Paul J Norman

Paul J Norman

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Paul J Norman

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In vitro education of human natural killer cells by KIR3DL1.

Life Sci Alliance 2019 Dec 13;2(6). Epub 2019 Nov 13.

Departments of Structural Biology and Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA, USA

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http://dx.doi.org/10.26508/lsa.201900434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856763PMC
December 2019

A subset of HLA-DP molecules serve as ligands for the natural cytotoxicity receptor NKp44.

Nat Immunol 2019 09 29;20(9):1129-1137. Epub 2019 Jul 29.

Research Department Virus Immunology, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.

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http://dx.doi.org/10.1038/s41590-019-0448-4DOI Listing
September 2019

KIR3DL1/S1 Allotypes Contribute Differentially to the Development of Behçet Disease.

J Immunol 2019 Sep 12;203(6):1629-1635. Epub 2019 Aug 12.

Clinical and Diagnostic Oral Sciences, Queen Mary University of London, Blizard Institute, E1 2AT London, United Kingdom;

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http://dx.doi.org/10.4049/jimmunol.1801178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731450PMC
September 2019

Natural Killer Cells Offer Differential Protection From Leukemia in Chinese Southern Han.

Front Immunol 2019 16;10:1646. Epub 2019 Jul 16.

Division of Biomedical Informatics and Personalized Medicine, Department of Microbiology and Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

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http://dx.doi.org/10.3389/fimmu.2019.01646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646668PMC
July 2019

Genetic analyses of diverse populations improves discovery for complex traits.

Nature 2019 06 19;570(7762):514-518. Epub 2019 Jun 19.

Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://dx.doi.org/10.1038/s41586-019-1310-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785182PMC
June 2019

Fluctuating and Geographically Specific Selection Characterize Rapid Evolution of the Human Region.

Front Immunol 2019 17;10:989. Epub 2019 May 17.

Department of Neurology, University of California, San Francisco, San Francisco, CA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.00989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533848PMC
May 2019

High-Resolution Genetic and Phenotypic Analysis of KIR2DL1 Alleles and Their Association with Pre-Eclampsia.

J Immunol 2018 11 24;201(9):2593-2601. Epub 2018 Sep 24.

Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge CB2 0SW, United Kingdom;

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http://dx.doi.org/10.4049/jimmunol.1800860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258046PMC
November 2018

Human NK Cells Downregulate Zap70 and Syk in Response to Prolonged Activation or DNA Damage.

J Immunol 2018 02 20;200(3):1146-1158. Epub 2017 Dec 20.

Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305; and

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http://dx.doi.org/10.4049/jimmunol.1700542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780205PMC
February 2018

KIR2DS5 allotypes that recognize the C2 epitope of HLA-C are common among Africans and absent from Europeans.

Immun Inflamm Dis 2017 12 6;5(4):461-468. Epub 2017 Jul 6.

Departments of Structural Biology and Microbiology and Immunology, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1002/iid3.178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691316PMC
December 2017

Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles.

PLoS Genet 2017 Jun 26;13(6):e1006862. Epub 2017 Jun 26.

Dept. of Structural Biology & Dept. of Microbiology & Immunology, School of Medicine, Stanford University, Stanford, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507469PMC
June 2017

Deciphering the killer-cell immunoglobulin-like receptor system at super-resolution for natural killer and T-cell biology.

Immunology 2017 03 14;150(3):248-264. Epub 2016 Dec 14.

Department of Pathology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1111/imm.12684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290243PMC
March 2017

Resurrecting KIR2DP1: A Key Intermediate in the Evolution of Human Inhibitory NK Cell Receptors That Recognize HLA-C.

J Immunol 2017 03 25;198(5):1961-1973. Epub 2017 Jan 25.

Department of Structural Biology, School of Medicine, Stanford University, Stanford, CA 94305; and

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1601835
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http://dx.doi.org/10.4049/jimmunol.1601835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321844PMC
March 2017

Class I HLA haplotypes form two schools that educate NK cells in different ways.

Sci Immunol 2016 09 9;1(3). Epub 2016 Sep 9.

Departments of Structural Biology and Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA, 94305, USA; Stanford Immunology, Stanford University School of Medicine, Stanford, CA, 94305, USA.

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http://dx.doi.org/10.1126/sciimmunol.aag1672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110269PMC
September 2016

Regulation of Adaptive NK Cells and CD8 T Cells by HLA-C Correlates with Allogeneic Hematopoietic Cell Transplantation and with Cytomegalovirus Reactivation.

J Immunol 2015 Nov 28;195(9):4524-36. Epub 2015 Sep 28.

Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305; Stanford Immunology, Stanford University School of Medicine, Stanford, CA 94305; and

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http://dx.doi.org/10.4049/jimmunol.1401990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610859PMC
November 2015

The production of KIR-Fc fusion proteins and their use in a multiplex HLA class I binding assay.

J Immunol Methods 2015 Oct 19;425:79-87. Epub 2015 Jun 19.

Department of Structural Biology, Stanford University School of Medicine, Stanford, USA; Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2015.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604020PMC
October 2015

Chimpanzee susceptibility to hepatitis C virus infection correlates with presence of Pt-KIR3DS2 and Pt-KIR2DL9: paired activating and inhibitory natural killer cell receptors.

Immunogenetics 2015 Oct 12;67(10):625-8. Epub 2015 Aug 12.

Departments of Structural Biology and Microbiology and Immunology, Stanford University, Fairchild D-159, 299 Campus Drive West, Stanford, CA, 94305, USA.

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http://dx.doi.org/10.1007/s00251-015-0863-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575274PMC
October 2015

Polymorphic HLA-C Receptors Balance the Functional Characteristics of KIR Haplotypes.

J Immunol 2015 Oct 26;195(7):3160-70. Epub 2015 Aug 26.

Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305; and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305

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http://dx.doi.org/10.4049/jimmunol.1501358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575877PMC
October 2015

Very long haplotype tracts characterized at high resolution from HLA homozygous cell lines.

Immunogenetics 2015 Sep 22;67(9):479-85. Epub 2015 Jul 22.

Departments of Structural Biology and Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA, 94305, USA,

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http://link.springer.com/10.1007/s00251-015-0857-y
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http://dx.doi.org/10.1007/s00251-015-0857-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540692PMC
September 2015

Co-evolution of MHC class I and variable NK cell receptors in placental mammals.

Immunol Rev 2015 09;267(1):259-82

Department of Structural Biology and Department of Microbiology and Immunology, School of Medicine, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1111/imr.12326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587382PMC
September 2015

POPULATION GENETICS. Genomic evidence for the Pleistocene and recent population history of Native Americans.

Authors:
Maanasa Raghavan Matthias Steinrücken Kelley Harris Stephan Schiffels Simon Rasmussen Michael DeGiorgio Anders Albrechtsen Cristina Valdiosera María C Ávila-Arcos Anna-Sapfo Malaspinas Anders Eriksson Ida Moltke Mait Metspalu Julian R Homburger Jeff Wall Omar E Cornejo J Víctor Moreno-Mayar Thorfinn S Korneliussen Tracey Pierre Morten Rasmussen Paula F Campos Peter de Barros Damgaard Morten E Allentoft John Lindo Ene Metspalu Ricardo Rodríguez-Varela Josefina Mansilla Celeste Henrickson Andaine Seguin-Orlando Helena Malmström Thomas Stafford Suyash S Shringarpure Andrés Moreno-Estrada Monika Karmin Kristiina Tambets Anders Bergström Yali Xue Vera Warmuth Andrew D Friend Joy Singarayer Paul Valdes Francois Balloux Ilán Leboreiro Jose Luis Vera Hector Rangel-Villalobos Davide Pettener Donata Luiselli Loren G Davis Evelyne Heyer Christoph P E Zollikofer Marcia S Ponce de León Colin I Smith Vaughan Grimes Kelly-Anne Pike Michael Deal Benjamin T Fuller Bernardo Arriaza Vivien Standen Maria F Luz Francois Ricaut Niede Guidon Ludmila Osipova Mikhail I Voevoda Olga L Posukh Oleg Balanovsky Maria Lavryashina Yuri Bogunov Elza Khusnutdinova Marina Gubina Elena Balanovska Sardana Fedorova Sergey Litvinov Boris Malyarchuk Miroslava Derenko M J Mosher David Archer Jerome Cybulski Barbara Petzelt Joycelynn Mitchell Rosita Worl Paul J Norman Peter Parham Brian M Kemp Toomas Kivisild Chris Tyler-Smith Manjinder S Sandhu Michael Crawford Richard Villems David Glenn Smith Michael R Waters Ted Goebel John R Johnson Ripan S Malhi Mattias Jakobsson David J Meltzer Andrea Manica Richard Durbin Carlos D Bustamante Yun S Song Rasmus Nielsen Eske Willerslev

Science 2015 Aug 21;349(6250):aab3884. Epub 2015 Jul 21.

Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.

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http://dx.doi.org/10.1126/science.aab3884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733658PMC
August 2015

Loss and Gain of Natural Killer Cell Receptor Function in an African Hunter-Gatherer Population.

PLoS Genet 2015 Aug 20;11(8):e1005439. Epub 2015 Aug 20.

Departments of Structural Biology and Microbiology & Immunology, Stanford University School of Medicine, Stanford, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546388PMC
August 2015

Signature Patterns of MHC Diversity in Three Gombe Communities of Wild Chimpanzees Reflect Fitness in Reproduction and Immune Defense against SIVcpz.

PLoS Biol 2015 May 28;13(5):e1002144. Epub 2015 May 28.

Department of Structural Biology and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1002144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447270PMC
May 2015

KIR diversity in Māori and Polynesians: populations in which HLA-B is not a significant KIR ligand.

Immunogenetics 2014 Nov 21;66(11):597-611. Epub 2014 Aug 21.

Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA.

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http://dx.doi.org/10.1007/s00251-014-0794-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198482PMC
November 2014

Natural selection on marine carnivores elaborated a diverse family of classical MHC class I genes exhibiting haplotypic gene content variation and allelic polymorphism.

Immunogenetics 2012 Dec 22;64(12):915-33. Epub 2012 Sep 22.

Department of Structural Biology, Stanford University School of Medicine, Fairchild D-159 299 Campus Drive West, Stanford, CA 94305, USA.

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http://link.springer.com/10.1007/s00251-012-0651-z
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http://dx.doi.org/10.1007/s00251-012-0651-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518486PMC
December 2012

Variable NK cell receptors exemplified by human KIR3DL1/S1.

J Immunol 2011 Jul;187(1):11-9

Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.4049/jimmunol.0902332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223120PMC
July 2011

Co-evolution of KIR2DL3 with HLA-C in a human population retaining minimal essential diversity of KIR and HLA class I ligands.

Proc Natl Acad Sci U S A 2009 Nov 16;106(44):18692-7. Epub 2009 Oct 16.

Department of Structural Biology and Microbiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1073/pnas.0906051106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774017PMC
November 2009

Chimpanzees use more varied receptors and ligands than humans for inhibitory killer cell Ig-like receptor recognition of the MHC-C1 and MHC-C2 epitopes.

J Immunol 2009 Mar;182(6):3628-37

Department of Structural Biology, and Department of Microbiology and Immunology, School of Medicine, Stanford University, Stanford, CA 94305.

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http://dx.doi.org/10.4049/jimmunol.0803401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854666PMC
March 2009

Polymorphic sites away from the Bw4 epitope that affect interaction of Bw4+ HLA-B with KIR3DL1.

J Immunol 2008 Nov;181(9):6293-300

Department of Structural Biology, Stanford University, Stanford, CA 94305, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634290PMC
http://dx.doi.org/10.4049/jimmunol.181.9.6293DOI Listing
November 2008

Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3.

J Immunol 2008 Mar;180(6):3969-79

Department of Structural Biology, School of Medicine, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.4049/jimmunol.180.6.3969DOI Listing
March 2008

Episodes of natural selection shaped the interactions of IgA-Fc with FcalphaRI and bacterial decoy proteins.

J Immunol 2007 Jun;178(12):7943-54

Department of Structural Biology and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.4049/jimmunol.178.12.7943DOI Listing
June 2007

Reduced telomere length in rheumatoid arthritis is independent of disease activity and duration.

Ann Rheum Dis 2007 Apr 17;66(4):476-80. Epub 2006 Nov 17.

Department of Rheumatology, Twin Research and Genetic Epidemiology Unit, Kings College London School of Medicine at Guy's, King's and St Thomas', London SE1 7EH, UK.

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http://dx.doi.org/10.1136/ard.2006.059188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1856061PMC
April 2007

High KIR diversity in Amerindians is maintained using few gene-content haplotypes.

Immunogenetics 2006 Jun 5;58(5-6):474-80. Epub 2006 May 5.

Department of Structural Biology, Stanford University School of Medicine, Sherman Fairchild Building, Stanford, CA, USA.

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http://dx.doi.org/10.1007/s00251-006-0108-3DOI Listing
June 2006

Complex interactions: the immunogenetics of human leukocyte antigen and killer cell immunoglobulin-like receptors.

Semin Hematol 2005 Apr;42(2):65-75

Departments of Structural Biology and Microbiology, Stanford University School of Medicine, 299 Campus Drive West, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1053/j.seminhematol.2005.01.007DOI Listing
April 2005

Isolation, purification and flow cytometric analysis of human intrahepatic lymphocytes using an improved technique.

Lab Invest 2005 Feb;85(2):285-96

Institute of Liver Study, King's College Hospital, London, UK.

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http://dx.doi.org/10.1038/labinvest.3700219DOI Listing
February 2005

SNP haplotypes and allele frequencies show evidence for disruptive and balancing selection in the human leukocyte receptor complex.

Immunogenetics 2004 Jul 5;56(4):225-37. Epub 2004 Jun 5.

Clinical Transplantation Laboratory, Guy's Hospital, 3rd Floor New Guy's House, St. Thomas' Street, London, SE1 9RT, UK.

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http://dx.doi.org/10.1007/s00251-004-0674-1DOI Listing
July 2004

DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3.

Immunogenetics 2003 Jun 16;55(3):165-171. Epub 2003 May 16.

Clinical Transplantation Laboratory, Guy's Hospital, 3rd Floor New Guy's House, St. Thomas' Street, London, SE1 9RT, UK.

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http://dx.doi.org/10.1007/s00251-003-0561-1DOI Listing
June 2003

A multi-laboratory characterization of the KIR genotypes of 10th International Histocompatibility Workshop cell lines.

Hum Immunol 2003 May;64(5):567-71

Cancer Research, UK Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.1016/s0198-8859(03)00042-9DOI Listing
May 2003

A comparison of HLA-DR and -DQ allele and haplotype frequencies in Trinidadian populations of African, South Asian, and mixed ancestry.

Hum Immunol 2002 Nov;63(11):1045-54

Department of Pre-Clinical Sciences, Faculty of Medical Sciences, University of the West Indies, St. Augustine, Trinidad.

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http://dx.doi.org/10.1016/s0198-8859(02)00437-8DOI Listing
November 2002