Publications by authors named "Paul Meltzer"

100Publications

LRRC15 antibody-drug conjugates show promise as osteosarcoma therapeutics in preclinical studies.

Pediatr Blood Cancer 2020 Oct 16:e28771. Epub 2020 Oct 16.

Department of Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1002/pbc.28771DOI Listing
October 2020

Genome-Wide Analysis of the FOXA1 Transcriptional Network Identifies Novel Protein-Coding and Long Noncoding RNA Targets in Colorectal Cancer Cells.

Mol Cell Biol 2020 Oct 13;40(21). Epub 2020 Oct 13.

Regulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA

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http://dx.doi.org/10.1128/MCB.00224-20DOI Listing
October 2020

Inflammation suppression prevents tumor cell proliferation in a mouse model of thyroid cancer.

Am J Cancer Res 2020 1;10(6):1857-1870. Epub 2020 Jun 1.

Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda, MD 20892, Maryland, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339265PMC
June 2020

Deposition of Centromeric Histone H3 Variant CENP-A/Cse4 into Chromatin Is Facilitated by Its C-Terminal Sumoylation.

Genetics 2020 04 28;214(4):839-854. Epub 2020 Feb 28.

Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892

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http://dx.doi.org/10.1534/genetics.120.303090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153950PMC
April 2020

A Circular RNA from the Locus Controls Cell Cycle Progression by Suppressing p53 Levels.

Mol Cell Biol 2020 04 13;40(9). Epub 2020 Apr 13.

Regulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

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http://dx.doi.org/10.1128/MCB.00473-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156218PMC
April 2020

1q21.1 deletion and a rare functional polymorphism in siblings with thrombocytopenia-absent radius-like phenotypes.

Cold Spring Harb Mol Case Stud 2019 12 13;5(6). Epub 2019 Dec 13.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20859, USA.

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http://dx.doi.org/10.1101/mcs.a004564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913155PMC
December 2019

CNVScope: Visually Exploring Copy Number Aberrations in Cancer Genomes.

Cancer Inform 2019 2;18:1176935119890290. Epub 2019 Dec 2.

Genetics Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1177/1176935119890290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887803PMC
December 2019

RNA Sequencing of the NCI-60: Integration into CellMiner and CellMiner CDB.

Cancer Res 2019 07 21;79(13):3514-3524. Epub 2019 May 21.

Developmental Therapeutic Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-2047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615556PMC
July 2019

Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background.

Blood 2019 06 16;133(24):2610-2614. Epub 2019 Apr 16.

Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; and.

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http://dx.doi.org/10.1182/blood.2018864173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566592PMC
June 2019

Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells.

Sci Rep 2019 03 14;9(1):4544. Epub 2019 Mar 14.

Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://www.nature.com/articles/s41598-019-41058-8
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http://dx.doi.org/10.1038/s41598-019-41058-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418139PMC
March 2019

CDC73 Germline Mutation in a Family With Mixed Epithelial and Stromal Tumors.

Urology 2019 02 16;124:91-97. Epub 2018 Nov 16.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00904295183120
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http://dx.doi.org/10.1016/j.urology.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382532PMC
February 2019

Dynamics of Genome Alterations in Crohn's Disease-Associated Colorectal Carcinogenesis.

Clin Cancer Res 2018 10 2;24(20):4997-5011. Epub 2018 Jul 2.

Institute of Pathology, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-0630DOI Listing
October 2018

Targeting Notch1 and IKKα Enhanced NF-κB Activation in CD133 Skin Cancer Stem Cells.

Mol Cancer Ther 2018 09 29;17(9):2034-2048. Epub 2018 Jun 29.

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461743PMC
September 2018

A Non-canonical Polycomb Dependency in Synovial Sarcoma.

Cancer Cell 2018 03;33(3):344-346

Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.02.013DOI Listing
March 2018

Genomic and metabolic characterization of a chromophobe renal cell carcinoma cell line model (UOK276).

Genes Chromosomes Cancer 2017 10 24;56(10):719-729. Epub 2017 Jul 24.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1002/gcc.22476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561006PMC
October 2017

Targeting MYC as a Therapeutic Intervention for Anaplastic Thyroid Cancer.

J Clin Endocrinol Metab 2017 07;102(7):2268-2280

Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.

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http://dx.doi.org/10.1210/jc.2016-3771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505205PMC
July 2017

Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis).

J Clin Oncol 2017 May 28;35(14):1561-1569. Epub 2017 Mar 28.

Shivaani Kummar, Geraldine O'Sullivan Coyne, Khanh T. Do, Baris Turkbey, Paul S. Meltzer, Eric Polley, Peter L. Choyke, Robert Meehan, Yvonne Horneffer, Ann Lih, Amul Choudhary, Sandra A. Mitchell, Lee J. Helman, James H. Doroshow, and Alice P. Chen, National Cancer Institute, National Institutes of Health, Bethesda; and Rasa Vilimas and Lamin Juwara, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD.

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http://dx.doi.org/10.1200/JCO.2016.71.1994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455706PMC
May 2017

Somatic mutations in murine models of leukemia and lymphoma: Disease specificity and clinical relevance.

Genes Chromosomes Cancer 2017 Jun 31;56(6):472-483. Epub 2017 Mar 31.

Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1002/gcc.22451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399546PMC
June 2017

DNA Breaks and End Resection Measured Genome-wide by End Sequencing.

Mol Cell 2016 09 28;63(5):898-911. Epub 2016 Jul 28.

Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.06.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299834PMC
September 2016

Bromodomain and Extraterminal Protein Inhibitor JQ1 Suppresses Thyroid Tumor Growth in a Mouse Model.

Clin Cancer Res 2017 Jan 20;23(2):430-440. Epub 2016 Jul 20.

Laboratory of Molecular Biology, National Cancer Institute, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241246PMC
January 2017

Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant.

Am J Hum Genet 2016 05 14;98(5):830-842. Epub 2016 Apr 14.

Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863475PMC
May 2016

caOmicsV: an R package for visualizing multidimensional cancer genomic data.

BMC Bioinformatics 2016 Mar 22;17:141. Epub 2016 Mar 22.

Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 6138, 37 Convent Drive, Bethesda, MD, 20892-4265, USA.

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http://dx.doi.org/10.1186/s12859-016-0989-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804509PMC
March 2016

Impact of telomere length on survival in classic and variant hairy cell leukemia.

Leuk Res 2015 Dec 24;39(12):1360-6. Epub 2015 Sep 24.

Laboratory of Molecular Biology, National Cancer Institute (NCI), NIH, United States. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2015.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661072PMC
December 2015

Characterization of the metastatic phenotype of a panel of established osteosarcoma cells.

Oncotarget 2015 Oct;6(30):29469-81

Molecular Oncology Section - Metastasis Biology Group, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.18632/oncotarget.5177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745740PMC
October 2015

Osteosarcoma: Current Treatment and a Collaborative Pathway to Success.

J Clin Oncol 2015 Sep 24;33(27):3029-35. Epub 2015 Aug 24.

Michael S. Isakoff, Center for Cancer and Blood Disorders, Connecticut Children's Medical Center, Hartford, CT; Stefan S. Bielack, Klinikum Stuttgart, Olgahospital, Stuttgart, Germany; Paul Meltzer, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; and Richard Gorlick, The Children's Hospital of Montefiore; Bronx, NY.

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http://dx.doi.org/10.1200/JCO.2014.59.4895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979196PMC
September 2015

Caspase-8 expression is predictive of tumour response to death receptor 5 agonist antibody in Ewing's sarcoma.

Br J Cancer 2015 Sep 20;113(6):894-901. Epub 2015 Aug 20.

Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1038/bjc.2015.298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578089PMC
September 2015

Patterns of somatic uniparental disomy identify novel tumor suppressor genes in colorectal cancer.

Carcinogenesis 2015 Oct 4;36(10):1103-10. Epub 2015 Aug 4.

Unitat de Biologia Cellular i Genètica Mèdica, Departament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Catalonia 08193, Spain, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Catalonia 08193, Spain,

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http://dx.doi.org/10.1093/carcin/bgv115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598814PMC
October 2015

Distinct methylation profiles characterize fusion-positive and fusion-negative rhabdomyosarcoma.

Mod Pathol 2015 Sep 31;28(9):1214-24. Epub 2015 Jul 31.

Cancer Molecular Pathology Section, Laboratory of Pathology, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/modpathol.2015.82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345526PMC
September 2015

An Integrated Prognostic Classifier for Stage I Lung Adenocarcinoma Based on mRNA, microRNA, and DNA Methylation Biomarkers.

J Thorac Oncol 2015 Jul;10(7):1037-48

*Laboratory of Human Carcinogenesis, NCI-CCR, National Institutes of Health, Bethesda, Maryland; †Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan; ‡Genetics Branch, NCI-CCR, National Institutes of Health, Bethesda, Maryland; §Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan; ‖Department of Chemical and Biological Working Environment, National Institute of Occupational Health, Oslo, Norway; and ¶Genomics and Epigenomics of Cancer Prediction Program, Institute of Predictive and Personalized Medicine of Cancer (IMPPC), Badalona (Barcelona), Spain.

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http://dx.doi.org/10.1097/JTO.0000000000000560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493931PMC
July 2015

EWS-FLI1 employs an E2F switch to drive target gene expression.

Nucleic Acids Res 2015 Mar 20;43(5):2780-9. Epub 2015 Feb 20.

Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna 1090, Austria Dept. of Pediatrics, Medical University, Vienna 1090, Austria

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http://dx.doi.org/10.1093/nar/gkv123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357724PMC
March 2015

Avalanching mutations in biallelic mismatch repair deficiency syndrome.

Nat Genet 2015 Mar;47(3):194-6

Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/ng.3227DOI Listing
March 2015

Molecular profiling and targeted therapy for advanced thoracic malignancies: a biomarker-derived, multiarm, multihistology phase II basket trial.

J Clin Oncol 2015 Mar 9;33(9):1000-7. Epub 2015 Feb 9.

Ariel Lopez-Chavez, Anish Thomas, Arun Rajan, Mark Raffeld, Betsy Morrow, Ronan Kelly, Corey Allan Carter, Udayan Guha, Keith Killian, Christopher C. Lau, Zied Abdullaev, Liqiang Xi, Svetlana Pack, Paul S. Meltzer, David J. Liewehr, Seth M. Steinberg, Arlene Berman, Eva Szabo, Yisong Wang, and Giuseppe Giaccone, National Cancer Institute; Austin Doyle, Cancer Therapy Evaluation Program, Bethesda, MD; Ariel Lopez-Chavez, Christopher L. Corless, Alan Sandler, Carol Beadling, and Andrea Warrick, Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Ariel Lopez-Chavez, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL; and Yisong Wang and Giuseppe Giaccone, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC.

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http://jco.ascopubs.org/content/early/2015/02/03/JCO.2014.58
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.58.2007
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http://dx.doi.org/10.1200/JCO.2014.58.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356709PMC
March 2015

Activation of integrin-ERBB2 signaling in undifferentiated thyroid cancer.

Am J Cancer Res 2014 19;4(6):776-88. Epub 2014 Nov 19.

Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda, MD 20892.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266711PMC
December 2014

Building through breaking: the development of cancer neochromosomes.

Cancer Cell 2014 Nov 10;26(5):593-5. Epub 2014 Nov 10.

Genetics Branch, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.10.013DOI Listing
November 2014

Mutations of epigenetic regulatory genes are common in thymic carcinomas.

Sci Rep 2014 Dec 8;4:7336. Epub 2014 Dec 8.

1] Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 [2] Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC 20007.

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http://dx.doi.org/10.1038/srep07336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258655PMC
December 2014

Replicon: a software to accurately predict DNA replication timing in metazoan cells.

Front Genet 2014 3;5:378. Epub 2014 Nov 3.

Genetics Branch, Center for Cancer Research, National Institutes of Health Bethesda, MD, USA.

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http://journal.frontiersin.org/article/10.3389/fgene.2014.00
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http://dx.doi.org/10.3389/fgene.2014.00378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217517PMC
November 2014

Genetic and epigenetic analysis of monozygotic twins discordant for testicular cancer.

Int J Mol Epidemiol Genet 2014 22;5(3):135-9. Epub 2014 Oct 22.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services Rockville, Maryland, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214260PMC
November 2014