Publications by authors named "Paul J Declerck"

89Publications

Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition.

Front Cardiovasc Med 2020 22;7:622473. Epub 2020 Dec 22.

Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.

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December 2020

Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity.

Int J Mol Sci 2020 Aug 15;21(16). Epub 2020 Aug 15.

Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, B-3000 Leuven, Belgium.

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August 2020

Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction.

J Thromb Haemost 2020 03 20;18(3):681-692. Epub 2020 Feb 20.

Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.

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March 2020

Development of anti-matrix metalloproteinase-2 (MMP-2) nanobodies as potential therapeutic and diagnostic tools.

Nanomedicine 2020 02 24;24:102103. Epub 2019 Oct 24.

Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy. Electronic address:

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February 2020

Defective TAFI activation in hemophilia A mice is a major contributor to joint bleeding.

Blood 2018 10 19;132(15):1593-1603. Epub 2018 Jul 19.

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA.

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October 2018

A Genome-wide Study of Common and Rare Genetic Variants Associated with Circulating Thrombin Activatable Fibrinolysis Inhibitor.

Thromb Haemost 2018 02 29;118(2):298-308. Epub 2018 Jan 29.

Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

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February 2018

Targeting plasminogen activator inhibitor-1 in tetracycline-induced pleural injury in rabbits.

Am J Physiol Lung Cell Mol Physiol 2018 01 31;314(1):L54-L68. Epub 2017 Aug 31.

Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler , Tyler, Texas.

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January 2018

Lys 42/43/44 and Arg 12 of thrombin-activable fibrinolysis inhibitor comprise a thrombomodulin exosite essential for its antifibrinolytic potential.

Thromb Haemost 2017 07 22;117(8):1509-1517. Epub 2017 Jun 22.

Paul Y. Kim, Thrombosis and Atherosclerosis Research Institute, 237 Barton St. East, Hamilton, Ontario, L8L 2X2, Canada, Tel.: +1 905 521 2100, Fax: +1 905 575 2646, E-mail:

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July 2017

State of play and clinical prospects of antibody gene transfer.

J Transl Med 2017 06 7;15(1):131. Epub 2017 Jun 7.

Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven - University of Leuven, Campus Gasthuisberg O&N 2, P.B. 820, Herestraat 49, 3000, Leuven, Belgium.

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June 2017

Biopharmaceuticals: Reference Products and Biosimilars to Treat Inflammatory Diseases.

Ther Drug Monit 2017 08;39(4):308-315

*Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Therapeutic and Diagnostic Antibodies, KU Leuven, Leuven, Belgium; †Division of Neurology and Multiple Sclerosis Regional Center, AOU San Luigi, Orbassano, Turin, Italy; and Departments of ‡Rheumatology and §Pharmacovigilance, Université François-Rabelais de Tours, Tours, France.

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August 2017

Generation and in vitro characterisation of inhibitory nanobodies towards plasminogen activator inhibitor 1.

Thromb Haemost 2016 Nov 8;116(6):1032-1040. Epub 2016 Sep 8.

Paul Declerck, Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven, Campus Gasthuisberg, O&N2, PB 820, Herestraat 49, B-3000 Leuven, Belgium, Tel.: +32 16 32 34 31, Fax: +32 16 32 34 60, E-mail:

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November 2016

Inhibition of Thrombin-Activatable Fibrinolysis Inhibitor and Plasminogen Activator Inhibitor-1 Reduces Ischemic Brain Damage in Mice.

Stroke 2016 09 28;47(9):2419-22. Epub 2016 Jul 28.

From the Laboratory for Thrombosis Research, KU Leuven Campus Kulak Kortrijk, Belgium (F.D., N.V., H.D., K.V., S.F.D.M.); and Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium (T.W., M.P., A.G., P.J.D.).

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September 2016

Haemostatic biomarkers are associated with long-term recurrent vascular events after ischaemic stroke.

Thromb Haemost 2016 08 30;116(3):537-43. Epub 2016 Jun 30.

Annie Pedersen, MD, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Box 440, SE-405 30 Gothenburg, Sweden, Tel.: +46 31 343 48 11, Fax: +46 31 842 160, E-mail:

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August 2016

Prevention of Serpin Misfolding by RNA Aptamers.

Cell Chem Biol 2016 06;23(6):639-40

Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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June 2016

Harmonization of Infliximab and Anti-Infliximab Assays Facilitates the Comparison Between Originators and Biosimilars in Clinical Samples.

Inflamm Bowel Dis 2016 Apr;22(4):969-75

*Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium; and †Department of Clinical and Experimental Medicine, Translational Research in Gastrointestinal Disorders, University Hospitals Leuven, Leuven, Belgium.

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April 2016

Innovative thrombolytic strategy using a heterodimer diabody against TAFI and PAI-1 in mouse models of thrombosis and stroke.

Blood 2015 Feb 24;125(8):1325-32. Epub 2014 Dec 24.

Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium;

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February 2015