Paul Kubes

Paul Kubes

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Neutrophils and NETs in modulating acute and chronic inflammation.

Blood 2019 May 21;133(20):2178-2185. Epub 2019 Mar 21.

Department of Physiology and Pharmacology, Cumming School of Medicine and Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AL, Canada.

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http://dx.doi.org/10.1182/blood-2018-11-844530DOI Listing
May 2019

Exploring the complex role of chemokines and chemoattractants in vivo on leukocyte dynamics.

Immunol Rev 2019 May;289(1):9-30

Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1111/imr.12757DOI Listing
May 2019

Rise and shine: Open your eyes to produce anti-inflammatory NETs.

J Leukoc Biol 2019 May 14. Epub 2019 May 14.

Department of Physiology and Pharmacology, Calvin Phoebe & Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1002/JLB.3CE0419-130RDOI Listing
May 2019

The Neutrophil's Role During Health and Disease.

Physiol Rev 2019 04;99(2):1223-1248

Snyder Institute of Chronic Diseases, University of Calgary , Calgary, Alberta , Canada ; and Department of Pathology, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts.

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http://dx.doi.org/10.1152/physrev.00012.2018DOI Listing
April 2019

Neutrophil Extracellular Traps Confine Pseudomonas aeruginosa Ocular Biofilms and Restrict Brain Invasion.

Cell Host Microbe 2019 Apr 28;25(4):526-536.e4. Epub 2019 Mar 28.

University of Calgary, Department of Physiology and Pharmacology, Calvin Phoebe & Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, Calgary, AB, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2019.02.007DOI Listing
April 2019

Innate immune cells orchestrate the repair of sterile injury in the liver and beyond.

Eur J Immunol 2019 Apr 19. Epub 2019 Apr 19.

Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, T2N 4N1, Canada.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.20184748
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http://dx.doi.org/10.1002/eji.201847485DOI Listing
April 2019

Unraveling the host's immune response to infection: Seeing is believing.

J Leukoc Biol 2019 Feb 18. Epub 2019 Feb 18.

University of Calgary Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1002/JLB.4RI1218-503RDOI Listing
February 2019

Neutrophils: New insights and open questions.

Sci Immunol 2018 Dec 7;3(30). Epub 2018 Dec 7.

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1126/sciimmunol.aat4579DOI Listing
December 2018

The surreptitious survival of the emerging pathogen Staphylococcus lugdunensis within macrophages as an immune evasion strategy.

Cell Microbiol 2018 Nov 7;20(11):e12869. Epub 2018 Aug 7.

Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1111/cmi.12869DOI Listing
November 2018

Sex-hormone-driven innate antibodies protect females and infants against EPEC infection.

Nat Immunol 2018 10 24;19(10):1100-1111. Epub 2018 Sep 24.

Calvin Phoebe & Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1038/s41590-018-0211-2DOI Listing
October 2018

Lymph Nodes: The Unrecognized Barrier against Pathogens.

ACS Infect Dis 2018 Aug 1;4(8):1158-1161. Epub 2018 Jun 1.

Calvin, Phoebe & Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine , University of Calgary , Calgary , Alberta T2N 4N1 , Canada.

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http://dx.doi.org/10.1021/acsinfecdis.8b00111DOI Listing
August 2018

α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis.

Cell Host Microbe 2018 08 19;24(2):271-284.e3. Epub 2018 Jul 19.

Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295203PMC
August 2018

Start a fire, kill the bug: The role of platelets in inflammation and infection.

Innate Immun 2018 08 26;24(6):335-348. Epub 2018 Jul 26.

Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1177/1753425918789255DOI Listing
August 2018

Death to the neutrophil! A resolution for acute respiratory distress syndrome?

Eur Respir J 2018 08 2;52(2). Epub 2018 Aug 2.

Dept of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1183/13993003.01274-2018DOI Listing
August 2018

Perinodal Adipose Tissue Participates in Immune Protection through a Lymphatic Vessel-Independent Route.

J Immunol 2018 07 14;201(1):296-305. Epub 2018 May 14.

Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada;

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http://dx.doi.org/10.4049/jimmunol.1800151DOI Listing
July 2018

Macrophages play an essential role in trauma-induced sterile inflammation and tissue repair.

Eur J Trauma Emerg Surg 2018 Jun 17;44(3):335-349. Epub 2018 Apr 17.

Department of Pharmacology and Physiology, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1007/s00068-018-0956-1DOI Listing
June 2018

Neutrophil heterogeneity: Bona fide subsets or polarization states?

J Leukoc Biol 2018 05 20;103(5):829-838. Epub 2018 Feb 20.

Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1002/JLB.3RI0917-361RDOI Listing
May 2018

Immune Responses in the Liver.

Annu Rev Immunol 2018 04 12;36:247-277. Epub 2018 Jan 12.

Calvin, Phoebe & Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta T2N 4N1, Canada; email: ,

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http://dx.doi.org/10.1146/annurev-immunol-051116-052415DOI Listing
April 2018

Neutrophils and neutrophil extracellular traps in the liver and gastrointestinal system.

Nat Rev Gastroenterol Hepatol 2018 Apr 31;15(4):206-221. Epub 2018 Jan 31.

Department of Physiology and Pharmacology, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, HRIC 3280 Hospital Drive N.W., Calgary, Alberta T2N 4N1, Canada.

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http://dx.doi.org/10.1038/nrgastro.2017.183DOI Listing
April 2018

Neutrophils recruited through high endothelial venules of the lymph nodes via PNAd intercept disseminating .

Proc Natl Acad Sci U S A 2018 03 29;115(10):2449-2454. Epub 2018 Jan 29.

Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada T2N 1N4;

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http://dx.doi.org/10.1073/pnas.1715756115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877924PMC
March 2018

The enigmatic neutrophil: what we do not know.

Authors:
Paul Kubes

Cell Tissue Res 2018 03 5;371(3):399-406. Epub 2018 Feb 5.

Departments of Physiology and Pharmacology, Microbiology and Immunology and Critical Care Medicine, Snyder Institute for Chronic Disease, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1007/s00441-018-2790-5DOI Listing
March 2018

Visualizing the Tumor Microenvironment of Liver Metastasis by Spinning Disk Confocal Microscopy.

Methods Mol Biol 2016 ;1458:203-15

Calvin, Phoebe & Joan Snyder Institute for Chronic Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1007/978-1-4939-3801-8_15DOI Listing
January 2018

Transient von Willebrand factor-mediated platelet influx stimulates liver regeneration after partial hepatectomy in mice.

Liver Int 2017 11 5;37(11):1731-1737. Epub 2017 Mar 5.

Surgical Research Laboratory Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1111/liv.13386DOI Listing
November 2017

Visualizing the function and fate of neutrophils in sterile injury and repair.

Science 2017 10;358(6359):111-116

Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada.

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http://www.sciencemag.org/lookup/doi/10.1126/science.aam9690
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http://dx.doi.org/10.1126/science.aam9690DOI Listing
October 2017

iNKT Cells Orchestrate a Switch from Inflammation to Resolution of Sterile Liver Injury.

Immunity 2017 10;47(4):752-765.e5

Snyder institute of Chronic Diseases, University of Calgary, Calgary, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.09.016DOI Listing
October 2017

Measurement of bacterial capture and phagosome maturation of Kupffer cells by intravital microscopy.

Methods 2017 09 15;128:12-19. Epub 2017 May 15.

Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/j.ymeth.2017.05.004DOI Listing
September 2017

Antibody-dependent fragmentation is a newly identified mechanism of cell killing in vivo.

Sci Rep 2017 09 5;7(1):10515. Epub 2017 Sep 5.

Snyder institute of Chronic Diseases, University of Calgary, Calgary, Canada.

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http://dx.doi.org/10.1038/s41598-017-10420-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585239PMC
September 2017

Bispecific antibody targets multiple Pseudomonas aeruginosa evasion mechanisms in the lung vasculature.

J Clin Invest 2017 Jun 2;127(6):2249-2261. Epub 2017 May 2.

Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1172/JCI89652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451222PMC
June 2017

PKN1 Directs Polarized RAB21 Vesicle Trafficking via RPH3A and Is Important for Neutrophil Adhesion and Ischemia-Reperfusion Injury.

Cell Rep 2017 06;19(12):2586-2597

Department of Pharmacology, Vascular Biology and Therapeutic Program, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.05.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548392PMC
June 2017

Splenic Ly6G mature and Ly6G immature neutrophils contribute to eradication of .

J Exp Med 2017 05 19;214(5):1333-1350. Epub 2017 Apr 19.

Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada

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http://dx.doi.org/10.1084/jem.20161621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413339PMC
May 2017

An emerging role for neutrophil extracellular traps in noninfectious disease.

Nat Med 2017 Mar;23(3):279-287

Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada.

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http://dx.doi.org/10.1038/nm.4294DOI Listing
March 2017

Monocyte Conversion During Inflammation and Injury.

Arterioscler Thromb Vasc Biol 2017 01 20;37(1):35-42. Epub 2016 Oct 20.

From the Department of Microbiology, Immunology, and Infectious Diseases (R.M.K., P.K.) and Department of Physiology and Pharmacology (P.K., J.F.D.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Canada.

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http://dx.doi.org/10.1161/ATVBAHA.116.308198DOI Listing
January 2017

Prolonged Activation of Invariant Natural Killer T Cells and T2-Skewed Immunity in Stroke Patients.

Front Neurol 2017 19;8. Epub 2017 Jan 19.

Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada; Department of Critical Care, Snyder Institute for Critical Care, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.3389/fneur.2017.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244395PMC
January 2017

Innate Immune Cell Trafficking and Function During Sterile Inflammation of the Liver.

Gastroenterology 2016 12 8;151(6):1087-1095. Epub 2016 Oct 8.

Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada; Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.09.048DOI Listing
December 2016

Platelets and infection.

Semin Immunol 2016 12 18;28(6):536-545. Epub 2016 Oct 18.

Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2016.10.005DOI Listing
December 2016

The versatile platelet contributes to inflammation, infection, hemostasis, coagulation and cancer.

Authors:
Paul Kubes

Semin Immunol 2016 12;28(6):535

Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/j.smim.2016.11.002DOI Listing
December 2016

Intravital Imaging of Myeloid Cells: Inflammatory Migration and Resident Patrolling.

Microbiol Spectr 2016 12;4(6)

Department of Physiology and Pharmacology.

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http://dx.doi.org/10.1128/microbiolspec.MCHD-0042-2016DOI Listing
December 2016

Recent advances in understanding neutrophils.

F1000Res 2016 23;5:2912. Epub 2016 Dec 23.

Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada; Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada; Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.12688/f1000research.9691.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225409PMC
December 2016

Pondering neutrophil extracellular traps with healthy skepticism.

Cell Microbiol 2016 Oct 23;18(10):1349-57. Epub 2016 Aug 23.

Department of Physiology and Pharmacology, Immunology Research Group, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, T2N 4N1, Canada.

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http://dx.doi.org/10.1111/cmi.12652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025378PMC
October 2016

GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation.

J Cell Biol 2016 Oct;215(1):107-119

Princess Margaret Cancer Center, Toronto, Ontario M5G 1L7, Canada Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 1L7, Canada Department of Immunology, University of Toronto, Toronto, Ontario M5S 1L7, Canada Department of Medicine, University of Toronto, Toronto, Ontario M5S 1L7, Canada Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada

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http://dx.doi.org/10.1083/jcb.201603109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057286PMC
October 2016

iNKT Cell Emigration out of the Lung Vasculature Requires Neutrophils and Monocyte-Derived Dendritic Cells in Inflammation.

Cell Rep 2016 09;16(12):3260-3272

Department of Physiology and Pharmacology, University of Calgary, Calgary, AB T2N 4N1, Canada; Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, AB T2N 4N1, Canada; Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB T2N 4N1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.07.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318399PMC
September 2016

Gastrointestinal cancer: Neutrophils and cancer: guilt by association.

Nat Rev Gastroenterol Hepatol 2016 07 2;13(7):381-2. Epub 2016 Jun 2.

Department of Physiology and Pharmacology, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, HRIC 3280 Hospital Drive N.W., Calgary, Alberta T2N 4N1, Canada.

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http://dx.doi.org/10.1038/nrgastro.2016.90DOI Listing
July 2016

CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria.

Cell Host Microbe 2016 Jul 23;20(1):99-106. Epub 2016 Jun 23.

The Calvin, Phoebe & Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, T2N 4N1, Canada; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, T2N 4N1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2016.06.002DOI Listing
July 2016

Identification and treatment of the Staphylococcus aureus reservoir in vivo.

J Exp Med 2016 06 20;213(7):1141-51. Epub 2016 Jun 20.

Snyder Institute for Chronic Diseases, University of Calgary, Calgary AB T2N 1N4, Alberta, Canada Department of Physiology and Pharmacology, University of Calgary, Calgary AB T2N 1N4, Alberta, Canada.

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http://dx.doi.org/10.1084/jem.20160334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925027PMC
June 2016

A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair.

Cell 2016 Apr 7;165(3):668-78. Epub 2016 Apr 7.

Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada; Immunology Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674163026
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http://dx.doi.org/10.1016/j.cell.2016.03.009DOI Listing
April 2016

Allogeneic Bone Marrow Transplant from MRL/MpJ Super-Healer Mice Does Not Improve Articular Cartilage Repair in the C57Bl/6 Strain.

PLoS One 2015 29;10(6):e0131661. Epub 2015 Jun 29.

McCaig Institute for Bone and Joint Health, Department of Surgery, University of Calgary, Calgary, Alberta, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131661PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486721PMC
March 2016

Platelets in inflammation and infection.

Platelets 2015 25;26(4):286-92. Epub 2015 Mar 25.

Department of Microbiology, Immunology and Infectious Diseases and.

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http://dx.doi.org/10.3109/09537104.2015.1010441DOI Listing
February 2016

Neutrophil Extracellular Traps Provide a Grip on the Enigmatic Pathogenesis of Acute Pancreatitis.

Gastroenterology 2015 Dec 23;149(7):1682-5. Epub 2015 Oct 23.

Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.10.027DOI Listing
December 2015

Imaging the dynamic platelet-neutrophil response in sterile liver injury and repair in mice.

Hepatology 2015 Nov 28;62(5):1593-605. Epub 2015 Sep 28.

Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://doi.wiley.com/10.1002/hep.28003
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http://dx.doi.org/10.1002/hep.28003DOI Listing
November 2015

Active Negative Pressure Peritoneal Therapy After Abbreviated Laparotomy: The Intraperitoneal Vacuum Randomized Controlled Trial.

Ann Surg 2015 Jul;262(1):38-46

*Department of Surgery, University of Calgary and the Foothills Medical Centre, Calgary, Alberta, Canada †Regional Trauma Program, University of Calgary and the Foothills Medical Centre, Calgary, Alberta, Canada ‡Department of Community Health Sciences, University of Calgary, TRW (Teaching, Research, and Wellness), Calgary, Alberta, Canada §Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada ¶Alberta Health Services-Research Excellence Support Team, University of Calgary and the Foothills Medical Centre, Calgary, Alberta, Canada ‖Department of Oncology, University of Calgary and the Foothills Medical Centre, Calgary, Alberta, Canada **Department of Microbiology, Immunology, and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada ††Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, University of Calgary, Health Research Innovation Centre, Calgary, Alberta, Canada; and ‡‡Hotchkiss Brain Institute, University of Calgary and the Foothills Medical Centre, Health Research Innovation Centre, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1097/SLA.0000000000001095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463030PMC
July 2015

Intravital imaging - dynamic insights into natural killer T cell biology.

Front Immunol 2015 20;6:240. Epub 2015 May 20.

Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary , Calgary, AB , Canada.

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http://dx.doi.org/10.3389/fimmu.2015.00240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438604PMC
June 2015

A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury.

J Exp Med 2015 Apr 23;212(4):447-56. Epub 2015 Mar 23.

Immunology Research Group, Snyder Institute for Chronic Diseases; Department of Microbiology, Immunology, and Infectious Diseases; and Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada Immunology Research Group, Snyder Institute for Chronic Diseases; Department of Microbiology, Immunology, and Infectious Diseases; and Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada

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http://dx.doi.org/10.1084/jem.20141539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387291PMC
April 2015

Interactions between CD44 and Hyaluronan in Leukocyte Trafficking.

Front Immunol 2015 17;6:68. Epub 2015 Feb 17.

Snyder Institute for Chronic Diseases, University of Calgary , Calgary, AB , Canada.

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http://dx.doi.org/10.3389/fimmu.2015.00068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330908PMC
March 2015

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature.

Nat Commun 2015 Mar 26;6:6673. Epub 2015 Mar 26.

Department of Physiology and Pharmacology, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, HRIC 3280 Hospital Drive N.W., Calgary, Alberta, Canada T2N 4N1.

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http://dx.doi.org/10.1038/ncomms7673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389265PMC
March 2015

Virus-induced NETs--critical component of host defense or pathogenic mediator?

PLoS Pathog 2015 Jan 8;11(1):e1004546. Epub 2015 Jan 8.

Department of Physiology and Pharmacology, Calvin, Phoebe & Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1371/journal.ppat.1004546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287541PMC
January 2015

Integration of metabolic and inflammatory mediator profiles as a potential prognostic approach for septic shock in the intensive care unit.

Crit Care 2015 Jan 15;19:11. Epub 2015 Jan 15.

Bio-NMR-Centre, Department of Biological Sciences, University of Calgary, 2500 University Drive Northwest, Calgary, AB, T2N 1N4, Canada.

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http://dx.doi.org/10.1186/s13054-014-0729-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340832PMC
January 2015

Neutrophil crawling in capillaries; a novel immune response to Staphylococcus aureus.

PLoS Pathog 2014 Oct 9;10(10):e1004379. Epub 2014 Oct 9.

The Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada; Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada; Department of Critical Care, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1371/journal.ppat.1004379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192594PMC
October 2014

The systemic immune response to trauma: an overview of pathophysiology and treatment.

Lancet 2014 Oct 17;384(9952):1455-65. Epub 2014 Oct 17.

School of Health and Population Sciences, University of Birmingham, Birmingham, UK; Division of Health Sciences, University of Warwick, Coventry, UK. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(14)60687-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729362PMC
October 2014

Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia.

Proc Natl Acad Sci U S A 2014 Sep 9;111(38):13936-41. Epub 2014 Sep 9.

Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada T2N 4N1; Department of Physiology and Pharmacology,

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http://dx.doi.org/10.1073/pnas.1404769111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183287PMC
September 2014

Corrigendum to "Coronin 1 is dispensable for leukocyte recruitment and liver injury in concanavalin A-induced hepatitis" [Immunol. Lett. 153 (1-2) (2013) 62-70].

Immunol Lett 2014 Jul 13;160(1):105. Epub 2014 Apr 13.

Biozentrum, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.imlet.2014.04.002DOI Listing
July 2014

Resolution mediator chemerin15 reprograms the wound microenvironment to promote repair and reduce scarring.

Curr Biol 2014 Jun 29;24(12):1406-1414. Epub 2014 May 29.

School of Physiology & Pharmacology, Medical Sciences, University Walk, Bristol University, Bristol BS8 1TD, UK; School of Biochemistry, Medical Sciences, University Walk, Bristol University, Bristol BS8 1TD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064685PMC
June 2014

Metabolic profiling of serum samples by 1H nuclear magnetic resonance spectroscopy as a potential diagnostic approach for septic shock.

Crit Care Med 2014 May;42(5):1140-9

1Bio-NMR-Centre, Department of Biological Sciences, University of Calgary, Calgary, AB, Canada. 2Critical Care Epidemiologic and Biologic Tissue Resource (CCEPTR), Department of Critical Care Medicine, University of Calgary, Calgary, AB, Canada. 3Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada. 4Department of Physiology and Biophysics, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1097/CCM.0000000000000142DOI Listing
May 2014

Neonates, antibiotics and the microbiome.

Nat Med 2014 May;20(5):469-70

Calvin, Phoebe & Joan Snyder Institute for Chronic Diseases and the Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1038/nm.3558DOI Listing
May 2014

Many fences make better neighbors.

Sci Transl Med 2014 May;6(237):237fs22

Department of Physiology and Pharmacology, Snyder Institute of Chronic Disease, University of Calgary, T2N 4N1, Canada.

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http://dx.doi.org/10.1126/scitranslmed.3009391DOI Listing
May 2014

Macrophages in the liver prevent metastasis by efficiently eliminating circulating tumor cells after monoclonal antibody immunotherapy.

Oncoimmunology 2014 17;3:e28441. Epub 2014 Apr 17.

Department of Molecular Cell Biology and Immunology; VU University Medical Center; Amsterdam, The Netherlands ; Department of Surgery; VU University Medical Center; Amsterdam, The Netherlands.

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http://dx.doi.org/10.4161/onci.28441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063143PMC
April 2014

Kupffer cells and activation of endothelial TLR4 coordinate neutrophil adhesion within liver sinusoids during endotoxemia.

Am J Physiol Gastrointest Liver Physiol 2013 Dec 10;305(11):G797-806. Epub 2013 Oct 10.

Director, Snyder Institute for Chronic Disease, Dept. of Physiology and Pharmacology, Univ. of Calgary, Alberta, Canada, 3330 Hospital Dr. NW, Calgary, AB, T2N 4N1, Canada.

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http://dx.doi.org/10.1152/ajpgi.00058.2013DOI Listing
December 2013

Therapeutic advantage of anti-VAP-1 over anti-α4 integrin antibody in concanavalin a-induced hepatitis.

Hepatology 2013 Oct 6;58(4):1413-23. Epub 2013 Aug 6.

Calvin, Phoebe & Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1002/hep.26469DOI Listing
October 2013

A prospective evaluation of the temporal matrix metalloproteinase response after severe traumatic brain injury in humans.

J Neurotrauma 2013 Oct 6;30(20):1717-26. Epub 2013 Sep 6.

1 Department of Surgery, University of Calgary and the Foothills Medical Center , Calgary, Alberta, Canada .

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http://dx.doi.org/10.1089/neu.2012.2841DOI Listing
October 2013

Association between the cerebral inflammatory and matrix metalloproteinase responses after severe traumatic brain injury in humans.

J Neurotrauma 2013 Oct 28;30(20):1727-36. Epub 2013 Aug 28.

1 Department of Surgery, University of Calgary and the Foothills Medical Centre , Calgary, Alberta, Canada .

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http://dx.doi.org/10.1089/neu.2012.2842DOI Listing
October 2013

Immune surveillance by the liver.

Nat Immunol 2013 Oct 18;14(10):996-1006. Epub 2013 Sep 18.

1] Calvin, Phoebe & Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada. [2] Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1038/ni.2691DOI Listing
October 2013

Immune surveillance by the liver.

Nat Immunol 2013 Oct 18;14(10):996-1006. Epub 2013 Sep 18.

1] Calvin, Phoebe & Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada. [2] Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1038/ni.2691DOI Listing
October 2013

Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance.

Nat Immunol 2013 Aug 16;14(8):785-92. Epub 2013 Jun 16.

Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Department of Physiology and Pharmacology, University of Calgary, Alberta, Canada.

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http://dx.doi.org/10.1038/ni.2631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972575PMC
August 2013

Incidence, prevalence, and occurrence rate of infection among adults hospitalized after traumatic brain injury: study protocol for a systematic review and meta-analysis.

Syst Rev 2013 Aug 24;2:68. Epub 2013 Aug 24.

Department of Critical Care Medicine, University of Calgary and the Foothills Medical Centre, 3134 Hospital Drive NW, Calgary, Alberta T2N 5A1, Canada.

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http://dx.doi.org/10.1186/2046-4053-2-68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765722PMC
August 2013

Hydrogen sulfide, another simple gas with complex biology.

Am J Physiol Gastrointest Liver Physiol 2013 Jun 2;304(12):G1066-9. Epub 2013 May 2.

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http://dx.doi.org/10.1152/ajpgi.00125.2013DOI Listing
June 2013

Coronin 1 is dispensable for leukocyte recruitment and liver injury in concanavalin A-induced hepatitis.

Immunol Lett 2013 Jun 12;153(1-2):62-70. Epub 2013 Jul 12.

Biozentrum, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.imlet.2013.06.005DOI Listing
June 2013