Publications


No evidence to support a role for Helicobacter pylori infection and plasminogen binding protein in autoimmune pancreatitis and IgG4-related disease in a UK cohort.
Pancreatology 2017 Apr 5. Epub 2017 Apr 5.
Peter Medawar Building, Nuffield Department Medicine, Oxford University, UK; Translational Gastroenterology Unit and NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK.




Human parvovirus 4 'PARV4' remains elusive despite a decade of study.
F1000Res 2017 27;6:82. Epub 2017 Jan 27.
Nuffield Department of Medicine, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford, OX1 3SY, UK; Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK; NIHR Biomedical Research Centre, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK.


Cysteinyl leukotriene E4 activates human group 2 innate lymphoid cells and enhances the effect of prostaglandin D2 and epithelial cytokines.
J Allergy Clin Immunol 2017 Jan 20. Epub 2017 Jan 20.
Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Oxford NIHR Biomedical Research Centre, Core Translational Immunology Laboratory, Oxford, United Kingdom. Electronic address:




Hepitopes: A live interactive database of HLA class I epitopes in hepatitis B virus.
Wellcome Open Res 2016 Nov 15;1. Epub 2016 Nov 15.
Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK; Nuffield Department of Experimental Medicine, University of Oxford, Oxford, UK.




Human T cell responses to Japanese encephalitis virus in health and disease.
J Exp Med 2016 Jun 30;213(7):1331-52. Epub 2016 May 30.
Institute of Infection and Global Health, University of Liverpool, Liverpool L69 7BE, England, UK Health Protection Research Unit for Emerging and Zoonotic Infections, University of Liverpool, Liverpool L69 7BE, England, UK Walton Center National Health Service Foundation Trust, Liverpool L9 7LJ, England, UK.



Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1.
J Hepatol 2016 May 29;64(5):1118-27. Epub 2015 Dec 29.
Centre for Liver Research and NIHR Biomedical Research Unit in Liver Disease, Institute of Immunology & Immunotherapy, University of Birmingham, United Kingdom; University Hospital of Birmingham NHS Foundation Trust, United Kingdom. Electronic address:

HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults.
J Infect Dis 2016 Apr 9;213(8):1248-52. Epub 2015 Dec 9.
Nuffield Department of Medicine Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Trust NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford.

LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation.
J Immunol 2016 Mar 1;196(5):2085-94. Epub 2016 Feb 1.
Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kindgom; Oxford National Institute for Health Research Biomedical Research Centre, Oxford OX3 9DU, United Kingdom


Adenoviral Vector Vaccination Induces a Conserved Program of CD8(+) T Cell Memory Differentiation in Mouse and Man.
Cell Rep 2015 Nov 12;13(8):1578-88. Epub 2015 Nov 12.
Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, UK; NIHR Biomedical Research Centre, Oxford OX3 9DU, UK.

Differential Immune Profiles in Two Pandemic Influenza A(H1N1)pdm09 Virus Waves at Pandemic Epicenter.
Arch Med Res 2015 Nov 13;46(8):651-8. Epub 2015 Dec 13.
Medical Research Unit in Immunochemistry, Specialties Hospital, National Medical Center Siglo XXI, IMSS, Mexico City, Mexico; Visiting Professor of Immunology, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Electronic address:

Ongoing burden of disease and mortality from HIV/CMV coinfection in Africa in the antiretroviral therapy era.
Front Microbiol 2015 24;6:1016. Epub 2015 Sep 24.
Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford Oxford, UK ; Department of Infectious Diseases and Microbiology, John Radcliffe Hospital, Oxford University Hospitals NHS Trust Oxford, UK.

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells.
PLoS Pathog 2015 Oct 20;11(10):e1005177. Epub 2015 Oct 20.
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America; Division of Hematology/Oncology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.


POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer.
Clin Cancer Res 2015 Jul 15;21(14):3347-55. Epub 2015 Apr 15.
Molecular and Population Genetics Laboratory, The Wellcome Trust Centre for Human Genetics, University of Oxford. Roosevelt Drive, Oxford, United Kingdom. Oxford Cancer Centre, Churchill Hospital, Oxford, United Kingdom.

Molecular Analyses Define Vα7.2-Jα33+ MAIT Cell Depletion in HIV Infection: A Case-Control Study.
Medicine (Baltimore) 2015 Jul;94(29):e1134
From the Peter Medawar Building for Pathogen Research (JEU, PP, CC, PG, REP, CBW, PK), University of Oxford, Oxford, UK; Department of Microbiology and Immunology (JEU, RFH), University of Otago, Dunedin, New Zealand; Ragon Institute of MGH, MIT and Harvard (CC), Cambridge, Massachusetts, USA; Division of Infectious Diseases (AR), University Hospital Berne and University of Berne, Berne; Division of Infectious Diseases and Hospital Epidemiology and Institute of Medical Virology (HFG), University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Prevalence and Characteristics of Hepatitis B Virus (HBV) Coinfection among HIV-Positive Women in South Africa and Botswana.
PLoS One 2015 28;10(7):e0134037. Epub 2015 Jul 28.
Nuffield Department of Medicine, University of Oxford, Peter Medawar Building for Pathogen Research, Oxford, United Kingdom; Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Headington, Oxford, United Kingdom; NIHR Biomedical Research Centre, John Radcliffe Hospital, Headley Way, Headington, Oxford, United Kingdom.

Prostaglandin D2 and leukotriene E4 synergize to stimulate diverse TH2 functions and TH2 cell/neutrophil crosstalk.
J Allergy Clin Immunol 2015 May 19;135(5):1358-66.e1-11. Epub 2014 Oct 19.
Oxford NIHR Biomedical Research Centre, Translational Immunology Laboratory, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Increased IgG4 responses to multiple food and animal antigens indicate a polyclonal expansion and differentiation of pre-existing B cells in IgG4-related disease.
Ann Rheum Dis 2015 May 2;74(5):944-7. Epub 2015 Feb 2.
Sanquin Blood Supply, Division Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.


An expanded taxonomy of hepatitis C virus genotype 6: Characterization of 22 new full-length viral genomes.
Virology 2015 Feb 10;476:355-63. Epub 2015 Jan 10.
The Viral Oncology Center, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address:

A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory.
Sci Transl Med 2014 Nov;6(261):261ra153
Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK. The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK. National Institute for Health Research Oxford Biomedical Research Centre, and Translational Gastroenterology Unit, Oxford OX3 7LE, UK.

CD161 defines a transcriptional and functional phenotype across distinct human T cell lineages.
Cell Rep 2014 Nov 23;9(3):1075-88. Epub 2014 Oct 23.
Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, UK; NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford OX3 9TU, UK. Electronic address:

Epidemiology and impact of HIV coinfection with hepatitis B and hepatitis C viruses in Sub-Saharan Africa.
J Clin Virol 2014 Sep 5;61(1):20-33. Epub 2014 Jun 5.
Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK; Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK; NIHR Biomedical Research Centre, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK.


Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver.
PLoS Pathog 2014 Jun 26;10(6):e1004210. Epub 2014 Jun 26.
Viral Hepatitis Laboratory, Singapore Institute for Clinical Sciences, Agency of Science Technology and Research (A*STAR), Singapore; Program Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore; School of Immunity and Infection, College of Medical and Dental Science, University of Birmingham, Edgbaston Birmingham, United Kingdom.

PARV4: an emerging tetraparvovirus.
PLoS Pathog 2014 May 1;10(5):e1004036. Epub 2014 May 1.
Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, United Kingdom; Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Oxford, United Kingdom; NIHR Biomedical Research Centre, John Radcliffe Hospital, Headington, Oxford, United Kingdom.

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells.
J Allergy Clin Immunol 2014 Apr 31;133(4):1184-94. Epub 2013 Dec 31.
Oxford NIHR Biomedical Research Centre, Translational Immunology Laboratory, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.


Mutant prolactin receptor and familial hyperprolactinemia.
N Engl J Med 2013 Nov 6;369(21):2012-20. Epub 2013 Nov 6.
From the Academic Endocrine Unit, Radcliffe Department of Medicine (P.J.N., C.M.G., R.V.T.), Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine (C.B.W., P.K.), Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology (M.B., P.A.M.), and the Structural Genomics Consortium (C.B.), University of Oxford, Oxford, and Glasgow Royal Infirmary, Glasgow (S.J.C., M.A., R.S.D.) - all in the United Kingdom.



CD8αα Expression Marks Terminally Differentiated Human CD8+ T Cells Expanded in Chronic Viral Infection.
Front Immunol 2013 6;4:223. Epub 2013 Aug 6.
Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford , Oxford , UK ; Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.

Infection frequency of hepatitis C virus and IL28B haplotypes in Papua New Guinea, Fiji, and Kiribati.
PLoS One 2013 20;8(8):e66749. Epub 2013 Aug 20.
Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom ; Walter+Eliza Hall Institute for Medical Research, Melbourne, Victoria, Australia.





Eight novel hepatitis C virus genomes reveal the changing taxonomic structure of genotype 6.
J Gen Virol 2013 Jan 26;94(Pt 1):76-80. Epub 2012 Sep 26.
Vaccine Institute, 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, PR China.

Low levels of peripheral CD161++CD8+ mucosal associated invariant T (MAIT) cells are found in HIV and HIV/TB co-infection.
PLoS One 2013 31;8(12):e83474. Epub 2013 Dec 31.
KwaZulu-Natal Research Institute for Tuberculosis and HIV, Durban, South Africa ; HIV Pathogenesis Programme, University of KwaZulu-Natal, Durban, South Africa ; The Ragon Institute of MGH, Massachusetts Institute of Technology, and Harvard, Harvard Medical School, Cambridge, Massachusetts, United States of America.



Profibrogenic chemokines and viral evolution predict rapid progression of hepatitis C to cirrhosis.
Proc Natl Acad Sci U S A 2012 Sep 24;109(36):14562-7. Epub 2012 Jul 24.
Hepatic Pathogenesis Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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