Publications by authors named "Paul Erbel"

16Publications

An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient.

Authors:
Jean Quancard Theo Klein Shan-Yu Fung Martin Renatus Nicola Hughes Laura Israël John J Priatel Sohyeong Kang Michael A Blank Rosa I Viner Jutta Blank Achim Schlapbach Paul Erbel Jayachandran Kizhakkedathu Frédéric Villard René Hersperger Stuart E Turvey Joerg Eder Frédéric Bornancin Christopher M Overall

Nat Chem Biol 2019 03 28;15(3):304-313. Epub 2019 Jan 28.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.

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March 2019

Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D.

Authors:
Anna Vulpetti Nils Ostermann Stefan Randl Taeyoung Yoon Aengus Mac Sweeney Frederic Cumin Edwige Lorthiois Simon Rüdisser Paul Erbel Jürgen Maibaum

ACS Med Chem Lett 2018 May 24;9(5):490-495. Epub 2018 Apr 24.

Novartis Pharma AG, Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland.

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May 2018

Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors.

Authors:
Anna Vulpetti Stefan Randl Simon Rüdisser Nils Ostermann Paul Erbel Aengus Mac Sweeney Thomas Zoller Bahaa Salem Bernd Gerhartz Frederic Cumin Ulrich Hommel Claudio Dalvit Edwige Lorthiois Jürgen Maibaum

J Med Chem 2017 03 20;60(5):1946-1958. Epub 2017 Feb 20.

Novartis Institutes for BioMedical Research, Novartis Pharma AG , Novartis Campus, CH-4056 Basel, Switzerland.

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March 2017

Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5.

Authors:
Eva Altmann Paul Erbel Martin Renatus Michael Schaefer Anita Schlierf Adelaide Druet Laurence Kieffer Mickael Sorge Keith Pfister Ulrich Hassiepen Matthew Jones Simon Ruedisser Daniela Ostermeier Bruno Martoglio Anne B Jefferson Jean Quancard

Angew Chem Int Ed Engl 2017 01 16;56(5):1294-1297. Epub 2016 Dec 16.

Novartis Institutes for BioMedical Research, Novartis Campus, 4002, Basel, Switzerland.

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January 2017

Small-molecule factor D inhibitors targeting the alternative complement pathway.

Authors:
Jürgen Maibaum Sha-Mei Liao Anna Vulpetti Nils Ostermann Stefan Randl Simon Rüdisser Edwige Lorthiois Paul Erbel Bernd Kinzel Fabrice A Kolb Samuel Barbieri Julia Wagner Corinne Durand Kamal Fettis Solene Dussauge Nicola Hughes Omar Delgado Ulrich Hommel Ty Gould Aengus Mac Sweeney Bernd Gerhartz Frederic Cumin Stefanie Flohr Anna Schubart Bruce Jaffee Richard Harrison Antonio Maria Risitano Jörg Eder Karen Anderson

Nat Chem Biol 2016 Dec 24;12(12):1105-1110. Epub 2016 Oct 24.

Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.

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December 2016

Structure-based design and optimization of potent inhibitors of the adenoviral protease.

Authors:
Philipp Grosche Finton Sirockin Aengus Mac Sweeney Paul Ramage Paul Erbel Samu Melkko Anna Bernardi Nicola Hughes David Ellis Keith D Combrink Nadine Jarousse Eva Altmann

Bioorg Med Chem Lett 2015 Feb 24;25(3):438-43. Epub 2014 Dec 24.

Novartis Institute for Biomedical Research, Novartis Campus, CH-4002 Basel, Switzerland. Electronic address:

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February 2015

Discovery and structure-based optimization of adenain inhibitors.

Authors:
Aengus Mac Sweeney Philipp Grosche David Ellis Keith Combrink Paul Erbel Nicola Hughes Finton Sirockin Samu Melkko Anna Bernardi Paul Ramage Nadine Jarousse Eva Altmann

ACS Med Chem Lett 2014 Aug 20;5(8):937-41. Epub 2014 Jun 20.

Novartis Institute for Biomedical Research , Novartis Campus, CH-4002 Basel, Switzerland.

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August 2014

Mechanism of substrate specificity in Bacillus subtilis ResA, a thioredoxin-like protein involved in cytochrome c maturation.

Authors:
Christopher L Colbert Qiong Wu Paul J A Erbel Kevin H Gardner Johann Deisenhofer

Proc Natl Acad Sci U S A 2006 Mar 13;103(12):4410-5. Epub 2006 Mar 13.

Howard Hughes Medical Institute, and Department of Biochemistry, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA.

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March 2006

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.

Authors:
Paul Erbel Nikolaus Schiering Allan D'Arcy Martin Renatus Markus Kroemer Siew Pheng Lim Zheng Yin Thomas H Keller Subhash G Vasudevan Ulrich Hommel

Nat Struct Mol Biol 2006 Apr 12;13(4):372-3. Epub 2006 Mar 12.

Novartis Institutes for Biomedical Research, Protease Platform, 4002 Basel, Switzerland.

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April 2006

Purification and crystallization of dengue and West Nile virus NS2B-NS3 complexes.

Authors:
Allan D'Arcy Maxime Chaillet Nikolaus Schiering Frederic Villard Siew Pheng Lim Peggy Lefeuvre Paul Erbel

Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 Feb 27;62(Pt 2):157-62. Epub 2006 Jan 27.

Novartis Institutes of Biomedical Research, Protease Platform, Klybeckstrasse 144, CH 4002 Basel, Switzerland.

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February 2006

Structural basis of ARNT PAS-B dimerization: use of a common beta-sheet interface for hetero- and homodimerization.

Authors:
Paul B Card Paul J A Erbel Kevin H Gardner

J Mol Biol 2005 Oct 6;353(3):664-77. Epub 2005 Sep 6.

Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-8816, USA.

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October 2005

Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor.

Authors:
Jinsong Yang Lei Zhang Paul J A Erbel Kevin H Gardner Kan Ding Joseph A Garcia Richard K Bruick

J Biol Chem 2005 Oct 29;280(43):36047-54. Epub 2005 Aug 29.

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9038, USA.

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October 2005

Cyclic enterobacterial common antigen: potential contaminant of bacterially expressed protein preparations.

Authors:
Paul J A Erbel Ronald Seidel Scott E Macintosh Lisa N Gentile Juan C Amor Richard A Kahn James H Prestegard Lawrence P McIntosh Kevin H Gardner

J Biomol NMR 2004 Jun;29(2):199-204

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas TX 75390-9038, USA.

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June 2004

Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor.

Authors:
Paul J A Erbel Paul B Card Ozgur Karakuzu Richard K Bruick Kevin H Gardner

Proc Natl Acad Sci U S A 2003 Dec 10;100(26):15504-9. Epub 2003 Dec 10.

Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

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December 2003

Identification and biosynthesis of cyclic enterobacterial common antigen in Escherichia coli.

Authors:
Paul J A Erbel Kathleen Barr Ninguo Gao Gerrit J Gerwig Paul D Rick Kevin H Gardner

J Bacteriol 2003 Mar;185(6):1995-2004

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9038, USA.

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March 2003

Studies on the relevance of the glycan at Asn-52 of the alpha-subunit of human chorionic gonadotropin in the alphabeta dimer.

Authors:
Paul J A Erbel Simon R Haseley Johannis P Kamerling Johannes F G Vliegenthart

Biochem J 2002 Jun;364(Pt 2):485-95

Department of Bio-Organic Chemistry, Bijvoet Center, Utrecht University, P.O. Box 80.075, NL-3508 TB Utrecht, The Netherlands.

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June 2002