Paul Kalitsis

Topoisomerase IIα is essential for maintenance of mitotic chromosome structure.

Authors:

Christian F Nielsen Tao Zhang Marin Barisic Paul Kalitsis Damien F Hudson

Proc Natl Acad Sci U S A 2020 06 15;117(22):12131-12142. Epub 2020 May 15.

Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC 3052, Australia;

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June 2020

Loss of TOP3B leads to increased R-loop formation and genome instability.

Authors:

Tao Zhang Mathew Wallis Vida Petrovic Jackie Challis Paul Kalitsis Damien F Hudson

Open Biol 2019 12 4;9(12):190222. Epub 2019 Dec 4.

Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria 3052, Australia.

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December 2019

Effect of MUC1 length polymorphisms on the NLRP3 inflammasome response of human macrophages.

Authors:

Poshmaal Dhar Sohinee Sarkar Garrett Z Ng Paul Kalitsis Muhammad A Saeed Michael A McGuckin Justine A Ellis Philip Sutton

Hum Immunol 2019 Oct 15;80(10):878-882. Epub 2019 Jun 15.

Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria 3052, Australia; Faculty of Veterinary and Agricultural Science, The University of Melbourne, Parkville, VIC 3010, Australia; Department of Paediatrics, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address:

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October 2019

Knocking in Multifunctional Gene Tags into SMC Complex Subunits Using Gene Editing.

Authors:

Paul Kalitsis Tao Zhang Ji Hun Kim Christian F Nielsen Kathryn M Marshall Damien F Hudson

Methods Mol Biol 2019 ;2004:91-102

Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC, Australia.

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March 2020

A Roberts Syndrome Individual With Differential Genotoxin Sensitivity and a DNA Damage Response Defect.

Authors:

Michael J McKay Jeffery Craig Paul Kalitsis Sergei Kozlov Sandra Verschoor Phillip Chen Pavel Lobachevsky Raja Vasireddy Yuqian Yan Jacinta Ryan George McGillivray Ravi Savarirayan Martin F Lavin Robert G Ramsay Huiling Xu

Int J Radiat Oncol Biol Phys 2019 04 30;103(5):1194-1202. Epub 2018 Nov 30.

Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Clinical Pathology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia; College of Life Sciences, Shanxi Normal University, Linfen, Shanxi, China. Electronic address:

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April 2019

Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells.

Authors:

Cedric S Tremblay Jesslyn Saw Sung Kai Chiu Nicholas C Wong Kirill Tsyganov Sarah Ghotb Alison N Graham Feng Yan Andrew A Guirguis Stefan E Sonderegger Nicole Lee Paul Kalitsis John Reynolds Stephen B Ting David R Powell Stephen M Jane David J Curtis

Nat Commun 2018 08 30;9(1):3535. Epub 2018 Aug 30.

Australian Centre for Blood Diseases, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia.

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August 2018

Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers.

Authors:

Maheshi Udugama Elaine Sanij Hsiao P J Voon Jinbae Son Linda Hii Jeremy D Henson F Lyn Chan Fiona T M Chang Yumei Liu Richard B Pearson Paul Kalitsis Jeffrey R Mann Philippe Collas Ross D Hannan Lee H Wong

Proc Natl Acad Sci U S A 2018 05 18;115(18):4737-4742. Epub 2018 Apr 18.

Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia;

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May 2018

Identification of an Immortalized Human Airway Epithelial Cell Line with Dyskinetic Cilia.

Authors:

Li Eon Kuek Paul Griffin Paul Martinello Alison N Graham Paul Kalitsis Philip J Robinson Graham A Mackay

Am J Respir Cell Mol Biol 2018 09;59(3):375-382

1 Department of Pharmacology and Therapeutics, and.

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September 2018

The Role of Centromere Defects in Cancer.

Authors:

Thian Thian Beh Paul Kalitsis

Prog Mol Subcell Biol 2017;56:541-554

Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Melbourne, 3052, Australia.

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May 2019

Condensin, master organizer of the genome.

Authors:

Paul Kalitsis Tao Zhang Kathryn M Marshall Christian F Nielsen Damien F Hudson

Chromosome Res 2017 03 9;25(1):61-76. Epub 2017 Feb 9.

From Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, VIC, 3052, Australia.

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March 2017

Loss of RMI2 Increases Genome Instability and Causes a Bloom-Like Syndrome.

Authors:

Damien F Hudson David J Amor Amber Boys Kathy Butler Lorna Williams Tao Zhang Paul Kalitsis

PLoS Genet 2016 Dec 15;12(12):e1006483. Epub 2016 Dec 15.

Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Parkville, Victoria, Australia.

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December 2016

Active centromere and chromosome identification in fixed cell lines.

Authors:

Thian T Beh Ruth N MacKinnon Paul Kalitsis

Mol Cytogenet 2016 22;9:28. Epub 2016 Mar 22.

Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Melbourne, VIC 3052 Australia ; Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville, Melbourne, VIC 3052 Australia.

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March 2016

Condensin I and II behaviour in interphase nuclei and cells undergoing premature chromosome condensation.

Authors:

Tao Zhang James R Paulson Muhammed Bakhrebah Ji Hun Kim Cameron Nowell Paul Kalitsis Damien F Hudson

Chromosome Res 2016 05 23;24(2):243-69. Epub 2016 Mar 23.

Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, VIC, 3052, Australia.

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May 2016

Activation by zinc of the human gastrin gene promoter in colon cancer cells in vitro and in vivo.

Authors:

Kathryn M Marshall Marie Laval Ortis Estacio Damien F Hudson Paul Kalitsis Arthur Shulkes Graham S Baldwin Oneel Patel

Metallomics 2015 Oct 25;7(10):1390-8. Epub 2015 Sep 25.

The Department of Surgery, University of Melbourne, Austin Health, Studley Rd, Heidelberg, Victoria 3084, Australia.

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October 2015

Contribution of the two genes encoding histone variant h3.3 to viability and fertility in mice.

Authors:

Michelle C W Tang Shelley A Jacobs Deidre M Mattiske Yu May Soh Alison N Graham An Tran Shu Ly Lim Damien F Hudson Paul Kalitsis Moira K O'Bryan Lee H Wong Jeffrey R Mann

PLoS Genet 2015 Feb 12;11(2):e1004964. Epub 2015 Feb 12.

Genetics Theme, Murdoch Children's Research Institute, Parkville, Victoria, Australia.

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February 2015

Disruption of a conserved CAP-D3 threonine alters condensin loading on mitotic chromosomes leading to chromosome hypercondensation.

Authors:

Muhammed Bakhrebah Tao Zhang Jeff R Mann Paul Kalitsis Damien F Hudson

J Biol Chem 2015 Mar 20;290(10):6156-67. Epub 2015 Jan 20.

From the Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Victoria 3052 and the Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia

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March 2015

Chromosome Y centromere array deletion leads to impaired centromere function.

Authors:

Alison N Graham Paul Kalitsis

PLoS One 2014 22;9(1):e86875. Epub 2014 Jan 22.

Murdoch Childrens Research Institute, Melbourne, Victoria, Australia ; Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.

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September 2014

Condensin I associates with structural and gene regulatory regions in vertebrate chromosomes.

Authors:

Ji Hun Kim Tao Zhang Nicholas C Wong Nadia Davidson Jovana Maksimovic Alicia Oshlack William C Earnshaw Paul Kalitsis Damien F Hudson

Nat Commun 2013 ;4:2537

1] Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Melbourne, Victoria 3052, Australia [2] Department of Paediatrics, University of Melbourne, Parkville, Melbourne, Victoria 3052, Australia.

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May 2014

Normal DNA methylation dynamics in DICER1-deficient mouse embryonic stem cells.

Authors:

Jonathan Ip Paul Canham K H Andy Choo Yoshimi Inaba Shelley A Jacobs Paul Kalitsis Deidre M Mattiske Jane Ng Richard Saffery Nicholas C Wong Lee H Wong Jeffrey R Mann

PLoS Genet 2012 Sep 6;8(9):e1002919. Epub 2012 Sep 6.

Theme of Genetic Disorders, Murdoch Childrens Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.

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September 2012

The evolutionary life cycle of the resilient centromere.

Authors:

Paul Kalitsis K H Andy Choo

Chromosoma 2012 Aug 11;121(4):327-40. Epub 2012 Apr 11.

Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Victoria 3052, Australia.

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August 2012

Contrasting roles of condensin I and condensin II in mitotic chromosome formation.

Authors:

Lydia C Green Paul Kalitsis Tsz M Chang Miri Cipetic Ji Hun Kim Owen Marshall Lynne Turnbull Cynthia B Whitchurch Paola Vagnarelli Kumiko Samejima William C Earnshaw K H Andy Choo Damien F Hudson

J Cell Sci 2012 Mar 17;125(Pt 6):1591-604. Epub 2012 Feb 17.

Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Victoria 3052, Australia.

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March 2012

Streptavidin-Binding Peptide (SBP)-tagged SMC2 allows single-step affinity fluorescence, blotting or purification of the condensin complex.

Authors:

Ji Hun Kim Tsz M Chang Alison N Graham K H A Choo Paul Kalitsis Damien F Hudson

BMC Biochem 2010 Dec 31;11:50. Epub 2010 Dec 31.

Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.

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December 2010

Inherent promoter bidirectionality facilitates maintenance of sequence integrity and transcription of parasitic DNA in mammalian genomes.

Authors:

Paul Kalitsis Richard Saffery

BMC Genomics 2009 Oct 27;10:498. Epub 2009 Oct 27.

Chromosome and Chromatin Research, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Melbourne 3052, Victoria, Australia.

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October 2009

Orchestrating twosome and foursome chromosome parties.

Authors:

Paul Kalitsis K H Andy Choo

Dev Cell 2009 Sep;17(3):305-7

Murdoch Childrens Research Institute, Royal Children's Hospital and Melbourne University Department of Paediatrics, Parkville, Melbourne, Victoria, 3052, Australia.

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September 2009

Rapid evolution of mouse Y centromere repeat DNA belies recent sequence stability.

Authors:

Mark D Pertile Alison N Graham K H Andy Choo Paul Kalitsis

Genome Res 2009 Dec 8;19(12):2202-13. Epub 2009 Sep 8.

Murdoch Childrens Research Institute, Victoria, Australia.

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December 2009

An improved Diagnostic PCR Assay for identification of Cryptic Heterozygosity for CGG Triplet Repeat Alleles in the Fragile X Gene (FMR1).

Authors:

Mahmoud S Khaniani Paul Kalitsis Trent Burgess Howard R Slater

Mol Cytogenet 2008 Apr 8;1. Epub 2008 Apr 8.

Cyto-Molecular Diagnostics Research Group, Melbourne, Australia.

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April 2008

Mouse telocentric sequences reveal a high rate of homogenization and possible role in Robertsonian translocation.

Authors:

Paul Kalitsis Belinda Griffiths K H Andy Choo

Proc Natl Acad Sci U S A 2006 Jun 26;103(23):8786-91. Epub 2006 May 26.

Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Victoria 3052, Australia.

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June 2006

Spef1, a conserved novel testis protein found in mouse sperm flagella.

Authors:

Sarah W Chan Kerry J Fowler K H Andy Choo Paul Kalitsis

Gene 2005 Jul;353(2):189-99

Chromosome Research Laboratory, Murdoch Children's Research Institute, Royal Children's Hospital, Department of Paediatrics, University of Melbourne, Parkville 3052, Melbourne, Australia.

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July 2005