelling the Diagnosis: The Electronic Nose as Diagnostic Tool in Inflammatory Arthritis. A Case-Reference Study.

PLoS One 2016 16;11(3):e0151715. Epub 2016 Mar 16.

Division of Clinical Immunology and Rheumatology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151715PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794231PMC
July 2016

Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis.

Proc Natl Acad Sci U S A 2016 07 5;113(29):8284-9. Epub 2016 Jul 5.

Amsterdam Rheumatology and Immunology Center, Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands;

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http://www.pnas.org/content/early/2016/06/30/1605635113.full
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http://dx.doi.org/10.1073/pnas.1605635113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961187PMC
July 2016

A clinically based protein discovery strategy to identify potential biomarkers of response to anti-TNF-α treatment of psoriatic arthritis.

Proteomics Clin Appl 2016 06 28;10(6):645-62. Epub 2015 Sep 28.

School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland.

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http://dx.doi.org/10.1002/prca.201500051DOI Listing
June 2016

Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction.

PLoS One 2015 30;10(10):e0140815. Epub 2015 Oct 30.

Department of Clinical Immunology and Rheumatology, Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140815PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627806PMC
June 2016

Preclinical Potency and Biodistribution Studies of an AAV 5 Vector Expressing Human Interferon-β (ART-I02) for Local Treatment of Patients with Rheumatoid Arthritis.

PLoS One 2015 24;10(6):e0130612. Epub 2015 Jun 24.

Arthrogen B.V., Amsterdam, the Netherlands; Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130612PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479517PMC
April 2016

Towards prevention of autoantibody-positive rheumatoid arthritis: from lifestyle modification to preventive treatment.

Rheumatology (Oxford) 2016 Apr 15;55(4):607-14. Epub 2015 Sep 15.

Department of Rheumatology, University of Ghent, Ghent, Belgium, Department of Medicine, University of Cambridge, Cambridge and Research and Development, GlaxoSmithKline, Stevenage, UK

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http://dx.doi.org/10.1093/rheumatology/kev347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795536PMC
April 2016

Human lymph-node CD8(+) T cells display an altered phenotype during systemic autoimmunity.

Clin Transl Immunology 2016 Apr 1;5(4):e67. Epub 2016 Apr 1.

Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology and Immunology Center (ARC), Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands; Department of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/cti.2016.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855272PMC
April 2016

TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.

PLoS One 2015 7;10(4):e0122271. Epub 2015 Apr 7.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122271PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388675PMC
March 2016

Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression.

Ann Rheum Dis 2016 Feb 1;75(2):430-8. Epub 2014 Dec 1.

Department of Experimental Immunology and Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2014-205635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336378PMC
February 2016

The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts.

Ann Rheum Dis 2016 Feb 2;75(2):422-9. Epub 2014 Dec 2.

Department of Experimental Immunology and Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2014-205809DOI Listing
February 2016

Two novel α7 nicotinic acetylcholine receptor ligands: in vitro properties and their efficacy in collagen-induced arthritis in mice.

PLoS One 2015 24;10(1):e0116227. Epub 2015 Jan 24.

Department of Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands; Arthrogen BV, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116227PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305287PMC
February 2016

Prevalence of Anti-Citrullinated Protein Antibodies and IgM Rheumatoid Factor in First-Degree Relatives of Dutch Rheumatoid Arthritis Patients.

Arthritis Rheumatol 2015 Dec;67(12):3324-6

Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/art.39412DOI Listing
December 2015

Epigenetic mechanisms and drug discovery in rheumatology.

Clin Med (Lond) 2015 Dec;15 Suppl 6:s64-71

Immuno-inflammation Therapy Area Unit, GlaxoSmithKline, Medicines Research Centre, Stevenage, UK

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http://dx.doi.org/10.7861/clinmedicine.15-6-s64DOI Listing
December 2015

Discovery of Innovative Therapies for Rare Immune-Mediated Inflammatory Diseases via Off-Label Prescription of Biologics: The Case of IL-6 Receptor Blockade in Castleman's Disease.

Front Immunol 2015 11;6:625. Epub 2015 Dec 11.

Amsterdam Rheumatology and immunology Center; Academic Medical Center, University of Amsterdam , Amsterdam , Netherlands.

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http://dx.doi.org/10.3389/fimmu.2015.00625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676110PMC
December 2015

Histological characteristics of ligament healing after bio-enhanced repair of the transected goat ACL.

J Exp Orthop 2015 Dec 28;2(1). Epub 2015 Feb 28.

Department of Orthopedic Surgery, Orthopaedic Research Center Amsterdam, Academic Medical Center, University of Amsterdam, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s40634-015-0021-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544611PMC
December 2015

Does the multi-biomarker disease activity score have diagnostic value in early rheumatoid arthritis and unclassified arthritis?

Ann Rheum Dis 2015 Nov 2;74(11):2097-9. Epub 2015 Sep 2.

Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands University of Cambridge, Cambridge, UK Ghent University, Ghent, Belgium GlaxoSmithKline, Stevenage, UK.

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http://dx.doi.org/10.1136/annrheumdis-2015-207911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680142PMC
November 2015

Apolipoprotein A-I Limits the Negative Effect of Tumor Necrosis Factor on Lymphangiogenesis.

Arterioscler Thromb Vasc Biol 2015 Nov 10;35(11):2443-50. Epub 2015 Sep 10.

From the Lipid Research Group, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia (R.B., F.T., F.P., L.F.C.T., L.H., P.J.B., K.A.R.); Department of Immune Imaging, Centenary Institute, Newtown, New South Wales, Australia (R.B., A.C., W.W.); Lipid Research Group, Heart Research Institute, Sydney, New South Wales, Australia (R.B., F.T., F.P., L.F.C.T., L.H., P.J.B., K.A.R.); Department of Clinical Immunology and Rheumatology, Academic Medical Centre, Amsterdam, the Netherlands (P.P.T.); GlaxoSmithKline, Stevenage, United Kingdom (P.P.T.); Department of Rheumatology, Ghent University, Ghent, Belgium (P.P.T.); Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia (A.C., P.J.B., K.A.R.); Discipline of Dermatology, Sydney Medical School, Sydney, New South Wales, Australia (W.W.); and Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia (W.W.).

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http://dx.doi.org/10.1161/ATVBAHA.115.305777DOI Listing
November 2015

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.

Authors:
S Hong Lee Enda M Byrne Christina M Hultman Anna Kähler Anna A E Vinkhuyzen Stephan Ripke Ole A Andreassen Thomas Frisell Alexander Gusev Xinli Hu Robert Karlsson Vasilis X Mantzioris John J McGrath Divya Mehta Eli A Stahl Qiongyi Zhao Kenneth S Kendler Patrick F Sullivan Alkes L Price Michael O'Donovan Yukinori Okada Bryan J Mowry Soumya Raychaudhuri Naomi R Wray William Byerley Wiepke Cahn Rita M Cantor Sven Cichon Paul Cormican David Curtis Srdjan Djurovic Valentina Escott-Price Pablo V Gejman Lyudmila Georgieva Ina Giegling Thomas F Hansen Andrés Ingason Yunjung Kim Bettina Konte Phil H Lee Andrew McIntosh Andrew McQuillin Derek W Morris Markus M Nöthen Colm O'Dushlaine Ann Olincy Line Olsen Carlos N Pato Michele T Pato Benjamin S Pickard Danielle Posthuma Henrik B Rasmussen Marcella Rietschel Dan Rujescu Thomas G Schulze Jeremy M Silverman Srinivasa Thirumalai Thomas Werge Ingrid Agartz Farooq Amin Maria H Azevedo Nicholas Bass Donald W Black Douglas H R Blackwood Richard Bruggeman Nancy G Buccola Khalid Choudhury Robert C Cloninger Aiden Corvin Nicholas Craddock Mark J Daly Susmita Datta Gary J Donohoe Jubao Duan Frank Dudbridge Ayman Fanous Robert Freedman Nelson B Freimer Marion Friedl Michael Gill Hugh Gurling Lieuwe De Haan Marian L Hamshere Annette M Hartmann Peter A Holmans René S Kahn Matthew C Keller Elaine Kenny George K Kirov Lydia Krabbendam Robert Krasucki Jacob Lawrence Todd Lencz Douglas F Levinson Jeffrey A Lieberman Dan-Yu Lin Don H Linszen Patrik K E Magnusson Wolfgang Maier Anil K Malhotra Manuel Mattheisen Morten Mattingsdal Steven A McCarroll Helena Medeiros Ingrid Melle Vihra Milanova Inez Myin-Germeys Benjamin M Neale Roel A Ophoff Michael J Owen Jonathan Pimm Shaun M Purcell Vinay Puri Digby J Quested Lizzy Rossin Douglas Ruderfer Alan R Sanders Jianxin Shi Pamela Sklar David St Clair T Scott Stroup Jim Van Os Peter M Visscher Durk Wiersma Stanley Zammit S Louis Bridges Hyon K Choi Marieke J H Coenen Niek de Vries Philippe Dieud Jeffrey D Greenberg Tom W J Huizinga Leonid Padyukov Katherine A Siminovitch Paul P Tak Jane Worthington Philip L De Jager Joshua C Denny Peter K Gregersen Lars Klareskog Xavier Mariette Robert M Plenge Mart van Laar Piet van Riel

Int J Epidemiol 2015 Oct;44(5):1706-21

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http://dx.doi.org/10.1093/ije/dyv136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881824PMC
October 2015

JNK-dependent downregulation of FoxO1 is required to promote the survival of fibroblast-like synoviocytes in rheumatoid arthritis.

Ann Rheum Dis 2015 Sep 8;74(9):1763-71. Epub 2014 May 8.

Department of Experimental Immunology and Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2013-203610DOI Listing
September 2015

Nuclear Factor-κB-inducing Kinase Is Expressed in Synovial Endothelial Cells in Patients with Early Arthritis and Correlates with Markers of Inflammation: A Prospective Cohort Study.

J Rheumatol 2015 Sep 15;42(9):1573-81. Epub 2015 Jul 15.

From the Division of Clinical Immunology and Rheumatology, the Department of Experimental Immunology, and the Department of Radiology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands; GlaxoSmithKline, Stevenage; University of Cambridge, Cambridge, UK.K.I. Maijer, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; A.R. Noort, MSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; M.J. de Hair, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; C. van der Leij, MD, Department of Radiology, Academic Medical Center/University of Amsterdam; K.P. van Zoest, BSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; I.Y. Choi, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; D.M. Gerlag, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline; M. Maas, MD, PhD, Department of Radiology, Academic Medical Center/University of Amsterdam; P.P. Tak, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline, Stevenage, and University of Cambridge; S.W. Tas, MD, PhD, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam.

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http://dx.doi.org/10.3899/jrheum.150245DOI Listing
September 2015

Single-joint Assessment for the Evaluation of Intraarticular Treatment: Responsiveness and Discrimination of the Composite Change Index.

J Rheumatol 2015 Sep 15;42(9):1672-6. Epub 2015 Jul 15.

From the Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; Arthrogen B.V., Amsterdam; Department of Rheumatology, Atrium Medical Center, Heerlen, the Netherlands.C.J. Aalbers, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and Arthrogen B.V.; D.M. Gerlag, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; M.J. Vervoordeldonk, PhD, Arthrogen B.V.; P.P. Tak, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and Arthrogen B.V., and GlaxoSmithKline, and University of Cambridge; R.B. Landewé, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and Department of Rheumatology, Atrium Medical Center.

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http://dx.doi.org/10.3899/jrheum.140956DOI Listing
September 2015

Btk inhibition suppresses agonist-induced human macrophage activation and inflammatory gene expression in RA synovial tissue explants.

Ann Rheum Dis 2015 Aug 24;74(8):1603-11. Epub 2014 Apr 24.

Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2013-204143DOI Listing
August 2015

Tertiary Lymphoid Structures in Rheumatoid Arthritis: NF-κB-Inducing Kinase-Positive Endothelial Cells as Central Players.

Am J Pathol 2015 Jul 9;185(7):1935-43. Epub 2015 May 9.

Department of Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2015.03.012DOI Listing
July 2015

Summary of Sensitivity and Specificity for Psoriatic Arthritis in a South African Cohort according to Classification Criteria.

J Rheumatol 2015 Jun 15;42(6):960-2. Epub 2015 Apr 15.

From the Department of Internal Medicine, Prince Mshiyeni Memorial Hospital, Nelson R. Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa; and the Division of Clinical Immunology and Rheumatology, European League Against Rheumatism (EULAR) and Federation of Clinical Immunology Societies (FOCIS) Center of Excellence, Academic Medical Center/University of Amsterdam, University of Amsterdam, the Netherlands.A.B. Maharaj, MB, BS (Varanasi), H Dip Int Med(SA), FCP (SA), Certificate in Rheumatology (SA), Department of Internal Medicine, Prince Mshiyeni Memorial Hospital, Nelson R. Mandela School of Medicine, University of KwaZulu Natal, and Division of Clinical Immunology and Rheumatology, EULAR and FOCIS Center of Excellence, Academic Medical Center/University of Amsterdam; J. Govender, BSc (Hons)(UDW), MB, ChB (Medunsa); K. Maharaj, MB, ChB (Natal), FCP (SA); M. Rajkaran, MBChB (Wits), FCP(SA), Department of Internal Medicine, Prince Mshiyeni Memorial Hospital, Nelson R. Mandela School of Medicine, University of KwaZulu Natal; P.P. Tak, MD, PhD (UvA), Division of Clinical Immunology and Rheumatology, EULAR and FOCIS Center of Excellence, Academic Medical Center/University of Amsterdam.

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http://dx.doi.org/10.3899/jrheum.141537DOI Listing
June 2015

MRP8/14 serum levels as a strong predictor of response to biological treatments in patients with rheumatoid arthritis.

Ann Rheum Dis 2015 Mar 2;74(3):499-505. Epub 2013 Dec 2.

Department of Paediatric Rheumatology and Immunology, University Children's Hospital Muenster, Muenster, Germany Institute of Immunology, University Hospital Muenster, Muenster, Germany.

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http://dx.doi.org/10.1136/annrheumdis-2013-203923DOI Listing
March 2015

Spondyloarthritis in African blacks.

J Rheumatol 2015 Jan;42(1):139

Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.3899/jrheum.141023DOI Listing
January 2015

CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis.

Arthritis Res Ther 2015 Jan 17;17. Epub 2015 Jan 17.

Departments of Experimental Immunology, Internal Medicine, and Genetics, Room K0-140, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13075-015-0518-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325944PMC
January 2015

NF-κB-inducing kinase is a key regulator of inflammation-induced and tumour-associated angiogenesis.

J Pathol 2014 Nov 28;234(3):375-85. Epub 2014 Aug 28.

Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, The Netherlands; Department of Experimental Immunology, Academic Medical Center/University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/path.4403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194146PMC
November 2014

Serum 14-3-3η is a novel marker that complements current serological measurements to enhance detection of patients with rheumatoid arthritis.

J Rheumatol 2014 Nov 15;41(11):2104-13. Epub 2014 Aug 15.

From the University of Alberta, Edmonton, Alberta; Augurex Life Sciences Corp., North Vancouver, British Columbia; Mount Sinai Hospital, Toronto, Ontario, Canada; Quest Diagnostics Nichols Institute, San Juan Capistrano; Stanford University Medical Center, Palo Alto, California; Hospital for Special Surgery, New York, New York; Brigham and Women's Hospital, Boston, Massachusetts, USA; Vrije Universiteit University Medical Center; Academic Medical Center/University of Amsterdam; Jan van Breemen Research Institute, Reade organization, Amsterdam; the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands; University of Cambridge, Cambridge; GlaxoSmithKline, Stevenage, UK.W.P. Maksymowych, MD, Professor of Medicine, University of Alberta; S.J. Naides, MD, Quest Diagnostics Nichols Institute; V. Bykerk, MD, Hospital for Special Surgery; K.A. Siminovitch, MD, Mount Sinai Hospital; D. van Schaardenburg, MD, Jan van Breemen Research Institute; M. Boers, MD, Vrije Universiteit University Medical Center; R. Landewé, MD, Academic Medical Center/University of Amsterdam; D. van der Heijde, MD, Department of Rheumatology, Leiden University Medical Center; P-P. Tak, MD, Academic Medical Center/University of Amsterdam, University of Cambridge, GlaxoSmithKline; M.C. Genovese, MD, Stanford University Medical Center; M.E. Weinblatt, MD, Brigham and Women's Hospital; E.C. Keystone, MD, Mount Sinai Hospital; O.S. Zhukov, MS; R.W. Abolhosn, BS; J.M. Popov, MD, PhD, Quest Diagnostics Nichols Institute; K. Britsemmer, MD, Jan van Breemen Research Institute; A.W. van Kuijk, MD, Academic Medical Center/University of Amsterdam; A. Marotta, PhD, Augurex Life Sciences Corp.

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http://dx.doi.org/10.3899/jrheum.131446DOI Listing
November 2014

Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation.

Nat Commun 2014 Nov 13;5:5418. Epub 2014 Nov 13.

1] Arthritis and Tissue Degeneration Program and David C. Rosensweig Center for Genomics Research, Hospital for Special Surgery, New York, New York 10021, USA [2] Department of Medicine, Weill Cornell Medical College, New York, New York 10021, USA [3] Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/ncomms6418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249944PMC
November 2014

Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene.

PLoS One 2014 10;9(2):e87645. Epub 2014 Feb 10.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America ; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America ; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087645PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919745PMC
October 2014

Tie2 signaling cooperates with TNF to promote the pro-inflammatory activation of human macrophages independently of macrophage functional phenotype.

PLoS One 2014 3;9(1):e82088. Epub 2014 Jan 3.

Department of Experimental Immunology, University of Amsterdam, Amsterdam, the Netherlands ; Department of Clinical Immunology and Rheumatology, University of Amsterdam, Amsterdam, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082088PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880273PMC
September 2014

CD20+ B cell depletion alters T cell homing.

J Immunol 2014 May 2;192(9):4242-53. Epub 2014 Apr 2.

Department of Immunobiology, Biomedical Primate Research Centre, 2280 GH Rijswijk, The Netherlands;

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http://dx.doi.org/10.4049/jimmunol.1303125DOI Listing
May 2014

Peripheral joint inflammation in early onset spondyloarthritis is not specifically related to enthesitis.

Ann Rheum Dis 2014 Apr 25;73(4):735-40. Epub 2013 Apr 25.

Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, , Amsterdam, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2012-203155DOI Listing
April 2014

Genetics of rheumatoid arthritis contributes to biology and drug discovery.

Nature 2014 Feb 25;506(7488):376-81. Epub 2013 Dec 25.

1] Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [2] Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [3] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature12873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098PMC
February 2014

Early start and stop of biologics: has the time come?

BMC Med 2014 Feb 6;12:25. Epub 2014 Feb 6.

Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm 17176, Sweden.

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http://dx.doi.org/10.1186/1741-7015-12-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915229PMC
February 2014

Undifferentiated spondyloarthritis vs ankylosing spondylitis and psoriatic arthritis: a real-life prospective cohort study of clinical presentation and response to treatment.

Rheumatology (Oxford) 2013 Oct 16;52(10):1873-8. Epub 2013 Jul 16.

Academic Medical Center/University of Amsterdam, Department of Clinical Immunology and Rheumatology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/rheumatology/ket239DOI Listing
October 2013

Tumor necrosis factor inhibition modulates thrombospondin-1 expression in human inflammatory joint disease through altered NR4A2 activity.

Am J Pathol 2013 Oct 6;183(4):1243-1257. Epub 2013 Aug 6.

UCD Veterinary Sciences Centre, University College Dublin, Belfield, Ireland; Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2013.06.029DOI Listing
October 2013

A prospective, randomized, placebo-controlled study to identify biomarkers associated with active treatment in psoriatic arthritis: effects of adalimumab treatment on lesional and nonlesional skin.

Dermatology 2012 21;225(4):298-303. Epub 2012 Dec 21.

Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000343290DOI Listing
September 2013

Anti-TNF therapy reduces serum levels of chemerin in rheumatoid arthritis: a new mechanism by which anti-TNF might reduce inflammation.

PLoS One 2013 27;8(2):e57802. Epub 2013 Feb 27.

Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584053PMC
September 2013

Progression of structural damage is not related to rituximab serum levels in rheumatoid arthritis patients.

Rheumatology (Oxford) 2013 Aug 24;52(8):1462-6. Epub 2013 Apr 24.

Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/rheumatology/ket137DOI Listing
August 2013

Local administration of soluble CD40:Fc to the salivary glands of non-obese diabetic mice does not ameliorate autoimmune inflammation.

PLoS One 2012 26;7(12):e51375. Epub 2012 Dec 26.

Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051375PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530540PMC
July 2013

Presence and role of anti-citrullinated protein antibodies in experimental arthritis models.

Arthritis Rheum 2013 Apr;65(4):939-48

Academic Medical Center and University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/art.37839DOI Listing
April 2013

How to perform and analyse synovial biopsies.

Best Pract Res Clin Rheumatol 2013 Apr;27(2):195-207

Division of Clinical Immunology and Rheumatology, Academic Medical Centre/University of Amsterdam, F4-105, P.O. Box 22700, 1100 DE Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.berh.2013.03.006DOI Listing
April 2013

The resolution of inflammation.

Nat Rev Immunol 2013 01 30;13(1):59-66. Epub 2012 Nov 30.

Rheumatology Research Group at the Centre for Translational Inflammation Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, Birmingham, B15 2WD, UK.

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http://dx.doi.org/10.1038/nri3362DOI Listing
January 2013