Paul D Robbins

Paul D Robbins

UNVERIFIED PROFILE

Are you Paul D Robbins?   Register this Author

Register author
Paul D Robbins

Paul D Robbins

Publications by authors named "Paul D Robbins"

Are you Paul D Robbins?   Register this Author

99Publications

2056Reads

47Profile Views

Murine models of accelerated aging and musculoskeletal disease.

Bone 2019 Aug 4;125:122-127. Epub 2019 Mar 4.

Institute on the Biology of Aging and Metabolism, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, United States of America; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, United States of America. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.03.002DOI Listing
August 2019

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy.

EBioMedicine 2019 Jul 5;45:588-605. Epub 2019 Jul 5.

Uxía Nogueira-Recalde, Irene Lorenzo Gómez, Francisco J. Blanco and Beatriz Caramés, Grupo de Biología del Cartílago, Servicio de Reumatología, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complejo Hospitalario Universitario de A Coruña, Sergas, A Coruña, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2019.06.049DOI Listing
July 2019

Creating the Next Generation of Translational Geroscientists.

J Am Geriatr Soc 2019 Jul 9. Epub 2019 Jul 9.

Robert and Arlene Kogod Center on Aging and the Division of Geriatric Medicine and Gerontology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgs.16055DOI Listing
July 2019

Signal Transduction, Ageing and Disease.

Subcell Biochem 2019;91:227-247

Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-981-13-3681-2_9DOI Listing
June 2019

Oxidative stress-induced senescence markedly increases disc cell bioenergetics.

Mech Ageing Dev 2019 06 17;180:97-106. Epub 2019 Apr 17.

Department of Orthopedic Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA, 15213, USA; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00476374183019
Publisher Site
http://dx.doi.org/10.1016/j.mad.2019.04.006DOI Listing
June 2019

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs.

J Vis Exp 2019 Jun 28(148). Epub 2019 Jun 28.

Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota; Institute on the Biology of Aging and Metabolism, University of Minnesota;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/58133DOI Listing
June 2019

Measuring biological age in mice using differential mass spectrometry.

Aging (Albany NY) 2019 Feb;11(3):1045-1061

Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.101810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382423PMC
February 2019

Mouse Models of Accelerated Cellular Senescence.

Methods Mol Biol 2019 ;1896:203-230

Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/978-1-4939-8931-7_17
Publisher Site
http://dx.doi.org/10.1007/978-1-4939-8931-7_17DOI Listing
January 2019

Methods to Quantify the NF-κB Pathway During Senescence.

Methods Mol Biol 2019 ;1896:231-250

Department of Molecular Medicine and Center on Aging, The Scripps Research Institute, Jupiter, FL, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/978-1-4939-8931-7_18
Publisher Site
http://dx.doi.org/10.1007/978-1-4939-8931-7_18DOI Listing
January 2019

Cellular senescence in intervertebral disc aging and degeneration.

Curr Mol Biol Rep 2018 Dec 25;4(4):180-190. Epub 2018 Oct 25.

Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s40610-018-0108-8
Publisher Site
http://dx.doi.org/10.1007/s40610-018-0108-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248341PMC
December 2018

Development of Clinical Trials to Extend Healthy Lifespan.

Cardiovasc Endocrinol Metab 2018 Dec;7(4):80-83

Department of Medicine, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/XCE.0000000000000159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428447PMC
December 2018

Treating Age-Related Diseases with Somatic Stem Cells.

Adv Exp Med Biol 2018 ;1056:29-45

Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-319-74470-4_3DOI Listing
November 2018

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Authors:
Clotilde Théry Kenneth W Witwer Elena Aikawa Maria Jose Alcaraz Johnathon D Anderson Ramaroson Andriantsitohaina Anna Antoniou Tanina Arab Fabienne Archer Georgia K Atkin-Smith D Craig Ayre Jean-Marie Bach Daniel Bachurski Hossein Baharvand Leonora Balaj Shawn Baldacchino Natalie N Bauer Amy A Baxter Mary Bebawy Carla Beckham Apolonija Bedina Zavec Abderrahim Benmoussa Anna C Berardi Paolo Bergese Ewa Bielska Cherie Blenkiron Sylwia Bobis-Wozowicz Eric Boilard Wilfrid Boireau Antonella Bongiovanni Francesc E Borràs Steffi Bosch Chantal M Boulanger Xandra Breakefield Andrew M Breglio Meadhbh Á Brennan David R Brigstock Alain Brisson Marike Ld Broekman Jacqueline F Bromberg Paulina Bryl-Górecka Shilpa Buch Amy H Buck Dylan Burger Sara Busatto Dominik Buschmann Benedetta Bussolati Edit I Buzás James Bryan Byrd Giovanni Camussi David Rf Carter Sarah Caruso Lawrence W Chamley Yu-Ting Chang Chihchen Chen Shuai Chen Lesley Cheng Andrew R Chin Aled Clayton Stefano P Clerici Alex Cocks Emanuele Cocucci Robert J Coffey Anabela Cordeiro-da-Silva Yvonne Couch Frank Aw Coumans Beth Coyle Rossella Crescitelli Miria Ferreira Criado Crislyn D'Souza-Schorey Saumya Das Amrita Datta Chaudhuri Paola de Candia Eliezer F De Santana Olivier De Wever Hernando A Del Portillo Tanguy Demaret Sarah Deville Andrew Devitt Bert Dhondt Dolores Di Vizio Lothar C Dieterich Vincenza Dolo Ana Paula Dominguez Rubio Massimo Dominici Mauricio R Dourado Tom Ap Driedonks Filipe V Duarte Heather M Duncan Ramon M Eichenberger Karin Ekström Samir El Andaloussi Celine Elie-Caille Uta Erdbrügger Juan M Falcón-Pérez Farah Fatima Jason E Fish Miguel Flores-Bellver András Försönits Annie Frelet-Barrand Fabia Fricke Gregor Fuhrmann Susanne Gabrielsson Ana Gámez-Valero Chris Gardiner Kathrin Gärtner Raphael Gaudin Yong Song Gho Bernd Giebel Caroline Gilbert Mario Gimona Ilaria Giusti Deborah Ci Goberdhan André Görgens Sharon M Gorski David W Greening Julia Christina Gross Alice Gualerzi Gopal N Gupta Dakota Gustafson Aase Handberg Reka A Haraszti Paul Harrison Hargita Hegyesi An Hendrix Andrew F Hill Fred H Hochberg Karl F Hoffmann Beth Holder Harry Holthofer Baharak Hosseinkhani Guoku Hu Yiyao Huang Veronica Huber Stuart Hunt Ahmed Gamal-Eldin Ibrahim Tsuneya Ikezu Jameel M Inal Mustafa Isin Alena Ivanova Hannah K Jackson Soren Jacobsen Steven M Jay Muthuvel Jayachandran Guido Jenster Lanzhou Jiang Suzanne M Johnson Jennifer C Jones Ambrose Jong Tijana Jovanovic-Talisman Stephanie Jung Raghu Kalluri Shin-Ichi Kano Sukhbir Kaur Yumi Kawamura Evan T Keller Delaram Khamari Elena Khomyakova Anastasia Khvorova Peter Kierulf Kwang Pyo Kim Thomas Kislinger Mikael Klingeborn David J Klinke Miroslaw Kornek Maja M Kosanović Árpád Ferenc Kovács Eva-Maria Krämer-Albers Susanne Krasemann Mirja Krause Igor V Kurochkin Gina D Kusuma Sören Kuypers Saara Laitinen Scott M Langevin Lucia R Languino Joanne Lannigan Cecilia Lässer Louise C Laurent Gregory Lavieu Elisa Lázaro-Ibáñez Soazig Le Lay Myung-Shin Lee Yi Xin Fiona Lee Debora S Lemos Metka Lenassi Aleksandra Leszczynska Isaac Ts Li Ke Liao Sten F Libregts Erzsebet Ligeti Rebecca Lim Sai Kiang Lim Aija Linē Karen Linnemannstöns Alicia Llorente Catherine A Lombard Magdalena J Lorenowicz Ákos M Lörincz Jan Lötvall Jason Lovett Michelle C Lowry Xavier Loyer Quan Lu Barbara Lukomska Taral R Lunavat Sybren Ln Maas Harmeet Malhi Antonio Marcilla Jacopo Mariani Javier Mariscal Elena S Martens-Uzunova Lorena Martin-Jaular M Carmen Martinez Vilma Regina Martins Mathilde Mathieu Suresh Mathivanan Marco Maugeri Lynda K McGinnis Mark J McVey David G Meckes Katie L Meehan Inge Mertens Valentina R Minciacchi Andreas Möller Malene Møller Jørgensen Aizea Morales-Kastresana Jess Morhayim François Mullier Maurizio Muraca Luca Musante Veronika Mussack Dillon C Muth Kathryn H Myburgh Tanbir Najrana Muhammad Nawaz Irina Nazarenko Peter Nejsum Christian Neri Tommaso Neri Rienk Nieuwland Leonardo Nimrichter John P Nolan Esther Nm Nolte-'t Hoen Nicole Noren Hooten Lorraine O'Driscoll Tina O'Grady Ana O'Loghlen Takahiro Ochiya Martin Olivier Alberto Ortiz Luis A Ortiz Xabier Osteikoetxea Ole Østergaard Matias Ostrowski Jaesung Park D Michiel Pegtel Hector Peinado Francesca Perut Michael W Pfaffl Donald G Phinney Bartijn Ch Pieters Ryan C Pink David S Pisetsky Elke Pogge von Strandmann Iva Polakovicova Ivan Kh Poon Bonita H Powell Ilaria Prada Lynn Pulliam Peter Quesenberry Annalisa Radeghieri Robert L Raffai Stefania Raimondo Janusz Rak Marcel I Ramirez Graça Raposo Morsi S Rayyan Neta Regev-Rudzki Franz L Ricklefs Paul D Robbins David D Roberts Silvia C Rodrigues Eva Rohde Sophie Rome Kasper Ma Rouschop Aurelia Rughetti Ashley E Russell Paula Saá Susmita Sahoo Edison Salas-Huenuleo Catherine Sánchez Julie A Saugstad Meike J Saul Raymond M Schiffelers Raphael Schneider Tine Hiorth Schøyen Aaron Scott Eriomina Shahaj Shivani Sharma Olga Shatnyeva Faezeh Shekari Ganesh Vilas Shelke Ashok K Shetty Kiyotaka Shiba Pia R-M Siljander Andreia M Silva Agata Skowronek Orman L Snyder Rodrigo Pedro Soares Barbara W Sódar Carolina Soekmadji Javier Sotillo Philip D Stahl Willem Stoorvogel Shannon L Stott Erwin F Strasser Simon Swift Hidetoshi Tahara Muneesh Tewari Kate Timms Swasti Tiwari Rochelle Tixeira Mercedes Tkach Wei Seong Toh Richard Tomasini Ana Claudia Torrecilhas Juan Pablo Tosar Vasilis Toxavidis Lorena Urbanelli Pieter Vader Bas Wm van Balkom Susanne G van der Grein Jan Van Deun Martijn Jc van Herwijnen Kendall Van Keuren-Jensen Guillaume van Niel Martin E van Royen Andre J van Wijnen M Helena Vasconcelos Ivan J Vechetti Tiago D Veit Laura J Vella Émilie Velot Frederik J Verweij Beate Vestad Jose L Viñas Tamás Visnovitz Krisztina V Vukman Jessica Wahlgren Dionysios C Watson Marca Hm Wauben Alissa Weaver Jason P Webber Viktoria Weber Ann M Wehman Daniel J Weiss Joshua A Welsh Sebastian Wendt Asa M Wheelock Zoltán Wiener Leonie Witte Joy Wolfram Angeliki Xagorari Patricia Xander Jing Xu Xiaomei Yan María Yáñez-Mó Hang Yin Yuana Yuana Valentina Zappulli Jana Zarubova Vytautas Žėkas Jian-Ye Zhang Zezhou Zhao Lei Zheng Alexander R Zheutlin Antje M Zickler Pascale Zimmermann Angela M Zivkovic Davide Zocco Ewa K Zuba-Surma

J Extracell Vesicles 2018 23;7(1):1535750. Epub 2018 Nov 23.

Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland.

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1
Publisher Site
http://dx.doi.org/10.1080/20013078.2018.1535750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322352PMC
November 2018

Arthritis gene therapy is becoming a reality.

Nat Rev Rheumatol 2018 Jul;14(7):381-382

Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41584-018-0009-5DOI Listing
July 2018

Hsp90 inhibitors as senolytic drugs to extend healthy aging.

Cell Cycle 2018 23;17(9):1048-1055. Epub 2018 Jul 23.

a Department of Molecular Medicine and The Center on Aging , The Scripps Research Institute , Jupiter , FL , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15384101.2018.1475828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110594PMC
July 2018

Nuclear Genomic Instability and Aging.

Annu Rev Biochem 2018 06;87:295-322

Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute Florida, Jupiter, Florida 33458, USA; email:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-biochem-062917-012239DOI Listing
June 2018

Senotherapeutics for healthy ageing.

Nat Rev Drug Discov 2018 05 13;17(5):377. Epub 2018 Apr 13.

Department of Molecular Medicine and The Center on Aging, The Scripps Research Institute, Jupiter, FL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrd.2018.44DOI Listing
May 2018

Gene Delivery to Joints by Intra-Articular Injection.

Hum Gene Ther 2018 01;29(1):2-14

3 Department of Metabolism and Aging, The Scripps Research Institute , Jupiter, Florida.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/hum.2017.181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773261PMC
January 2018

Arthritis Gene Therapy Approved in Korea.

J Am Acad Orthop Surg 2018 01;26(2):e36-e38

From the Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, MN (Dr. Evans), the Department of Orthopaedics and Rehabilitation, University of Florida College of Medicine, Gainesville, FL (Dr. Ghivizzani), and the Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL (Dr. Robbins).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5435/JAAOS-D-17-00695DOI Listing
January 2018

Extracellular vesicles and aging.

Authors:
Paul D Robbins

Stem Cell Investig 2017 19;4:98. Epub 2017 Dec 19.

Department of Molecular Medicine and the Center on Aging, the Scripps Research Institute, Jupiter, Florida, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/sci.2017.12.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762993PMC
December 2017

ADAMTS5 Deficiency Protects Mice From Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration.

Spine (Phila Pa 1976) 2017 Oct;42(20):1521-1528

*Department of Orthopedic Surgery, University of Pittsburgh School of Medicine, PA †Department of Medicine, University of Pittsburgh School of Medicine, PA ‡Department of Environmental and Occupational Health, University of Pittsburgh, PA §McGill Scoliosis and Spine Group, Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada ¶Department of Metabolism & Aging, The Scripps Research Institute, FL ||Department of Physical Medicine and Rehabilitation, University of Pittsburgh, PA **Department of Orthopedic Surgery, Harvard Medical School, Brigham and Women's Hospital, MA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/BRS.0000000000002258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633483PMC
October 2017

The Clinical Potential of Senolytic Drugs.

J Am Geriatr Soc 2017 Oct 4;65(10):2297-2301. Epub 2017 Sep 4.

Department of Molecular Medicine and the Center on Aging, Scripps Research Institute, Jupiter, Florida.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgs.14969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641223PMC
October 2017

Inhibition of NF-κB improves the stress resistance and myogenic differentiation of MDSPCs isolated from naturally aged mice.

PLoS One 2017 22;12(6):e0179270. Epub 2017 Jun 22.

Department of Orthopaedic Surgery, Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179270PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480862PMC
September 2017

Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype.

Mech Ageing Dev 2017 09 19;166:16-23. Epub 2017 Aug 19.

Department of Orthopaedic Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2017.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632945PMC
September 2017

Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2 Scripps Symposium on the Biology of Aging.

Aging Cell 2017 08 6;16(4):610-614. Epub 2017 Jun 6.

Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL, 33458, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/acel.12620
Publisher Site
http://dx.doi.org/10.1111/acel.12620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506446PMC
August 2017

Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism.

Aging Cell 2017 06 23;16(3):480-487. Epub 2017 Feb 23.

Department of Metabolism and Aging, The Scripps Research Institute-Florida, Jupiter, FL, 33458, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/acel.12571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418207PMC
June 2017

Quantitative Analysis of Cellular Senescence in Culture and In Vivo.

Curr Protoc Cytom 2017 01 5;79:9.51.1-9.51.25. Epub 2017 Jan 5.

Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, Florida.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpcy.16DOI Listing
January 2017

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms.

J Gerontol A Biol Sci Med Sci 2016 11 16;71(11):1388-1394. Epub 2016 Aug 16.

Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055650PMC
http://dx.doi.org/10.1093/gerona/glw112DOI Listing
November 2016

NF-κB activation with aging: characterization and therapeutic inhibition.

Methods Mol Biol 2015 ;1280:543-57

Department of Metabolism and Aging, The Scripps Research Institute, 130 Scripps Way, #3B3, Jupiter, FL, 33458, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-2422-6_32DOI Listing
November 2015

IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice.

Eur J Immunol 2015 Nov 1;45(11):3114-25. Epub 2015 Sep 1.

Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.201445403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823813PMC
November 2015

D-Amino Acid Substitution of Peptide-Mediated NF-κB Suppression in mdx Mice Preserves Therapeutic Benefit in Skeletal Muscle, but Causes Kidney Toxicity.

Mol Med 2015 May 22;21:442-52. Epub 2015 May 22.

Neurology Service, Department of Veterans Affairs Medical Center, Pittsburgh, Pennsylvania, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2119/molmed.2013.00141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559531PMC
May 2015

Cell-type specific penetrating peptides: therapeutic promises and challenges.

Molecules 2015 Jul 20;20(7):13055-70. Epub 2015 Jul 20.

Department of Metabolism and Aging, Scripps Florida, Jupiter, FL 33458, USA.

View Article

Download full-text PDF

Source
http://www.mdpi.com/1420-3049/20/7/13055
Publisher Site
http://dx.doi.org/10.3390/molecules200713055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331998PMC
July 2015

D-Amino Acid Substitution of Peptide-Mediated NF-κB Suppression in mdx Mice Preserves Therapeutic Benefit in Skeletal Muscle, but Causes Kidney Toxicity.

Mol Med 2015 May 22;21:442-52. Epub 2015 May 22.

Neurology Service, Department of Veterans Affairs Medical Center, Pittsburgh, Pennsylvania, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2119/molmed.2013.00141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559531PMC
May 2015

Regulation of substrate oxidation preferences in muscle by the peptide hormone adropin.

Diabetes 2014 Oct 21;63(10):3242-52. Epub 2014 May 21.

Department of Metabolism and Aging, Scripps Research Institute, Jupiter, FL Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, MO

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db14-0388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171656PMC
October 2014

Regulation of immune responses by extracellular vesicles.

Nat Rev Immunol 2014 Mar;14(3):195-208

Departments of Surgery and Immunology and T.E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nri3622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350779PMC
March 2014

Pharmacologic IKK/NF-κB inhibition causes antigen presenting cells to undergo TNFα dependent ROS-mediated programmed cell death.

Sci Rep 2014 Jan 10;4:3631. Epub 2014 Jan 10.

1] Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219 [2] Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, Florida 33458.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep03631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887388PMC
January 2014

SIRT1 associates with eIF2-alpha and regulates the cellular stress response.

Sci Rep 2011 9;1:150. Epub 2011 Nov 9.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep00150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252071PMC
September 2013

Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs.

Mech Ageing Dev 2013 Jan-Feb;134(1-2):35-42. Epub 2012 Dec 19.

Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2012.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558562PMC
July 2013

Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration.

J Orthop Res 2013 Jul 6;31(7):1150-7. Epub 2013 Feb 6.

Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jor.22320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668354PMC
July 2013

Isolation of muscle-derived stem/progenitor cells based on adhesion characteristics to collagen-coated surfaces.

Methods Mol Biol 2013 ;976:53-65

Department of Orthopaedic Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-62703-317-6_5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731996PMC
July 2013

An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints.

J Orthop Res 2013 Jun 11;31(6):831-7. Epub 2013 Mar 11.

Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, E1641 Biomedical Science Tower, Pittsburgh, Pennsylvania 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jor.22204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628921PMC
June 2013

DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism.

J Bone Miner Res 2013 May;28(5):1214-28

Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbmr.1851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662975PMC
May 2013

Arthritis gene therapy and its tortuous path into the clinic.

Transl Res 2013 Apr 29;161(4):205-16. Epub 2013 Jan 29.

Department of Orthopedic Surgery, Harvard Medical School, Boston, Mass., USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.trsl.2013.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602127PMC
April 2013

Protein transduction domains: applications for molecular medicine.

Curr Gene Ther 2012 Oct;12(5):374-80

Research Associate, Dept. of Developmental Biology, University of Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
October 2012

Exosomes released from Mycoplasma infected tumor cells activate inhibitory B cells.

PLoS One 2012 27;7(4):e36138. Epub 2012 Apr 27.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036138PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338602PMC
September 2012

The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner.

Aging Cell 2012 Aug 22;11(4):714-6. Epub 2012 May 22.

Department of Chemistry, University of California, Riverside, CA 92521-0403, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1474-9726.2012.00828.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399950PMC
August 2012

Immunosuppressive exosomes: a new approach for treating arthritis.

Int J Rheumatol 2012 6;2012:573528. Epub 2012 Mar 6.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2012/573528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324137PMC
August 2012

Plasma-derived MHC class II+ exosomes from tumor-bearing mice suppress tumor antigen-specific immune responses.

Eur J Immunol 2012 Jul;42(7):1778-84

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.201141978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471134PMC
July 2012

The roles of tumor-derived exosomes in cancer pathogenesis.

Clin Dev Immunol 2011 30;2011:842849. Epub 2011 Nov 30.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2011/842849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235485PMC
April 2012

NF-κB negatively impacts the myogenic potential of muscle-derived stem cells.

Mol Ther 2012 Mar 13;20(3):661-8. Epub 2011 Dec 13.

Stem Cell Research Center, School of Medicine and Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mt.2011.261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293604PMC
March 2012

Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model.

PLoS One 2011 2;6(8):e22517. Epub 2011 Aug 2.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022517PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149056PMC
December 2011

NF-κB in Aging and Disease.

Aging Dis 2011 Dec 2;2(6):449-65. Epub 2011 Dec 2.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295063PMC
December 2011

Premature aging-related peripheral neuropathy in a mouse model of progeria.

Mech Ageing Dev 2011 Aug 11;132(8-9):437-42. Epub 2011 May 11.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, PA 15213-1863, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2011.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179831PMC
August 2011

Dedifferentiation rescues senescence of progeria cells but only while pluripotent.

Stem Cell Res Ther 2011 Jun 1;2(3):28. Epub 2011 Jun 1.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, 523 Bridgeside Point II, 450 Technology Drive, Pittsburgh, PA 15219, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/scrt69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152996PMC
June 2011

Getting arthritis gene therapy into the clinic.

Nat Rev Rheumatol 2011 04 7;7(4):244-9. Epub 2010 Dec 7.

Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RN-115, Boston, MA 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrrheum.2010.193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460537PMC
April 2011

Identification and characterization of tissue-specific protein transduction domains using peptide phage display.

Methods Mol Biol 2011 ;683:277-89

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Biomedical Science Tower, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-60761-919-2_20DOI Listing
February 2011

Induction of pregnancy during established EAE halts progression of CNS autoimmune injury via pregnancy-specific serum factors.

J Neuroimmunol 2011 Jan 14;230(1-2):105-13. Epub 2010 Oct 14.

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, 760 Biomedical Research Tower, 460 W 12th Avenue, Columbus, OH 43210-1239, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jneuroim.2010.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021646PMC
January 2011

In vivo expression of HGF/NK1 and GLP-1 From dsAAV vectors enhances pancreatic ß-cell proliferation and improves pathology in the db/db mouse model of diabetes.

Diabetes 2010 Dec 14;59(12):3108-16. Epub 2010 Sep 14.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db09-1886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992772PMC
December 2010

Accelerated aging of intervertebral discs in a mouse model of progeria.

J Orthop Res 2010 Dec;28(12):1600-7

Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jor.21153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477798PMC
December 2010

Cationic and tissue-specific protein transduction domains identification, characterization, and therapeutic application.

Adv Genet 2010 ;69:83-95

Department of Microbiology and Molecular Genetics, 450 Technology Drive, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00652660106900
Publisher Site
http://dx.doi.org/10.1016/S0065-2660(10)69007-4DOI Listing
November 2010

Identification of a cardiac specific protein transduction domain by in vivo biopanning using a M13 phage peptide display library in mice.

PLoS One 2010 Aug 17;5(8):e12252. Epub 2010 Aug 17.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012252PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923200PMC
August 2010

Dendritic cells transduced to express interleukin 4 reduce diabetes onset in both normoglycemic and prediabetic nonobese diabetic mice.

PLoS One 2010 Jul 29;5(7):e11848. Epub 2010 Jul 29.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011848PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912295PMC
July 2010

SIRT1 negatively regulates the mammalian target of rapamycin.

PLoS One 2010 Feb 15;5(2):e9199. Epub 2010 Feb 15.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009199PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821410PMC
February 2010

B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function.

Eur J Immunol 2009 Nov;39(11):3084-90

Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.200939407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075967PMC
November 2009

Gene therapy of the rheumatic diseases: 1998 to 2008.

Arthritis Res Ther 2009 30;11(1):209. Epub 2009 Jan 30.

Center for Advanced Orthopaedic Studies, Harvard Medical School, BIDMC-RN115, 330 Brookline Avenue, Boston, MA 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/ar2563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688220PMC
September 2009

Orthopedic gene therapy in 2008.

Mol Ther 2009 Feb 9;17(2):231-44. Epub 2008 Dec 9.

Center for Molecular Orthopaedics, Harvard Medical School, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mt.2008.265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835052PMC
February 2009

PTD-mediated loading of tumor-seeking lymphocytes with prodrug-activating enzymes.

AAPS J 2008 Dec 23;10(4):614-21. Epub 2008 Dec 23.

Department of Immunology, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, 5150 Center Avenue, Suite 1A-106, Pittsburgh, Pennsylvania. 15232, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/s12248-008-9066-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628208PMC
December 2008