Paul K Brindle

Paul K Brindle

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Paul K Brindle

Paul K Brindle

Publications by authors named "Paul K Brindle"

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32Publications

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The p300 and CBP Transcriptional Coactivators Are Required for β-Cell and α-Cell Proliferation.

Diabetes 2018 03 7;67(3):412-422. Epub 2017 Dec 7.

Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.2337/db17-0237DOI Listing
March 2018

Mutation of the CH1 Domain in the Histone Acetyltransferase CREBBP Results in Autism-Relevant Behaviors in Mice.

PLoS One 2016 5;11(1):e0146366. Epub 2016 Jan 5.

Department of Biochemistry, St Jude Children's Research Hospital, Memphis, TN 38105, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146366PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701386PMC
August 2016

T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs.

PLoS One 2014 23;9(7):e102076. Epub 2014 Jul 23.

Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102076PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108324PMC
April 2015

Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation.

Proc Natl Acad Sci U S A 2014 Dec 17;111(48):17116-21. Epub 2014 Nov 17.

Peptide Biology Laboratories, The Salk Institute for Biological Studies, La Jolla, CA 92037;

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http://dx.doi.org/10.1073/pnas.1420389111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260582PMC
December 2014

Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function.

Mol Cell Biol 2014 Nov 25;34(21):3993-4007. Epub 2014 Aug 25.

Division of Transplant Immunology, Department of Pathology and Laboratory Medicine and Biesecker Center for Study of Pediatric Liver Diseases, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/MCB.00919-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386456PMC
November 2014

Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression.

Nucleic Acids Res 2014 Oct 23;42(18):11363-82. Epub 2014 Sep 23.

Department of Biochemistry, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1093/nar/gku827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191404PMC
October 2014

Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300.

Nucleic Acids Res 2013 Dec 12;41(22):10199-214. Epub 2013 Sep 12.

Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, Department of Surgery, Creighton University, Omaha, NE 68178, USA, Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN 38105, USA and Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978.

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http://dx.doi.org/10.1093/nar/gkt824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905850PMC
December 2013

Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity.

Nat Med 2013 Sep 18;19(9):1173-7. Epub 2013 Aug 18.

1] Division of Transplant Immunology, Department of Pathology and Laboratory Medicine and Biesecker Center for Study of Pediatric Liver Diseases, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA. [2].

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http://dx.doi.org/10.1038/nm.3286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793393PMC
September 2013

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.

Nat Genet 2012 Oct 2;44(10):1104-10. Epub 2012 Sep 2.

Department of Translational Genomics, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/ng.2396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915822PMC
October 2012

Is histone acetylation the most important physiological function for CBP and p300?

Aging (Albany NY) 2012 Apr;4(4):247-55

Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371760PMC
http://dx.doi.org/10.18632/aging.100453DOI Listing
April 2012

Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments.

Learn Mem 2011 23;18(3):161-9. Epub 2011 Feb 23.

Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1101/lm.1939811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056518PMC
June 2011

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.

EMBO J 2011 Jan 3;30(2):249-62. Epub 2010 Dec 3.

Nuclear Receptor Biology Section, CEB, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://emboj.embopress.org/cgi/doi/10.1038/emboj.2010.318
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http://dx.doi.org/10.1038/emboj.2010.318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025463PMC
January 2011

Double null cells reveal that CBP and p300 are dispensable for p53 targets p21 and Mdm2 but variably required for target genes of other signaling pathways.

Cell Cycle 2011 Jan 15;10(2):212-21. Epub 2011 Jan 15.

Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048793PMC
http://dx.doi.org/10.4161/cc.10.2.14542DOI Listing
January 2011

CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation.

EMBO J 2010 Nov 21;29(21):3660-72. Epub 2010 Sep 21.

Department of Biochemistry, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1038/emboj.2010.235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982758PMC
November 2010

Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases.

Epigenetics 2010 Jan 27;5(1):9-15. Epub 2010 Jan 27.

Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829352PMC
http://dx.doi.org/10.4161/epi.5.1.10449DOI Listing
January 2010

Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development.

Mol Cell Biol 2009 Jul 11;29(14):3894-904. Epub 2009 May 11.

Department of Biochemistry, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1128/MCB.01598-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704754PMC
July 2009

Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms.

EMBO J 2007 Jun 24;26(12):2890-903. Epub 2007 May 24.

Department of Biochemistry, St Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.

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http://emboj.embopress.org/cgi/doi/10.1038/sj.emboj.7601734
Publisher Site
http://dx.doi.org/10.1038/sj.emboj.7601734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1894772PMC
June 2007

A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes.

Learn Mem 2006 Sep-Oct;13(5):609-17. Epub 2006 Sep 15.

Department of Neurobiology & Behavior, Center for the Neurobiology of Learning & Memory, University of California at Irvine 92697, and Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1101/lm.213906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783615PMC
November 2006

Differential role for CBP and p300 CREB-binding domain in motor skill learning.

Behav Neurosci 2006 Jun;120(3):724-9

Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1037/0735-7044.120.3.724DOI Listing
June 2006

Mammalian gene expression program resiliency: the roles of multiple coactivator mechanisms in hypoxia-responsive transcription.

Cell Cycle 2006 Jan 16;5(2):142-6. Epub 2006 Jan 16.

Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.4161/cc.5.2.2353DOI Listing
January 2006

Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression.

EMBO J 2005 Nov 20;24(22):3846-58. Epub 2005 Oct 20.

Department of Biochemistry, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1038/sj.emboj.7600846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283945PMC
November 2005

Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency.

Cancer Cell 2004 Feb;5(2):177-89

Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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February 2004

A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis.

Nature 2002 Oct;419(6908):738-43

Department of Biochemistry, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA.

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http://www.nature.com/articles/nature01062
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http://dx.doi.org/10.1038/nature01062DOI Listing
October 2002