Paul G Shiels

Paul G Shiels

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Paul G Shiels

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Fabry Disease: A New Model of Premature Ageing?

Nephron 2019 Sep 27:1-4. Epub 2019 Sep 27.

Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

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http://dx.doi.org/10.1159/000503290DOI Listing
September 2019

Long-lived animals with negligible senescence: clues for ageing research.

Biochem Soc Trans 2019 08 31;47(4):1157-1164. Epub 2019 Jul 31.

Wolfson Wohl Translational Research Centre, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1QH, U.K.

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http://dx.doi.org/10.1042/BST20190105DOI Listing
August 2019

Allostatic load and ageing: linking the microbiome and nutrition with age-related health.

Biochem Soc Trans 2019 08 15;47(4):1165-1172. Epub 2019 Aug 15.

Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Campus Flemingsberg, Stockholm, Sweden.

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http://dx.doi.org/10.1042/BST20190110DOI Listing
August 2019

Understanding the role of the cytoprotective transcription factor nuclear factor erythroid 2-related factor 2-lessons from evolution, the animal kingdom and rare progeroid syndromes.

Nephrol Dial Transplant 2019 Jul 13. Epub 2019 Jul 13.

Institute of Cancer Sciences, Wolfson Wohl Translational Research Centre, University of Glasgow, Bearsden, Glasgow, UK.

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http://dx.doi.org/10.1093/ndt/gfz120DOI Listing
July 2019

Adverse childhood experiences, epigenetics and telomere length variation in childhood and beyond: a systematic review of the literature.

Eur Child Adolesc Psychiatry 2019 Apr 9. Epub 2019 Apr 9.

Institute of Health and Wellbeing, MVLS, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1007/s00787-019-01329-1DOI Listing
April 2019

MicroRNAs in AKI and Kidney Transplantation.

Clin J Am Soc Nephrol 2019 03 2;14(3):454-468. Epub 2019 Jan 2.

Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Wilrijk, Belgium;

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http://dx.doi.org/10.2215/CJN.08020718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419285PMC
March 2019

Methyl Donor Nutrients in Chronic Kidney Disease: Impact on the Epigenetic Landscape.

J Nutr 2019 03;149(3):372-380

Wolfson Wohl Translational Research Centre, Institute of Cancer Sciences, University of Glasgow, Bearsden, Glasgow, UK.

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https://academic.oup.com/jn/advance-article/doi/10.1093/jn/n
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http://dx.doi.org/10.1093/jn/nxy289DOI Listing
March 2019

Senescent Cells in Early Vascular Ageing and Bone Disease of Chronic Kidney Disease-A Novel Target for Treatment.

Toxins (Basel) 2019 02 1;11(2). Epub 2019 Feb 1.

Division of Renal Medicine, Department of Clinical Science, Technology and Intervention, Karolinska University Hospital, 14186 Stockholm, Sweden.

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http://dx.doi.org/10.3390/toxins11020082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409791PMC
February 2019

Role of accelerated aging in limb muscle wasting of patients with COPD.

Int J Chron Obstruct Pulmon Dis 2018 25;13:1987-1998. Epub 2018 Jun 25.

ELEGI Colt Laboratory, MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK,

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http://dx.doi.org/10.2147/COPD.S155952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022820PMC
January 2019

A molecular signature for delayed graft function.

Aging Cell 2018 10 9;17(5):e12825. Epub 2018 Aug 9.

Wolfson Wohl Translational Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1111/acel.12825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156499PMC
October 2018

Extracellular Vesicles, Ageing, and Therapeutic Interventions.

Cells 2018 Aug 18;7(8). Epub 2018 Aug 18.

Wolfson Wohl Cancer Research Centre, College of Medical, Veterinary & Life Sciences, Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK.

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http://dx.doi.org/10.3390/cells7080110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115766PMC
August 2018

Perceived Neighbourhood Problems over Time and Associations with Adiposity.

Int J Environ Res Public Health 2018 08 28;15(9). Epub 2018 Aug 28.

Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK.

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http://dx.doi.org/10.3390/ijerph15091854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164418PMC
August 2018

The role of thiamine dependent enzymes in obesity and obesity related chronic disease states: A systematic review.

Clin Nutr ESPEN 2018 06 15;25:8-17. Epub 2018 Mar 15.

Academic Unit of Surgery, School of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow, G31 2ER, United Kingdom.

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http://dx.doi.org/10.1016/j.clnesp.2018.02.007DOI Listing
June 2018

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom.

Nat Rev Nephrol 2018 04 15;14(4):265-284. Epub 2018 Jan 15.

Division of Renal Diseases and Hypertension, 12700 East 19th Avenue, Room 7015 Mail Stop C281, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1038/nrneph.2017.169DOI Listing
April 2018

Telomere Homeostasis: Interplay with Magnesium.

Int J Mol Sci 2018 Jan 5;19(1). Epub 2018 Jan 5.

Section of Epigenetics, Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK.

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http://dx.doi.org/10.3390/ijms19010157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796106PMC
January 2018

Inflammation and premature aging in advanced chronic kidney disease.

Am J Physiol Renal Physiol 2017 Oct 12;313(4):F938-F950. Epub 2017 Jul 12.

Divsion of Renal Medicine, Department of Clinical Science Technology and Intervention, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1152/ajprenal.00256.2017DOI Listing
October 2017

The role of epigenetics in renal ageing.

Nat Rev Nephrol 2017 Aug 19;13(8):471-482. Epub 2017 Jun 19.

Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Huddinge, Karolinska Institutet, SE-14157 Stockholm, Sweden.

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http://dx.doi.org/10.1038/nrneph.2017.78DOI Listing
August 2017

Current epigenetic aspects the clinical kidney researcher should embrace.

Clin Sci (Lond) 2017 Jul 30;131(14):1649-1667. Epub 2017 Jun 30.

Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1042/CS20160596DOI Listing
July 2017

Circulating markers of ageing and allostatic load: A slow train coming.

Pract Lab Med 2017 Apr 19;7:49-54. Epub 2016 Apr 19.

University of Glasgow, Institute of Cancer Sciences, Wolfson-Wohl Translational Cancer Research Centre, Glasgow, UK.

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http://dx.doi.org/10.1016/j.plabm.2016.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574864PMC
April 2017

Telomere Attrition and Elongation after Chronic Dialysis Initiation in Patients with End-Stage Renal Disease.

Blood Purif 2016 20;41(1-3):25-33. Epub 2015 Oct 20.

Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

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http://dx.doi.org/10.1159/000440971DOI Listing
December 2016

Segmental Aging Underlies the Development of a Parkinson Phenotype in the AS/AGU Rat.

Cells 2016 Oct 17;5(4). Epub 2016 Oct 17.

Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK.

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http://dx.doi.org/10.3390/cells5040038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187522PMC
October 2016

Biological Ageing, Inflammation and Nutrition: How Might They Impact on Systemic Sclerosis?

Curr Aging Sci 2015 ;8(2):123-30

Glasgow Ageing Research Network, Wolfson Wohl Translational Research Centre, Institute of Cancer Sciences, MVLS, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK.

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http://dx.doi.org/10.2174/187460980801150727110353DOI Listing
August 2016

Microvesicles as Vehicles for Tissue Regeneration: Changing of the Guards.

Curr Pathobiol Rep 2016 27;4(4):181-187. Epub 2016 Aug 27.

Wolfson Wohl, Translational Research Centre, Institute of Cancer Sciences, MVLS, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, G61 1QH UK.

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http://dx.doi.org/10.1007/s40139-016-0115-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101251PMC
August 2016

Microvesicles but Not Exosomes from Pathfinder Cells Stimulate Functional Recovery of the Pancreas in a Mouse Streptozotocin-Induced Diabetes Model.

Rejuvenation Res 2016 Jun 10;19(3):223-32. Epub 2016 Feb 10.

1 Institute of Cancer Sciences, University of Glasgow , Wolfson Wohl Cancer Research Centre, Glasgow, United Kingdom .

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https://www.liebertpub.com/doi/10.1089/rej.2015.1723
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http://dx.doi.org/10.1089/rej.2015.1723DOI Listing
June 2016

Nutrients and ageing: what can we learn about ageing interactions from animal biology?

Curr Opin Clin Nutr Metab Care 2016 Jan;19(1):19-25

aDivision of Renal Medicine, Karolinska University Hospital at Huddinge, Karolinska Institutet Stockholm, Sweden bDivision of Nephrology, Department of Internal Medicine, University Hospital Maastricht, the Netherlands cInstitute of Cancer Sciences, Wolfson Wohl Translational Research Center, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1097/MCO.0000000000000234DOI Listing
January 2016

Premature aging in chronic kidney disease and chronic obstructive pulmonary disease: similarities and differences.

Curr Opin Clin Nutr Metab Care 2015 Nov;18(6):528-34

aDivision of Nephrology, Department of Internal Medicine, University Hospital Maastricht, Maastricht, the Netherlands bInstitute of Cancer Sciences, Wolfson Wohl Translational Research Centre, University of Glasgow, Glasgow, UK cDivision of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1097/MCO.0000000000000218DOI Listing
November 2015

Chronic kidney disease and premature ageing.

Nat Rev Nephrol 2014 Dec 7;10(12):732-42. Epub 2014 Oct 7.

Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Huddinge, Karolinska Institutet, SE-14157 Stockholm, Sweden.

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http://dx.doi.org/10.1038/nrneph.2014.185DOI Listing
December 2014

Assessment of candidate ocular biomarkers of ageing in a South African adult population: relationship with chronological age and systemic biomarkers.

Mech Ageing Dev 2013 Jul-Aug;134(7-8):338-45. Epub 2013 May 20.

International Centre for Eye Health, Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine (LSHTM), Keppel Street, London WC1E 7HT, UK.

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http://dx.doi.org/10.1016/j.mad.2013.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710972PMC
February 2014

SIRT2: tumour suppressor or tumour promoter in operable breast cancer?

Eur J Cancer 2014 Jan 29;50(2):290-301. Epub 2013 Oct 29.

Institute of Cancer Sciences, University of Glasgow, Glasgow G11 6NT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2013.10.005DOI Listing
January 2014

Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease.

Aging Cell 2013 Dec 12;12(6):1141-3. Epub 2013 Aug 12.

MRC - University of Glasgow Centre for Virus Research, Glasgow, UK.

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http://dx.doi.org/10.1111/acel.12125DOI Listing
December 2013

Corneal endothelial cells provide evidence of accelerated cellular senescence associated with HIV infection: a case-control study.

PLoS One 2013 27;8(2):e57422. Epub 2013 Feb 27.

International Centre for Eye Health, Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0057422PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584030PMC
September 2013

Accelerated biological ageing in HIV-infected individuals in South Africa: a case-control study.

AIDS 2013 Sep;27(15):2375-84

aInternational Centre for Eye Health, Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK bDesmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa cDepartment of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London dInstitute of Cancer Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, Scotland eMRC Tropical Epidemiology Group, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.

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http://dx.doi.org/10.1097/QAD.0b013e328363bf7fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805356PMC
September 2013

Ocular parameters of biological ageing in HIV-infected individuals in South Africa: relationship with chronological age and systemic biomarkers of ageing.

Mech Ageing Dev 2013 Sep 27;134(9):400-6. Epub 2013 Aug 27.

International Centre for Eye Health, Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine (LSHTM), Keppel Street, London WC1E 7HT, UK; Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2013.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818088PMC
September 2013

Exploiting paracrine mechanisms of tissue regeneration to repair damaged organs.

Transplant Res 2013 Jun 20;2(1):10. Epub 2013 Jun 20.

Department of Surgery, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Western Infirmary, Glasgow G11 6NT, UK.

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http://dx.doi.org/10.1186/2047-1440-2-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718694PMC
June 2013

Do symptoms of depression predict telomere length? Evidence from the west of Scotland twenty-07 study.

Psychosom Med 2013 Apr 19;75(3):288-96. Epub 2013 Mar 19.

School of Sport and Exercise Sciences, University of Birmingham, Birmingham, England, UK.

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http://dx.doi.org/10.1097/PSY.0b013e318289e6b5DOI Listing
April 2013

The eye as a model of ageing in translational research--molecular, epigenetic and clinical aspects.

Ageing Res Rev 2013 Mar 27;12(2):490-508. Epub 2012 Dec 27.

International Centre for Eye Health, Dept. of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

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http://dx.doi.org/10.1016/j.arr.2012.11.002DOI Listing
March 2013

Pathfinder cells provide a novel therapeutic intervention for acute kidney injury.

Rejuvenation Res 2013 Feb;16(1):11-20

Instititute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

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http://dx.doi.org/10.1089/rej.2012.1350DOI Listing
February 2013

Interaction of personality traits with social deprivation in determining mental wellbeing and health behaviours.

J Public Health (Oxf) 2012 Dec 2;34(4):615-24. Epub 2012 May 2.

Glasgow Clinical Research Facility, 1st Floor, Tennent Building, 38 Church Street, Western Infirmary, Glasgow G11 6NT, UK.

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https://academic.oup.com/jpubhealth/article-lookup/doi/10.10
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http://dx.doi.org/10.1093/pubmed/fds030DOI Listing
December 2012

CDKN2A might be better than telomere length in determining individual health status.

Authors:
Paul G Shiels

BMJ 2012 Mar 6;344:e1415. Epub 2012 Mar 6.

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http://dx.doi.org/10.1136/bmj.e1415DOI Listing
March 2012

Telomeres, ageing and oxidation.

SEB Exp Biol Ser 2009 ;62:117-37

University of Glasgow, Department of Surgery, UK.

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July 2011

Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.

PLoS Genet 2011 Jul 14;7(7):e1002178. Epub 2011 Jul 14.

Department of Epidemiology, M. D. Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1371/journal.pgen.1002178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136437PMC
July 2011

Senescent phenotypes and telomere lengths of peripheral blood T-cells mobilized by acute exercise in humans.

Exerc Immunol Rev 2010 ;16:40-55

Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3855 Holman Street, Houston, Texas 77204, USA.

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October 2010

Improving precision in investigating aging: why telomeres can cause problems.

Authors:
Paul G Shiels

J Gerontol A Biol Sci Med Sci 2010 Aug 10;65(8):789-91. Epub 2010 Jun 10.

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http://dx.doi.org/10.1093/gerona/glq095DOI Listing
August 2010

Isolation, characterization, and differentiation of thy1.1-sorted pancreatic adult progenitor cell populations.

Stem Cells Dev 2009 Dec;18(10):1389-98

Division of Cancer Sciences and Molecular Pathology, Department of Surgery, University of Glasgow, Glasgow G31 2ER, Scotland, United Kingdom.

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http://dx.doi.org/10.1089/scd.2008.0301DOI Listing
December 2009

Nitrones for understanding and ameliorating the oxidative stress associated with aging.

Age (Dordr) 2009 Dec;31(4):269-76

Centre for the Chemical Research of Ageing, WestCHEM Department of Chemistry, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1007/s11357-009-9098-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813050PMC
December 2009

Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.

Mech Ageing Dev 2008 Dec 14;129(12):745-51. Epub 2008 Oct 14.

MRC Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Royal Victoria Hospital, Edinburgh EH4 2DN, UK.

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http://dx.doi.org/10.1016/j.mad.2008.09.020DOI Listing
December 2008

Association between telomere length and heart disease in a narrow age cohort of older people.

Exp Gerontol 2007 Jun 20;42(6):571-3. Epub 2006 Dec 20.

Geriatric Medicine Unit, University of Edinburgh, The Royal Victoria Hospital, Craigleith Road, Edinburgh, Scotland, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S05315565060045
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http://dx.doi.org/10.1016/j.exger.2006.12.002DOI Listing
June 2007

The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people.

Neurosci Lett 2006 Oct 21;406(3):260-4. Epub 2006 Aug 21.

Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, UK.

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http://dx.doi.org/10.1016/j.neulet.2006.07.055DOI Listing
October 2006

Simvastatin inhibits lymphocyte function in normal subjects and patients with cardiovascular disease.

Atherosclerosis 2004 Aug;175(2):305-13

Renal Research Group, Division of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

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http://dx.doi.org/10.1016/j.atherosclerosis.2004.03.018DOI Listing
August 2004