Publications by authors named "Paul Nghiem"

100Publications

Clinical benefit of baseline imaging in Merkel cell carcinoma: Analysis of 584 patients.

J Am Acad Dermatol 2021 Feb 21;84(2):330-339. Epub 2020 Jul 21.

Department of Medicine, Division of Dermatology, University of Washington, Seattle, Washington; Fred Hutchinson Cancer Research Center, Seattle, Washington. Electronic address:

View Article and Find Full Text PDF
February 2021

Immune checkpoint inhibitors to treat cutaneous malignancies.

J Am Acad Dermatol 2020 Nov 24;83(5):1239-1253. Epub 2020 May 24.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medicine, New York, New York. Electronic address:

View Article and Find Full Text PDF
November 2020

The 6-4 photoproduct is the trigger of UV-induced replication blockage and ATR activation.

Proc Natl Acad Sci U S A 2020 06 22;117(23):12806-12816. Epub 2020 May 22.

Division of Dermatology, Department of Medicine, University of Washington, Seattle, WA 98109;

View Article and Find Full Text PDF
June 2020

Perspectives on the recommendations for skin cancer management during the COVID-19 pandemic.

J Am Acad Dermatol 2020 Jul 6;83(1):295-296. Epub 2020 May 6.

Department of Dermatology, Columbia University Irving Medical Center, New York, New York.

View Article and Find Full Text PDF
July 2020

Polyomavirus-driven Merkel cell carcinoma: Prospects for therapeutic vaccine development.

Mol Carcinog 2020 07 27;59(7):807-821. Epub 2020 Mar 27.

Department of Medicine, Division of Dermatology, University of Washington, Seattle, Washington.

View Article and Find Full Text PDF
July 2020

Imaging of Merkel Cell Carcinoma: What Imaging Experts Should Know.

Radiographics 2019 Nov-Dec;39(7):2069-2084

From the Division of Nuclear Medicine, Department of Radiology (G.A., F.B.), and Division of Dermatology, Department of Medicine (T.A., K.L., P.N.), University of Washington, 1959 NE Pacific St, Box 356113, Seattle, WA 98195-6113; and Department of Radiology, Virginia Commonwealth University Health System, Richmond, Va (S.A.F.).

View Article and Find Full Text PDF
July 2020

Less Toxic, More Effective Treatment-A Win-Win for Patients With Merkel Cell Carcinoma.

JAMA Dermatol 2019 Sep 4. Epub 2019 Sep 4.

University of Washington, Seattle.

View Article and Find Full Text PDF
September 2019

Treatment Patterns, Overall Survival, and Total Healthcare Costs of Advanced Merkel Cell Carcinoma in the USA.

Appl Health Econ Health Policy 2019 10;17(5):733-740

Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. North, Mail Stop M3-B232, Seattle, WA, 98109, USA.

View Article and Find Full Text PDF
October 2019

Travel burden associated with rare cancers: The example of Merkel cell carcinoma.

Cancer Med 2019 05 5;8(5):2580-2586. Epub 2019 Apr 5.

Division of Dermatology, Department of Medicine, University of Washington, Seattle, Washington.

View Article and Find Full Text PDF
May 2019

Merkel cell polyomavirus-specific immune responses in patients with Merkel cell carcinoma receiving anti-PD-1 therapy.

J Immunother Cancer 2018 11 27;6(1):131. Epub 2018 Nov 27.

Department of Medicine, Divisions of Dermatology and Medical Oncology, University of Washington, 850 Republican Street, Seattle, WA, 98109, USA.

View Article and Find Full Text PDF
November 2018

The biology and treatment of Merkel cell carcinoma: current understanding and research priorities.

Nat Rev Clin Oncol 2018 12;15(12):763-776

Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and National Cancer Institute (NCI), NIH, Bethesda, MD, USA.

View Article and Find Full Text PDF
December 2018

One in a hundred million: Merkel cell carcinoma in pediatric and young adult patients is rare but more likely to present at advanced stages based on US registry data.

J Am Acad Dermatol 2019 06 27;80(6):1758-1760. Epub 2018 Aug 27.

Fred Hutchinson Cancer Research Center, Seattle, Washington; Seattle Cancer Care Alliance, Seattle, Washington; University of Washington, Seattle, Washington. Electronic address:

View Article and Find Full Text PDF
June 2019

Clinical Benefit from Tyrosine Kinase Inhibitors in Metastatic Merkel Cell Carcinoma: A Case Series of 5 Patients.

Am J Case Rep 2018 Apr 30;19:505-511. Epub 2018 Apr 30.

Department of Internal Medicine/Division of Medical Oncology, University of Washington, Seattle, WA, USA.

View Article and Find Full Text PDF
April 2018

Targeting Merkel Cell Carcinoma by Engineered T Cells Specific to T-Antigens of Merkel Cell Polyomavirus.

Clin Cancer Res 2018 08 18;24(15):3644-3655. Epub 2018 Apr 18.

Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.

View Article and Find Full Text PDF
August 2018

The association between geographic location and incidence of Merkel cell carcinoma in comparison to melanoma: An international assessment.

Eur J Cancer 2018 05 20;94:47-60. Epub 2018 Mar 20.

Section of Cancer Surveillance, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69008 Lyon, France.

View Article and Find Full Text PDF
May 2018

Merkel Cell Carcinoma in the Age of Immunotherapy: Facts and Hopes.

Clin Cancer Res 2018 05 7;24(9):2035-2043. Epub 2017 Dec 7.

Division of Dermatology, Department of Medicine, University of Washington, Seattle, Washington.

View Article and Find Full Text PDF
May 2018

Immune evasion mechanisms and immune checkpoint inhibition in advanced merkel cell carcinoma.

Oncoimmunology 2017;6(10):e1338237. Epub 2017 Aug 31.

Department of Surgery and Medicine, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.

View Article and Find Full Text PDF
August 2017

Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics.

J Am Acad Dermatol 2018 03 2;78(3):457-463.e2. Epub 2017 Nov 2.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Divisions of Medical Oncology and Dermatology, Department of Medicine, University of Washington, Seattle, Washington. Electronic address:

View Article and Find Full Text PDF
March 2018

Merkel cell carcinoma.

Nat Rev Dis Primers 2017 Oct 26;3:17077. Epub 2017 Oct 26.

Division of Dermatology, Department of Medicine, University of Washington, Seattle, Washington, USA.

View Article and Find Full Text PDF
October 2017

Response.

J Natl Cancer Inst 2017 10;109(10)

University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

View Article and Find Full Text PDF
October 2017

DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing.

Cell Rep 2017 04;19(1):162-174

Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., C1-015, Seattle, WA 98109-1024, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., C1-015, Seattle, WA 98109-1024, USA; Department of Molecular Life Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. Electronic address:

View Article and Find Full Text PDF
April 2017

Systematic literature review of efficacy, safety and tolerability outcomes of chemotherapy regimens in patients with metastatic Merkel cell carcinoma.

Future Oncol 2017 Jun 28;13(14):1263-1279. Epub 2017 Mar 28.

Translational Skin Cancer Research, German Cancer Consortium (DKTK), Partner site Essen Düsseldorf, University Hospital Essen, Essen, Germany.

View Article and Find Full Text PDF
June 2017

Biomedical Research as a Team Sport.

Authors:
Paul Nghiem

J Invest Dermatol 2017 04;137(4):783-786

Division of Dermatology, University of Washington, Seattle, Washington, USA. Electronic address:

View Article and Find Full Text PDF
April 2017

Factors influencing radiation treatment recommendations in early-stage Merkel cell carcinoma: a survey of US-based radiation oncologists.

Expert Rev Anticancer Ther 2017 03 29;17(3):281-287. Epub 2017 Jan 29.

a Department of Radiation Oncology, University of Washington, Seattle, WA (YDT, SA, JJL, UP); Department of Medicine (Medical Oncology), University of Washington, Seattle, WA (SB); Division of Dermatology , University of Washington , Seattle , WA , USA.

View Article and Find Full Text PDF
March 2017

Polyomavirus-Negative Merkel Cell Carcinoma: A More Aggressive Subtype Based on Analysis of 282 Cases Using Multimodal Tumor Virus Detection.

J Invest Dermatol 2017 04 1;137(4):819-827. Epub 2016 Nov 1.

Division of Dermatology, Department of Medicine, University of Washington, Seattle, Washington, USA; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. Electronic address:

View Article and Find Full Text PDF
April 2017

Rationale for immune-based therapies in Merkel polyomavirus-positive and -negative Merkel cell carcinomas.

Immunotherapy 2016 07;8(8):907-21

Department of Medicine (Pathology & Dermatology), University of Washington, USA.

View Article and Find Full Text PDF
July 2016

Adjuvant Radiation Therapy and Chemotherapy in Merkel Cell Carcinoma: Survival Analyses of 6908 Cases From the National Cancer Data Base.

J Natl Cancer Inst 2016 09 31;108(9). Epub 2016 May 31.

University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA (SB, BES, JGI, AM, UP, DB, PN); Massachusetts General Hospital, Boston, MA (AJS); H. Lee Moffitt Cancer Center, Tampa, FL (VKS); The University of Texas MD Anderson Cancer Center, Houston, TX (JEG)

View Article and Find Full Text PDF
September 2016

Analysis of Prognostic Factors from 9387 Merkel Cell Carcinoma Cases Forms the Basis for the New 8th Edition AJCC Staging System.

Ann Surg Oncol 2016 10 19;23(11):3564-3571. Epub 2016 May 19.

Department of Surgery, University of Michigan Health System and Medical School, Ann Arbor, MI, USA.

View Article and Find Full Text PDF
October 2016

PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma.

N Engl J Med 2016 Jun 19;374(26):2542-52. Epub 2016 Apr 19.

From the University of Washington Medical Center (P.T.N., S. Bhatia, N.J.M., E.M.S., M.M.S., J.A.T., M.A.C.), Fred Hutchinson Cancer Research Center (P.T.N., S. Bhatia, S.P.F., L.L., J.A.T., M.A.C.), Cancer Immunotherapy Trials Network (S.P.F., L.L., M.A.C.), and Cancer Research and Biostatistics (A.M., L.R.S.) - all in Seattle; Johns Hopkins University School of Medicine and Kimmel Cancer Center, Baltimore (E.J.L., S. Berry, D.M.P., W.H.S., J.C.S., J.M.T., S.L.T.), and Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda. (E.S.) - both in Maryland; Winship Cancer Institute of Emory University, Atlanta (R.R.K.); Merck Research Laboratories, Kenilworth, NJ (L.A., E.K.C., S.M.T., J.H.Y.); University of California, San Francisco, San Francisco (A.D.), and Stanford University, Stanford (H.E.K., K.M., S.A.R.) - both in California; Mt. Sinai Medical Center, New York (P.A.F.); Yale University, New Haven, CT (H.M.K.); and Ohio State University, Columbus (T.O.).

View Article and Find Full Text PDF
June 2016

Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma.

Sci Rep 2016 Feb 23;6:21678. Epub 2016 Feb 23.

Translational Skin Cancer Research, German Cancer Consortium (DKTK), University Hospital Essen, Germany.

View Article and Find Full Text PDF
February 2016

Why Do Airline Pilots and Flight Crews Have an Increased Incidence of Melanoma?

JAMA Oncol 2015 Sep;1(6):829-30

Division of Dermatology, Department of Medicine, University of Washington, Seattle.

View Article and Find Full Text PDF
September 2015

Merkel Cell Carcinoma: Intersection of Immune Dysfunction, Infection, and Malignant Progression.

Authors:
Paul Nghiem

J Investig Dermatol Symp Proc 2015 Jul;17(1):36

University of Washington Dermatology, Fred Hutchinson Cancer Research Center, Michael Piepkorn Endowed Chair in Dermatology Research, UW Medical Center at Lake Union, Seattle, Washington, USA.

View Article and Find Full Text PDF
July 2015

How does the Merkel polyomavirus lead to a lethal cancer? Many answers, many questions, and a new mouse model.

J Invest Dermatol 2015 May;135(5):1221-1224

Department of Medicine/Dermatology, University of Washington, Seattle, Washington, USA; Department of Pathology, University of Washington, Seattle, Washington, USA; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; Seattle Cancer Care Alliance, Seattle, Washington, USA. Electronic address:

View Article and Find Full Text PDF
May 2015

Identification of ATR-Chk1 pathway inhibitors that selectively target p53-deficient cells without directly suppressing ATR catalytic activity.

Cancer Res 2014 Dec 21;74(24):7534-45. Epub 2014 Oct 21.

Division of Dermatology, Department of Medicine, University of Washington, Seattle, Washington. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

View Article and Find Full Text PDF
December 2014

CD8+ lymphocyte intratumoral infiltration as a stage-independent predictor of Merkel cell carcinoma survival: a population-based study.

Am J Clin Pathol 2014 Oct;142(4):452-8

From the Departments of Medicine/Dermatology and Pathology at the University of Washington, Seattle; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle WA.

View Article and Find Full Text PDF
October 2014

Milestones in the staging, classification, and biology of Merkel cell carcinoma.

J Natl Compr Canc Netw 2014 Sep;12(9):1255-62

From the School of Medicine, School of Public Health, Institute for Translational Health Sciences, Department of Medicine/Dermatology, and Department of Pathology, University of Washington; Clinical Research Division, Fred Hutchinson Cancer Research Center; and Seattle Cancer Care Alliance, Seattle, Washington. From the School of Medicine, School of Public Health, Institute for Translational Health Sciences, Department of Medicine/Dermatology, and Department of Pathology, University of Washington; Clinical Research Division, Fred Hutchinson Cancer Research Center; and Seattle Cancer Care Alliance, Seattle, Washington. From the School of Medicine, School of Public Health, Institute for Translational Health Sciences, Department of Medicine/Dermatology, and Department of Pathology, University of Washington; Clinical Research Division, Fred Hutchinson Cancer Research Center; and Seattle Cancer Care Alliance, Seattle, Washington. From the School of Medicine, School of Public Health, Institute for Translational Health Sciences, Department of Medicine/Dermatology, and Department of Pathology, University of Washington; Clinical Research Division, Fred Hutchinson Cancer Research Center; and Seattle Cancer Care Alliance, Seattle, Washington. From the School of Medicine, School of Public Health, Institute for Translational Health Sciences, Department of Medicine/Dermatology, and Department of Pathology, University of Washington; Clinical Research Division, Fred Hutchinson Cancer Research Center; and Seattle Cancer Care Alliance, Seattle, Washington.

View Article and Find Full Text PDF
September 2014

Downregulation of MHC-I expression is prevalent but reversible in Merkel cell carcinoma.

Cancer Immunol Res 2014 Nov 12;2(11):1071-9. Epub 2014 Aug 12.

Department of Medicine, Division of Dermatology, University of Washington, Seattle, Washington. Department of Pathology, University of Washington, Seattle, Washington. Fred Hutchinson Cancer Research Center, Seattle, Washington.

View Article and Find Full Text PDF
November 2014

Dermatofibrosarcoma protuberans, version 1.2014.

J Natl Compr Canc Netw 2014 Jun;12(6):863-8

From University of Michigan Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Roswell Park Cancer Institute; UC San Diego Moores Cancer Center; Moffitt Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Memorial Sloan-Kettering Cancer Center; University of Colorado Cancer Center; Fred & Pamela Buffett Cancer Center at The Nebraska Medical Center; The University of Texas MD Anderson Cancer Center; Duke Cancer Institute; Fox Chase Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Dana-Farber/Brigham and Women's Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

View Article and Find Full Text PDF
June 2014

Effect of host, tumor, diagnostic, and treatment variables on outcomes in a large cohort with Merkel cell carcinoma.

JAMA Dermatol 2014 Jul;150(7):716-23

Fred Hutchinson Cancer Research Center, Seattle, Washington4Division of Dermatology, Department of Medicine, University of Washington, Seattle.

View Article and Find Full Text PDF
July 2014

Pathogen-driven cancers and emerging immune therapeutic strategies.

Cancer Immunol Res 2014 Jan;2(1):9-14

Authors' Affiliation: Department of Dermatology/Medicine, University of Washington, Seattle, Washington.

View Article and Find Full Text PDF
January 2014

T-cell responses to oncogenic merkel cell polyomavirus proteins distinguish patients with merkel cell carcinoma from healthy donors.

Clin Cancer Res 2014 Apr 13;20(7):1768-78. Epub 2014 Feb 13.

Authors' Affiliations: Center for Cancer Immune Therapy (CCIT), Department of Hematology, University Hospital Herlev, Herlev, Denmark; General Dermatology, Medical University of Graz, Graz, Austria; Departments of Medicine/Dermatology, Pathology, University of Washington; Fred Hutchinson Cancer Research Center, Seattle Cancer Center Care Alliance, Seattle, Washington; and Department of Oncology, University Hospital Herlev, Herlev, Denmark.

View Article and Find Full Text PDF
April 2014

Relationships among primary tumor size, number of involved nodes, and survival for 8044 cases of Merkel cell carcinoma.

J Am Acad Dermatol 2014 Apr 9;70(4):637-643. Epub 2014 Feb 9.

Department of Medicine/Dermatology, University of Washington, Seattle, Washington; Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, Washington; Seattle Cancer Care Alliance, Seattle, Washington. Electronic address:

View Article and Find Full Text PDF
April 2014

Clinical utility of a circulating tumor cell assay in Merkel cell carcinoma.

J Am Acad Dermatol 2014 Mar 31;70(3):449-55. Epub 2013 Dec 31.

Department of Medicine/Dermatology, University of Washington, Seattle, Washington. Electronic address:

View Article and Find Full Text PDF
March 2014

Pathologic nodal evaluation is increasingly commonly performed for patients with Merkel cell carcinoma.

J Am Acad Dermatol 2013 Oct;69(4):653-4

Department of Dermatology/Medicine, University of Washington, Seattle, Washington; Department of Pathology, University of Washington, Seattle, Washington.

View Article and Find Full Text PDF
October 2013

Merkel polyomavirus-specific T cells fluctuate with merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers.

Clin Cancer Res 2013 Oct 6;19(19):5351-60. Epub 2013 Aug 6.

Authors' Affiliations: Departments of Medicine/Dermatology, Pathology, Medicine, Laboratory Medicine, Global Health, University of Washington; Fred Hutchinson Cancer Research Center; Benaroya Research Institute, Seattle, Washington; and Department of Medicine/Dermatology, Saga University, Nabeshima, Japan.

View Article and Find Full Text PDF
October 2013

Mechanisms of Caffeine-Induced Inhibition of UVB Carcinogenesis.

Front Oncol 2013 17;3:144. Epub 2013 Jun 17.

Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey , Piscataway, NJ , USA ; Allan H. Conney Laboratory for Anticancer Research, Guangdong University of Technology , Guangzhou , China.

View Article and Find Full Text PDF
June 2013

Merkel cell polyomavirus large T antigen has growth-promoting and inhibitory activities.

J Virol 2013 Jun 20;87(11):6118-26. Epub 2013 Mar 20.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

View Article and Find Full Text PDF
June 2013

Emerging and mechanism-based therapies for recurrent or metastatic Merkel cell carcinoma.

Curr Treat Options Oncol 2013 Jun;14(2):249-63

Departments of Medicine/Dermatology, Pathology, University of Washington, 850 Republican Street, Seattle, WA 98109, USA.

View Article and Find Full Text PDF
June 2013

Vascular E-selectin expression correlates with CD8 lymphocyte infiltration and improved outcome in Merkel cell carcinoma.

J Invest Dermatol 2013 Aug 25;133(8):2065-73. Epub 2013 Jan 25.

Department of Medicine/Dermatology, University of Washington, Seattle, Washington 98109, USA.

View Article and Find Full Text PDF
August 2013

Systemic immune suppression predicts diminished Merkel cell carcinoma-specific survival independent of stage.

J Invest Dermatol 2013 Mar 29;133(3):642-646. Epub 2012 Nov 29.

Divisions of Dermatology and Medical Oncology, Department of Internal Medicine, University of Washington, Seattle, Washington, USA. Electronic address:

View Article and Find Full Text PDF
March 2013

Complete Spontaneous Regression of Merkel Cell Carcinoma Metastatic to the Liver: Did Lifestyle Modifications and Dietary Supplements Play a Role?

Glob Adv Health Med 2012 Nov 1;1(5):22-3. Epub 2012 Nov 1.

Paul Nghiem, MD, PhD, is the Michael Piepkorn Endowed Chair in Dermatology Research in the Division of Dermatology, Department of Medicine, University of Washington, the Fred Hutchinson Cancer Research Center, and the Seattle Cancer Care Alliance, United States.

View Article and Find Full Text PDF
November 2012

Diagnostic biopsy does not commonly induce intratumoral CD8 T cell infiltration in Merkel cell carcinoma.

PLoS One 2012 31;7(7):e41465. Epub 2012 Jul 31.

Dermatology/Medicine, University of Washington, Seattle, Washington, United States of America.

View Article and Find Full Text PDF
April 2013

Inhibition of UVB-induced nonmelanoma skin cancer: a path from tea to caffeine to exercise to decreased tissue fat.

Top Curr Chem 2013 ;329:61-72

Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, NJ 08854, USA.

View Article and Find Full Text PDF
March 2013

Surgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet.

Proc Natl Acad Sci U S A 2012 Jun 21;109(23):9065-70. Epub 2012 May 21.

Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

View Article and Find Full Text PDF
June 2012