Publications by authors named "Paul N Bishop"

69Publications

Analysis of opticin binding to collagen fibrils identifies a single binding site in the gap region and a high specificity towards thin heterotypic fibrils containing collagens II, and XI or V/XI.

PLoS One 2020 7;15(8):e0234672. Epub 2020 Aug 7.

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234672PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413481PMC
October 2020

Intravitreal Pharmacokinetic Study of the Antiangiogenic Glycoprotein Opticin.

Mol Pharm 2020 07 9;17(7):2390-2397. Epub 2020 Jun 9.

Division of Cardiovascular Sciences, School of Medical Sciences, FBMH, University of Manchester, Manchester M13 9PT, United Kingdom.

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http://dx.doi.org/10.1021/acs.molpharmaceut.0c00151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341526PMC
July 2020

Loss-of-Function Mutations in the CFH Gene Affecting Alternatively Encoded Factor H-like 1 Protein Cause Dominant Early-Onset Macular Drusen.

Ophthalmology 2019 10 21;126(10):1410-1421. Epub 2019 Mar 21.

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom; Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, St. Mary's Hospital, Manchester, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01616420183317
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http://dx.doi.org/10.1016/j.ophtha.2019.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856713PMC
October 2019

Efficacy and Safety of Glycosidic Enzymes for Improved Gene Delivery to the Retina following Intravitreal Injection in Mice.

Mol Ther Methods Clin Dev 2018 Jun 22;9:192-202. Epub 2017 Dec 22.

Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1016/j.omtm.2017.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948313PMC
June 2018

In vivo effect of opticin deficiency in cartilage in a surgically induced mouse model of osteoarthritis.

Sci Rep 2018 01 11;8(1):457. Epub 2018 Jan 11.

Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/s41598-017-18047-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765138PMC
January 2018

Bruch's Membrane Compartmentalizes Complement Regulation in the Eye with Implications for Therapeutic Design in Age-Related Macular Degeneration.

Front Immunol 2017 19;8:1778. Epub 2017 Dec 19.

Division of Evolution and Genomic Medicine, Faculty of Biology Medicine and Health, School of Biological Sciences, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2017.01778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742201PMC
December 2017

The eye as a complement dysregulation hotspot.

Semin Immunopathol 2018 01 25;40(1):65-74. Epub 2017 Sep 25.

Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1007/s00281-017-0649-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794836PMC
January 2018

Characterisation of the metabolome of ocular tissues and post-mortem changes in the rat retina.

Exp Eye Res 2016 08 24;149:8-15. Epub 2016 May 24.

Centre for Ophthalmology and Vision Sciences, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, M13 9PL, UK; Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, M13 9WL, UK; Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, M13 9WL, UK.

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http://dx.doi.org/10.1016/j.exer.2016.05.019DOI Listing
August 2016

Molecular findings from 537 individuals with inherited retinal disease.

J Med Genet 2016 Nov 11;53(11):761-767. Epub 2016 May 11.

Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, St Mary's Hospital, Manchester, UK.

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http://jmg.bmj.com/lookup/doi/10.1136/jmedgenet-2016-103837
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http://dx.doi.org/10.1136/jmedgenet-2016-103837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106339PMC
November 2016

Whole Genome Sequencing Increases Molecular Diagnostic Yield Compared with Current Diagnostic Testing for Inherited Retinal Disease.

Ophthalmology 2016 May 9;123(5):1143-50. Epub 2016 Feb 9.

Manchester Centre for Genomic Medicine, Saint Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom; Institute of Human Development, University of Manchester, Manchester, United Kingdom; Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ophtha.2016.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845717PMC
May 2016

Age and Smoking Related Changes in Metal Ion Levels in Human Lens: Implications for Cataract Formation.

PLoS One 2016 21;11(1):e0147576. Epub 2016 Jan 21.

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147576PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721641PMC
August 2016

Enrichment of Bruch's Membrane from Human Donor Eyes.

J Vis Exp 2015 Nov 15(105). Epub 2015 Nov 15.

Centre for Ophthalmology & Vision Sciences, Institute of Human Development, University of Manchester; Centre for Advanced Discovery and Experimental Therapeutics, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre;

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http://dx.doi.org/10.3791/53382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692728PMC
November 2015

Restoration of Vision with Ectopic Expression of Human Rod Opsin.

Curr Biol 2015 Aug 30;25(16):2111-22. Epub 2015 Jul 30.

Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09609822150083
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http://dx.doi.org/10.1016/j.cub.2015.07.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540256PMC
August 2015

Assessment of Proteins Associated With Complement Activation and Inflammation in Maculae of Human Donors Homozygous Risk at Chromosome 1 CFH-to-F13B.

Invest Ophthalmol Vis Sci 2015 Jul;56(8):4870-9

Center for Translational Medicine John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, Utah, United States.

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http://dx.doi.org/10.1167/iovs.15-17009DOI Listing
July 2015

WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.

Sci Signal 2015 Jun 30;8(383):ra65. Epub 2015 Jun 30.

Institut de Neurobiologie de la Méditerranée (INMED), INSERM Unité 901, 13273 Marseille, France. Aix-Marseille Université, UMR 901, 13273 Marseille, France.

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http://dx.doi.org/10.1126/scisignal.aaa0354DOI Listing
June 2015

Routine versus As-Needed Bevacizumab with 12-Weekly Assessment Intervals for Neovascular Age-Related Macular Degeneration: 92-Week Results of the GMAN Trial.

Ophthalmology 2015 Jul 17;122(7):1348-55. Epub 2015 Apr 17.

Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom; Centre for Ophthalmology & Vision Sciences, and Centre for Advanced Discovery & Experimental Therapeutics (CADET), Institute of Human Development, University of Manchester, Manchester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ophtha.2015.03.017DOI Listing
July 2015

The role of extracellular matrix in retinal vascular development and preretinal neovascularization.

Authors:
Paul N Bishop

Exp Eye Res 2015 Apr;133:30-6

Centre for Hearing & Vision Research, Institute of Human Development, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PL, UK; Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2014.10.021DOI Listing
April 2015

Age-related macular degeneration and the role of the complement system.

Mol Immunol 2015 Sep 21;67(1):43-50. Epub 2015 Mar 21.

Centre for Ophthalmology & Vision Sciences, Institute of Human Development, University of Manchester, Manchester, UK; Centre for Advanced Discovery & Experimental Therapeutics, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK; Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2015.02.032DOI Listing
September 2015

Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease.

Biochem Biophys Res Commun 2015 May 20;460(3):549-54. Epub 2015 Mar 20.

Centre for Advanced Discovery and Experimental Therapeutics, Central Manchester University Hospitals NHS Foundation Trust (CMFT), Manchester M13 9WL, United Kingdom; Centre for Endocrinology & Diabetes, Institute of Human Development, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom; School of Biological Sciences, Faculty of Science, and Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; Department of Pharmacology, Medical Sciences Division, University of Oxford, Oxford OX1 3QT, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.03.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427106PMC
May 2015

Role of Factor H and Related Proteins in Regulating Complement Activation in the Macula, and Relevance to Age-Related Macular Degeneration.

J Clin Med 2015 Jan;4(1):18-31

Centre for Hearing & Vision Research, Institute of Human Development, AV Hill Building, University of Manchester, Oxford Road, Manchester M13 9PL, UK ; Centre for Advanced Discovery and Experimental Therapeutics, University of Manchester and Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, UK ; Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester M13 9WH, UK.

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http://www.mdpi.com/2077-0383/4/1/18
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http://dx.doi.org/10.3390/jcm4010018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340553PMC
January 2015

Complementing the Sugar Code: Role of GAGs and Sialic Acid in Complement Regulation.

Front Immunol 2015 2;6:25. Epub 2015 Feb 2.

Centre for Hearing and Vision Research, Institute of Human Development, University of Manchester , Manchester , UK ; Centre for Advanced Discovery and Experimental Therapeutics, University of Manchester and Central Manchester University Hospitals NHS Foundation Trust , Manchester , UK.

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http://dx.doi.org/10.3389/fimmu.2015.00025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313701PMC
February 2015

Identification of factor H-like protein 1 as the predominant complement regulator in Bruch's membrane: implications for age-related macular degeneration.

J Immunol 2014 Nov 10;193(10):4962-70. Epub 2014 Oct 10.

Centre for Hearing and Vision Research, Institute of Human Development, University of Manchester, Manchester M13 9PT, United Kingdom; Centre for Advanced Discovery and Experimental Therapeutics, University of Manchester and Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, United Kingdom; Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester M13 9WL, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1401613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225158PMC
November 2014

Age-dependent changes in heparan sulfate in human Bruch's membrane: implications for age-related macular degeneration.

Invest Ophthalmol Vis Sci 2014 Jul 29;55(8):5370-9. Epub 2014 Jul 29.

Centre for Hearing & Vision Research, Institute of Human Development, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1167/iovs.14-14126DOI Listing
July 2014

Vision impairment and dual sensory problems in middle age.

Ophthalmic Physiol Opt 2014 Jul 29;34(4):479-88. Epub 2014 May 29.

School of Psychological Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/opo.12138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273649PMC
July 2014

The role of complement in age-related macular degeneration: heparan sulphate, a ZIP code for complement factor H?

J Innate Immun 2014 7;6(4):407-16. Epub 2013 Dec 7.

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1159/000356513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086042PMC
May 2015

The proteoglycan glycomatrix: a sugar microenvironment essential for complement regulation.

Front Immunol 2013 Nov 26;4:412. Epub 2013 Nov 26.

Centre for Hearing and Vision Research, Institute of Human Development, Faculty of Medicine and Human Sciences, University of Manchester , Manchester , UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840399PMC
http://dx.doi.org/10.3389/fimmu.2013.00412DOI Listing
November 2013

Iron, zinc, and copper in retinal physiology and disease.

Surv Ophthalmol 2013 Nov-Dec;58(6):585-609

Centre for Advanced Discovery and Experimental Therapeutics, Institute of Human Development, University of Manchester and Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.survophthal.2012.12.002DOI Listing
February 2014

Repeatability of visual function measures in age-related macular degeneration.

Graefes Arch Clin Exp Ophthalmol 2014 Feb 25;252(2):201-6. Epub 2013 Jul 25.

Manchester Royal Eye Hospital, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1007/s00417-013-2421-5DOI Listing
February 2014

Characterization of opticin digestion by proteases involved in osteoarthritis development.

Joint Bone Spine 2014 Mar 8;81(2):137-41. Epub 2013 Jul 8.

Cellular Inflammation and Cartilage Research Group, IMIM (Hospital del Mar Research Institute), C/Dr. Aigüader 88, 08003 Barcelona, Spain; Department of Rheumatology, Universitat Autònoma de Barcelona, Hospital del Mar, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.jbspin.2013.05.007DOI Listing
March 2014

Seven new loci associated with age-related macular degeneration.

Authors:
Lars G Fritsche Wei Chen Matthew Schu Brian L Yaspan Yi Yu Gudmar Thorleifsson Donald J Zack Satoshi Arakawa Valentina Cipriani Stephan Ripke Robert P Igo Gabriëlle H S Buitendijk Xueling Sim Daniel E Weeks Robyn H Guymer Joanna E Merriam Peter J Francis Gregory Hannum Anita Agarwal Ana Maria Armbrecht Isabelle Audo Tin Aung Gaetano R Barile Mustapha Benchaboune Alan C Bird Paul N Bishop Kari E Branham Matthew Brooks Alexander J Brucker William H Cade Melinda S Cain Peter A Campochiaro Chi-Chao Chan Ching-Yu Cheng Emily Y Chew Kimberly A Chin Itay Chowers David G Clayton Radu Cojocaru Yvette P Conley Belinda K Cornes Mark J Daly Baljean Dhillon Albert O Edwards Evangelos Evangelou Jesen Fagerness Henry A Ferreyra James S Friedman Asbjorg Geirsdottir Ronnie J George Christian Gieger Neel Gupta Stephanie A Hagstrom Simon P Harding Christos Haritoglou John R Heckenlively Frank G Holz Guy Hughes John P A Ioannidis Tatsuro Ishibashi Peronne Joseph Gyungah Jun Yoichiro Kamatani Nicholas Katsanis Claudia N Keilhauer Jane C Khan Ivana K Kim Yutaka Kiyohara Barbara E K Klein Ronald Klein Jaclyn L Kovach Igor Kozak Clara J Lee Kristine E Lee Peter Lichtner Andrew J Lotery Thomas Meitinger Paul Mitchell Saddek Mohand-Saïd Anthony T Moore Denise J Morgan Margaux A Morrison Chelsea E Myers Adam C Naj Yusuke Nakamura Yukinori Okada Anton Orlin M Carolina Ortube Mohammad I Othman Chris Pappas Kyu Hyung Park Gayle J T Pauer Neal S Peachey Olivier Poch Rinki Ratna Priya Robyn Reynolds Andrea J Richardson Raymond Ripp Guenther Rudolph Euijung Ryu José-Alain Sahel Debra A Schaumberg Hendrik P N Scholl Stephen G Schwartz William K Scott Humma Shahid Haraldur Sigurdsson Giuliana Silvestri Theru A Sivakumaran R Theodore Smith Lucia Sobrin Eric H Souied Dwight E Stambolian Hreinn Stefansson Gwen M Sturgill-Short Atsushi Takahashi Nirubol Tosakulwong Barbara J Truitt Evangelia E Tsironi André G Uitterlinden Cornelia M van Duijn Lingam Vijaya Johannes R Vingerling Eranga N Vithana Andrew R Webster H-Erich Wichmann Thomas W Winkler Tien Y Wong Alan F Wright Diana Zelenika Ming Zhang Ling Zhao Kang Zhang Michael L Klein Gregory S Hageman G Mark Lathrop Kari Stefansson Rando Allikmets Paul N Baird Michael B Gorin Jie Jin Wang Caroline C W Klaver Johanna M Seddon Margaret A Pericak-Vance Sudha K Iyengar John R W Yates Anand Swaroop Bernhard H F Weber Michiaki Kubo Margaret M Deangelis Thierry Léveillard Unnur Thorsteinsdottir Jonathan L Haines Lindsay A Farrer Iris M Heid Gonçalo R Abecasis

Nat Genet 2013 Apr 3;45(4):433-9, 439e1-2. Epub 2013 Mar 3.

Institute of Human Genetics, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1038/ng.2578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739472PMC
April 2013

Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions.

J Immunol 2013 Mar 30;190(5):2049-57. Epub 2013 Jan 30.

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1201751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672945PMC
March 2013

Concentration of various trace elements in the rat retina and their distribution in different structures.

Metallomics 2012 Dec;4(12):1245-54

Centre for Advanced Discovery and Experimental Therapeutics, Institute of Human Development, University of Manchester and Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Oxford Road, Manchester, M13 9PT, UK.

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http://xlink.rsc.org/?DOI=c2mt20157g
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http://dx.doi.org/10.1039/c2mt20157gDOI Listing
December 2012

Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera.

Invest Ophthalmol Vis Sci 2012 Nov 7;53(12):7528-38. Epub 2012 Nov 7.

Centre for Ophthalmology and Vision Research, Institute of Human Development, Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1167/iovs.12-10797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493184PMC
November 2012

Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness.

J Biol Chem 2012 Aug 5;287(33):28027-36. Epub 2012 Jun 5.

Medical and Human Sciences, University of Manchester, Manchester M13 9PT, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M111.331157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431625PMC
August 2012

Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA).

Genome Med 2012 Apr 30;4(4):35. Epub 2012 Apr 30.

School of Biomedicine and Manchester NIHR Biomedical Research Centre, AV Hill Building, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.

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http://dx.doi.org/10.1186/gm334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446263PMC
April 2012

The vitreous glycoprotein opticin inhibits preretinal neovascularization.

Invest Ophthalmol Vis Sci 2012 Jan 25;53(1):228-34. Epub 2012 Jan 25.

School of Biomedicine, University of Manchester, UK.

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http://dx.doi.org/10.1167/iovs.11-8514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292360PMC
January 2012

Glycosidic enzymes enhance retinal transduction following intravitreal delivery of AAV2.

Mol Vis 2011 30;17:1771-83. Epub 2011 Jun 30.

School of Biomedicine, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133842PMC
November 2011

Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology.

Biochem Soc Trans 2010 Oct;38(5):1342-8

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1042/BST0381342DOI Listing
October 2010

Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina.

J Biol Chem 2010 Sep 26;285(39):30192-202. Epub 2010 Jul 26.

Faculty of Life Sciences, Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.103986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943316PMC
September 2010

Structural effects of fibulin 5 missense mutations associated with age-related macular degeneration and cutis laxa.

Invest Ophthalmol Vis Sci 2010 May 10;51(5):2356-62. Epub 2009 Dec 10.

Genetic Medicine, Manchester Academic Health Science Centre, Central Manchester University Hospitals NHS Foundation Trust, St. Mary's Hospital, Manchester, United Kingdom.

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http://dx.doi.org/10.1167/iovs.09-4620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868478PMC
May 2010

Fibulin 5 forms a compact dimer in physiological solutions.

J Biol Chem 2009 Sep 17;284(38):25938-43. Epub 2009 Jul 17.

Genetic Medicine, Manchester Academic Health Science Centre, Faculty of Medical and Human Sciences, University of Manchester, Manchester M13 9PL, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M109.011627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757994PMC
September 2009

Vitreous as a substrate for vitreolysis.

Authors:
Paul N Bishop

Dev Ophthalmol 2009 3;44:7-19. Epub 2009 Jun 3.

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https://www.karger.com/Article/FullText/223939
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http://dx.doi.org/10.1159/000223939DOI Listing
December 2009

LRRCE: a leucine-rich repeat cysteine capping motif unique to the chordate lineage.

BMC Genomics 2008 Dec 12;9:599. Epub 2008 Dec 12.

Faculty of Life Sciences, Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/1471-2164-9-599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637281PMC
December 2008

Missense and nonsense mutations in the alternatively-spliced exon 2 of COL2A1 cause the ocular variant of Stickler syndrome.

Hum Mutat 2008 Jan;29(1):83-90

Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://doi.wiley.com/10.1002/humu.20603
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http://dx.doi.org/10.1002/humu.20603DOI Listing
January 2008

Novel mutations in the small leucine-rich repeat protein/proteoglycan (SLRP) genes in high myopia.

Hum Mutat 2007 Apr;28(4):336-44

Collagen Research Unit, Biocenter and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1002/humu.20444DOI Listing
April 2007

Neoplastic transformation of ciliary body epithelium is associated with loss of opticin expression.

Br J Ophthalmol 2007 Feb 27;91(2):230-2. Epub 2006 Sep 27.

Unit of Ophthalmology, Department of Medicine, University Clinical Departments, Duncan Building, Daulby Street, Liverpool L69 3GA, UK.

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http://dx.doi.org/10.1136/bjo.2006.102582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857628PMC
February 2007

Structural correlations in the family of small leucine-rich repeat proteins and proteoglycans.

J Struct Biol 2006 Aug 19;155(2):294-305. Epub 2006 May 19.

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, Michael Smith Building, University of Manchester, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1016/j.jsb.2006.01.016DOI Listing
August 2006

Regulation of eye size by the retinal basement membrane and vitreous body.

Invest Ophthalmol Vis Sci 2006 Aug;47(8):3586-94

Department of Neurobiology, University of Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1167/iovs.05-1480DOI Listing
August 2006

Focus on molecules: opticin.

Exp Eye Res 2007 Sep 5;85(3):303-4. Epub 2006 May 5.

Faculty of Life Sciences and Faculty of Medical and Human Sciences, University of Manchester, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1016/j.exer.2006.03.012DOI Listing
September 2007

Crystal structure of the biglycan dimer and evidence that dimerization is essential for folding and stability of class I small leucine-rich repeat proteoglycans.

J Biol Chem 2006 May 17;281(19):13324-32. Epub 2006 Mar 17.

Department of Biochemistry, University of Alberta, Edmonton, Canada.

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http://dx.doi.org/10.1074/jbc.M513470200DOI Listing
May 2006

On the calculation of the binding force between decorin and collagen.

J Biomech 2006 3;39(6):1159-60; author reply 1160-2. Epub 2006 Mar 3.

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http://dx.doi.org/10.1016/j.jbiomech.2006.01.011DOI Listing
August 2006

Opticin binds to heparan and chondroitin sulfate proteoglycans.

Invest Ophthalmol Vis Sci 2005 Dec;46(12):4417-23

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences and Academic Unit of Eye & Vision Science, School of Medicine, University of Manchester, United Kingdom.

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http://dx.doi.org/10.1167/iovs.05-0883DOI Listing
December 2005

Species specific membrane anchoring of nyctalopin, a small leucine-rich repeat protein.

Hum Mol Genet 2005 Jul 19;14(13):1877-87. Epub 2005 May 19.

Academic Unit of Medical Genetics, School of Medicine and Centre for Molecular Medicine, Faculty of Medical and Human Sciences, Universiy of Manchester, Manchester, UK.

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http://academic.oup.com/hmg/article/14/13/1877/621101/Specie
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http://dx.doi.org/10.1093/hmg/ddi194DOI Listing
July 2005

Matrix metalloproteinase-1 associates with intracellular organelles and confers resistance to lamin A/C degradation during apoptosis.

Am J Pathol 2005 May;166(5):1555-63

Department of Pathology, Institute of Ophthalmology, University College London and Moorfields Eye Hospital, 11 Bath St., London EC1V 9EL.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1606407PMC
http://dx.doi.org/10.1016/S0002-9440(10)62371-1DOI Listing
May 2005

Crystal structure of the dimeric protein core of decorin, the archetypal small leucine-rich repeat proteoglycan.

Proc Natl Acad Sci U S A 2004 Nov 22;101(44):15633-8. Epub 2004 Oct 22.

Department of Biochemistry and Alberta Synchrotron Institute, University of Alberta, Edmonton, Alberta, Canada T6G 2H7.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0402976101
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http://dx.doi.org/10.1073/pnas.0402976101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC524833PMC
November 2004

Age-related changes on the surface of vitreous collagen fibrils.

Invest Ophthalmol Vis Sci 2004 Apr;45(4):1041-6

Wellcome Trust Centre for Cell-Matrix Research, School of Biological Sciences and. Research Group in Eye & Vision Science, School of Medicine, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1167/iovs.03-1017DOI Listing
April 2004

Characterization of opticin and evidence of stable dimerization in solution.

J Biol Chem 2003 Nov 1;278(46):45280-7. Epub 2003 Sep 1.

Wellcome Trust Centre for Cell-Matrix Research, School of Biological Sciences and Research Group in Eye & Vision Science, The Medical School, University of Manchester, Manchester M13 9PT, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M303117200DOI Listing
November 2003

Age-dependent changes in the basal retinovitreous adhesion.

Invest Ophthalmol Vis Sci 2003 May;44(5):1793-800

Research Group in Eye and Vision Science, School of Medicine, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1167/iovs.02-0802DOI Listing
May 2003

Light and X-ray scattering show decorin to be a dimer in solution.

J Biol Chem 2003 May 21;278(20):18353-9. Epub 2003 Feb 21.

Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.

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http://dx.doi.org/10.1074/jbc.M211936200DOI Listing
May 2003

Vitreous phenotype: genotype correlation in Stickler syndrome.

Graefes Arch Clin Exp Ophthalmol 2002 Jan;240(1):63-5; author reply 66

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http://dx.doi.org/10.1007/s00417-001-0380-8DOI Listing
January 2002