Publications by authors named "Paul Kirschmeier"

60Publications

Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

Cancer Discov 2018 02 3;8(2):196-215. Epub 2017 Nov 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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February 2018

New class of azaheptapyridine FPT inhibitors as potential cancer therapy agents.

Bioorg Med Chem Lett 2014 Feb 2;24(4):1228-31. Epub 2014 Jan 2.

Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.

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February 2014

Semi-synthetic aristolactams--inhibitors of CDK2 enzyme.

Bioorg Med Chem Lett 2010 Feb 7;20(4):1384-7. Epub 2010 Jan 7.

Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.

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February 2010

Discovery of C-imidazole azaheptapyridine FPT inhibitors.

Bioorg Med Chem Lett 2010 Feb 6;20(3):1134-6. Epub 2009 Dec 6.

Schering Plough Research Institute, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.

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February 2010

Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification.

J Biol Chem 2008 Sep 9;283(37):25150-63. Epub 2008 Jul 9.

Lineberger Comprehensive Cancer Center, Division of Pharmacotherapy and Experimental Therapeutics, Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA.

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September 2008

Combining the farnesyltransferase inhibitor lonafarnib with paclitaxel results in enhanced growth inhibitory effects on human ovarian cancer models in vitro and in vivo.

Gynecol Oncol 2008 Apr 31;109(1):97-106. Epub 2008 Jan 31.

Schering-Plough Research Institute, Biological Research-Oncology, 2015 Galloping Hill Road, K15-2-2700, Kenilworth, NJ 07033, USA.

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April 2008

Enhancement of the antitumor activity of tamoxifen and anastrozole by the farnesyltransferase inhibitor lonafarnib (SCH66336).

Anticancer Drugs 2007 Sep;18(8):923-31

Department of Biological Research - Oncology, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA.

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September 2007

AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines.

Cancer Biol Ther 2007 May 9;6(5):755-62. Epub 2007 Feb 9.

Department of Tumor Biology, Schering-Plough Research Institute, Kenilworth, New Jersey, USA.

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May 2007

Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors.

Cancer Biol Ther 2006 Apr 19;5(4):419-26. Epub 2006 Apr 19.

DNAX Research Institute, Schering-Plough Research Institute, Kenilworth, New Jersey 07333, USA.

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April 2006

Lipid posttranslational modifications. Farnesyl transferase inhibitors.

J Lipid Res 2006 Jan 8;47(1):15-31. Epub 2005 Nov 8.

Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.

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January 2006

Farnesyl protein transferase inhibitors targeting the catalytic zinc for enhanced binding.

Bioorg Med Chem Lett 2004 Dec;14(23):5877-80

Schering-Plough Research Institute, 2015 Galloping Hill Road, K-15-3-3545, Kenilworth, NJ 07033, USA.

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December 2004

Farnesyltransferase inhibitors as anticancer agents: critical crossroads.

Curr Opin Drug Discov Devel 2004 Jul;7(4):478-86

Department of Chemical Research, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033-1300, USA.

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July 2004

Farnesyl transferase inhibitors: mechanism of action, translational studies and clinical evaluation.

Cancer Biol Ther 2003 Jul-Aug;2(4 Suppl 1):S96-104

Department of Biological Research-Oncology, Shering Plough Research Institute, Kenilworth, New Jersey 07033, USA.

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February 2004

Sch-66336 (sarasar) and other benzocycloheptapyridyl farnesyl protein transferase inhibitors: discovery, biology and clinical observations.

Curr Top Med Chem 2003 ;3(10):1103-14

Department of Medicinal Chemistry, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA.

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June 2003

Preclinical and clinical evaluation of farnesyltransferase inhibitors.

Curr Oncol Rep 2003 Mar;5(2):99-107

Schering-Plough Research Institute, 2015 Galloping Hill Road, K-15-3-3200, Kenilworth, NJ 07033-1300, USA.

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March 2003

Transcriptional regulation during p21WAF1/CIP1-induced apoptosis in human ovarian cancer cells.

J Biol Chem 2002 Sep 22;277(39):36329-37. Epub 2002 Jul 22.

Tumor Biology Department, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA.

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September 2002