Publications by authors named "Paul G Ekert"

63Publications

Immune profiling of pediatric solid tumors.

J Clin Invest 2020 Jul;130(7):3391-3402

Cancer Immunology Program, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1172/JCI137181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324195PMC
July 2020

Targeted therapy and disease monitoring in CNTRL-FGFR1-driven leukaemia.

Pediatr Blood Cancer 2019 10 28;66(10):e27897. Epub 2019 Jun 28.

Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.

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http://dx.doi.org/10.1002/pbc.27897DOI Listing
October 2019

Clinker: visualizing fusion genes detected in RNA-seq data.

Gigascience 2018 07;7(7)

Murdoch Children's Research Institute, The Royal Children's Hospital, Flemington, Road, Parkville Vic 3052 Australia.

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http://dx.doi.org/10.1093/gigascience/giy079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065480PMC
July 2018

MicroRNA-155 expression and function in AML: An evolving paradigm.

Exp Hematol 2018 06 27;62:1-6. Epub 2018 Mar 27.

Murdoch Childrens Research Institute, Parkville, 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2018.03.007DOI Listing
June 2018

Dysregulation of BCL-2 family proteins by leukemia fusion genes.

J Biol Chem 2017 09 17;292(35):14325-14333. Epub 2017 Jul 17.

From the Murdoch Children's Research Institute,

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http://www.jbc.org/lookup/doi/10.1074/jbc.R117.799056
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http://dx.doi.org/10.1074/jbc.R117.799056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582828PMC
September 2017

Quantitative proteomic analysis of EZH2 inhibition in acute myeloid leukemia reveals the targets and pathways that precede the induction of cell death.

Proteomics Clin Appl 2017 09 15;11(9-10). Epub 2017 May 15.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Australia.

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http://dx.doi.org/10.1002/prca.201700013DOI Listing
September 2017

Genetic determinants of anthracycline cardiotoxicity - ready for the clinic?

Br J Clin Pharmacol 2017 05 24;83(5):1141-1142. Epub 2017 Jan 24.

Murdoch Childrens Research Institute, Royal Children's Hospital, Flemington Road, Parkville, Victoria, 3052, Australia.

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http://dx.doi.org/10.1111/bcp.13195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401963PMC
May 2017

Letting the breaks off MYCN.

Cell Death Differ 2016 12 14;23(12):1904-1905. Epub 2016 Oct 14.

Cancer Research, Department of Cell Biology, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Melbourne, Victoria 3052, Australia.

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http://dx.doi.org/10.1038/cdd.2016.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136483PMC
December 2016

The molecular relationships between apoptosis, autophagy and necroptosis.

Semin Cell Dev Biol 2015 Mar 28;39:63-9. Epub 2015 Feb 28.

Division of Cell Signalling and Cell Death, Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia; Murdoch Childrens Research Institute, Royal Children's Hospital, Flemington Rd, Parkville, Victoria 3052, Australia; Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Flemington Rd, Parkville, Victoria 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2015.02.003DOI Listing
March 2015

Interleukin-3-mediated regulation of β-catenin in myeloid transformation and acute myeloid leukemia.

J Leukoc Biol 2014 Jul 5;96(1):83-91. Epub 2014 Mar 5.

Centre for Cancer Biology and School of Molecular and Biomedical Science and Centre for Stem Cell Research and Departments of Haematology and Department of Pharmacy and Medical Sciences, The University of South Australia, Adelaide, South Australia, Australia School of Medicine, The University of Adelaide, Adelaide, South Australia, Australia;

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http://dx.doi.org/10.1189/jlb.2AB1013-559RDOI Listing
July 2014

Role of p53 in cAMP/PKA pathway mediated apoptosis.

Apoptosis 2013 Dec;18(12):1492-9

Department of Biochemistry, La Trobe Institute of Molecular Science, La Trobe University, Kingsbury Drive, Bundoora, VIC, 3086, Australia.

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http://dx.doi.org/10.1007/s10495-013-0895-6DOI Listing
December 2013

Exploring the utility of human DNA methylation arrays for profiling mouse genomic DNA.

Genomics 2013 Jul 29;102(1):38-46. Epub 2013 Apr 29.

Cancer and Disease Epigenetics Group, Murdoch Childrens Research Institute, Department of Paediatrics, The University of Melbourne, Royal Children's Hospital, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1016/j.ygeno.2013.04.014DOI Listing
July 2013

Signalling by the βc family of cytokines.

Cytokine Growth Factor Rev 2013 Jun 25;24(3):189-201. Epub 2013 Mar 25.

The Centre for Cancer Biology, SA Pathology, Frome Road, Adelaide, South Australia 5000, Australia.

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http://dx.doi.org/10.1016/j.cytogfr.2013.03.002DOI Listing
June 2013

p53-Dependent transcriptional responses to interleukin-3 signaling.

PLoS One 2012 14;7(2):e31428. Epub 2012 Feb 14.

Children's Cancer Centre, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031428PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279357PMC
July 2012

Crossing paths: interactions between the cell death machinery and growth factor survival signals.

Cell Mol Life Sci 2010 May 16;67(10):1619-30. Epub 2010 Feb 16.

Children's Cancer Centre, Murdoch Children's Research Institute, Royal Children's Hospital, Department of Paediatrics, University of Melbourne, Flemington Rd Parkville, Melbourne, 3052, Australia.

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http://dx.doi.org/10.1007/s00018-010-0288-8DOI Listing
May 2010

Triggering of apoptosis by Puma is determined by the threshold set by prosurvival Bcl-2 family proteins.

J Mol Biol 2008 Dec 25;384(2):313-23. Epub 2008 Sep 25.

Department of Biochemistry, La Trobe University, Victoria 3086, Australia.

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http://dx.doi.org/10.1016/j.jmb.2008.09.041DOI Listing
December 2008

Programmed anuclear cell death delimits platelet life span.

Cell 2007 Mar;128(6):1173-86

Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740700196
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http://dx.doi.org/10.1016/j.cell.2007.01.037DOI Listing
March 2007

Two sisters with IMAGe syndrome: cytomegalic adrenal histopathology, support for autosomal recessive inheritance and literature review.

Am J Med Genet A 2006 Aug;140(16):1778-84

Genetic Health Services Victoria, Royal Children's Hospital, Melbourne, Australia.

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http://dx.doi.org/10.1002/ajmg.a.31365DOI Listing
August 2006

Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1.

J Cell Sci 2006 Jun 30;119(Pt 12):2572-82. Epub 2006 May 30.

Children's Cancer Centre, Royal Children's Hospital, Parkville 3052, Australia.

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http://dx.doi.org/10.1242/jcs.02985DOI Listing
June 2006

Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma.

Blood 2006 Sep 16;108(5):1461-8. Epub 2006 May 16.

Children's Cancer Centre, Murdoch Children's Research Centre, Royal Children's Hospital, Flemington Rd, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1182/blood-2006-03-014209DOI Listing
September 2006

Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance.

Proc Natl Acad Sci U S A 2005 Nov 1;102(45):16182-7. Epub 2005 Nov 1.

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1073/pnas.0502828102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283416PMC
November 2005

The mitochondrial death squad: hardened killers or innocent bystanders?

Curr Opin Cell Biol 2005 Dec 10;17(6):626-30. Epub 2005 Oct 10.

The Walter and Eliza Hall Institute, 1G Royal Parade Parkville, Victoria 3050, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S095506740500138
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http://dx.doi.org/10.1016/j.ceb.2005.09.001DOI Listing
December 2005

Monolysocardiolipins accumulate in Barth syndrome but do not lead to enhanced apoptosis.

J Lipid Res 2005 Jun 1;46(6):1182-95. Epub 2005 Apr 1.

Laboratory of Genetic Metabolic Diseases, Department of Clinical Chemistry, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M500056-JLR200
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http://dx.doi.org/10.1194/jlr.M500056-JLR200DOI Listing
June 2005

Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9.

J Cell Biol 2004 Jun;165(6):775-80

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1083/jcb.200312030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172407PMC
June 2004

Caspase-8 levels affect necessity for mitochondrial amplification in death ligand-induced glioma cell apoptosis.

Mol Carcinog 2004 Mar;39(3):173-82

Department of Haematology and Oncology, Royal Children's Hospital, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1002/mc.20011DOI Listing
March 2004

Insights into the pathogenesis of cerebral lesions in incontinentia pigmenti.

Pediatr Neurol 2003 Aug;29(2):148-50

Department of Pediatrics, Murdoch Children's Research Institute and Howard Florey Institute, and Royal Women's and Royal Children's Hospital, Parkville, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1016/s0887-8994(03)00150-4DOI Listing
August 2003

Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis.

J Biol Chem 2004 Feb 21;279(6):4313-21. Epub 2003 Oct 21.

Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, VIC 3050, Australia.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M305661200
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http://dx.doi.org/10.1074/jbc.M305661200DOI Listing
February 2004

A novel Apaf-1-independent putative caspase-2 activation complex.

J Cell Biol 2002 Dec 2;159(5):739-45. Epub 2002 Dec 2.

Hanson Institute, Adelaide, Australia 5000.

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http://dx.doi.org/10.1083/jcb.200209004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173397PMC
December 2002

A novel Apaf-1-independent putative caspase-2 activation complex.

J Cell Biol 2002 Dec 2;159(5):739-45. Epub 2002 Dec 2.

Hanson Institute, Adelaide, Australia 5000.

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http://dx.doi.org/10.1083/jcb.200209004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173397PMC
December 2002

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.

J Biol Chem 2002 Jan 16;277(1):445-54. Epub 2001 Oct 16.

Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia.

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http://dx.doi.org/10.1074/jbc.M109891200DOI Listing
January 2002