Paul Giacomin

Paul Giacomin

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Paul Giacomin

Paul Giacomin

Publications by authors named "Paul Giacomin"

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A C-Terminal Fragment of Chlorotoxin Retains Bioactivity and Inhibits Cell Migration.

Front Pharmacol 2019 20;10:250. Epub 2019 Mar 20.

Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.

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http://dx.doi.org/10.3389/fphar.2019.00250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435586PMC
March 2019

Helminth-induced regulatory T cells and suppression of allergic responses.

Curr Opin Immunol 2018 10 29;54:1-6. Epub 2018 May 29.

Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2018.05.007DOI Listing
October 2018

Chronic Helminth Infection Perturbs the Gut-Brain Axis, Promotes Neuropathology, and Alters Behavior.

J Infect Dis 2018 09;218(9):1511-1516

UQ Spatial Epidemiology Laboratory, School of Veterinary Science, The University of Queensland, Gatton, Australia.

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http://dx.doi.org/10.1093/infdis/jiy092DOI Listing
September 2018

Polypyridylruthenium(II) complexes exert in vitro and in vivo nematocidal activity and show significant inhibition of parasite acetylcholinesterases.

Int J Parasitol Drugs Drug Resist 2018 04 29;8(1):1-7. Epub 2017 Nov 29.

Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, 4878, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ijpddr.2017.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724747PMC
April 2018

The NLRP3 Inflammasome Suppresses Protective Immunity to Gastrointestinal Helminth Infection.

Cell Rep 2018 04;23(4):1085-1098

Australian Institute of Tropical Health and Medicine, James Cook University, Smithfield, QLD 4878, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.03.097DOI Listing
April 2018

A medicinal plant compound, capnoidine, prevents the onset of inflammation in a mouse model of colitis.

J Ethnopharmacol 2018 Jan 21;211:17-28. Epub 2017 Sep 21.

Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns QLD 4878, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2017.09.024DOI Listing
January 2018

Characterization of secreted proteins and extracellular vesicles provides new insights into host-parasite communication.

J Extracell Vesicles 2018 21;7(1):1428004. Epub 2018 Jan 21.

Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.

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http://dx.doi.org/10.1080/20013078.2018.1428004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795766PMC
January 2018

The relationship between treatment for Strongyloides stercoralis infection and type 2 diabetes mellitus in an Australian Aboriginal population: A three-year cohort study.

Diabetes Res Clin Pract 2017 Dec 23;134:8-16. Epub 2017 Sep 23.

Public Health Medicine, Centre for Chronic Disease Prevention, Australian Institute of Tropical Health and Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, PO Box 6811, Cairns 4870, QLD, Australia.

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http://dx.doi.org/10.1016/j.diabres.2017.09.012DOI Listing
December 2017

Quantitative evaluation of root canal surface roughness after filing with adaptive reciprocating and continuous rotary instruments.

Microsc Res Tech 2017 Jun 31;80(6):657-661. Epub 2017 Jan 31.

Discipline of Dentistry, College of Medicine and Dentistry, James Cook University, Cairns, Queensland, Australia.

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http://dx.doi.org/10.1002/jemt.22845DOI Listing
June 2017

An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease.

J Biol Chem 2017 06 4;292(24):10288-10294. Epub 2017 May 4.

From the Centre for Biodiscovery and Molecular Development of Therapeutics, AITHM, James Cook University, Cairns, Queensland 4870, Australia

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http://dx.doi.org/10.1074/jbc.M117.779215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473231PMC
June 2017

Helminth Immunomodulation in Autoimmune Disease.

Front Immunol 2017 24;8:453. Epub 2017 Apr 24.

Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.

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http://dx.doi.org/10.3389/fimmu.2017.00453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401880PMC
April 2017

Changes in duodenal tissue-associated microbiota following hookworm infection and consecutive gluten challenges in humans with coeliac disease.

Sci Rep 2016 11 9;6:36797. Epub 2016 Nov 9.

Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Australia.

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http://dx.doi.org/10.1038/srep36797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101533PMC
November 2016

Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma.

Sci Transl Med 2016 10;8(362):362ra143

Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.

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http://dx.doi.org/10.1126/scitranslmed.aaf8807DOI Listing
October 2016

Helminths and Intestinal Flora Team Up to Improve Gut Health.

Trends Parasitol 2016 09 24;32(9):664-666. Epub 2016 May 24.

Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S14714922163005
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http://dx.doi.org/10.1016/j.pt.2016.05.006DOI Listing
September 2016

Compounds Derived from the Bhutanese Daisy, Ajania nubigena, Demonstrate Dual Anthelmintic Activity against Schistosoma mansoni and Trichuris muris.

PLoS Negl Trop Dis 2016 08 4;10(8):e0004908. Epub 2016 Aug 4.

Centre for Biodiscovery and Molecular Development of Therapeutics, Queensland Tropical Health Alliance, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns Campus, Cairns, Australia.

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http://dx.doi.org/10.1371/journal.pntd.0004908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973903PMC
August 2016

Identification of lead chemotherapeutic agents from medicinal plants against blood flukes and whipworms.

Sci Rep 2016 08 30;6:32101. Epub 2016 Aug 30.

Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.

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http://dx.doi.org/10.1038/srep32101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004179PMC
August 2016

Experimental hookworm infection and escalating gluten challenges are associated with increased microbial richness in celiac subjects.

Sci Rep 2015 Sep 18;5:13797. Epub 2015 Sep 18.

Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.

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http://dx.doi.org/10.1038/srep13797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585380PMC
September 2015

Suppression of inflammation by helminths: a role for the gut microbiota?

Philos Trans R Soc Lond B Biol Sci 2015 Aug;370(1675)

Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK

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http://dx.doi.org/10.1098/rstb.2014.0296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528494PMC
August 2015

Does Strongyloides stercoralis infection protect against type 2 diabetes in humans? Evidence from Australian Aboriginal adults.

Diabetes Res Clin Pract 2015 Mar 21;107(3):355-61. Epub 2015 Jan 21.

Public Health Medicine, Centre for Chronic Disease Prevention, Australian Institute of Tropical Health and Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, PO Box 6811, Cairns 4870, QLD, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S01688227150002
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http://dx.doi.org/10.1016/j.diabres.2015.01.012DOI Listing
March 2015

In vivo assessment of caries excavation with a fluorescence camera compared to direct bacteriological sampling and quantitative analysis using flow cytometry.

Lasers Med Sci 2015 Feb 19;30(2):843-9. Epub 2013 Oct 19.

School of Medicine and Dentistry, James Cook University (Cairns Campus), Smithfield, QLD, 4878, Australia.

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http://dx.doi.org/10.1007/s10103-013-1459-2DOI Listing
February 2015

Probing of a human proteome microarray with a recombinant pathogen protein reveals a novel mechanism by which hookworms suppress B-cell receptor signaling.

J Infect Dis 2015 Feb 19;211(3):416-25. Epub 2014 Aug 19.

Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns.

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http://dx.doi.org/10.1093/infdis/jiu451DOI Listing
February 2015

Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease.

J Allergy Clin Immunol 2015 Feb 20;135(2):508-16. Epub 2014 Sep 20.

Center for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.07.022DOI Listing
February 2015

Impact of experimental hookworm infection on the human gut microbiota.

J Infect Dis 2014 Nov 3;210(9):1431-4. Epub 2014 May 3.

Australian Institute of Tropical Health and Medicine, Queensland Tropical Health Alliance Laboratory, James Cook University, Cairns.

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http://dx.doi.org/10.1093/infdis/jiu256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195438PMC
November 2014

Secreted proteomes of different developmental stages of the gastrointestinal nematode Nippostrongylus brasiliensis.

Mol Cell Proteomics 2014 Oct 3;13(10):2736-51. Epub 2014 Jul 3.

From the ‡Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute for Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia;

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http://dx.doi.org/10.1074/mcp.M114.038950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188999PMC
October 2014

Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis.

Nature 2013 Dec 3;504(7478):153-7. Epub 2013 Nov 3.

1] Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [2] Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [3] Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nature12687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949438PMC
December 2013

Hookworm excretory/secretory products induce interleukin-4 (IL-4)+ IL-10+ CD4+ T cell responses and suppress pathology in a mouse model of colitis.

Infect Immun 2013 Jun 1;81(6):2104-11. Epub 2013 Apr 1.

Centre for Biodiscovery and Molecular Development of Therapeutics, Queensland Tropical Health Alliance, James Cook University, Cairns, Queensland, Australia.

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http://dx.doi.org/10.1128/IAI.00563-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676036PMC
June 2013

Resistin-like molecule α promotes pathogenic Th17 cell responses and bacterial-induced intestinal inflammation.

J Immunol 2013 Mar 25;190(5):2292-300. Epub 2013 Jan 25.

Institute of Immunology, Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1200706
Publisher Site
http://dx.doi.org/10.4049/jimmunol.1200706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601830PMC
March 2013

Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection.

J Immunol 2012 Nov 28;189(9):4371-8. Epub 2012 Sep 28.

Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1200691
Publisher Site
http://dx.doi.org/10.4049/jimmunol.1200691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478488PMC
November 2012

Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation.

Genes Dev 2011 Dec;25(23):2480-8

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.175950.111
Publisher Site
http://dx.doi.org/10.1101/gad.175950.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243058PMC
December 2011

The role of complement in innate, adaptive and eosinophil-dependent immunity to the nematode Nippostrongylus brasiliensis.

Mol Immunol 2008 Jan 1;45(2):446-55. Epub 2007 Aug 1.

School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia 5005, Australia.

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http://dx.doi.org/10.1016/j.molimm.2007.05.029DOI Listing
January 2008

Impaired resistance in early secondary Nippostrongylus brasiliensis infections in mice with defective eosinophilopoeisis.

Int J Parasitol 2007 Oct 4;37(12):1367-78. Epub 2007 May 4.

School of Molecular and Biomedical Science, The University of Adelaide, North Terrace, Adelaide, SA 5005, Australia.

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http://dx.doi.org/10.1016/j.ijpara.2007.04.006DOI Listing
October 2007

Loss of complement activation and leukocyte adherence as Nippostrongylus brasiliensis develops within the murine host.

Infect Immun 2005 Nov;73(11):7442-9

School of Molecular and Biomedical Science, University of Adelaide, North Terrace, Adelaide, South Australia, Australia 5005.

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http://dx.doi.org/10.1128/IAI.73.11.7442-7449.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1273855PMC
November 2005

Oxygen-sensing pathway for SK channels in the ovine adrenal medulla.

Clin Exp Pharmacol Physiol 2005 Oct;32(10):882-7

School of Molecular and Biomedical Sciences, University of Adelaide, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1111/j.1440-1681.2010.04279.xDOI Listing
October 2005

Quantitation of complement and leukocyte binding to a parasitic helminth species.

J Immunol Methods 2004 Jun;289(1-2):201-10

School of Molecular and Biomedical Science, University of Adelaide, North Tce, South Australia, Australia.

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http://dx.doi.org/10.1016/j.jim.2004.04.024DOI Listing
June 2004

Time course of induction of increased human motor cortex excitability by nerve stimulation.

Neuroreport 2002 Jul;13(10):1271-3

Department of Physiology, Adelaide University, Adelaide, SA 5005, Australia.

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http://dx.doi.org/10.1097/00001756-200207190-00011DOI Listing
July 2002