Paul McKeigue

Paul McKeigue

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Paul McKeigue

Paul McKeigue

Publications by authors named "Paul McKeigue"

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Biomarker panels associated with progression of renal disease in type 1 diabetes.

Diabetologia 2019 Sep 20;62(9):1616-1627. Epub 2019 Jun 20.

MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1007/s00125-019-4915-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677704PMC
September 2019

Quantifying performance of a diagnostic test as the expected information for discrimination: Relation to the -statistic.

Authors:
Paul McKeigue

Stat Methods Med Res 2019 Jun 6;28(6):1841-1851. Epub 2018 Jul 6.

Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1177/0962280218776989DOI Listing
June 2019

Sample size requirements for learning to classify with high-dimensional biomarker panels.

Authors:
Paul McKeigue

Stat Methods Med Res 2019 Mar 28;28(3):904-910. Epub 2017 Nov 28.

Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1177/0962280217738807DOI Listing
March 2019

Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis.

Pharmacogenomics J 2018 09 31;18(5):657-664. Epub 2018 Aug 31.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/s41397-018-0040-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150911PMC
September 2018

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.

Diabetes 2018 07 27;67(7):1414-1427. Epub 2018 Apr 27.

Wellcome Centre Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.

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http://dx.doi.org/10.2337/db17-0914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014557PMC
July 2018

Author Correction: GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

Nat Commun 2018 06 29;9(1):2536. Epub 2018 Jun 29.

Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.

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http://dx.doi.org/10.1038/s41467-018-04857-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026128PMC
June 2018

Automated pathway and reaction prediction facilitates in silico identification of unknown metabolites in human cohort studies.

J Chromatogr B Analyt Technol Biomed Life Sci 2017 Dec 4;1071:58-67. Epub 2017 Apr 4.

Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2017.04.002DOI Listing
December 2017

Modelling cumulative exposure for inference about drug effects in observational studies.

Pharmacoepidemiol Drug Saf 2017 Dec 12;26(12):1527-1533. Epub 2017 Oct 12.

Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.

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http://doi.wiley.com/10.1002/pds.4327
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http://dx.doi.org/10.1002/pds.4327DOI Listing
December 2017

GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

Nat Commun 2017 11 17;8(1):1584. Epub 2017 Nov 17.

Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.

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http://dx.doi.org/10.1038/s41467-017-01490-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691155PMC
November 2017

GeneImp: Fast Imputation to Large Reference Panels Using Genotype Likelihoods from Ultralow Coverage Sequencing.

Genetics 2017 05 27;206(1):91-104. Epub 2017 Mar 27.

Centre for Population Health Sciences, Usher Institute, University of Edinburgh, EH8 9AG, United Kingdom

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http://dx.doi.org/10.1534/genetics.117.200063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419496PMC
May 2017

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins.

J Med Genet 2016 12 1;53(12):835-845. Epub 2016 Sep 1.

Department of Atherosclerosis Research, Children's Hospital Oakland Research Institute, Oakland, California, USA.

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http://dx.doi.org/10.1136/jmedgenet-2016-103966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309131PMC
December 2016

The impact of health behaviours on incident cardiovascular disease in Europeans and South Asians--a prospective analysis in the UK SABRE study.

PLoS One 2015 2;10(3):e0117364. Epub 2015 Mar 2.

Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117364PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346401PMC
January 2016

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.

Authors:
Iris Postmus Stella Trompet Harshal A Deshmukh Michael R Barnes Xiaohui Li Helen R Warren Daniel I Chasman Kaixin Zhou Benoit J Arsenault Louise A Donnelly Kerri L Wiggins Christy L Avery Paula Griffin QiPing Feng Kent D Taylor Guo Li Daniel S Evans Albert V Smith Catherine E de Keyser Andrew D Johnson Anton J M de Craen David J Stott Brendan M Buckley Ian Ford Rudi G J Westendorp P Eline Slagboom Naveed Sattar Patricia B Munroe Peter Sever Neil Poulter Alice Stanton Denis C Shields Eoin O'Brien Sue Shaw-Hawkins Y-D Ida Chen Deborah A Nickerson Joshua D Smith Marie Pierre Dubé S Matthijs Boekholdt G Kees Hovingh John J P Kastelein Paul M McKeigue John Betteridge Andrew Neil Paul N Durrington Alex Doney Fiona Carr Andrew Morris Mark I McCarthy Leif Groop Emma Ahlqvist Joshua C Bis Kenneth Rice Nicholas L Smith Thomas Lumley Eric A Whitsel Til Stürmer Eric Boerwinkle Julius S Ngwa Christopher J O'Donnell Ramachandran S Vasan Wei-Qi Wei Russell A Wilke Ching-Ti Liu Fangui Sun Xiuqing Guo Susan R Heckbert Wendy Post Nona Sotoodehnia Alice M Arnold Jeanette M Stafford Jingzhong Ding David M Herrington Stephen B Kritchevsky Gudny Eiriksdottir Leonore J Launer Tamara B Harris Audrey Y Chu Franco Giulianini Jean G MacFadyen Bryan J Barratt Fredrik Nyberg Bruno H Stricker André G Uitterlinden Albert Hofman Fernando Rivadeneira Valur Emilsson Oscar H Franco Paul M Ridker Vilmundur Gudnason Yongmei Liu Joshua C Denny Christie M Ballantyne Jerome I Rotter L Adrienne Cupples Bruce M Psaty Colin N A Palmer Jean-Claude Tardif Helen M Colhoun Graham Hitman Ronald M Krauss J Wouter Jukema Mark J Caulfield

Nat Commun 2014 Oct 28;5:5068. Epub 2014 Oct 28.

1] NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London EC1M 6BQ, UK [2] Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M6BQ, UK.

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http://dx.doi.org/10.1038/ncomms6068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220464PMC
October 2014

QRISK2 validation by ethnic group.

Heart 2014 Mar 24;100(5):437. Epub 2013 Dec 24.

International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, , London, UK.

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http://dx.doi.org/10.1136/heartjnl-2013-305333DOI Listing
March 2014

Admixture mapping of prostate cancer in African Americans participating in the North Carolina-Louisiana Prostate Cancer Project (PCaP).

Prostate 2014 Jan 4;74(1):1-9. Epub 2013 Sep 4.

Department of Epidemiology, Division of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Lineberger Comprehensive Cancer Center, Division of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1002/pros.22722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934014PMC
January 2014

Inference of identity by descent in population isolates and optimal sequencing studies.

Eur J Hum Genet 2013 Oct 30;21(10):1140-5. Epub 2013 Jan 30.

MRC Institute of Genetics and Molecular Medicine (MRC IGMM), MRC Human Genetics Unit, University of Edinburgh, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1038/ejhg.2012.307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778345PMC
October 2013

Extending admixture mapping to nuclear pedigrees: application to sarcoidosis.

Genet Epidemiol 2013 Apr 31;37(3):256-66. Epub 2013 Jan 31.

Centre for Population Health Sciences, Medical School, University of Edinburgh, Teviot Place, Edinburgh EH9 9AG, United Kingdom.

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http://dx.doi.org/10.1002/gepi.21710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756835PMC
April 2013

Circulating IL-6 concentrations and associated anthropometric and metabolic parameters in South Asian men and women in comparison to European whites.

Cytokine 2013 Jan 29;61(1):29-32. Epub 2012 Sep 29.

Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.cyto.2012.09.002DOI Listing
January 2013

Southall And Brent REvisited: Cohort profile of SABRE, a UK population-based comparison of cardiovascular disease and diabetes in people of European, Indian Asian and African Caribbean origins.

Int J Epidemiol 2012 Feb 1;41(1):33-42. Epub 2010 Nov 1.

International Centre for Circulatory Health, Imperial College London, 59-61 North Wharf Road, London W2 1LA, UK.

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http://dx.doi.org/10.1093/ije/dyq175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304519PMC
February 2012

Abundant pleiotropy in human complex diseases and traits.

Am J Hum Genet 2011 Nov;89(5):607-18

Centre for Population Health Sciences, The University of Edinburgh, Edinburgh EH8 9AG, UK.

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http://dx.doi.org/10.1016/j.ajhg.2011.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213397PMC
November 2011

FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans.

Rheumatology (Oxford) 2011 Jul 4;50(7):1206-10. Epub 2011 Feb 4.

Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

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http://dx.doi.org/10.1093/rheumatology/keq456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670581PMC
July 2011

30 Year patterns of mortality in Tobago, West Indies, 1976-2005: impact of glucose intolerance and alcohol intake.

PLoS One 2011 Jan 25;6(1):e14588. Epub 2011 Jan 25.

Division of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014588PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026774PMC
January 2011

Genomic runs of homozygosity record population history and consanguinity.

PLoS One 2010 Nov 15;5(11):e13996. Epub 2010 Nov 15.

Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013996PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981575PMC
November 2010

Case ascertainment and estimated incidence of drug-induced long-QT syndrome: study in Southwest France.

Br J Clin Pharmacol 2008 Sep 15;66(3):386-95. Epub 2008 Jul 15.

Non-Communicable Disease Epidemiology UnitLondon School of Hygiene & Tropical MedicineKeppel Street, WC1E 7HT London, UK.

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http://doi.wiley.com/10.1111/j.1365-2125.2008.03229.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2125.2008.03229.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526236PMC
September 2008

Statin induced myopathy and myalgia: time trend analysis and comparison of risk associated with statin class from 1991-2006.

PLoS One 2008 Jun 25;3(6):e2522. Epub 2008 Jun 25.

Department of Epidemiology & Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002522PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2432025PMC
June 2008

Linkage and mutational analysis of CLCN2 in childhood absence epilepsy.

Epilepsy Res 2007 Jul 18;75(2-3):145-53. Epub 2007 Jun 18.

General and Adolescent Paediatric Unit, Centre for Human Molecular Genetics, UCL Institute Child Health, University College London, The Rayne Building, 5 University Street, London WC1E 6JJ, UK.

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http://dx.doi.org/10.1016/j.eplepsyres.2007.05.004DOI Listing
July 2007

A genomewide admixture mapping panel for Hispanic/Latino populations.

Am J Hum Genet 2007 Jun 20;80(6):1171-8. Epub 2007 Apr 20.

Department of Anthropology, The Pennsylvania State University, University Park, PA 16801, USA.

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http://dx.doi.org/10.1086/518564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867104PMC
June 2007

Genetic evidence for the convergent evolution of light skin in Europeans and East Asians.

Mol Biol Evol 2007 Mar 20;24(3):710-22. Epub 2006 Dec 20.

Department of Anthropology, The Pennsylvania State University, PA, USA.

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http://dx.doi.org/10.1093/molbev/msl203DOI Listing
March 2007

Admixture in Mexico City: implications for admixture mapping of type 2 diabetes genetic risk factors.

Hum Genet 2007 Feb 26;120(6):807-19. Epub 2006 Oct 26.

Department of Anthropology, University of Toronto at Mississauga, 3359 Mississauga Rd. Room 4026, South Bldg, L5L 1C6, Mississauga, ON, Canada,

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http://link.springer.com/10.1007/s00439-006-0273-3
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http://dx.doi.org/10.1007/s00439-006-0273-3DOI Listing
February 2007

The role of diabetes and components of the metabolic syndrome in stroke and coronary heart disease mortality in U.K. white and African-Caribbean populations.

Diabetes Care 2006 Sep;29(9):2127-9

National Heart and Lung Institute, Imperial College at St. Mary's, Norfolk Place, London W2 1PG, U.K.

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http://dx.doi.org/10.2337/dc06-0779DOI Listing
September 2006

EUDRAGENE: European collaboration to establish a case-control DNA collection for studying the genetic basis of adverse drug reactions.

Pharmacogenomics 2006 Jun;7(4):633-8

London School of Hygiene & Tropical Medicine, Non-Communicable Disease Epidemiology Unit, Keppel Street, London, UK.

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https://www.futuremedicine.com/doi/10.2217/14622416.7.4.633
Publisher Site
http://dx.doi.org/10.2217/14622416.7.4.633DOI Listing
June 2006

Microalbuminuria and coronary heart disease risk in an ethnically diverse UK population: a prospective cohort study.

J Am Soc Nephrol 2005 Dec 5;16(12):3702-10. Epub 2005 Oct 5.

National Heart and Lung Institute, Imperial College at St. Mary's, Norfolk Place, London W2 IPG, UK.

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http://dx.doi.org/10.1681/ASN.2005060584DOI Listing
December 2005

Prospects for admixture mapping of complex traits.

Authors:
Paul M McKeigue

Am J Hum Genet 2005 Jan 11;76(1):1-7. Epub 2004 Nov 11.

Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.

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http://dx.doi.org/10.1086/426949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1196412PMC
January 2005

Specific elevation in plasma tissue plasminogen activator antigen concentrations in South Asians relative to Europeans.

Blood Coagul Fibrinolysis 2003 Dec;14(8):755-60

Epidemiology Unit, London School of Hygiene & Tropical Medicine, London, UK.

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http://dx.doi.org/10.1097/01.mbc.0000061353.72909.3fDOI Listing
December 2003

Association of African genetic admixture with resting metabolic rate and obesity among women.

Obes Res 2003 Jul;11(7):904-11

Department of Nutrition Sciences and the Clinical Nutrition Research Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

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http://dx.doi.org/10.1038/oby.2003.124DOI Listing
July 2003

Control of confounding of genetic associations in stratified populations.

Am J Hum Genet 2003 Jun;72(6):1492-1504

Epidemiology Unit, London School of Hygiene and Tropical Medicine, Umited Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180309PMC
http://dx.doi.org/10.1086/375613DOI Listing
June 2003

Skin pigmentation, biogeographical ancestry and admixture mapping.

Hum Genet 2003 Apr 11;112(4):387-99. Epub 2003 Feb 11.

Department of Anthropology, Penn State University, 409 Carpenter Bld., University Park, PA 16802, USA.

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http://dx.doi.org/10.1007/s00439-002-0896-yDOI Listing
April 2003

Problems of reporting genetic associations with complex outcomes.

Lancet 2003 Mar;361(9360):865-72

Department of Epidemiology and Public Health, University College London, WC1E 6BT, London, UK.

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http://dx.doi.org/10.1016/s0140-6736(03)12715-8DOI Listing
March 2003

Preterm birth and licorice consumption during pregnancy.

Am J Epidemiol 2002 Nov;156(9):803-5

Department of Medicine, University of Helsinki, Finland.

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http://dx.doi.org/10.1093/aje/kwf130DOI Listing
November 2002

Long-term consequences of polycystic ovary syndrome: results of a 31 year follow-up study.

Hum Fertil (Camb) 2000 ;3(2):101-105

Epidemiology Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

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January 2000