Paul Modrich

Paul Modrich

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Paul Modrich

Paul Modrich

Publications by authors named "Paul Modrich"

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Human MutLγ, the MLH1-MLH3 heterodimer, is an endonuclease that promotes DNA expansion.

Proc Natl Acad Sci U S A 2020 Feb 3;117(7):3535-3542. Epub 2020 Feb 3.

Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901;

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http://dx.doi.org/10.1073/pnas.1914718117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035508PMC
February 2020

The mutagen and carcinogen cadmium is a high-affinity inhibitor of the zinc-dependent MutLα endonuclease.

Proc Natl Acad Sci U S A 2018 07 25;115(28):7314-7319. Epub 2018 Jun 25.

Department of Biochemistry, Duke University Medical Center, Durham, NC 27710;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1807319115
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http://dx.doi.org/10.1073/pnas.1807319115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048502PMC
July 2018

Interaction of proliferating cell nuclear antigen with PMS2 is required for MutLα activation and function in mismatch repair.

Proc Natl Acad Sci U S A 2017 05 24;114(19):4930-4935. Epub 2017 Apr 24.

Department of Biochemistry, Duke University Medical Center, Durham, NC 27710;

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http://dx.doi.org/10.1073/pnas.1702561114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441711PMC
May 2017

Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture).

Authors:
Paul Modrich

Angew Chem Int Ed Engl 2016 07 20;55(30):8490-501. Epub 2016 May 20.

Howard Hughes Medical Institute and Department of Biochemistry, Duke University, Medical Center, Durham, NC, 27710, USA.

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http://dx.doi.org/10.1002/anie.201601412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193110PMC
July 2016

The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation.

J Biol Chem 2016 Jun 27;291(25):13216-28. Epub 2016 Apr 27.

From the Department of Biochemistry and the Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 115, Taiwan Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710 and

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http://www.jbc.org/content/early/2016/04/27/jbc.M116.721357.
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http://www.jbc.org/lookup/doi/10.1074/jbc.M116.721357
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http://dx.doi.org/10.1074/jbc.M116.721357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933235PMC
June 2016

The 2015 Nobel Prize in Chemistry The Discovery of Essential Mechanisms that Repair DNA Damage.

J Assoc Genet Technol 2016 ;42(1):37-41

Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill.

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May 2016

MutL traps MutS at a DNA mismatch.

Proc Natl Acad Sci U S A 2015 Sep 17;112(35):10914-9. Epub 2015 Aug 17.

Department of Physics, North Carolina State University, Raleigh, NC 27695;

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http://dx.doi.org/10.1073/pnas.1505655112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568282PMC
September 2015

Hydrolytic function of Exo1 in mammalian mismatch repair.

Nucleic Acids Res 2014 Jun 14;42(11):7104-12. Epub 2014 May 14.

Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA

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http://dx.doi.org/10.1093/nar/gku420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066806PMC
June 2014

Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system.

J Biol Chem 2014 Feb 8;289(8):5074-82. Epub 2014 Jan 8.

From the Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7260 and.

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http://dx.doi.org/10.1074/jbc.M113.542787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931066PMC
February 2014

Christian Raetz: scientist and friend extraordinaire.

Annu Rev Biochem 2013 7;82:1-24. Epub 2013 Mar 7.

Department of Biochemistry and Molecular Biology and Center for Membrane Biology, University of Texas Medical School, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1146/annurev-biochem-012512-091530DOI Listing
November 2013

Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation.

Proc Natl Acad Sci U S A 2013 Jul 9;110(30):12277-82. Epub 2013 Jul 9.

Department of Biochemistry and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1073/pnas.1311325110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725108PMC
July 2013

PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro.

DNA Repair (Amst) 2011 Nov 25;10(11):1145-53. Epub 2011 Sep 25.

Department of Biochemistry, Box 3711, Duke University Medical Center, Durham, NC 27710, United States.

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http://dx.doi.org/10.1016/j.dnarep.2011.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222275PMC
November 2011

Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβ.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 Aug 26;67(Pt 8):947-52. Epub 2011 Jul 26.

Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.

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http://scripts.iucr.org/cgi-bin/paper?S1744309111019300
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http://dx.doi.org/10.1107/S1744309111019300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151135PMC
August 2011

PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair.

Proc Natl Acad Sci U S A 2010 Sep 16;107(37):16066-71. Epub 2010 Aug 16.

Department of Biochemistry and Howard Hughes Medical Institute, Box 3711, Duke University Medical Center, Durham, NC 27710.

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http://dx.doi.org/10.1073/pnas.1010662107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941292PMC
September 2010

PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.

Proc Natl Acad Sci U S A 2010 Jul 12;107(30):13384-9. Epub 2010 Jul 12.

Department of Cell Biology, and Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1073/pnas.1008589107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922181PMC
July 2010

MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta.

J Biol Chem 2010 Apr 12;285(15):11730-9. Epub 2010 Feb 12.

Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1074/jbc.M110.104125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857047PMC
April 2010

Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway.

J Biol Chem 2010 Feb 22;285(8):5974-82. Epub 2009 Dec 22.

Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1074/jbc.M109.076109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820822PMC
February 2010

Involvement of the beta clamp in methyl-directed mismatch repair in vitro.

J Biol Chem 2009 Nov 25;284(47):32782-91. Epub 2009 Sep 25.

Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.054528
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http://dx.doi.org/10.1074/jbc.M109.054528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781695PMC
November 2009

Functions of MutLalpha, replication protein A (RPA), and HMGB1 in 5'-directed mismatch repair.

J Biol Chem 2009 Aug 10;284(32):21536-44. Epub 2009 Jun 10.

Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1074/jbc.M109.021287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755878PMC
August 2009

Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks.

Nucleic Acids Res 2009 Jul 25;37(13):4420-9. Epub 2009 May 25.

Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science-Park Research Division, Smithville, TX 78957, USA.

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http://dx.doi.org/10.1093/nar/gkp399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715249PMC
July 2009

A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair.

Proc Natl Acad Sci U S A 2009 May 6;106(21):8495-500. Epub 2009 May 6.

Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1073/pnas.0903654106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677980PMC
May 2009

Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair.

Proc Natl Acad Sci U S A 2008 Nov 29;105(44):16906-11. Epub 2008 Oct 29.

Department of Microbiology, University of California, Davis, CA 95616, USA.

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http://dx.doi.org/10.1073/pnas.0809380105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579351PMC
November 2008

The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair.

J Biol Chem 2008 May 7;283(19):13310-9. Epub 2008 Mar 7.

Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1074/jbc.M800606200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423938PMC
May 2008

Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha.

Mol Cell 2008 Jan;29(1):112-21

Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.molcel.2007.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820111PMC
January 2008

Saccharomyces cerevisiae MutLalpha is a mismatch repair endonuclease.

J Biol Chem 2007 Dec 19;282(51):37181-90. Epub 2007 Oct 19.

Department of Biochemistry and Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1074/jbc.M707617200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2302834PMC
December 2007

Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair.

Proc Natl Acad Sci U S A 2007 Jul 9;104(31):12709-13. Epub 2007 Jul 9.

Department of Biochemistry and Howard Hughes Medical Institute, Box 3711, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1073/pnas.0705129104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913546PMC
July 2007

Structure of the human MutSalpha DNA lesion recognition complex.

Mol Cell 2007 May;26(4):579-92

Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.molcel.2007.04.018DOI Listing
May 2007

Analysis of the excision step in human DNA mismatch repair.

Methods Enzymol 2006 ;408:273-84

Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, USA.

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http://dx.doi.org/10.1016/S0076-6879(06)08017-7DOI Listing
February 2007

Mechanisms in eukaryotic mismatch repair.

Authors:
Paul Modrich

J Biol Chem 2006 Oct 11;281(41):30305-9. Epub 2006 Aug 11.

Department of Biochemistry and Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1074/jbc.R600022200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234602PMC
October 2006

Mismatch repair-dependent iterative excision at irreparable O6-methylguanine lesions in human nuclear extracts.

J Biol Chem 2006 Aug 12;281(32):22674-83. Epub 2006 Jun 12.

Howard Hughes Medical Institute and Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1074/jbc.M603667200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234603PMC
August 2006

Endonucleolytic function of MutLalpha in human mismatch repair.

Cell 2006 Jul;126(2):297-308

Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740600812
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http://dx.doi.org/10.1016/j.cell.2006.05.039DOI Listing
July 2006

The beta sliding clamp binds to multiple sites within MutL and MutS.

J Biol Chem 2006 May 16;281(20):14340-9. Epub 2006 Mar 16.

The Rockefeller University, New York, New York 10021, USA.

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http://dx.doi.org/10.1074/jbc.M601264200DOI Listing
May 2006

DNA mismatch repair: functions and mechanisms.

Chem Rev 2006 Feb;106(2):302-23

Department of Biochemistry and Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1021/cr0404794DOI Listing
February 2006

Human mismatch repair: reconstitution of a nick-directed bidirectional reaction.

J Biol Chem 2005 Dec 27;280(48):39752-61. Epub 2005 Sep 27.

Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1074/jbc.M509701200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1435381PMC
December 2005

HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

Mol Cell 2005 Mar;17(6):793-803

Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1016/j.molcel.2005.02.015DOI Listing
March 2005

Methyl-directed repair of DNA base-pair mismatches in vitro. 1983.

DNA Repair (Amst) 2005 Jan;4(1):134-8; discussion 133, 139

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http://dx.doi.org/10.1016/j.dnarep.2004.07.003DOI Listing
January 2005

Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites.

J Biol Chem 2004 Jul 22;279(27):28402-10. Epub 2004 Apr 22.

Department of Biochemistry and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1074/jbc.M312108200DOI Listing
July 2004

A defined human system that supports bidirectional mismatch-provoked excision.

Mol Cell 2004 Jul;15(1):31-41

Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.molcel.2004.06.016DOI Listing
July 2004

Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.

Chem Biol 2004 Jun;11(6):787-97

Program in Cell Biology and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021 USA.

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http://dx.doi.org/10.1016/j.chembiol.2004.04.008DOI Listing
June 2004

The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase.

Oncogene 2004 May;23(21):3749-56

Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bldg 37, Rm 3068, 37 Convent Drive, Bethesda, MD 20892-4255, USA.

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http://dx.doi.org/10.1038/sj.onc.1207462DOI Listing
May 2004

Hydrolytically deficient MutS E694A is defective in the MutL-dependent activation of MutH and in the mismatch-dependent assembly of the MutS.MutL.heteroduplex complex.

J Biol Chem 2003 Dec 23;278(49):49505-11. Epub 2003 Sep 23.

Howard Hughes Medical Institute and Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M308738200
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http://dx.doi.org/10.1074/jbc.M308738200DOI Listing
December 2003

Mechanism of 5'-directed excision in human mismatch repair.

Mol Cell 2003 Nov;12(5):1077-86

Department of Biochemistry, Box 3711, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/s1097-2765(03)00428-3DOI Listing
November 2003

Assembly and molecular activities of the MutS tetramer.

J Biol Chem 2003 Sep 25;278(36):34667-73. Epub 2003 Jun 25.

Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1074/jbc.M305513200DOI Listing
September 2003

Differential and simultaneous adenosine di- and triphosphate binding by MutS.

J Biol Chem 2003 May 6;278(20):18557-62. Epub 2003 Mar 6.

Department of Biochemistry and Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1074/jbc.M301101200DOI Listing
May 2003

Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma.

Mol Cancer Ther 2002 Jul;1(9):727-36

Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.

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July 2002

Human exonuclease I is required for 5' and 3' mismatch repair.

J Biol Chem 2002 Apr 24;277(15):13302-11. Epub 2002 Jan 24.

Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1074/jbc.M111854200DOI Listing
April 2002