Publications

A genome-wide CRISPR screen reconciles the role of N-linked glycosylation in galectin-3 transport to the cell surface.
J Cell Sci 2017 Oct 3;130(19):3234-3247. Epub 2017 Aug 3.
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.
Cell Metab 2016 Nov 27;24(5):740-752. Epub 2016 Oct 27.
Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK. Electronic address:

A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I.
Biochem J 2015 Oct 28;471(1):79-88. Epub 2015 Jul 28.
Department of Clinical Biochemistry, Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Wellcome Trust/MRC Building, Biomedical Campus, Hills Road, Cambridge, CB2 0XY, U.K.

Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.
Cell Host Microbe 2015 Oct 1;18(4):409-23. Epub 2015 Oct 1.
Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK. Electronic address:


UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases.
Am J Hum Genet 2015 Feb 29;96(2):221-34. Epub 2015 Jan 29.
Department of Medical and Molecular Genetics, King's College London, London SE1 9RT, UK. Electronic address:


Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins.
J Cell Biol 2014 Jun;205(6):847-62
Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, England, UK Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, England, UK


Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB.
Hum Mol Genet 2013 Nov 28;22(22):4616-26. Epub 2013 Jun 28.
Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research (CIMR), Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK.

Role for the obesity-related FTO gene in the cellular sensing of amino acids.
Proc Natl Acad Sci U S A 2013 Feb 28;110(7):2557-62. Epub 2013 Jan 28.
University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

Tapasin-related protein TAPBPR is an additional component of the MHC class I presentation pathway.
Proc Natl Acad Sci U S A 2013 Feb 11;110(9):3465-70. Epub 2013 Feb 11.
Department of Pathology, Cambridge Institute of Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.

Proteomic plasma membrane profiling reveals an essential role for gp96 in the cell surface expression of LDLR family members, including the LDL receptor and LRP6.
J Proteome Res 2012 Mar 7;11(3):1475-84. Epub 2012 Feb 7.
Cambridge Institute for Medical Research, University of Cambridge , Hills Road, Cambridge, CB2 0XY, United Kingdom.

Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II.
J Biol Chem 2010 Nov 24;285(48):37641-9. Epub 2010 Sep 24.
From theDepartment of Medicine, University of Cambridge School of Clinical Medicine, Box 157, Addenbrooke's Hospital, Hills Road, Cambridge, Cambridgeshire CB2 0QQ, United Kingdom.


Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
Proc Natl Acad Sci U S A 2008 Feb 29;105(5):1656-61. Epub 2008 Jan 29.
Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Hills Road, Cambridge CB2 0XY, United Kingdom.

Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII.
J Biol Chem 2006 Feb 20;281(8):5094-105. Epub 2005 Dec 20.
Cambridge Institute for Medical Research, Department of Clinical Biochemistry, University of Cambridge, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, United Kingdom.

Loss of function of a lupus-associated FcgammaRIIb polymorphism through exclusion from lipid rafts.
Nat Med 2005 Oct 18;11(10):1056-8. Epub 2005 Sep 18.
Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Cambridge CB2 2XY, UK.




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