Paul Horrocks

Paul Horrocks

UNVERIFIED PROFILE

Are you Paul Horrocks?   Register this Author

Register author
Paul Horrocks

Paul Horrocks

Publications by authors named "Paul Horrocks"

Are you Paul Horrocks?   Register this Author

41Publications

566Reads

14Profile Views

The relative rate of kill of the MMV Malaria Box compounds provides links to the mode of antimalarial action and highlights scaffolds of medicinal chemistry interest.

J Antimicrob Chemother 2020 Feb;75(2):362-370

Institute for Science and Technology in Medicine, Keele University, Staffordshire, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jac/dkz443DOI Listing
February 2020

Discovery, synthesis and antibacterial evaluation of phenolic compounds from Cylicodiscus gabunensis.

BMC Complement Altern Med 2019 Jul 24;19(1):183. Epub 2019 Jul 24.

School of Pharmacy and Bioengineering, Keele University, Stoke-on-Trent, ST4 7QB, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12906-019-2589-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651987PMC
July 2019

Flavonoid Versus Artemisinin Anti-malarial Activity in Whole-Leaf Extracts.

Front Plant Sci 2019 30;10:984. Epub 2019 Jul 30.

Centre for Novel Agricultural Products, Department of Biology, University of York, York, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpls.2019.00984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683762PMC
July 2019

Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays.

PLoS Negl Trop Dis 2018 07 12;12(7):e0006639. Epub 2018 Jul 12.

Centre for Applied Entomology and Parasitology, School of Life Sciences, Keele University, Newcastle-under-Lyme, Staffordshire, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0006639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057649PMC
July 2018

The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents.

Bioorg Med Chem Lett 2018 04 27;28(7):1219-1222. Epub 2018 Feb 27.

Institute for Science and Technology in Medicine, Keele University, Staffordshire, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2018.02.051DOI Listing
April 2018

G-Quadruplex DNA Motifs in the Malaria Parasite Plasmodium falciparum and Their Potential as Novel Antimalarial Drug Targets.

Antimicrob Agents Chemother 2018 03 23;62(3). Epub 2018 Feb 23.

Centre for Applied Entomology and Parasitology, Faculty of Natural Sciences, Keele University, Keele, Staffordshire, United Kingdom

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.01828-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826154PMC
March 2018

Investigation of the antibiofilm capacity of peptide-modified stainless steel.

R Soc Open Sci 2018 Mar 7;5(3):172165. Epub 2018 Mar 7.

Institute for Science and Technology in Medicine, Keele University, Stoke-on-Trent ST4 7QB, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1098/rsos.172165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882733PMC
March 2018

A validated bioluminescence-based assay for the rapid determination of the initial rate of kill for discovery antimalarials.

J Antimicrob Chemother 2017 03;72(3):717-726

Institute for Science and Technology in Medicine, Keele University, Staffordshire ST5 5BG, UK.

View Article

Download full-text PDF

Source
https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/
Publisher Site
http://dx.doi.org/10.1093/jac/dkw449DOI Listing
March 2017

A characterization of the antimalarial activity of the bark of Cylicodiscus gabunensis Harms.

J Ethnopharmacol 2017 Feb 9;198:221-225. Epub 2017 Jan 9.

Institute for Science and Technology in Medicine, Keele University, Staffordshire ST5 5BG, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2017.01.014DOI Listing
February 2017

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

Triaging informative cis-regulatory elements for the combinatorial control of temporal gene expression during Plasmodium falciparum intraerythrocytic development.

Parasit Vectors 2015 Feb 5;8:81. Epub 2015 Feb 5.

Institute for Science and Technology in Medicine, Keele University, Staffordshire, ST5 5BG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13071-015-0701-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322800PMC
February 2015

Lemierre's Syndrome: Recognising a Typical Presentation of a Rare Condition.

Case Rep Infect Dis 2015 27;2015:797415. Epub 2015 Jan 27.

Keele University Medical School, Keele University, Staffordshire ST5 5BG, UK ; Royal Stoke University Hospital, Newcastle Road, Stoke-on-Trent, Staffordshire ST4 6QG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2015/797415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323061PMC
February 2015

Homopolymer tract organization in the human malarial parasite Plasmodium falciparum and related Apicomplexan parasites.

BMC Genomics 2014 Oct 3;15:848. Epub 2014 Oct 3.

Institute for Science and Technology in Medicine, Keele University, Stoke-on-Trent ST5 5BG, Staffordshire, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2164-15-848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194402PMC
October 2014

Functional analysis of the 5' untranslated region of the phosphoglutamase 2 transcript in Plasmodium falciparum.

Acta Trop 2013 Jul 6;127(1):69-74. Epub 2013 Apr 6.

Institute for Science and Technology in Medicine, Keele University, Staffordshire ST5 5BG, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actatropica.2013.03.007DOI Listing
July 2013

Analysis of the spatial and temporal arrangement of transcripts over intergenic regions in the human malarial parasite Plasmodium falciparum.

BMC Genomics 2013 Apr 19;14:267. Epub 2013 Apr 19.

Institute for Science and Technology in Medicine, Keele University, Huxley Building, Staffordshire ST5 5BG, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2164-14-267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681616PMC
April 2013

A quantitative analysis of Plasmodium falciparum transfection using DNA-loaded erythrocytes.

Mol Biochem Parasitol 2013 Feb 11;187(2):117-20. Epub 2013 Jan 11.

Institute for Science and Technology in Medicine, Keele University, Staffordshire ST5 5BG, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molbiopara.2013.01.001DOI Listing
February 2013

Evaluation of bioluminescence-based assays of anti-malarial drug activity.

Malar J 2013 Feb 8;12:58. Epub 2013 Feb 8.

Institute for Science and Technology in Medicine, Keele University, Staffordshire, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1475-2875-12-58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571881PMC
February 2013

Comparison of the absolute and relative efficiencies of electroporation-based transfection protocols for Plasmodium falciparum.

Malar J 2012 Jun 21;11:210. Epub 2012 Jun 21.

Institute for Science and Technology in Medicine, Keele University, Staffordshire, ST5 5BG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1475-2875-11-210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407700PMC
June 2012

An improved single-step lysis protocol to measure luciferase bioluminescence in Plasmodium falciparum.

Malar J 2012 Feb 10;11:42. Epub 2012 Feb 10.

Institute for Science and Technology in Medicine, Keele University, Staffordshire ST5 5BG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1475-2875-11-42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293040PMC
February 2012

Developing novel strategies to prevent parasitic infections.

Expert Rev Anti Infect Ther 2011 Jul;9(7):783-5

Centre for Infection and Immunology, Division of Clinical Sciences, St George's, University of London, London, SW170RE, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/eri.11.62DOI Listing
July 2011

Analysis of the molecular mechanisms governing the stage-specific expression of a prototypical housekeeping gene during intraerythrocytic development of P. falciparum.

J Mol Biol 2011 Apr 24;408(2):205-21. Epub 2011 Feb 24.

Institute for Science and Technology in Medicine, Keele University, Staffordshire ST5 5BG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2011.02.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081073PMC
April 2011

Control of gene expression in Plasmodium falciparum - ten years on.

Mol Biochem Parasitol 2009 Mar 6;164(1):9-25. Epub 2008 Dec 6.

Institute for Science and Technology in Medicine, Keele University, Staffordshire ST5 5BG, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molbiopara.2008.11.010DOI Listing
March 2009

Deciphering the ubiquitin-mediated pathway in apicomplexan parasites: a potential strategy to interfere with parasite virulence.

PLoS One 2008 Jun 11;3(6):e2386. Epub 2008 Jun 11.

Department of Cell Biology and Neurosciences, University of California at Riverside, Riverside, California, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002386PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408969PMC
June 2008

Plasmodium falciparum var gene expression is developmentally controlled at the level of RNA polymerase II-mediated transcription initiation.

Mol Microbiol 2007 Feb;63(4):1237-47

Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Headington, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2958.2007.05587.xDOI Listing
February 2007

LC/ESI-MS demonstrates the absence of 5-methyl-2'-deoxycytosine in Plasmodium falciparum genomic DNA.

Mol Biochem Parasitol 2006 Dec 28;150(2):350-2. Epub 2006 Jul 28.

Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molbiopara.2006.07.003DOI Listing
December 2006

Microarray-based comparative genomic analyses of the human malaria parasite Plasmodium falciparum using Affymetrix arrays.

Mol Biochem Parasitol 2005 Dec 8;144(2):177-86. Epub 2005 Sep 8.

Pathogen Microarrays Group, The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molbiopara.2005.08.010DOI Listing
December 2005

Pexel/VTS: a protein-export motif in erythrocytes infected with malaria parasites.

Trends Parasitol 2005 Sep;21(9):396-9

Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pt.2005.07.004DOI Listing
September 2005

PfEMP1 expression is reduced on the surface of knobless Plasmodium falciparum infected erythrocytes.

J Cell Sci 2005 Jun;118(Pt 11):2507-18

Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.02381DOI Listing
June 2005

Towards a proteomic definition of CoArtem action in Plasmodium falciparum malaria.

Proteomics 2005 May;5(7):1849-58

Liverpool School of Tropical Medicine, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.200401076DOI Listing
May 2005

Variable var transition rates underlie antigenic variation in malaria.

Proc Natl Acad Sci U S A 2004 Jul 15;101(30):11129-34. Epub 2004 Jul 15.

Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0402347101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC503751PMC
July 2004

Transcription of subtelomerically located var gene variant in Plasmodium falciparum appears to require the truncation of an adjacent var gene.

Mol Biochem Parasitol 2004 Apr;134(2):193-9

Molecular Parasitology Group, Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molbiopara.2003.11.016DOI Listing
April 2004

Chloroquine resistance modulated in vitro by expression levels of the Plasmodium falciparum chloroquine resistance transporter.

J Biol Chem 2003 Aug 17;278(35):33593-601. Epub 2003 Jun 17.

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M302215200DOI Listing
August 2003

A well-conserved Plasmodium falciparum var gene shows an unusual stage-specific transcript pattern.

Mol Microbiol 2003 Jun;48(5):1339-48

Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, Headington, Oxford OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869446PMC
http://dx.doi.org/10.1046/j.1365-2958.2003.03505.xDOI Listing
June 2003

Purification of chromosomes from Plasmodium falciparum.

Methods Mol Med 2002 ;72:235-40

Malaria Program, Naval Medical Research Center, Silver Spring, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1385/1-59259-271-6:235DOI Listing
December 2002

Stage-specific promoter activity from stably maintained episomes in Plasmodium falciparum.

Int J Parasitol 2002 Sep;32(10):1203-6

Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, OX3 9DS, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0020-7519(02)00123-6DOI Listing
September 2002

Effect of var gene disruption on switching in Plasmodium falciparum.

Mol Microbiol 2002 Aug;45(4):1131-41

Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1046/j.1365-2958.2002.03085.xDOI Listing
August 2002