Paul DaSilva-Jardine

Paul DaSilva-Jardine

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Paul DaSilva-Jardine

Paul DaSilva-Jardine

Publications by authors named "Paul DaSilva-Jardine"

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22Publications

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Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol Production.

Circ Res 2018 May 9;122(10):1369-1384. Epub 2018 Mar 9.

From the Institut National de la Santé et de la Recherche Médicale (Inserm) U1065, Université Côte d'Azur, Centre Méditerranéen de Médecine Moléculaire (C3M), Atip-Avenir, Fédération Hospitalo-Universitaire (FHU) Oncoage, Nice, France (M.V., S.I., L.-E.A., E.G., S.M., L.B., R.G., L.Y.-C.)

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http://dx.doi.org/10.1161/CIRCRESAHA.117.312333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034181PMC
May 2018

Selective Activation of AMPK 1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.

J Pharmacol Exp Ther 2017 05 13;361(2):303-311. Epub 2017 Mar 13.

CVMET Research Unit (C.T.S., R.A.M., E.C., A.R., J.W., A.J., B.S.M., M.A., H.G., M.M., K.C., E.B., M.J.B., P.D.-J., T.R.), Worldwide Medicinal Chemistry (K.O.C., D.J.E.), and Pharmacokinetics, Dynamics, & Metabolism (A.S.K., D.A.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Worldwide Medicinal Chemistry (M.C., R.K., F.R., A.S., N.E.G.), and Drug Safety Research and Development (J.M.K., T.M.C., A.C.O., G.G.B.), Pfizer Worldwide Research and Development, Groton, Connecticut.

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http://dx.doi.org/10.1124/jpet.116.237925DOI Listing
May 2017

Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats.

Bioorg Med Chem Lett 2006 Apr 26;16(7):1799-802. Epub 2006 Jan 26.

Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.01.018DOI Listing
April 2006

Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands.

Bioorg Med Chem Lett 2005 Dec 10;15(24):5562-6. Epub 2005 Oct 10.

Cardiovascular and Metabolic Diseases, Medicinal Chemistry, Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA.

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http://dx.doi.org/10.1016/j.bmcl.2005.08.010DOI Listing
December 2005

Potent and selective, sulfamide-based human beta 3-adrenergic receptor agonists.

Bioorg Med Chem Lett 2004 Jun;14(12):3235-40

Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton, CT 06340, USA.

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http://dx.doi.org/10.1016/j.bmcl.2004.03.089DOI Listing
June 2004

Structure-activity relationship studies on 2-heteroaryl-4-arylimidazoles NPY5 receptor antagonists.

Bioorg Med Chem Lett 2003 Oct;13(20):3593-6

Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton, CT 06340, USA.

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October 2003

Structure-activity relationships in a series of NPY Y5 antagonists: 3-amido-9-ethylcarbazoles, core-modified analogues and amide isosteres.

Bioorg Med Chem Lett 2003 Jun;13(12):1989-92

Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton, CT 06340, USA.

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June 2003