Paul G Ince

Paul G Ince

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Paul G Ince

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Iba-1-/CD68+ microglia are a prominent feature of age-associated deep subcortical white matter lesions.

PLoS One 2019 25;14(1):e0210888. Epub 2019 Jan 25.

Department of Neuroscience, Sheffield Institute for Translational Neuroscience, The University of Sheffield, Sheffield, South Yorkshire, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210888PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347230PMC
November 2019

Neutrophil-Derived Microvesicle Induced Dysfunction of Brain Microvascular Endothelial Cells In Vitro.

Int J Mol Sci 2019 Oct 22;20(20). Epub 2019 Oct 22.

Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.

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http://dx.doi.org/10.3390/ijms20205227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834153PMC
October 2019

Quantitative histomorphometry of capillary microstructure in deep white matter.

Neuroimage Clin 2019 25;23:101839. Epub 2019 Apr 25.

Centre for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB), School of Computing and School of Medicine, University of Leeds, UK; LICAMM Leeds Institute of Cardiac and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, UK. Electronic address:

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http://dx.doi.org/10.1016/j.nicl.2019.101839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514265PMC
April 2019

Histological data of axons, astrocytes, and myelin in deep subcortical white matter populations.

Data Brief 2019 Apr 6;23:103762. Epub 2019 Mar 6.

Centre for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB) and Leeds Institute for Cardiac and Metabolic Medicine (LICAMM), School of Computing & School of Medicine, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1016/j.dib.2019.103762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660516PMC
April 2019

Local volume fraction distributions of axons, astrocytes, and myelin in deep subcortical white matter.

Neuroimage 2018 10 19;179:275-287. Epub 2018 Jun 19.

Centre for Computational Imaging Simulation Technologies in Biomedicine (CISTIB), Pam Liversidge Building, S1 3JD, Electronic and Electrical Engineering Department, The University of Sheffield, Sheffield, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S10538119183054
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http://dx.doi.org/10.1016/j.neuroimage.2018.06.040DOI Listing
October 2018

TREM2 expression in the human brain: a marker of monocyte recruitment?

Brain Pathol 2018 09 30;28(5):595-602. Epub 2017 Oct 30.

Clinical Neurosciences, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.

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http://dx.doi.org/10.1111/bpa.12564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221091PMC
September 2018

Targeted Genetic Screen in Amyotrophic Lateral Sclerosis Reveals Novel Genetic Variants with Synergistic Effect on Clinical Phenotype.

Front Mol Neurosci 2017 9;10:370. Epub 2017 Nov 9.

Maurice Wohl Clinical Neuroscience Institute, King's College London, Department of Basic and Clinical Neuroscience, London, United Kingdom; Maurice Wohl Clinical Neuroscience Institute, King's College London, Department of Basic and Clinical Neuroscience, London, United Kingdom; Suna and Inan Kirac Foundation, Neurodegeneration Research Laboratory, Bogazici University, Istanbul, Turkey; Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; Academic Unit of Neurology, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin, Republic of Ireland; Department of Neurology, Beaumont Hospital, Dublin, Republic of Ireland; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, United Kingdom; Biostatistics Department, Harvard School of Public Health, Boston, MA, United States; Department of Biostatistics, IoPPN, King's College London, London, United Kingdom; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, United States; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, United States; Population Genetics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Republic of Ireland; Maurice Wohl Clinical Neuroscience Institute, King's College London, Department of Basic and Clinical Neuroscience, London, United Kingdom; University of Exeter Medical School, Exeter University, St. Luke's Campus, Magdalen Street, Exeter EX1 2LU, United Kingdom; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), B-3000 Leuven, Belgium; VIB, Vesalius Research Center, Laboratory of Neurobiology, Leuven, Belgium; University Hospitals Leuven, Department of Neurology, Leuven, Belgium; Hospital San Rafael, Madrid, Spain; Faculty of Medicine, University of Southampton, Southampton, United Kingdom; Department of Biostatistics, IoPPN, King's College London, London, United Kingdom; Biomedical Research Centre for Mental Health, IoPPN, King's College London, London, United Kingdom; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; Maurice Wohl Clinical Neuroscience Institute, King's College London, Department of Basic and Clinical Neuroscience, London, United Kingdom; Maurice Wohl Clinical Neuroscience Institute, King's College London, Department of Basic and Clinical Neuroscience, London, United Kingdom; Maurice Wohl Clinical Neuroscience Institute, King's College London, Department of Basic and Clinical Neuroscience, London, United Kingdom; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), B-3000 Leuven, Belgium, VIB, Vesalius Research Center, Laboratory of Neurobiology, Leuven, Belgium; University Hospitals Leuven, Department of Neurology, Leuven, Belgium; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; SURFsara, Amsterdam, Netherlands; Emory University, Atlanta, United States; KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), B-3000 Leuven, Belgium; VIB, Vesalius Research Center, Laboratory of Neurobiology, Leuven, Belgium; University Hospitals Leuven, Department of Neurology, Leuven, Belgium; Hadassah University Hospital, Jerusalem, Israel; Tel-Aviv Medical Center, Tel-Aviv, Israel; Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia; Universidade de São Paulo, Brazil; Universidade de São Paulo, Brazil; Université de Limoges, France; Université François-Rabelais, Tours, France; IRCCS Instituto Auxologico Italiano, Milan, Italy; Universita degli Studi dei Torino, Turin, Italy; Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal; Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal; Hospital Carlos III, Madrid, Spain; Umeå University, Umeå, Sweden; Kantonspittal St. Gallen, St. Gallen, Switzerland; IRCCS Instituto Auxologico Italiano, Milan, Italy.

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http://dx.doi.org/10.3389/fnmol.2017.00370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684183PMC
November 2017

Metaflammasome components in the human brain: a role in dementia with Alzheimer's pathology?

Brain Pathol 2017 05 8;27(3):266-275. Epub 2016 Jun 8.

Clinical Neurosciences, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1111/bpa.12388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412675PMC
May 2017

Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria.

Amyotroph Lateral Scler Frontotemporal Degener 2017 05 5;18(3-4):153-174. Epub 2017 Jan 5.

n Nuffield Department of Clinical Neurosciences , University of Oxford , Oxford , UK.

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http://dx.doi.org/10.1080/21678421.2016.1267768DOI Listing
May 2017

C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons.

Nat Neurosci 2016 12 10;19(12):1610-1618. Epub 2016 Oct 10.

Institute of Clinical Neurobiology, University Hospital of Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.1038/nn.4407DOI Listing
December 2016

Motor neurone disease/amyotrophic lateral sclerosis associated with intermediate-length CAG repeat expansions in Ataxin-2 does not have 1C2-positive polyglutamine inclusions.

Neuropathol Appl Neurobiol 2016 06 7;42(4):377-89. Epub 2015 Jul 7.

Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1111/nan.12254DOI Listing
June 2016

Microglial immunophenotype in dementia with Alzheimer's pathology.

J Neuroinflammation 2016 06 2;13(1):135. Epub 2016 Jun 2.

Clinical Neurosciences, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, Southampton General Hospital, University of Southampton, Southampton, SO16 6YD, UK.

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http://dx.doi.org/10.1186/s12974-016-0601-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890505PMC
June 2016

Oligogenic inheritance of optineurin (OPTN) and C9ORF72 mutations in ALS highlights localisation of OPTN in the TDP-43-negative inclusions of C9ORF72-ALS.

Neuropathology 2016 Apr 24;36(2):125-34. Epub 2015 Aug 24.

Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1111/neup.12240DOI Listing
April 2016

Epidemiological pathology of Tau in the ageing brain: application of staging for neuropil threads (BrainNet Europe protocol) to the MRC cognitive function and ageing brain study.

Acta Neuropathol Commun 2016 Feb 8;4:11. Epub 2016 Feb 8.

Sheffield Institute for Translational Neuroscience, University of Sheffield, 385A Glossop Road, Sheffield, S10 2HQ, UK.

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http://dx.doi.org/10.1186/s40478-016-0275-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746919PMC
February 2016

Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain.

Brain Pathol 2015 Sep 20;25(5):565-74. Epub 2014 Nov 20.

Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1111/bpa.12216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861214PMC
September 2015

Genome-wide association study of neocortical Lewy-related pathology.

Ann Clin Transl Neurol 2015 Sep 18;2(9):920-31. Epub 2015 Aug 18.

Molecular Neurology, Research Program Unit, Biomedicum, University of Helsinki Helsinki, Finland ; Department of Neurology, Helsinki University Central Hospital Helsinki, Finland.

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http://dx.doi.org/10.1002/acn3.231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574809PMC
September 2015

Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy.

Acta Neuropathol 2015 Jul 6;130(1):63-75. Epub 2015 May 6.

Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield, S10 2HQ, UK.

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http://dx.doi.org/10.1007/s00401-015-1429-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468790PMC
July 2015

Intermediate length C9orf72 expansion in an ALS patient without classical C9orf72 neuropathology.

Amyotroph Lateral Scler Frontotemporal Degener 2015 Jun 1;16(3-4):249-51. Epub 2014 Dec 1.

Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield , UK.

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http://dx.doi.org/10.3109/21678421.2014.977296DOI Listing
June 2015

Alpha-synucleinopathy and neuropsychological symptoms in a population-based cohort of the elderly.

Alzheimers Res Ther 2015 13;7(1):19. Epub 2015 Apr 13.

Sheffield Institute for Translational Neuroscience, 385A Glossop Road, Sheffield, S10 2HQ UK.

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http://dx.doi.org/10.1186/s13195-015-0101-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394405PMC
April 2015

Age-associated white matter lesions: the MRC Cognitive Function and Ageing Study.

Brain Pathol 2015 Jan;25(1):35-43

Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1111/bpa.12219DOI Listing
January 2015

Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions.

Brain 2014 Jul 27;137(Pt 7):2040-51. Epub 2014 May 27.

1 Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield S10 2HQ, UK

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http://dx.doi.org/10.1093/brain/awu120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065024PMC
July 2014

TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.

Acta Neuropathol 2014 Mar 19;127(3):407-18. Epub 2014 Jan 19.

Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s00401-013-1239-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003885PMC
March 2014

Focal cortical dysplasia mimicking neoplasia.

Pract Neurol 2013 Oct 15;13(5):343-5. Epub 2013 Mar 15.

Department of Neurosurgery, Royal Hallamshire Hospital, Sheffield, UK.

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http://dx.doi.org/10.1136/practneurol-2012-000317DOI Listing
October 2013

From molecule to clinic and community for neurodegeneration: research to bridge translational gaps.

J Alzheimers Dis 2013 ;33 Suppl 1:S385-96

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.3233/JAD-2012-129006DOI Listing
June 2013

Chapter 5 Cytopathology of the motor neuron.

Handb Clin Neurol 2007 ;82:89-119

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http://dx.doi.org/10.1016/S0072-9752(07)80008-XDOI Listing
October 2012

The neuropathology of vascular disease in the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).

Curr Alzheimer Res 2012 Jul;9(6):687-96

The Irish Longitudinal Study on Ageing, Department of Medical Gerontology, Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.2174/156720512801322654DOI Listing
July 2012

Impact of less common and "disregarded" neurodegenerative pathologies on dementia burden in a population-based cohort.

J Alzheimers Dis 2012 ;28(2):485-93

Cognitive Neuroscience Laboratory, School of Psychology, Social Work and Social Policy, University of South Australia, SA, Australia.

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http://dx.doi.org/10.3233/JAD-2011-111268DOI Listing
May 2012

Aluminium, iron and copper in human brain tissues donated to the Medical Research Council's Cognitive Function and Ageing Study.

Metallomics 2012 Jan 1;4(1):56-65. Epub 2011 Nov 1.

The Birchall Centre, Lennard-Jones Laboratories, Keele University, Stoke-on-Trent, Staffordshire, ST5 5BG, UK.

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http://dx.doi.org/10.1039/c1mt00139fDOI Listing
January 2012

Sensory neuronopathy in patients harbouring recessive polymerase γ mutations.

Brain 2012 Jan 20;135(Pt 1):62-71. Epub 2011 Dec 20.

Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1093/brain/awr326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267986PMC
January 2012

Brain iron dysregulation and the risk of ageing white matter lesions.

Neuromolecular Med 2011 Dec 7;13(4):289-99. Epub 2011 Oct 7.

Human Genetics Department, Medical Division, National Research Centre, Dokki, Cairo, Egypt.

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http://link.springer.com/content/pdf/10.1007/s12017-011-8161
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http://link.springer.com/10.1007/s12017-011-8161-y
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http://dx.doi.org/10.1007/s12017-011-8161-yDOI Listing
December 2011

Molecular pathology and genetic advances in amyotrophic lateral sclerosis: an emerging molecular pathway and the significance of glial pathology.

Acta Neuropathol 2011 Dec 22;122(6):657-71. Epub 2011 Nov 22.

Department of Neuroscience, Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.

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http://link.springer.com/content/pdf/10.1007/s00401-011-0913
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http://link.springer.com/10.1007/s00401-011-0913-0
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http://dx.doi.org/10.1007/s00401-011-0913-0DOI Listing
December 2011

Epidemiological neuropathology: the MRC Cognitive Function and Aging Study experience.

J Alzheimers Dis 2011 ;25(2):359-72

Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.3233/JAD-2011-091402DOI Listing
November 2011

Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: a study in the MRC-CFAS population neuropathology cohort.

Neurosci Lett 2011 Nov 28;505(1):25-30. Epub 2011 Sep 28.

Sheffield Institute for Translational Neuroscience, University of Sheffield, 385A Glossop Road, Sheffield S102HQ, UK.

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http://dx.doi.org/10.1016/j.neulet.2011.09.049DOI Listing
November 2011

Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype.

Neurobiol Aging 2011 Oct 25;32(10):1795-807. Epub 2011 Jun 25.

Department of Neuroscience, Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2011.04.013DOI Listing
October 2011

TAR-DNA binding protein-43 and alterations in the hippocampus.

J Neural Transm (Vienna) 2011 May 6;118(5):683-9. Epub 2011 Jan 6.

Department of Pathology, Kuopio University Hospital, Kuopio, Finland.

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http://dx.doi.org/10.1007/s00702-010-0574-5DOI Listing
May 2011

Cardiovascular diseases and hippocampal infarcts.

Hippocampus 2011 Mar;21(3):281-7

Department of Pathology, Kuopio University Hospital, Finland.

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http://dx.doi.org/10.1002/hipo.20747DOI Listing
March 2011

HFE H63D, C282Y and AGTR1 A1166C polymorphisms and brain white matter lesions in the aging brain.

J Neurogenet 2011 Mar 21;25(1-2):7-14. Epub 2011 Feb 21.

Medical Research Division, National Research Centre, Cairo, Egypt.

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http://dx.doi.org/10.3109/01677063.2011.556206DOI Listing
March 2011

Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain.

Neurosci Lett 2010 Dec 29;486(3):246-51. Epub 2010 Sep 29.

Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S03043940100129
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http://dx.doi.org/10.1016/j.neulet.2010.09.063DOI Listing
December 2010

Broad clinical phenotypes associated with TAR-DNA binding protein (TARDBP) mutations in amyotrophic lateral sclerosis.

Neurogenetics 2010 May 17;11(2):217-25. Epub 2009 Sep 17.

Department of Neuroscience, Faculty of Medicine, Dentistry and Health, University of Sheffield, Medical School, Sheffield, UK.

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http://dx.doi.org/10.1007/s10048-009-0218-9DOI Listing
May 2010

Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer's disease, and dementia with Lewy bodies.

Acta Neuropathol 2010 May 21;119(5):579-89. Epub 2010 Jan 21.

Institute for Ageing and Health, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s00401-009-0635-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849937PMC
May 2010

The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia.

Brain 2010 May 19;133(Pt 5):1328-41. Epub 2010 Apr 19.

Laboratory for Neurodegenerative Research, School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin 4, Republic of Ireland.

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http://dx.doi.org/10.1093/brain/awq065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859152PMC
May 2010

Novel FUS/TLS mutations and pathology in familial and sporadic amyotrophic lateral sclerosis.

Arch Neurol 2010 Apr;67(4):455-61

Academic Unit of Neurology, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, England.

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http://dx.doi.org/10.1001/archneurol.2010.52DOI Listing
April 2010

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.

Authors:
Vivianna M Van Deerlin Patrick M A Sleiman Maria Martinez-Lage Alice Chen-Plotkin Li-San Wang Neill R Graff-Radford Dennis W Dickson Rosa Rademakers Bradley F Boeve Murray Grossman Steven E Arnold David M A Mann Stuart M Pickering-Brown Harro Seelaar Peter Heutink John C van Swieten Jill R Murrell Bernardino Ghetti Salvatore Spina Jordan Grafman John Hodges Maria Grazia Spillantini Sid Gilman Andrew P Lieberman Jeffrey A Kaye Randall L Woltjer Eileen H Bigio Marsel Mesulam Safa Al-Sarraj Claire Troakes Roger N Rosenberg Charles L White Isidro Ferrer Albert Lladó Manuela Neumann Hans A Kretzschmar Christine Marie Hulette Kathleen A Welsh-Bohmer Bruce L Miller Ainhoa Alzualde Adolfo Lopez de Munain Ann C McKee Marla Gearing Allan I Levey James J Lah John Hardy Jonathan D Rohrer Tammaryn Lashley Ian R A Mackenzie Howard H Feldman Ronald L Hamilton Steven T Dekosky Julie van der Zee Samir Kumar-Singh Christine Van Broeckhoven Richard Mayeux Jean Paul G Vonsattel Juan C Troncoso Jillian J Kril John B J Kwok Glenda M Halliday Thomas D Bird Paul G Ince Pamela J Shaw Nigel J Cairns John C Morris Catriona Ann McLean Charles DeCarli William G Ellis Stefanie H Freeman Matthew P Frosch John H Growdon Daniel P Perl Mary Sano David A Bennett Julie A Schneider Thomas G Beach Eric M Reiman Bryan K Woodruff Jeffrey Cummings Harry V Vinters Carol A Miller Helena C Chui Irina Alafuzoff Päivi Hartikainen Danielle Seilhean Douglas Galasko Eliezer Masliah Carl W Cotman M Teresa Tuñón M Cristina Caballero Martínez David G Munoz Steven L Carroll Daniel Marson Peter F Riederer Nenad Bogdanovic Gerard D Schellenberg Hakon Hakonarson John Q Trojanowski Virginia M-Y Lee

Nat Genet 2010 Mar 14;42(3):234-9. Epub 2010 Feb 14.

[1] Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. [2] These authors contributed equally to this work.

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http://dx.doi.org/10.1038/ng.536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828525PMC
March 2010

Age, neuropathology, and dementia.

N Engl J Med 2009 May;360(22):2302-9

Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1056/NEJMoa0806142DOI Listing
May 2009

Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia.

Am J Respir Crit Care Med 2008 Apr 17;177(8):887-95. Epub 2008 Jan 17.

Section of Infection and Inflammation, School of Medicine and Biomedical Sciences, University of Sheffield, LU107, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK.

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http://dx.doi.org/10.1164/rccm.200707-990OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643216PMC
April 2008

Investigation of the mitochondrial genome in patients with atypical motor neuron disease.

J Neurol 2007 Apr 31;254(4):482-7. Epub 2007 Mar 31.

Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle, Newcastle NE2 4HH, UK.

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http://dx.doi.org/10.1007/s00415-006-0399-1DOI Listing
April 2007

Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia.

J Immunol 2006 Nov;177(9):6480-8

School of Medicine and Biomedical Sciences, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.177.9.6480DOI Listing
November 2006

Motor neuron disease in a patient with a mitochondrial tRNAIle mutation.

Ann Neurol 2006 Mar;59(3):570-4

Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/ana.20758DOI Listing
March 2006

Neuropathology of vascular cognitive impairment and vascular dementia.

Int Psychogeriatr 2003 ;15 Suppl 1:71-5

Neuropathology, Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, UK.

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November 2005

Detection of mutations in whole genome-amplified DNA from laser-microdissected neurons.

J Neurosci Methods 2005 Aug 14;147(1):65-7. Epub 2005 Apr 14.

Academic Units of Neurology, The University of Sheffield, UK.

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August 2005

Vascular pathologies and cognition in a population-based cohort of elderly people.

J Neurol Sci 2004 Nov;226(1-2):13-7

Neuropathology, Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield, 'E' Floor, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK.

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November 2004

Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis.

J Neuropathol Exp Neurol 2004 Aug;63(8):831-40

Department of Neurology, Ludwig-Maximilians-University, Klinikum Grosshadern, Munich, Germany.

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August 2004

Differential expression of mGluR5 in human lumbosacral motoneurons.

Neuroreport 2004 Feb;15(2):271-3

Department of Neurology, Ludwig-Maximilians-University, Klinikum Grosshadern, Marchioninistr. 15, 81377 Munich, Germany.

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February 2004

Neuroferritinopathy: a window on the role of iron in neurodegeneration.

Blood Cells Mol Dis 2002 Nov-Dec;29(3):522-31

Institute of Human Genetics, International Centre for Life, Newcastle upon Tyne NE1 3BZ, United Kingdom.

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November 2003

Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection.

J Immunol 2003 Nov;171(10):5380-8

Division of Genomic Medicine, University of Sheffield School of Medicine and Biomedical Sciences, Sheffield, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.171.10.5380DOI Listing
November 2003

Clinical and neuropathological correlates of apolipoprotein E genotype in dementia with Lewy bodies.

Dement Geriatr Cogn Disord 2002 ;14(4):167-75

Medical Research Council/University of Newcastle upon Tyne, Centre Development in Clinical Brain Ageing, MRC Building, Newcastle upon Tyne, UK.

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March 2003

Selective loss of neurofilament expression in Cu/Zn superoxide dismutase (SOD1) linked amyotrophic lateral sclerosis.

J Neurochem 2002 Sep;82(5):1118-28

Academic Neurology Unit and Academic Unit of Pathology, The Medical School, University of Sheffield, South Yorkshire, UK.

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September 2002

Mitochondrial involvement in amyotrophic lateral sclerosis.

Neurochem Int 2002 May;40(6):543-51

Department of Neurology, E Floor, Medical School, Royal Hallamshire Hospital, University of Sheffield, Beech Hill Road, S10 2RX, UK.

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May 2002