Paul Nghiem

Paul Nghiem

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Paul Nghiem

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Imaging of Merkel Cell Carcinoma: What Imaging Experts Should Know.

Radiographics 2019 Nov-Dec;39(7):2069-2084

From the Division of Nuclear Medicine, Department of Radiology (G.A., F.B.), and Division of Dermatology, Department of Medicine (T.A., K.L., P.N.), University of Washington, 1959 NE Pacific St, Box 356113, Seattle, WA 98195-6113; and Department of Radiology, Virginia Commonwealth University Health System, Richmond, Va (S.A.F.).

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http://dx.doi.org/10.1148/rg.2019190102DOI Listing
November 2019

Treatment Patterns, Overall Survival, and Total Healthcare Costs of Advanced Merkel Cell Carcinoma in the USA.

Appl Health Econ Health Policy 2019 Oct;17(5):733-740

Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. North, Mail Stop M3-B232, Seattle, WA, 98109, USA.

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http://dx.doi.org/10.1007/s40258-019-00492-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748883PMC
October 2019

Less Toxic, More Effective Treatment-A Win-Win for Patients With Merkel Cell Carcinoma.

JAMA Dermatol 2019 Sep 4. Epub 2019 Sep 4.

University of Washington, Seattle.

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http://dx.doi.org/10.1001/jamadermatol.2019.2584DOI Listing
September 2019

One in a hundred million: Merkel cell carcinoma in pediatric and young adult patients is rare but more likely to present at advanced stages based on US registry data.

J Am Acad Dermatol 2019 06 27;80(6):1758-1760. Epub 2018 Aug 27.

Fred Hutchinson Cancer Research Center, Seattle, Washington; Seattle Cancer Care Alliance, Seattle, Washington; University of Washington, Seattle, Washington. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2018.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487227PMC
June 2019

Travel burden associated with rare cancers: The example of Merkel cell carcinoma.

Cancer Med 2019 May 5;8(5):2580-2586. Epub 2019 Apr 5.

Division of Dermatology, Department of Medicine, University of Washington, Seattle, Washington.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.2085
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http://dx.doi.org/10.1002/cam4.2085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536956PMC
May 2019

The biology and treatment of Merkel cell carcinoma: current understanding and research priorities.

Nat Rev Clin Oncol 2018 12;15(12):763-776

Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and National Cancer Institute (NCI), NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41571-018-0103-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319370PMC
December 2018

Merkel cell polyomavirus-specific immune responses in patients with Merkel cell carcinoma receiving anti-PD-1 therapy.

J Immunother Cancer 2018 11 27;6(1):131. Epub 2018 Nov 27.

Department of Medicine, Divisions of Dermatology and Medical Oncology, University of Washington, 850 Republican Street, Seattle, WA, 98109, USA.

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http://dx.doi.org/10.1186/s40425-018-0450-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258401PMC
November 2018

Targeting Merkel Cell Carcinoma by Engineered T Cells Specific to T-Antigens of Merkel Cell Polyomavirus.

Clin Cancer Res 2018 08 18;24(15):3644-3655. Epub 2018 Apr 18.

Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082703PMC
August 2018

Merkel Cell Carcinoma in the Age of Immunotherapy: Facts and Hopes.

Clin Cancer Res 2018 05 7;24(9):2035-2043. Epub 2017 Dec 7.

Division of Dermatology, Department of Medicine, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932211PMC
May 2018

The association between geographic location and incidence of Merkel cell carcinoma in comparison to melanoma: An international assessment.

Eur J Cancer 2018 05 20;94:47-60. Epub 2018 Mar 20.

Section of Cancer Surveillance, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69008 Lyon, France.

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http://dx.doi.org/10.1016/j.ejca.2018.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019703PMC
May 2018

Clinical Benefit from Tyrosine Kinase Inhibitors in Metastatic Merkel Cell Carcinoma: A Case Series of 5 Patients.

Am J Case Rep 2018 Apr 30;19:505-511. Epub 2018 Apr 30.

Department of Internal Medicine/Division of Medical Oncology, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.12659/AJCR.908649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952731PMC
April 2018

Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics.

J Am Acad Dermatol 2018 03 2;78(3):457-463.e2. Epub 2017 Nov 2.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Divisions of Medical Oncology and Dermatology, Department of Medicine, University of Washington, Seattle, Washington. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01909622173258
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http://dx.doi.org/10.1016/j.jaad.2017.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815902PMC
March 2018

Response.

J Natl Cancer Inst 2017 10;109(10)

University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://dx.doi.org/10.1093/jnci/djx053DOI Listing
October 2017

Merkel cell carcinoma.

Nat Rev Dis Primers 2017 Oct 26;3:17077. Epub 2017 Oct 26.

Division of Dermatology, Department of Medicine, University of Washington, Seattle, Washington, USA.

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http://www.nature.com/articles/nrdp201777
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http://dx.doi.org/10.1038/nrdp.2017.77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054450PMC
October 2017

Immune evasion mechanisms and immune checkpoint inhibition in advanced merkel cell carcinoma.

Oncoimmunology 2017 31;6(10):e1338237. Epub 2017 Aug 31.

Department of Surgery and Medicine, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.

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http://dx.doi.org/10.1080/2162402X.2017.1338237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665072PMC
August 2017

Systematic literature review of efficacy, safety and tolerability outcomes of chemotherapy regimens in patients with metastatic Merkel cell carcinoma.

Future Oncol 2017 Jun 28;13(14):1263-1279. Epub 2017 Mar 28.

Translational Skin Cancer Research, German Cancer Consortium (DKTK), Partner site Essen Düsseldorf, University Hospital Essen, Essen, Germany.

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http://dx.doi.org/10.2217/fon-2017-0072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040046PMC
June 2017

Polyomavirus-Negative Merkel Cell Carcinoma: A More Aggressive Subtype Based on Analysis of 282 Cases Using Multimodal Tumor Virus Detection.

J Invest Dermatol 2017 04 1;137(4):819-827. Epub 2016 Nov 1.

Division of Dermatology, Department of Medicine, University of Washington, Seattle, Washington, USA; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565758PMC
April 2017

Biomedical Research as a Team Sport.

Authors:
Paul Nghiem

J Invest Dermatol 2017 04;137(4):783-786

Division of Dermatology, University of Washington, Seattle, Washington, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.01.022DOI Listing
April 2017

DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing.

Cell Rep 2017 04;19(1):162-174

Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., C1-015, Seattle, WA 98109-1024, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., C1-015, Seattle, WA 98109-1024, USA; Department of Molecular Life Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423785PMC
April 2017

Factors influencing radiation treatment recommendations in early-stage Merkel cell carcinoma: a survey of US-based radiation oncologists.

Expert Rev Anticancer Ther 2017 03 29;17(3):281-287. Epub 2017 Jan 29.

a Department of Radiation Oncology, University of Washington, Seattle, WA (YDT, SA, JJL, UP); Department of Medicine (Medical Oncology), University of Washington, Seattle, WA (SB); Division of Dermatology , University of Washington , Seattle , WA , USA.

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http://dx.doi.org/10.1080/14737140.2017.1285233DOI Listing
March 2017

Analysis of Prognostic Factors from 9387 Merkel Cell Carcinoma Cases Forms the Basis for the New 8th Edition AJCC Staging System.

Ann Surg Oncol 2016 10 19;23(11):3564-3571. Epub 2016 May 19.

Department of Surgery, University of Michigan Health System and Medical School, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1245/s10434-016-5266-4DOI Listing
October 2016

Adjuvant Radiation Therapy and Chemotherapy in Merkel Cell Carcinoma: Survival Analyses of 6908 Cases From the National Cancer Data Base.

J Natl Cancer Inst 2016 09 31;108(9). Epub 2016 May 31.

University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA (SB, BES, JGI, AM, UP, DB, PN); Massachusetts General Hospital, Boston, MA (AJS); H. Lee Moffitt Cancer Center, Tampa, FL (VKS); The University of Texas MD Anderson Cancer Center, Houston, TX (JEG)

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http://dx.doi.org/10.1093/jnci/djw042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059142PMC
September 2016

Rationale for immune-based therapies in Merkel polyomavirus-positive and -negative Merkel cell carcinomas.

Immunotherapy 2016 07;8(8):907-21

Department of Medicine (Pathology & Dermatology), University of Washington, USA.

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http://dx.doi.org/10.2217/imt-2016-0009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827814PMC
July 2016

PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma.

N Engl J Med 2016 Jun 19;374(26):2542-52. Epub 2016 Apr 19.

From the University of Washington Medical Center (P.T.N., S. Bhatia, N.J.M., E.M.S., M.M.S., J.A.T., M.A.C.), Fred Hutchinson Cancer Research Center (P.T.N., S. Bhatia, S.P.F., L.L., J.A.T., M.A.C.), Cancer Immunotherapy Trials Network (S.P.F., L.L., M.A.C.), and Cancer Research and Biostatistics (A.M., L.R.S.) - all in Seattle; Johns Hopkins University School of Medicine and Kimmel Cancer Center, Baltimore (E.J.L., S. Berry, D.M.P., W.H.S., J.C.S., J.M.T., S.L.T.), and Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda. (E.S.) - both in Maryland; Winship Cancer Institute of Emory University, Atlanta (R.R.K.); Merck Research Laboratories, Kenilworth, NJ (L.A., E.K.C., S.M.T., J.H.Y.); University of California, San Francisco, San Francisco (A.D.), and Stanford University, Stanford (H.E.K., K.M., S.A.R.) - both in California; Mt. Sinai Medical Center, New York (P.A.F.); Yale University, New Haven, CT (H.M.K.); and Ohio State University, Columbus (T.O.).

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http://dx.doi.org/10.1056/NEJMoa1603702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927341PMC
June 2016

Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma.

Sci Rep 2016 Feb 23;6:21678. Epub 2016 Feb 23.

Translational Skin Cancer Research, German Cancer Consortium (DKTK), University Hospital Essen, Germany.

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http://dx.doi.org/10.1038/srep21678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763224PMC
February 2016

Why Do Airline Pilots and Flight Crews Have an Increased Incidence of Melanoma?

JAMA Oncol 2015 Sep;1(6):829-30

Division of Dermatology, Department of Medicine, University of Washington, Seattle.

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http://dx.doi.org/10.1001/jamaoncol.2015.0933DOI Listing
September 2015

Merkel Cell Carcinoma: Intersection of Immune Dysfunction, Infection, and Malignant Progression.

Authors:
Paul Nghiem

J Investig Dermatol Symp Proc 2015 Jul;17(1):36

University of Washington Dermatology, Fred Hutchinson Cancer Research Center, Michael Piepkorn Endowed Chair in Dermatology Research, UW Medical Center at Lake Union, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/jidsymp.2015.12DOI Listing
July 2015

How does the Merkel polyomavirus lead to a lethal cancer? Many answers, many questions, and a new mouse model.

J Invest Dermatol 2015 May;135(5):1221-1224

Department of Medicine/Dermatology, University of Washington, Seattle, Washington, USA; Department of Pathology, University of Washington, Seattle, Washington, USA; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; Seattle Cancer Care Alliance, Seattle, Washington, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2015.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402710PMC
May 2015

Identification of ATR-Chk1 pathway inhibitors that selectively target p53-deficient cells without directly suppressing ATR catalytic activity.

Cancer Res 2014 Dec 21;74(24):7534-45. Epub 2014 Oct 21.

Division of Dermatology, Department of Medicine, University of Washington, Seattle, Washington. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-2650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268153PMC
December 2014

Downregulation of MHC-I expression is prevalent but reversible in Merkel cell carcinoma.

Cancer Immunol Res 2014 Nov 12;2(11):1071-9. Epub 2014 Aug 12.

Department of Medicine, Division of Dermatology, University of Washington, Seattle, Washington. Department of Pathology, University of Washington, Seattle, Washington. Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://dx.doi.org/10.1158/2326-6066.CIR-14-0005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221542PMC
November 2014

CD8+ lymphocyte intratumoral infiltration as a stage-independent predictor of Merkel cell carcinoma survival: a population-based study.

Am J Clin Pathol 2014 Oct;142(4):452-8

From the Departments of Medicine/Dermatology and Pathology at the University of Washington, Seattle; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle WA.

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http://dx.doi.org/10.1309/AJCPIKDZM39CRPNCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174450PMC
October 2014

Milestones in the staging, classification, and biology of Merkel cell carcinoma.

J Natl Compr Canc Netw 2014 Sep;12(9):1255-62

From the School of Medicine, School of Public Health, Institute for Translational Health Sciences, Department of Medicine/Dermatology, and Department of Pathology, University of Washington; Clinical Research Division, Fred Hutchinson Cancer Research Center; and Seattle Cancer Care Alliance, Seattle, Washington. From the School of Medicine, School of Public Health, Institute for Translational Health Sciences, Department of Medicine/Dermatology, and Department of Pathology, University of Washington; Clinical Research Division, Fred Hutchinson Cancer Research Center; and Seattle Cancer Care Alliance, Seattle, Washington. From the School of Medicine, School of Public Health, Institute for Translational Health Sciences, Department of Medicine/Dermatology, and Department of Pathology, University of Washington; Clinical Research Division, Fred Hutchinson Cancer Research Center; and Seattle Cancer Care Alliance, Seattle, Washington. From the School of Medicine, School of Public Health, Institute for Translational Health Sciences, Department of Medicine/Dermatology, and Department of Pathology, University of Washington; Clinical Research Division, Fred Hutchinson Cancer Research Center; and Seattle Cancer Care Alliance, Seattle, Washington. From the School of Medicine, School of Public Health, Institute for Translational Health Sciences, Department of Medicine/Dermatology, and Department of Pathology, University of Washington; Clinical Research Division, Fred Hutchinson Cancer Research Center; and Seattle Cancer Care Alliance, Seattle, Washington.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161960PMC
http://dx.doi.org/10.6004/jnccn.2014.0123DOI Listing
September 2014

Effect of host, tumor, diagnostic, and treatment variables on outcomes in a large cohort with Merkel cell carcinoma.

JAMA Dermatol 2014 Jul;150(7):716-23

Fred Hutchinson Cancer Research Center, Seattle, Washington4Division of Dermatology, Department of Medicine, University of Washington, Seattle.

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http://dx.doi.org/10.1001/jamadermatol.2013.8116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141075PMC
July 2014

Dermatofibrosarcoma protuberans, version 1.2014.

J Natl Compr Canc Netw 2014 Jun;12(6):863-8

From University of Michigan Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Roswell Park Cancer Institute; UC San Diego Moores Cancer Center; Moffitt Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Memorial Sloan-Kettering Cancer Center; University of Colorado Cancer Center; Fred & Pamela Buffett Cancer Center at The Nebraska Medical Center; The University of Texas MD Anderson Cancer Center; Duke Cancer Institute; Fox Chase Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Dana-Farber/Brigham and Women's Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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http://dx.doi.org/10.6004/jnccn.2014.0081DOI Listing
June 2014

Relationships among primary tumor size, number of involved nodes, and survival for 8044 cases of Merkel cell carcinoma.

J Am Acad Dermatol 2014 Apr 9;70(4):637-643. Epub 2014 Feb 9.

Department of Medicine/Dermatology, University of Washington, Seattle, Washington; Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, Washington; Seattle Cancer Care Alliance, Seattle, Washington. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2013.11.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959572PMC
April 2014

T-cell responses to oncogenic merkel cell polyomavirus proteins distinguish patients with merkel cell carcinoma from healthy donors.

Clin Cancer Res 2014 Apr 13;20(7):1768-78. Epub 2014 Feb 13.

Authors' Affiliations: Center for Cancer Immune Therapy (CCIT), Department of Hematology, University Hospital Herlev, Herlev, Denmark; General Dermatology, Medical University of Graz, Graz, Austria; Departments of Medicine/Dermatology, Pathology, University of Washington; Fred Hutchinson Cancer Research Center, Seattle Cancer Center Care Alliance, Seattle, Washington; and Department of Oncology, University Hospital Herlev, Herlev, Denmark.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994405PMC
April 2014

Clinical utility of a circulating tumor cell assay in Merkel cell carcinoma.

J Am Acad Dermatol 2014 Mar 31;70(3):449-55. Epub 2013 Dec 31.

Department of Medicine/Dermatology, University of Washington, Seattle, Washington. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2013.10.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945022PMC
March 2014

Pathogen-driven cancers and emerging immune therapeutic strategies.

Cancer Immunol Res 2014 Jan;2(1):9-14

Authors' Affiliation: Department of Dermatology/Medicine, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1158/2326-6066.CIR-13-0179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135058PMC
January 2014

Merkel polyomavirus-specific T cells fluctuate with merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers.

Clin Cancer Res 2013 Oct 6;19(19):5351-60. Epub 2013 Aug 6.

Authors' Affiliations: Departments of Medicine/Dermatology, Pathology, Medicine, Laboratory Medicine, Global Health, University of Washington; Fred Hutchinson Cancer Research Center; Benaroya Research Institute, Seattle, Washington; and Department of Medicine/Dermatology, Saga University, Nabeshima, Japan.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790865PMC
October 2013

Pathologic nodal evaluation is increasingly commonly performed for patients with Merkel cell carcinoma.

J Am Acad Dermatol 2013 Oct;69(4):653-4

Department of Dermatology/Medicine, University of Washington, Seattle, Washington; Department of Pathology, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1016/j.jaad.2013.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775012PMC
October 2013

Vascular E-selectin expression correlates with CD8 lymphocyte infiltration and improved outcome in Merkel cell carcinoma.

J Invest Dermatol 2013 Aug 25;133(8):2065-73. Epub 2013 Jan 25.

Department of Medicine/Dermatology, University of Washington, Seattle, Washington 98109, USA.

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http://dx.doi.org/10.1038/jid.2013.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644376PMC
August 2013

Emerging and mechanism-based therapies for recurrent or metastatic Merkel cell carcinoma.

Curr Treat Options Oncol 2013 Jun;14(2):249-63

Departments of Medicine/Dermatology, Pathology, University of Washington, 850 Republican Street, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1007/s11864-013-0225-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651762PMC
June 2013

Merkel cell polyomavirus large T antigen has growth-promoting and inhibitory activities.

J Virol 2013 Jun 20;87(11):6118-26. Epub 2013 Mar 20.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1128/JVI.00385-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648111PMC
June 2013

Mechanisms of Caffeine-Induced Inhibition of UVB Carcinogenesis.

Front Oncol 2013 17;3:144. Epub 2013 Jun 17.

Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey , Piscataway, NJ , USA ; Allan H. Conney Laboratory for Anticancer Research, Guangdong University of Technology , Guangzhou , China.

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http://www.pnlab.org/clinical/documents/Mechanisms%20of%20ca
Web Search
http://journal.frontiersin.org/article/10.3389/fonc.2013.001
Publisher Site
http://dx.doi.org/10.3389/fonc.2013.00144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683821PMC
June 2013

Inhibition of UVB-induced nonmelanoma skin cancer: a path from tea to caffeine to exercise to decreased tissue fat.

Top Curr Chem 2013 ;329:61-72

Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, NJ 08854, USA.

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http://dx.doi.org/10.1007/128_2012_336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049109PMC
March 2013

Systemic immune suppression predicts diminished Merkel cell carcinoma-specific survival independent of stage.

J Invest Dermatol 2013 Mar 29;133(3):642-646. Epub 2012 Nov 29.

Divisions of Dermatology and Medical Oncology, Department of Internal Medicine, University of Washington, Seattle, Washington, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2012.388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570636PMC
March 2013

Importance of genetic studies in patients with multiple merkel cell carcinomas.

Acta Derm Venereol 2012 Nov;92(6):633; author reply p.634

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http://dx.doi.org/10.2340/00015555-1303DOI Listing
November 2012

Complete Spontaneous Regression of Merkel Cell Carcinoma Metastatic to the Liver: Did Lifestyle Modifications and Dietary Supplements Play a Role?

Glob Adv Health Med 2012 Nov 1;1(5):22-3. Epub 2012 Nov 1.

Paul Nghiem, MD, PhD, is the Michael Piepkorn Endowed Chair in Dermatology Research in the Division of Dermatology, Department of Medicine, University of Washington, the Fred Hutchinson Cancer Research Center, and the Seattle Cancer Care Alliance, United States.

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http://dx.doi.org/10.7453/gahmj.2012.1.5.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890101PMC
November 2012

Surgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet.

Proc Natl Acad Sci U S A 2012 Jun 21;109(23):9065-70. Epub 2012 May 21.

Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1073/pnas.1205810109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384184PMC
June 2012

Immunobiology of Merkel cell carcinoma: implications for immunotherapy of a polyomavirus-associated cancer.

Curr Oncol Rep 2011 Dec;13(6):488-97

Departments of Medicine/Medical Oncology, University of Washington, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, 98109, USA.

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http://link.springer.com/10.1007/s11912-011-0197-5
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http://dx.doi.org/10.1007/s11912-011-0197-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112947PMC
December 2011

Caffeine decreases phospho-Chk1 (Ser317) and increases mitotic cells with cyclin B1 and caspase 3 in tumors from UVB-treated mice.

Cancer Prev Res (Phila) 2011 Jul 19;4(7):1118-25. Epub 2011 Apr 19.

Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854-8020, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353410PMC
July 2011

Asymmetric lateral distribution of melanoma and Merkel cell carcinoma in the United States.

J Am Acad Dermatol 2011 Jul 21;65(1):35-9. Epub 2011 Apr 21.

Division of Dermatology, Department of Medicine, University of Washington, Seattle, Washington 98109, USA.

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http://dx.doi.org/10.1016/j.jaad.2010.05.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117975PMC
July 2011

Antibodies to merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in merkel cell carcinoma patients.

Cancer Res 2010 Nov 19;70(21):8388-97. Epub 2010 Oct 19.

Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98109, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-2128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970647PMC
November 2010